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PathWhiz ID | Pathway | Meta Data |
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PW002362 |
signaling
TGFbcoreandalteredHomo sapiens
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Creator: Guest: Anonymous Created On: November 19, 2015 at 04:36 Last Updated: November 19, 2015 at 04:36 |
PW145135 |
drug action
Thalidomide Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 15:09 Last Updated: October 07, 2023 at 15:09 |
PW176528 |
Thalidomide Predicted Metabolism PathwayHomo sapiens
Metabolites of Thalidomide are predicted with biotransformer.
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Creator: Omolola Created On: December 13, 2023 at 14:07 Last Updated: December 13, 2023 at 14:07 |
PW146083 |
drug action
Thallous chloride Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 17:22 Last Updated: October 07, 2023 at 17:22 |
PW146963 |
drug action
Thallous chloride Tl-201 Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 19:26 Last Updated: October 07, 2023 at 19:26 |
PW124119 |
signaling
THC on CB1Homo sapiens
The main psychoactive component in cannabis, △9-tetrahydrocannabinol (THC), acts on CB1 receptors in the brain located on synaptic terminals. THC, whose 3D structure closely resembles that of the endogenous cannabinoid anandamide, acts as a partial agonist on these receptors. Several behavioural effects of cannabis are feelings of euphoria, relaxation, lack of concentration,and altered time perception, while physiological effects range from increased appetite to rapid changes in heart rate. The mechanism of action of THC works through the activation CB1, which inhibits adenylate cyclase and lowers levels of cyclic AMP in the cell. This further inhibits protein kinase A complex, which affects regulating synaptic membrane exocytosis protein through an as yet unknown mechanism. This regulating protein is responsible for the release of GABA or ɣ-aminobutyric acid by exocytosis from the inhibitory terminal of the neuron. GABA is normally released to inhibit and regulate the release of dopamine in the brain. The binding of THC limits the exocytosis of GABA, and so dopamine is able to travel along synapses and bind to receptors. This promotes the well-known euphoric effects of cannabis. The activated CB1 receptor also interacts with its normal physiological targets, activating both MAPK and potassium channels and inhibiting calcium channels. These interactions and their physiological downstream effects are responsible for the numerous side effects associated with cannabis such as lack of concentration and impaired learning. The sustained effects of THC can be explained by the ability of CB1 receptors to influence long term plasticity in the brain.
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Creator: Alyssah Created On: August 26, 2020 at 10:12 Last Updated: August 26, 2020 at 10:12 |
PW000987 |
The Citric Acid Cycle TutorialHomo sapiens
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Creator: Guest: Anonymous Created On: July 17, 2015 at 11:43 Last Updated: July 17, 2015 at 11:43 |
PW000983 |
The Citric Acid Cycle Tutorial (2) - Pt.3 Adding LabelsHomo sapiens
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Creator: Guest: Anonymous Created On: July 16, 2015 at 15:26 Last Updated: July 16, 2015 at 15:26 |
PW000986 |
The Citric Acid Cycle Tutorial (2) - Pt.4 Adding SubPathwaysHomo sapiens
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Creator: Guest: Anonymous Created On: July 17, 2015 at 10:37 Last Updated: July 17, 2015 at 10:37 |
PW000973 |
The Citric Acid Cycle Tutorial (2) Pt.1 - Adding ReactionsHomo sapiens
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Creator: Guest: Anonymous Created On: July 14, 2015 at 11:57 Last Updated: July 14, 2015 at 11:57 |