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PathWhiz ID | Pathway | Meta Data |
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PW146322 |
drug action
Chromium picolinate Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 17:56 Last Updated: October 07, 2023 at 17:56 |
PW146839 |
drug action
Chromous sulfate Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 19:09 Last Updated: October 07, 2023 at 19:09 |
PW146121 |
drug action
Chymotrypsin Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 17:27 Last Updated: October 07, 2023 at 17:27 |
PW146749 |
drug action
Cianidanol Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 18:56 Last Updated: October 07, 2023 at 18:56 |
PW127769 |
drug action
Ciclesonide Action PathwayHomo sapiens
Ciclesonide is a glucocorticoid used in the relief of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents. It is also used to treat obstructive airway diseases like asthma, bronchoconstriction, and chronic obstructive pulmonary disease (COPD). Ciclesonide is a pro-drug so it is enzymatically hydrolyzed to C21-desisobutyryl-ciclesonide (des-ciclesonide or RM1), the active metabolite. Des-ciclesonide has anti-inflammatory activity with an affinity for the glucocorticoid receptor that is 120 times higher than ciclesonide. As des-ciclesonide is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) of influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Des-ciclesonide also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Ciclesonide is administered as an inhaler or as a nasal spray.
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Creator: Daphnee Created On: May 31, 2023 at 15:47 Last Updated: May 31, 2023 at 15:47 |
PW145419 |
drug action
Ciclesonide Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 15:47 Last Updated: October 07, 2023 at 15:47 |
PW123610 |
signaling
ciclic AMPHomo sapiens
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Creator: Guest: Anonymous Created On: September 27, 2019 at 13:48 Last Updated: September 27, 2019 at 13:48 |
PW125997 |
Ciclo de KrebsHomo sapiens
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Creator: Guest: Anonymous Created On: May 18, 2021 at 01:33 Last Updated: May 18, 2021 at 01:33 |
PW124247 |
Ciclo de Krebs y destino del esqueleto carbonado de los aminoácidos (CV)Homo sapiens
Ruta metabólica que forma parte de la respiración celular para generar energía a partir de la oxidación de Acetil-CoA.
Destino de los esqueletos carbonados de los aminoácidos que pueden alimentar el ciclo de Krebs.
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Creator: Valeria Created On: October 18, 2020 at 21:40 Last Updated: October 18, 2020 at 21:40 |
PW124278 |
Ciclo de la Urea (CV)Homo sapiens
Ruta metabólica en la cual se degradan aminoácidos para generar un único producto de excreción, la urea.
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Creator: Valeria Created On: October 25, 2020 at 12:33 Last Updated: October 25, 2020 at 12:33 |