PathWhiz

PathWhiz ID	Pathway	Meta Data
PW132370 View Pathway	metabolic Rilmenidine Drug Metabolism Homo sapiens Rilmenidine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Rilmenidine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:17 Last Updated: September 21, 2023 at 21:17
PW146439 View Pathway	drug action Rilmenidine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:12 Last Updated: October 07, 2023 at 18:12
PW000721 View Pathway	drug action Rilpivirine Action Pathway Homo sapiens Rilpivirine, sold as Edurant, is an antiretroviral drug that works as a non-nucleoside reverse transcriptase inhibitor (NNRTI) to treat HIV infections. NNRTI drugs work by entering the cell that HIV is present in, and binding to HIV's reverse transcriptase protein. This inactivates it, preventing HIV from being able to produce cDNA from its RNA genome, effectively stopping it from replicating its genome and spreading. While NNRTIs are able to prevent HIV from replicating, it does not destroy the virus, and it is only useful to help slow down the progression of the disease, not curing it. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: June 23, 2014 at 07:41 Last Updated: June 23, 2014 at 07:41
PW145855 View Pathway	drug action Rilpivirine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:49 Last Updated: October 07, 2023 at 16:49
PW124609 View Pathway	drug action Rilpivirine Mechanism of Action Homo sapiens Rilpivirine is an oral non- nucleoside reverse transcriptase inhibitor used to treat HIV-1. When HIV infects a cell, the virus first binds and fuses with the cell, releasing its nucleocapsid containing its RNA and reverse transcriptase into the cytosol of the cell. The reverse transcriptase converts the viral RNA into viral DNA. The viral DNA goes through the process of transcription and translation to produce viral proteins. These viral proteins are assembled and new HIV viruses buds from the cell. Nevirapine enters the cell through the solute carrier family 22 member 1 transporter and binds to and inhibits reverse transcriptase, preventing the formation of viral DNA from viral RNA. Since less viral DNA is formed, less of this DNA is available in the nucleus to undergo transcription and translation, consequently, less viral proteins are formed. This reduces the formation of new viruses since there are fewer viral proteins. Rilpivirine is only effective against HIV-1, and not against HIV-2. Signs and symptoms of HIV such as Chronic fatigue, rapid weight loss, nausea, vomiting, coughing and shortness of breath, recurring fever/chills, rashes/ sores may be relieved from taking rilpivirine. The internal conformational flexibility of rilpivirine and the plasticity of the binding site causes this drug to have high potency and reduces the chance of resistance compared to other NNRTI's. Side effects of nevirapine include rash, nausea, fever, fatigue, headache, stevens-johnson syndrome, liver injury, jaundice, joint ache, edema and blisters. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: March 28, 2021 at 22:02 Last Updated: March 28, 2021 at 22:02
PW126925 View Pathway	metabolic Rilpivirine Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: May 15, 2022 at 22:27 Last Updated: May 15, 2022 at 22:27
PW144851 View Pathway	drug action Riluzole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:33 Last Updated: October 07, 2023 at 14:33
PW176289 View Pathway	metabolic Riluzole Predicted Metabolism Pathway Homo sapiens Metabolites of Riluzole are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:43 Last Updated: December 04, 2023 at 14:43
PW127553 View Pathway	drug action Rimantadine Action Pathway Homo sapiens Rimantadine is an RNA synthesis inhibitor used to prevent influenza A infection.The mechanism of action of rimantadine is not fully understood. Rimantadine appears to exert its inhibitory effect early in the viral replicative cycle, possibly inhibiting the uncoating of the virus. It may play a role in the inhibition of the matrix protein 2 protein which is required for the uncoating of the protein. The inhibition of matrix protein 2 prevents the virus from replicating and further infecting cells. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: May 02, 2023 at 10:15 Last Updated: May 02, 2023 at 10:15
PW132468 View Pathway	metabolic Rimantadine Drug Metabolism Homo sapiens Rimantadine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Rimantadine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:55 Last Updated: September 21, 2023 at 21:55