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Reverse transcriptase protein Solute carrier family 22 member 6 Thymidylate kinase Nucleoside diphosphate kinase A Thymidine kinase, cytosolic Zidovudine 5'-Triphosphate Zidovudine Zidovudine dGTP Zidovudine monophosphate ATP Zidovudine diphosphate ADP ATP ADP ATP ADP H+ Magnesium Viral Proteins Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex HIV Infected Cell Integration Nucleus Viral RNA Viral DNA Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Transcription Translation Less viral proteins produced, fewer viruses can form. Cytosol Zidovudine triphosphate inhibits the activity of reverse transcriptase by competing with its substrate dGTP. Zidovudine triphosphate gets incorporated into viral DNA, but since it lacks the 3'-OH group which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, this causes DNA chain termination, preventing the growth of viral DNA. Extracellular Space Viral mRNA Viral mRNA Viral DNA
Nucleus reverse transcriptase SLC22A6 DTYMK NME1 TK1 Zidovudine 5'-Triphosphate Zidovudine Zidovudine dGTP Zidovudine monophosphate Adenosine triphosphate Zidovudine diphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Hydrogen Ion Viral Proteins NUP98 Unknown