PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176960 View Pathway	drug action Aztreonam Action Pathway Escherichia coli Aztreonam is a 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics.5 It was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria, ertapenem is used to treat various bacterial infections. Aztreonam exhibits a bactericidal mode of action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In Escherichia coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to PBPs 2 and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with the lengthening and strengthening of the peptidoglycan portion of the cell wall, thereby inhibiting cell wall synthesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 02, 2024 at 09:21 Last Updated: January 02, 2024 at 09:21
PW145153 View Pathway	drug action Azlocillin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:11 Last Updated: October 07, 2023 at 15:11
PW127498 View Pathway	drug action Azlocillin Action Pathway Clostridium perfringens (strain 13 / Type A) Azlocillin is a semisynthetic ampicillin-derived acylureido penicillin used for the treatment of bacterial infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. It inhibits specific penicillin-binding proteins located in the perisome of bacteria cells, which is the third and last stage of bacterial cell wall syntheis. This causes cell lysis and therefore the breakdown of the bacterial cell. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: March 21, 2023 at 02:37 Last Updated: March 21, 2023 at 02:37
PW176321 View Pathway	metabolic Azithromycin Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:03 Last Updated: December 07, 2023 at 15:03
PW144338 View Pathway	drug action Azithromycin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:26 Last Updated: October 07, 2023 at 13:26
PW126592 View Pathway	drug action Azithromycin Action Pathway (New) Homo sapiens Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. It is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. Like other macrolide antimicrobials, azithromycin binds to the 23S portion of the 50S bacterial ribosomal subunit. It inhibits bacterial protein synthesis by preventing the transit of aminoacyl-tRNA and the growing protein through the ribosome. Inhibition of protein synthesis kills the bacteria since essential proteins required for the bacteria to survive are not being produced. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 19, 2022 at 00:40 Last Updated: January 19, 2022 at 00:40
PW128343 View Pathway	drug action Azithromycin Action Pathway Homo sapiens Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It is commonly administered via oral consumption and diffuses throughout the body. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. Like other macrolide antimicrobials, azithromycin binds to the 23S portion of the 50S bacterial ribosomal subunit. It inhibits bacterial protein synthesis by preventing the addition of aminoacyl-tRNA to the growing protein through the ribosome. Inhibition of protein synthesis leads to apoptosis of the bacteria since essential proteins required for the bacteria to survive are not being produced. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 22, 2023 at 15:21 Last Updated: August 22, 2023 at 15:21
PW000345 View Pathway	drug action Azithromycin Action Pathway Homo sapiens Azithromycin, trade names include Zithromax and Azithrocin, is a semisynthetic azalide derived from erythromycin. Azalides are part of the macrolide antibiotic class. Azithromycin targets protein synthesis of bacteria by binding to the 50S subunit of the bacterial ribosome to inhibit mRNA translation and prevent bacteria growth. Macrolides are broad spectrum antibiotics. It is prescribed to treat bacterial infections including: sexually transmitted infections like chlamydia, pneumonia, strep throat, ear infections, sinusitis and more. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW175977 View Pathway	metabolic Azilsartan medoxomil Predicted Metabolism Pathway new Homo sapiens Metabolites of Azilsartan medoxomil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 12:56 Last Updated: November 29, 2023 at 12:56
PW145845 View Pathway	drug action Azilsartan medoxomil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:48 Last Updated: October 07, 2023 at 16:48