PathWhiz ID | Pathway | Meta Data |
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PW146066View Pathway |
drug action
Choline C 11 Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 17:19 Last Updated: October 07, 2023 at 17:19 |
PW132602View Pathway |
Choline C-11 Drug MetabolismHomo sapiens
Choline C-11 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Choline C-11 passes through the liver and is then excreted from the body mainly through the kidney.
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Creator: Ray Kruger Created On: September 21, 2023 at 22:35 Last Updated: September 21, 2023 at 22:35 |
PW146199View Pathway |
drug action
Choline C-11 Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 17:39 Last Updated: October 07, 2023 at 17:39 |
PW144268View Pathway |
drug action
Choline Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 13:04 Last Updated: October 07, 2023 at 13:04 |
PW002494View Pathway |
Choline MetabolismSaccharomyces cerevisiae
The metabolism of choline containing lipids begins with glycerone phosphate either reacting with glycerol-3-phosphate dehydrogenase resulting in the release of glycerol-3-phosphate or it can react with glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase resulting in the release of a 1-acylglycerone 3-phosphate. Glycerol-3-phosphate reacts with glycerol-3-phosphate O-acyltransferase resulting in the release of an acyl glycerol phosphate. 1-acylglycerone 3-phosphate 1-acyl dihydroxyacetone phosphate reductase resulting in the release of a acyl glycerol phosphate. The latter compound then reacts with a oleoyl-CoA: lysophosphatidate acyltransferase resulting in the release of a phosphatidic acid. The latter compound reacts with Phosphatidic acid phosphohydrolase 1 resulting in the release of diacyl glycerol. This compound can be metabolized through a CTP-dependent diacylglycerol kinase 1 resulting in the release of a phosphatidic acid.
Phosphatidylcholine is degraded by a phospholipase resulting in the release of choline and phosphatidic acid.
Phosphatidylcholine can react with lysophospholipase resulting in the release of two fatty acids and a glycerophosphocholine. The latter compound reacts with a glycerophosphodiester phosphodiesterase resulting in the release of glycerol 3-phosphate and choline. Choline is phosphorylated through a choline kinase resulting in the release of phosphorycholine which can react with choline-phosphate cytidyltransferase resulting in the release of citicoline. The latter compound reacts with a diacylglycerol through a diacylglycerol cholinephosphotransferase resulting in the release of a phosphatidylcholine.
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Creator: miguel ramirez Created On: March 03, 2016 at 11:10 Last Updated: March 03, 2016 at 11:10 |
PW132268View Pathway |
Choline salicylate Drug MetabolismHomo sapiens
Choline salicylate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Choline salicylate passes through the liver and is then excreted from the body mainly through the kidney.
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Creator: Ray Kruger Created On: September 21, 2023 at 20:30 Last Updated: September 21, 2023 at 20:30 |
PW146735View Pathway |
drug action
Choline salicylate Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 18:55 Last Updated: October 07, 2023 at 18:55 |
PW000098View Pathway |
disease
Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)Homo sapiens
Chondrodysplasia Punctata 2, X Linked Dominant (CDPX2; CPDXD; CPXD; Conradi-Hunermann Syndrome; Happle Syndrome; Conradi-Hunermann-Happle Syndrome is caused by a mutation in the gene encoding delta(8)-delta(7) sterol isomerase emopamil-binding protein (EBP). EBP contains the code for the enzyme 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, which normally catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. A defect in this enzyme causes accumulation of 8-dehydrocholesterol and 8(9)cholestenol in the plasma. Symptoms include alopecia, dysmorphism, hyperkeratosis, ichthyosis, kyphoscoliosis, limb abnormalities and deformities, and mental retardation.
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Creator: WishartLab Created On: August 01, 2013 at 15:52 Last Updated: August 01, 2013 at 15:52 |
PW121716View Pathway |
disease
Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)Mus musculus
Chondrodysplasia Punctata 2, X Linked Dominant (CDPX2; CPDXD; CPXD; Conradi-Hunermann Syndrome; Happle Syndrome; Conradi-Hunermann-Happle Syndrome is caused by a mutation in the gene encoding delta(8)-delta(7) sterol isomerase emopamil-binding protein (EBP). EBP contains the code for the enzyme 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, which normally catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. A defect in this enzyme causes accumulation of 8-dehydrocholesterol and 8(9)cholestenol in the plasma. Symptoms include alopecia, dysmorphism, hyperkeratosis, ichthyosis, kyphoscoliosis, limb abnormalities and deformities, and mental retardation.
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Creator: Ana Marcu Created On: September 10, 2018 at 15:49 Last Updated: September 10, 2018 at 15:49 |
PW127203View Pathway |
disease
Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)Homo sapiens
Chondrodysplasia Punctata 2, X Linked Dominant (CDPX2; CPDXD; CPXD; Conradi-Hunermann Syndrome; Happle Syndrome; Conradi-Hunermann-Happle Syndrome is caused by a mutation in the gene encoding delta(8)-delta(7) sterol isomerase emopamil-binding protein (EBP). EBP contains the code for the enzyme 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, which normally catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. A defect in this enzyme causes accumulation of 8-dehydrocholesterol and 8(9)cholestenol in the plasma. Symptoms include alopecia, dysmorphism, hyperkeratosis, ichthyosis, kyphoscoliosis, limb abnormalities and deformities, and mental retardation.
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Creator: Ray Kruger Created On: November 08, 2022 at 14:58 Last Updated: November 08, 2022 at 14:58 |