PathWhiz ID | Pathway | Meta Data |
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PW145155View Pathway |
drug action
Acetophenazine Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 15:11 Last Updated: October 07, 2023 at 15:11 |
PW124173View Pathway |
acetyl CoA production by PDH and Krebs cyclehuman
metabolic pathway of acetyl CoA production by PDH and Krebs cycle
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Creator: Guest: Anonymous Created On: September 22, 2020 at 15:42 Last Updated: September 22, 2020 at 15:42 |
PW128457View Pathway |
drug action
Acetyl sulfisoxazole Action PathwayEscherichia coli (strain K12)
Acetyl sulfisoxazole is an antibacterial from the sulfanilamide drug class. It is a broad-spectrum antibiotic indicated against urinary tract infections, meningococcal meningitis, acute otitis media, inclusion conjunctivitis, toxoplasmosis, and many others. Acetyl sulfisoxazole is a synthetic bacteriostatic, meaning that it stops the bacteria from growing. This drug binds competitively to the dihydropteroate synthase enzyme. This enzyme is essential to produce dihydrofolic acid in bacteria, when it is inhibited, the bacteria cannot grow anymore because they cannot produce DNA with the folic acid. Thus drug is administered as an oral tablet. N1-acetyl sulfisoxazole is metabolized to sulfisoxazole by digestive enzymes in the gastrointestinal tract and is absorbed as sulfisoxazole (the active compound).
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Creator: Daphnee Created On: August 29, 2023 at 12:52 Last Updated: August 29, 2023 at 12:52 |
PW132441View Pathway |
Acetyl sulfisoxazole Drug MetabolismHomo sapiens
Acetyl sulfisoxazole is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Acetyl sulfisoxazole passes through the liver and is then excreted from the body mainly through the kidney.
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Creator: Ray Kruger Created On: September 21, 2023 at 21:48 Last Updated: September 21, 2023 at 21:48 |
PW146741View Pathway |
drug action
Acetyl sulfisoxazole Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 18:56 Last Updated: October 07, 2023 at 18:56 |
PW120684View Pathway |
protein
Acetylation and Deacetylation of RelA in The NucleusHomo sapiens
NF-kB transcription factor plays a role in the inflammatory and immune response of mammals. Acetylation of RelA regulates NF-kB activity. Tumor necrosis factor activates tumor necrosis factor receptor, recruiting proteins FADD, TRADD, RIP and TRAF6 to activate the NF-kB pathway. Activation of IKK complex causes the phosphorylation of I-kappa-B-alpha and triggers its degradation. I-kappa-B-alpha normally sequesters KF-kB in the cytoplasm, following its degradation, RELA and p50 (subunits of NF-kB) are liberated can translocate to the nucleus to activate gene expression. RelA and p50 associate with p300 and CREB transcriptional co-activators causing the acetylation of RelA and increase in transcriptional activity. Acetylated RelaA is targeted for deacetylation by transcriptional co-repressor Histone deacetylation 3 (HDAC3). This promotes its binding to I-kappa-B-alpha causing NF-kB's transport out of the nucleus and reduces its activity.
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Creator: Debra Lipton Created On: September 10, 2018 at 14:46 Last Updated: September 10, 2018 at 14:46 |
PW145852View Pathway |
drug action
Acetylcarnitine Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 16:49 Last Updated: October 07, 2023 at 16:49 |
PW145524View Pathway |
drug action
Acetylcholine Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 16:00 Last Updated: October 07, 2023 at 16:00 |
PW123915View Pathway |
signaling
acetylcholine signalingRattus norvegicus
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Creator: Naveen Singh Created On: June 04, 2020 at 01:23 Last Updated: June 04, 2020 at 01:23 |
PW145663View Pathway |
drug action
Acetylcysteine Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 16:20 Last Updated: October 07, 2023 at 16:20 |