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Canalicular
multispecific
organic anion
transporter 2
Solute carrier
family 22
member 7
Canalicular
multispecific
organic anion
transporter 2
Canalicular
multispecific
organic anion
transporter 2
Canalicular
multispecific
organic anion
transporter 2
Cytochrome P450
3A4
UDP-
glucuronosyltransferase
2B7
UDP-
glucuronosyltransferase
2B7
3’-amino-3’-deoxythimidine
glucuronide
5’glucuronyl zidovudine
Zidovudine
Zidovudine
Zidovudine
Zidovudine
Zidovudine
3’-amino-3’-deoxythimidine
glucuronide
5’glucuronyl zidovudine
Zidovudine
Zidovudine
O2
FMNH2
NADPH
3'-Amino-3'-deoxythymidine
H+
H2 O
FMN
NADP
Uridine diphosphate glucuronic
acid
Uridine 5'-diphosphate
H+
Uridine diphosphate glucuronic
acid
H+
Uridine 5'-diphosphate
Excretion
Heme
Cytosol
Hepatocyte
Intestinal Epithelial Cell
Endoplasmic Reticulum
IV administration
Oral administration
Endoplasmic Reticulum
ABCC3
SLC22A7
ABCC3
ABCC3
ABCC3
CYP3A4
UGT2B7
UGT2B7
3’-amino-3’-
deoxythimidine
glucuronide
5’glucuronyl
zidovudine
Zidovudine
Zidovudine
Zidovudine
Zidovudine
Zidovudine
3’-amino-3’-
deoxythimidine
glucuronide
5’glucuronyl
zidovudine
Zidovudine
Zidovudine
Oxygen
FMNH2
NADPH
3'-Amino-3'-
deoxythymidine
Hydrogen Ion
Water
FMN
NADP
Uridine
diphosphate
glucuronic acid
Uridine
5'-diphosphate
Hydrogen Ion
Uridine
diphosphate
glucuronic acid
Hydrogen Ion
Uridine
5'-diphosphate
Excretion
ABCC3
SLC22A7
ABCC3
ABCC3
ABCC3
CYP3A4
UGT2B7
UGT2B7
3-a-3-d
5’g zid
Zidovu
Zidovu
Zidovu
Zidovu
Zidovu
3-a-3-d
5’g zid
Zidovu
Zidovu
O2
FMNH2
NADPH
3-A-3-d
H+
H2 O
FMN
NADP
UDPGlcA
UDP
H+
UDPGlcA
H+
UDP
Excre
Heme
Cytosol
Hepatocyte
Intestinal Epithelial Cell
Endoplasmic Reticulum
IV administration
Oral administration
Endoplasmic Reticulum
ABCC3
SLC22A7
ABCC3
ABCC3
ABCC3
CYP3A4
UGT2B7
UGT2B7
3-a-3-d
5’g zid
Zidovu
Zidovu
Zidovu
Zidovu
Zidovu
3-a-3-d
5’g zid
Zidovu
Zidovu
O2
FMNH2
NADPH
3-A-3-d
H+
H2O
FMN
NADP
UDPGlcA
UDP
H+
UDPGlcA
H+
UDP
Excre