PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176932 View Pathway	drug action Bacampicillin Action Pathway Escherichia coli Bacampicillin is a s an ampicillin prodrug used to treat various susceptible bacterial infections in the body, such as respiratory infections and skin and subcutaneous tissue infections. Bacampicillin exhibits a bactericidal mode of action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs). Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with the lengthening and strengthening of the peptidoglycan portion of the cell wall, thereby inhibiting cell wall synthesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 02, 2024 at 09:15 Last Updated: January 02, 2024 at 09:15
PW144481 View Pathway	drug action Aztreonam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:43 Last Updated: October 07, 2023 at 13:43
PW132363 View Pathway	metabolic Aztreonam Drug Metabolism Homo sapiens Aztreonam is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Aztreonam passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:13 Last Updated: September 21, 2023 at 21:13
PW176960 View Pathway	drug action Aztreonam Action Pathway Escherichia coli Aztreonam is a 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics.5 It was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria, ertapenem is used to treat various bacterial infections. Aztreonam exhibits a bactericidal mode of action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In Escherichia coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to PBPs 2 and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with the lengthening and strengthening of the peptidoglycan portion of the cell wall, thereby inhibiting cell wall synthesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 02, 2024 at 09:21 Last Updated: January 02, 2024 at 09:21
PW145153 View Pathway	drug action Azlocillin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:11 Last Updated: October 07, 2023 at 15:11
PW127498 View Pathway	drug action Azlocillin Action Pathway Clostridium perfringens (strain 13 / Type A) Azlocillin is a semisynthetic ampicillin-derived acylureido penicillin used for the treatment of bacterial infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. It inhibits specific penicillin-binding proteins located in the perisome of bacteria cells, which is the third and last stage of bacterial cell wall syntheis. This causes cell lysis and therefore the breakdown of the bacterial cell. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: March 21, 2023 at 02:37 Last Updated: March 21, 2023 at 02:37
PW176321 View Pathway	metabolic Azithromycin Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:03 Last Updated: December 07, 2023 at 15:03
PW144338 View Pathway	drug action Azithromycin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:26 Last Updated: October 07, 2023 at 13:26
PW126592 View Pathway	drug action Azithromycin Action Pathway (New) Homo sapiens Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. It is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. Like other macrolide antimicrobials, azithromycin binds to the 23S portion of the 50S bacterial ribosomal subunit. It inhibits bacterial protein synthesis by preventing the transit of aminoacyl-tRNA and the growing protein through the ribosome. Inhibition of protein synthesis kills the bacteria since essential proteins required for the bacteria to survive are not being produced. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 19, 2022 at 00:40 Last Updated: January 19, 2022 at 00:40
PW128343 View Pathway	drug action Azithromycin Action Pathway Homo sapiens Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It is commonly administered via oral consumption and diffuses throughout the body. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. Like other macrolide antimicrobials, azithromycin binds to the 23S portion of the 50S bacterial ribosomal subunit. It inhibits bacterial protein synthesis by preventing the addition of aminoacyl-tRNA to the growing protein through the ribosome. Inhibition of protein synthesis leads to apoptosis of the bacteria since essential proteins required for the bacteria to survive are not being produced. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 22, 2023 at 15:21 Last Updated: August 22, 2023 at 15:21