PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146565 View Pathway	drug action Tazemetostat Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:31 Last Updated: October 07, 2023 at 18:31
PW176555 View Pathway	metabolic Tazemetostat Predicted Metabolism Pathway Homo sapiens Metabolites of Tazemetostat are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 14, 2023 at 11:59 Last Updated: December 14, 2023 at 11:59
PW145473 View Pathway	drug action Tazobactam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:54 Last Updated: October 07, 2023 at 15:54
PW000889 View Pathway	metabolic TCA Arabidopsis thaliana BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Biswapriya Misra Created On: May 06, 2015 at 11:43 Last Updated: May 06, 2015 at 11:43
PW122549 View Pathway	metabolic tca Aeromonas media WS BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 30, 2019 at 05:29 Last Updated: July 30, 2019 at 05:29
PW123644 View Pathway	metabolic TCA Klebsiella pneumoniae BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 09, 2019 at 13:47 Last Updated: November 09, 2019 at 13:47
PW124445 View Pathway	metabolic TCA Escherichia coli The name of this metabolic pathway is derived from the citric acid (a tricarboxylic acid, often called citrate, as the ionized form predominates at biological pH[6]) that is consumed and then regenerated by this sequence of reactions to complete the cycle. The cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, releasing carbon dioxide. The NADH generated by the citric acid cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: January 13, 2021 at 12:42 Last Updated: January 13, 2021 at 12:42
PW122267 View Pathway	metabolic TCA and aminoacids Saccharomyces cerevisiae BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 25, 2018 at 11:59 Last Updated: October 25, 2018 at 11:59
PW122577 View Pathway	metabolic TCA Cycle Pseudomonas aeruginosa The citric acid cycle (also named tricarboxylic acid (TCA) cycle or the Krebs cycle), is a collection of 9 enzyme-catalyzed chemical reactions that occur in all living cells undergoing aerobic respiration. The citric acid cycle itself was officially identified in 1937 by Hans Adolf Krebs, who received the Nobel Prize for this discovery in 1953. In eukaryotes, the citric acid cycle occurs in the mitochondria. In prokaryotes, the TCA cycle occurs in the cytoplasm. The TCA cycle starts with acetyl-CoA, which is the â€œfuelâ€ for the entire cycle. This important molecule comes from the breakdown of glycogen (a stored form of glucose), fats, and many amino acids. At beginning, acetyl-CoA first transfers its 2-carbon acetyl group to the 4-carbon acceptor compound called oxaloacetate to form the 6-carbon compound (citrate) for which the cycle is named. The resulting citrate will have numbers of chemical transformations, whereby it loses one carboxyl group (leading to the 5-carbon compound called alpha-ketoglutarate) and then a second carboxyl group (leading to the 4-carbon compound called succinate). Succinate molecule is further oxidized to fumarate, then malate and finally oxaloacetate. The regeneration of the 4-carbon oxaloacetate, allows the TCA cycle to continue. Oxidation step generates energy that is transferring energy-rich electrons for NAD+ to form NADH in TCA cycle. Each acetyl group will generate 3 NADH in TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 16:59 Last Updated: August 12, 2019 at 16:59
PW002377 View Pathway	metabolic TCA Cycle Saccharomyces cerevisiae Citric acid cycle (also known as tricarboxylic acid cycle (TCA) and Krebs cycle) contains series of reactions that involved enzyme catalyzation which are essential for all living cells that require oxygen for cellular respiration. In mitochondria (for eukaryotes), TCA cycle begins with acetyl-CoA and oxaloacetic acid (oxaloacetate) be catalyzed to form citric acid (citrate) by citrate synthase 3. Then, 3-isopropylmalate dehydratase with cofactor 4Fe-4S can catalyze citrate to form cis-aconitic acid as the intermediate compound and catalyze cis-aconitic acid to form isocitric acid. Many TCA cycle intermediates are the precursors for other molecules' synthesis; and NADH (from NAD+) is the major energy that is produced by oxidative steps of the TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: December 08, 2015 at 11:50 Last Updated: December 08, 2015 at 11:50