PathWhiz

PathWhiz ID	Pathway	Meta Data
PW175940 View Pathway	metabolic Ticlopidine Predicted Metabolism Pathway Homo sapiens Ticlopidine PIS1M1, Ticlopidine PIS1M2, Ticlopidine PIS1M3,Ticlopidine PIS1M4, Ticlopidine PIS2M1, Ticlopidine PIS2M2, Ticlopidine PIS2M3 are metabolites of Ticlopidine predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 16, 2023 at 14:11 Last Updated: November 16, 2023 at 14:11
PW000689 View Pathway	drug action Tigecycline Action Pathway Homo sapiens Tigecycline is a glycylcycline, a class of antibiotics derived from tetracycline. Tigecycline has broad spectrum antibacterial abilities and is not susceptible to traditional tetracycline resistance mechanisms such as ribosomal protection and efflux by tetracycline-specific pumps. Tigecycline inhibits bacterial protein synthesis by binding to the A site of the 16s rRNA on the 30S ribosomal subunit. By binding to the A site, tigecycline prevents tRNA from docking onto the 16S rRNA with it’s codon ultimately halting the addition of amino acids to elongate peptide chains used in protein structures. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: April 26, 2014 at 16:35 Last Updated: April 26, 2014 at 16:35
PW124612 View Pathway	drug action Tigecycline Anti-bacterial Action Pathway Homo sapiens Tigecycline is an intravenous antibiotic drug used to treat infections caused by a variety of gram-positive and gram-negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae. Tigecycline first clinically-available drug in the class of glycylcyclines antibiotics. Glycylcyclines are derived from tetracycline which are analogues are specifically designed to overcome tetracycline resistance mediated by acquired efflux pumps and/or ribosomal protection. In bacterial protein synthesis, transcription and translation occur in the cytoplasm. Tigecycline targets protein translation. Translation occurs using the bacterial 70S ribosome composed of a 50S and a 30S subunit. The ribosome has 3 binding sites, A (acceptor site), P (peptidyl site) and E (exit site). The charged tRNA with an amino acid attached (amino-acyl tRNA) binds to the A site. The P site binds to the tRNA holding the growing polypeptide chain and the E site binds to the uncharged tRNA. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: March 29, 2021 at 22:17 Last Updated: March 29, 2021 at 22:17
PW144677 View Pathway	drug action Tigecycline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:11 Last Updated: October 07, 2023 at 14:11
PW146454 View Pathway	drug action Tilarginine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:14 Last Updated: October 07, 2023 at 18:14
PW132499 View Pathway	metabolic Tilbroquinol Drug Metabolism Homo sapiens Tilbroquinol is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Tilbroquinol passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:07 Last Updated: September 21, 2023 at 22:07
PW146612 View Pathway	drug action Tilbroquinol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:37 Last Updated: October 07, 2023 at 18:37
PW146912 View Pathway	drug action Tilmanocept Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:20 Last Updated: October 07, 2023 at 19:20
PW147015 View Pathway	metabolic Tiludronate Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:39 Last Updated: October 10, 2023 at 13:39
PW127946 View Pathway	drug action Tiludronic Acid Action Pathway Homo sapiens Tiludronic acid is a first-generation bisphosphonate used to treat Paget's disease, similar to etidronic acid and clodronic acid. Tiludronic acid binds to hydroxylapatite in the bone, during bone resorption it is released and taken up by osteoclasts through endocytosis. Once inside the osteoclast, it is released into the cytosol and goes to interrupt osteoclast activity and function. Tiludronic acid has a structure similar to pyrophosphate and due to this can be incorporated into ATP analogues that cannot be hydrolyzed. Due to this the osteoclast cannot utilize ATP and begins to go through apoptosis. If a patient has an overdose they may present with hypocalcemia, which can be treated with supportive care. Tiludronic acid should be taken 2 hours before or after consuming a meal and/or calcium supplements. Avoiding taking it with antacids as it will greatly reduce the bioavailability. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: June 21, 2023 at 13:56 Last Updated: June 21, 2023 at 13:56