Loader
Loading Pathway...
Canalicular multispecific organic anion transporter 2 Solute carrier family 22 member 7 Canalicular multispecific organic anion transporter 2 Canalicular multispecific organic anion transporter 2 Canalicular multispecific organic anion transporter 2 Cytochrome P450 3A4 UDP- glucuronosyltransferase 2B7 UDP- glucuronosyltransferase 2B7 3’-amino-3’-deoxythimidine glucuronide 5’glucuronyl zidovudine Zidovudine Zidovudine Zidovudine Zidovudine Zidovudine 3’-amino-3’-deoxythimidine glucuronide 5’glucuronyl zidovudine Zidovudine Zidovudine O2 FMNH2 NADPH 3'-Amino-3'-deoxythymidine H+ H2O FMN NADP Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ Uridine diphosphate glucuronic acid H+ Uridine 5'-diphosphate Excretion Heme Cytosol Hepatocyte Intestinal Epithelial Cell Endoplasmic Reticulum IV administration Oral administration
Endoplasmic Reticulum ABCC3 SLC22A7 ABCC3 ABCC3 ABCC3 CYP3A4 UGT2B7 UGT2B7 3’-amino-3’- deoxythimidine glucuronide 5’glucuronyl zidovudine Zidovudine Zidovudine Zidovudine Zidovudine Zidovudine 3’-amino-3’- deoxythimidine glucuronide 5’glucuronyl zidovudine Zidovudine Zidovudine Oxygen FMNH2 NADPH 3'-Amino-3'- deoxythymidine Hydrogen Ion Water FMN NADP Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion Uridine diphosphate glucuronic acid Hydrogen Ion Uridine 5'-diphosphate Excretion
ABCC3 SLC22A7 ABCC3 ABCC3 ABCC3 CYP3A4 UGT2B7 UGT2B7 3-a-3-d 5’g zid Zidovu Zidovu Zidovu Zidovu Zidovu 3-a-3-d 5’g zid Zidovu Zidovu O2 FMNH2 NADPH 3-A-3-d H+ H2O FMN NADP UDPGlcA UDP H+ UDPGlcA H+ UDP Excre Heme Cytosol Hepatocyte Intestinal Epithelial Cell Endoplasmic Reticulum IV administration Oral administration
Endoplasmic Reticulum ABCC3 SLC22A7 ABCC3 ABCC3 ABCC3 CYP3A4 UGT2B7 UGT2B7 3-a-3-d 5’g zid Zidovu Zidovu Zidovu Zidovu Zidovu 3-a-3-d 5’g zid Zidovu Zidovu O2 FMNH2 NADPH 3-A-3-d H+ H2O FMN NADP UDPGlcA UDP H+ UDPGlcA H+ UDP Excre