PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145513 View Pathway	drug action Cholic Acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:58 Last Updated: October 07, 2023 at 15:58
PW012887 View Pathway	metabolic Choline Biosynthesis I Arabidopsis thaliana Choline is a nitrogen-containing, water-soluble nutrient that is incorporated into the headgroups of membrane phospholipids such as phosphatidylcholine. Two pathways exist for choline biosynthesis whereby serine becomes choline. Both of these pathways take place in the cytosol. This is the first pathway of choline biosynthesis. First, serine decarboxylase (SDC) uses a proton and a pyridoxal 5'-phosphate cofactor to catalyze the conversion of L-serine to ethanolamine, producing carbon dioxide as a byproduct. Second, ethanolamine kinase, localized to the cell membrane (coloured dark green in the image), uses ATP to catalyze the conversion of ethanolamine to O-phosphoethanolamine. Note that this is only the probable ethanolamine kinase in Arabidopsis thaliana and requires further research to confirm its function. Steps 3, 4, and 5 are catalyzed by phosphoethanolamine N-methyltransferase (PEAMT). These three sequential N-methylation steps convert phosphoethanolamine to phosphocholine and utilize S-adenosyl-L-methionine as a methyl donor. The intermediates are as follows: O-Phosphoethanolamine, N-methylethanolamine phosphate, and N-dimethylethanolamine phosphate. Sixth, phosphoethanolamine/phosphocholine phosphatase catalyzes the synthesis of choline from phosphocholine. It requires magnesium as a cofactor. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 21, 2017 at 17:55 Last Updated: February 21, 2017 at 17:55
PW012888 View Pathway	metabolic Choline Biosynthesis II Arabidopsis thaliana Choline is a nitrogen-containing, water-soluble nutrient that is incorporated into the headgroups of membrane phospholipids such as phosphatidylcholine. Two pathways exist for choline biosynthesis whereby serine becomes choline. Both of these pathways take place in the cytosol. This is the second pathway of choline biosynthesis. First, serine decarboxylase (SDC) uses a proton and a pyridoxal 5'-phosphate cofactor to catalyze the conversion of L-serine to ethanolamine, producing carbon dioxide as a byproduct. Second, ethanolamine kinase, localized to the cell membrane (coloured dark green in the image), uses ATP to catalyze the conversion of ethanolamine to O-phosphoethanolamine. Note that this is only the probable ethanolamine kinase in Arabidopsis thaliana and requires further research to confirm its function. Steps 3, 4, and 5 are catalyzed by phosphoethanolamine N-methyltransferase (PEAMT). These three sequential N-methylation steps convert phosphoethanolamine to phosphocholine and utilize S-adenosyl-L-methionine as a methyl donor. The intermediates are as follows: O-Phosphoethanolamine, N-methylethanolamine phosphate, and N-dimethylethanolamine phosphate. Sixth, choline-phosphate cytidylyltransferase (CCT) uses CTP to convert phosphocholine to CDP-choline. Seventh, choline/ethanolaminephosphotransferase (AAPT) uses a 1,2-diacyl-sn-glycerol and either magnesium or manganese ions as cofactors to convert CDP-choline into a phosphatidyl choline, producing CMP and a proton as byproducts. Eighth, phospholipase D uses a calcium cofactor and water to convert a phosphatidylcholine to choline, producing a 1,2-diacyl-sn-glycerol 3-phosphate and a proton as byproducts. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 21, 2017 at 21:28 Last Updated: February 21, 2017 at 21:28
PW146066 View Pathway	drug action Choline C 11 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:19 Last Updated: October 07, 2023 at 17:19
PW132602 View Pathway	metabolic Choline C-11 Drug Metabolism Homo sapiens Choline C-11 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Choline C-11 passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:35 Last Updated: September 21, 2023 at 22:35
PW146199 View Pathway	drug action Choline C-11 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:39 Last Updated: October 07, 2023 at 17:39
PW144268 View Pathway	drug action Choline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:04 Last Updated: October 07, 2023 at 13:04
PW002494 View Pathway	metabolic Choline Metabolism Saccharomyces cerevisiae The metabolism of choline containing lipids begins with glycerone phosphate either reacting with glycerol-3-phosphate dehydrogenase resulting in the release of glycerol-3-phosphate or it can react with glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase resulting in the release of a 1-acylglycerone 3-phosphate. Glycerol-3-phosphate reacts with glycerol-3-phosphate O-acyltransferase resulting in the release of an acyl glycerol phosphate. 1-acylglycerone 3-phosphate 1-acyl dihydroxyacetone phosphate reductase resulting in the release of a acyl glycerol phosphate. The latter compound then reacts with a oleoyl-CoA: lysophosphatidate acyltransferase resulting in the release of a phosphatidic acid. The latter compound reacts with Phosphatidic acid phosphohydrolase 1 resulting in the release of diacyl glycerol. This compound can be metabolized through a CTP-dependent diacylglycerol kinase 1 resulting in the release of a phosphatidic acid. Phosphatidylcholine is degraded by a phospholipase resulting in the release of choline and phosphatidic acid. Phosphatidylcholine can react with lysophospholipase resulting in the release of two fatty acids and a glycerophosphocholine. The latter compound reacts with a glycerophosphodiester phosphodiesterase resulting in the release of glycerol 3-phosphate and choline. Choline is phosphorylated through a choline kinase resulting in the release of phosphorycholine which can react with choline-phosphate cytidyltransferase resulting in the release of citicoline. The latter compound reacts with a diacylglycerol through a diacylglycerol cholinephosphotransferase resulting in the release of a phosphatidylcholine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: March 03, 2016 at 11:10 Last Updated: March 03, 2016 at 11:10
PW132268 View Pathway	metabolic Choline salicylate Drug Metabolism Homo sapiens Choline salicylate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Choline salicylate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:30 Last Updated: September 21, 2023 at 20:30
PW146735 View Pathway	drug action Choline salicylate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:55 Last Updated: October 07, 2023 at 18:55