PathWhiz

PathWhiz ID	Pathway	Meta Data
PW315681 View Pathway	metabolic Pyruvate Decarboxylation to Acetyl-CoA Tannerella forsythia The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: October 04, 2024 at 22:14 Last Updated: October 04, 2024 at 22:14
PW315845 View Pathway	metabolic Pyruvate Decarboxylation to Acetyl-CoA Citrobacter youngae ATCC 29220 The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: October 04, 2024 at 23:42 Last Updated: October 04, 2024 at 23:42
PW315770 View Pathway	metabolic Pyruvate Decarboxylation to Acetyl-CoA Kingella oralis ATCC 51147 The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: October 04, 2024 at 23:01 Last Updated: October 04, 2024 at 23:01
PW315768 View Pathway	metabolic Pyruvate Decarboxylation to Acetyl-CoA Eikenella corrodens ATCC 23834 The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: October 04, 2024 at 22:59 Last Updated: October 04, 2024 at 22:59
PW315198 View Pathway	metabolic Pyruvate Decarboxylation to Acetyl-CoA Parabacteroides goldsteinii dnLKV18 The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: October 04, 2024 at 17:47 Last Updated: October 04, 2024 at 17:47
PW316002 View Pathway	metabolic Pyruvate Decarboxylation to Acetyl-CoA Veillonella dispar ATCC 17748 The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: October 05, 2024 at 01:03 Last Updated: October 05, 2024 at 01:03
PW000117 View Pathway	disease Pyruvate Dehydrogenase Complex Deficiency Homo sapiens Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1). PDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. This conversion step links glycolysis and the citric acid cycle. A defect in this complex causes accumulation of lactate and pyruvate in the blood; lactate and pyruvic acid in the spinal fluid; and lactate in the urine. Symptoms include lactic and metabolic acidosis, motor retardation, dystonia, growth and mental retardation, and respiratory distress. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 01, 2013 at 15:52 Last Updated: August 01, 2013 at 15:52
PW122012 View Pathway	disease Pyruvate Dehydrogenase Complex Deficiency Rattus norvegicus Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1). PDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. This conversion step links glycolysis and the citric acid cycle. A defect in this complex causes accumulation of lactate and pyruvate in the blood; lactate and pyruvic acid in the spinal fluid; and lactate in the urine. Symptoms include lactic and metabolic acidosis, motor retardation, dystonia, growth and mental retardation, and respiratory distress. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:51 Last Updated: September 10, 2018 at 15:51
PW127339 View Pathway	disease Pyruvate Dehydrogenase Complex Deficiency Homo sapiens Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1). PDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. This conversion step links glycolysis and the citric acid cycle. A defect in this complex causes accumulation of lactate and pyruvate in the blood; lactate and pyruvic acid in the spinal fluid; and lactate in the urine. Symptoms include lactic and metabolic acidosis, motor retardation, dystonia, growth and mental retardation, and respiratory distress. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: December 13, 2022 at 10:36 Last Updated: December 13, 2022 at 10:36
PW121787 View Pathway	disease Pyruvate Dehydrogenase Complex Deficiency Mus musculus Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1). PDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. This conversion step links glycolysis and the citric acid cycle. A defect in this complex causes accumulation of lactate and pyruvate in the blood; lactate and pyruvic acid in the spinal fluid; and lactate in the urine. Symptoms include lactic and metabolic acidosis, motor retardation, dystonia, growth and mental retardation, and respiratory distress. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:49 Last Updated: September 10, 2018 at 15:49