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Pyruvate
kinase PKM
Pyruvate
kinase
isozymes R/L
Solute carrier
family 2,
facilitated
glucose
transporter
member 2
Mitochondrial
pyruvate
carrier 1
Monocarboxylate
transporter 1
Neutral amino
acid
transporter
B(0)
Mitochondrial
citrate
transport
protein
Hexokinase-2
Glucose-6-
phosphate
isomerase
6-
phosphofructokinase,
liver type
Fructose-
bisphosphate
aldolase B
Glyceraldehyde-
3-phosphate
dehydrogenase
Phosphoglycerate
kinase 1
Phosphoglycerate
mutase 2
Alpha-enolase
Pyruvate
carboxylase,
mitochondrial
Pyruvate
dehydrogenase
complex
Citrate
synthase,
mitochondrial
L-lactate
dehydrogenase
A-like 6A
Aconitate
hydratase,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
alpha,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
beta,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
gamma,
mitochondrial
Oxoglutarate
dehydrogenase
complex
Succinyl-CoA
ligase
Succinate
dehydrogenase
Fumarate
hydratase,
mitochondrial
Malate
dehydrogenase,
cytoplasmic
Glutamate
dehydrogenase
1,
mitochondrial
Glutaminase
liver isoform,
mitochondrial
Transaldolase
Transketolase
Ribose-5-
phosphate
isomerase
6-
phosphogluconolactonase
Glucose-6-
phosphate
isomerase
Glucose-6-
phosphate
1-dehydrogenase
6-
phosphogluconate
dehydrogenase,
decarboxylating
Cytoplasmic
aconitate
hydratase
Isocitrate
dehydrogenase
[NADP]
cytoplasmic
D-Glucose
D-Glucose
Pyruvic acid
Pyruvic acid
L-Lactic acid
L-Glutamine
L-Glutamine
L-Glutamine
Citric acid
Citric acid
ATP
Glucose 6-phosphate
ADP
Fructose 6-phosphate
ATP
Fructose 1,6-bisphosphate
ADP
D-Glyceraldehyde 3-phosphate
NAD
Glyceric acid 1,3-biphosphate
NADH
ADP
3-
Phosphoglyceric
acid
ATP
2-Phospho-D-
glyceric acid
Phosphoenolpyruvic acid
H
2
O
ATP
ADP
ATP
HCO
3
-
ADP
P
i
Oxalacetic
acid
CoA
NAD
Acetyl-CoA
CO
2
NADH
H
2
O
CoA
NAD
NADH
Isocitric acid
NAD
Oxoglutaric
acid
CO
2
NADH
NAD
CoA
Succinyl-CoA
NADH
CO
2
P
i
GDP
Succinic acid
CoA
GTP
Q
FAD
Fumaric acid
QH
2
FADH
2
L-Malic acid
H
2
O
NAD
NADH
L-Glutamic
acid
H
2
O
NH
3
H
2
O
NH
3
D-Erythrose 4-phosphate
D-Sedoheptulose 7-phosphate
D-Ribose 5-phosphate
Xylulose 5-phosphate
D-Ribulose 5-phosphate
6-Phosphonoglucono-D-lactone
H
2
O
6-Phosphogluconic acid
β-D-Glucose 6-phosphate
NADP
NADPH
H
+
NADP
CO
2
NADPH
Isocitric acid
NADP
Oxoglutaric
acid
NADPH
CO
2
Magnesium
Potassium
Magnesium
Magnesium
Biotin
Manganese
Thiamine
pyrophosphate
Lipoamide
FAD
4Fe-4S
Magnesium
Thiamine
pyrophosphate
Lipoamide
FAD
Magnesium
Thiamine
pyrophosphate
4Fe-4S
Magnesium
L-Lactic acid
Lactate shuttle
Pentose Phosphate Shunt
Citric Acid Cycle
Inner Mitochondrial
Membrane
Outer Mitochondrial
Membrane
Mitochondrion
Cytosol
Glycolysis
Phosphoenolpyruvic acid
Pyruvic acid
L-Lactic acid
2-Phospho-D-glyceric acid
3-Phosphoglyceric acid
Glyceric acid
1,3-biphosphate
D-Glyceraldehyde
3-phosphate
Fructose 6-phosphate
Fructose 1,6-bisphosphate
Pyruvate kinase PKLR
L-lactate dehydrogenase
Pyruvate kinase PKM
Mitochondria
PKM
PKLR
SLC2A2
MPC1
SLC16A1
SLC1A5
Unknown
HK2
GPI
PFKL
ALDOB
GAPDH
PGK1
PGAM2
ENO1
PC
PDHA1
CS
LDHAL6A
ACO2
IDH3A
IDH3B
IDH3G
OGDH
SUCLG1
SUCLG2
SDHA
SDHB
SDHC
SDHD
FH
MDH1
GLUD1
GLS2
TALDO1
TKT
RPIA
PGLS
GPI
G6PD
PGD
ACO1
IDH1
D-Glucose
D-Glucose
Pyruvic acid
Pyruvic acid
L-Lactic acid
L-Glutamine
L-Glutamine
L-Glutamine
Citric acid
Citric acid
Adenosine
triphosphate
Glucose
6-phosphate
Adenosine
diphosphate
Fructose
6-phosphate
Adenosine
triphosphate
Fructose 1,6-
bisphosphate
Adenosine
diphosphate
D-
Glyceraldehyde
3-phosphate
NAD
Glyceric acid
1,3-biphosphate
NADH
Adenosine
diphosphate
3-
Phosphoglyceric
acid
Adenosine
triphosphate
2-Phospho-D-
glyceric acid
Phosphoenolpyruvic
acid
Water
Adenosine
triphosphate
Adenosine
diphosphate
Adenosine
triphosphate
Hydrogen
carbonate
Adenosine
diphosphate
Phosphate
Oxalacetic
acid
Coenzyme A
NAD
Acetyl-CoA
Carbon dioxide
NADH
Water
Coenzyme A
NAD
NADH
Isocitric acid
NAD
Oxoglutaric
acid
Carbon dioxide
NADH
NAD
Coenzyme A
Succinyl-CoA
NADH
Carbon dioxide
Phosphate
Guanosine
diphosphate
Succinic acid
Coenzyme A
Guanosine
triphosphate
Coenzyme Q10
FAD
Fumaric acid
QH(2)
FADH
L-Malic acid
Water
NAD
NADH
L-Glutamic
acid
Water
Ammonia
Water
Ammonia
D-Erythrose
4-phosphate
D-Sedoheptulose
7-phosphate
D-Ribose
5-phosphate
Xylulose
5-phosphate
D-Ribulose
5-phosphate
6-
Phosphonoglucono-
D-lactone
Water
6-
Phosphogluconic
acid
β-D-Glucose
6-phosphate
NADP
NADPH
Hydrogen Ion
NADP
Carbon dioxide
NADPH
Isocitric acid
NADP
Oxoglutaric
acid
NADPH
Carbon dioxide
L-Lactic acid