PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127736 View Pathway	drug action Sofosbuvir Action Pathway Homo sapiens Sofosbuvir is a direct-acting antiviral agent used to treat specific hepatitis C virus in combination with other anti-viral drugs Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. The lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. The virus is internalized by clathrin-dependent endocytosis. RNA is released from the mature Hepatitis C virion and translated at the rough endoplasmic reticulum into a single Genome polyprotein. The genome polyprotein is cleaved by host and viral proteases into 10 viral proteins. The nucleocapsid protein core and the two envelope proteins E1 and E2 form the N terminus of the polyprotein and are the structural components of HCV virions. The precursor also gives rise to the viroporin p7 and six non-structural (NS) proteins. Sofosbuvir is an inhibitor of the Hepatitis C Virus (HCV) Nonstructural protein 5B, which is an RNA-dependent RNA polymerase. RNA polymerase is required for viral RNA replication and assembly of HCV virions. By binding to nonstructural protein 5B outside of the active site of the enzyme, dasabuvir induces a conformational change. Viral RNA replication complexes localize to lipid raft-containing, detergent-resistant membranes created by the viral protein NS4B. For full viral replication and maturation, nonstructural protein 5B is required so viral RNA replication cannot occur. Envelope glycoproteins are acquired through budding into the endoplasmic reticulum lumen. The immature, non-infective virions are released via the cellular golgi apparatus. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: May 29, 2023 at 16:19 Last Updated: May 29, 2023 at 16:19
PW145896 View Pathway	drug action Sofosbuvir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:55 Last Updated: October 07, 2023 at 16:55
PW145460 View Pathway	drug action Solifenacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:52 Last Updated: October 07, 2023 at 15:52
PW127978 View Pathway	drug action Solifenacin M3 Bladder Muscle Relaxation Action Pathway Homo sapiens Solifenacin is a muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder. It can be found under the brand name Vesicare. It has a long duration of action as it is usually taken once daily. Solifenacin is a competitive muscarinic receptor antagonist. Solifenacin's antagonism of the M3 receptor prevents contraction of the detrusor muscle, while antagonism of the M2 receptor may prevent contraction of smooth muscle in the bladder. Solifenacin works to decrease bladder activity by inhibiting contraction of the smooth muscle wall surrounding the bladder. As a potent and selective muscarinic receptor antagonist, solifenacin acts specifically at the M3 receptor site. Possible side effects of using solifenacin may include dry mouth, headache, dizziness, and vertigo. Solifenacine is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 26, 2023 at 12:12 Last Updated: June 26, 2023 at 12:12
PW127941 View Pathway	drug action Solriamfetol Action Pathway Homo sapiens Solriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI). This drug is indicated for the daytime treatment of sleepiness associated with narcolepsy or obstructive sleep apnea. Solriamfetol was given FDA approval in 2019. Solriamfetol weakly binds to dopamine and norepinephrine transporters but not serotonin transporters. Those transporters are called sodium-dependent dopamine transporter and sodium-dependent noradrenaline transporter. This makes more dopamine and noradrenaline available in the synapses of the brain. In consequence, the postsynaptic has more of those neurotransmitters available. Norepinephrine and dopamine are important neurotransmitters in sleep-wake regulation. This drug is available as oral tablets. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 21, 2023 at 12:22 Last Updated: June 21, 2023 at 12:22
PW146888 View Pathway	drug action Solriamfetol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:17 Last Updated: October 07, 2023 at 19:17
PW176232 View Pathway	metabolic Solriamfetol Predicted Metabolism Pathway Homo sapiens Metabolites of Solriamfetol are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 13:00 Last Updated: December 04, 2023 at 13:00
PW145978 View Pathway	drug action Somatostatin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:07 Last Updated: October 07, 2023 at 17:07
PW124340 View Pathway	metabolic Some path Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 12, 2020 at 19:10 Last Updated: November 12, 2020 at 19:10
PW122143 View Pathway	signaling Sonic Hedgehog (Shh) Mus musculus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 13, 2018 at 20:35 Last Updated: September 13, 2018 at 20:35