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Pathways

PathWhiz ID Pathway Meta Data

PW146469

Pw146469 View Pathway
drug action

Abametapir Drug Metabolism Action Pathway

Homo sapiens

PW144261

Pw144261 View Pathway
drug action

Abarelix Drug Metabolism Action Pathway

Homo sapiens

PW128164

Pw128164 View Pathway
drug action

Abciximab Action Pathway

Bos taurus
Abciximab or Abcixifiban is a platelet aggregation inhibitor drug sold under the name ReoPro. It is administered intravenously, and can act to decrease platelet aggregation for up to two days after administration. Abciximab is an antigen binding fragment that targets glycoprotein IIb/IIIa receptors on the outer membrane of platelets. In the vein, Abciximab causes a conformational change in the integrins on the surface of activated platelets. This prevents the binding of fibrinogen to these integrins, which in turn prevents the platelets from being held together by these fibrinogen fibres. The conformational change also prevents the binding of von Willebrand factor to the platelets, which also prevents aggregation and adhesion.

PW128166

Pw128166 View Pathway
drug action

Abciximab Action Pathway

Mus musculus
Abciximab or Abcixifiban is a platelet aggregation inhibitor drug sold under the name ReoPro. It is administered intravenously, and can act to decrease platelet aggregation for up to two days after administration. Abciximab is an antigen binding fragment that targets glycoprotein IIb/IIIa receptors on the outer membrane of platelets. In the vein, Abciximab causes a conformational change in the integrins on the surface of activated platelets. This prevents the binding of fibrinogen to these integrins, which in turn prevents the platelets from being held together by these fibrinogen fibres. The conformational change also prevents the binding of von Willebrand factor to the platelets, which also prevents aggregation and adhesion.

PW122405

Pw122405 View Pathway
drug action

Abciximab Action Pathway

Homo sapiens
Abciximab or Abcixifiban is a platelet aggregation inhibitor drug sold under the name ReoPro. It is administered intravenously, and can act to decrease platelet aggregation for up to two days after administration. Abciximab is an antigen binding fragment that targets glycoprotein IIb/IIIa receptors on the outer membrane of platelets. In the vein, Abciximab causes a conformational change in the integrins on the surface of activated platelets. This prevents the binding of fibrinogen to these integrins, which in turn prevents the platelets from being held together by these fibrinogen fibres. The conformational change also prevents the binding of von Willebrand factor to the platelets, which also prevents aggregation and adhesion.

PW000291

Pw000291 View Pathway
drug action

Abciximab Action Pathway (old)

Homo sapiens
Abciximab (also known as c7E3 Fab) is integrin (integrin alpha-IIb and integrin beta-3) receptor antagonist. Binding of abciximab to integrin receptor will block any large molecule to attach on the receptor, which will lead to block any associated signal transduction pathways.

PW126077

Pw126077 View Pathway
drug action

Abciximab Drug Action

Homo sapiens
Abciximab or Abcixifiban is a platelet aggregation inhibitor drug sold under the name ReoPro (also called c7E3 Fab as it is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3). It can decrease platelet aggregation for up to two days after administration, which is intravenous. Abciximab is an antigen binding fragment that targets glycoprotein IIb/IIIa receptors on the outer membrane of human platelets. It acts as an integrin (integrin alpha-IIb and integrin beta-3) receptor antagonist - thus, binding of abciximab to integrin receptor will block any large molecule to attach on the receptor, which will lead to block any associated signal transduction pathways: in this case, those involved in platelet aggregation are inhibited as fibrinogen and other adhesive molecules are blocked by abciximab. In the vein, abciximab causes a conformational change in the integrins on the surface of activated platelets. This prevents the binding of fibrinogen to these integrins, which in turn prevents the platelets from being held together by these fibrinogen fibres. The conformational change also prevents the binding of von Willebrand factor to the platelets, which also prevents aggregation and adhesion. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. It also blocks the Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion. Altogether, abciximab increases bleeding time when administered. It has an initial plasma half-life of less than ten minutes and a second phase half-life of about half an hour, likely related to GPIIb/IIIa binding kinetics; however, it may occupy receptors for weeks due to its strong affinity. Abciximab is commonly used in the clinic during coronary artery procedures to prevent clotting during surgery.

PW146484

Pw146484 View Pathway
drug action

Abemaciclib Drug Metabolism Action Pathway

Homo sapiens

PW145650

Pw145650 View Pathway
drug action

Abiraterone Drug Metabolism Action Pathway

Homo sapiens

PW146900

Pw146900 View Pathway
drug action

Abrocitinib Drug Metabolism Action Pathway

Homo sapiens