PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128066 View Pathway	drug action Ticlopidine Action Pathway (new) Homo sapiens Ticlopidine is a platelet aggregation inhibitor also known as Ticlid, used to prevent strokes or transient ischemic attacks. It is administered orally as a prodrug that is metabolized into its active form, it then goes on to prevent the binding of ADP to the P2Y receptor. With ADP activation of the receptor inhibited this leads to impaired platelet aggregation and activation. Ticlopidine should be taken with a high fat meal, as it increases absorption of the drug and helps reduce any gastrointestinal irritation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: July 13, 2023 at 07:33 Last Updated: July 13, 2023 at 07:33
PW144339 View Pathway	drug action Ticlopidine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:26 Last Updated: October 07, 2023 at 13:26
PW124570 View Pathway	metabolic Ticlopidine Metabolic Pathway Homo sapiens Ticlopidine is metabolized extensively by the liver with only trace amounts of intact drug detected. At least 20 metabolites have been identified. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: March 02, 2021 at 17:36 Last Updated: March 02, 2021 at 17:36
PW000587 View Pathway	drug metabolism Ticlopidine Metabolism Pathway Homo sapiens Ticlopidine, marketed as Ticlid, is an antiplatelet drug that targets the P2Y12 receptor of platelets. Ticlopidine is taken orally and is a prodrug that must be metabolically activated before it can be effective. It first enters the liver and enters the endoplasmic reticulum where it is metabolized to form the active metabolite. First, it is catalyzed by cytochromes P450 2C19, 2B6 and 1A2 into 2-oxoclopidogrel. Secondly, it is processed by cytochromes P450 2B6, 2C9, 2C19, 3A4, 3A5, and serum paraoxonase/arylesterase 1 into the active metabolite of clopidogrel. The active metabolite of clopidogrel then enters the blood stream, where it binds irreversibly to the P2Y purinoreceptor 12 on the surface of platelet cells, preventing ADP from binding to and activating it. Clopidogrel prevents the activation of the Gi protein associated with the P2Y12 receptor from inactivating adenylate cyclase in the platelet, leading to a buildup of cAMP. This cAMP then activates calcium efflux pumps, preventing calcium buildup in the platelet, which would cause activation, and later, aggregation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: September 11, 2013 at 22:33 Last Updated: September 11, 2013 at 22:33
PW175940 View Pathway	metabolic Ticlopidine Predicted Metabolism Pathway Homo sapiens Ticlopidine PIS1M1, Ticlopidine PIS1M2, Ticlopidine PIS1M3,Ticlopidine PIS1M4, Ticlopidine PIS2M1, Ticlopidine PIS2M2, Ticlopidine PIS2M3 are metabolites of Ticlopidine predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 16, 2023 at 14:11 Last Updated: November 16, 2023 at 14:11
PW000689 View Pathway	drug action Tigecycline Action Pathway Homo sapiens Tigecycline is a glycylcycline, a class of antibiotics derived from tetracycline. Tigecycline has broad spectrum antibacterial abilities and is not susceptible to traditional tetracycline resistance mechanisms such as ribosomal protection and efflux by tetracycline-specific pumps. Tigecycline inhibits bacterial protein synthesis by binding to the A site of the 16s rRNA on the 30S ribosomal subunit. By binding to the A site, tigecycline prevents tRNA from docking onto the 16S rRNA with it’s codon ultimately halting the addition of amino acids to elongate peptide chains used in protein structures. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: April 26, 2014 at 16:35 Last Updated: April 26, 2014 at 16:35
PW124612 View Pathway	drug action Tigecycline Anti-bacterial Action Pathway Homo sapiens Tigecycline is an intravenous antibiotic drug used to treat infections caused by a variety of gram-positive and gram-negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae. Tigecycline first clinically-available drug in the class of glycylcyclines antibiotics. Glycylcyclines are derived from tetracycline which are analogues are specifically designed to overcome tetracycline resistance mediated by acquired efflux pumps and/or ribosomal protection. In bacterial protein synthesis, transcription and translation occur in the cytoplasm. Tigecycline targets protein translation. Translation occurs using the bacterial 70S ribosome composed of a 50S and a 30S subunit. The ribosome has 3 binding sites, A (acceptor site), P (peptidyl site) and E (exit site). The charged tRNA with an amino acid attached (amino-acyl tRNA) binds to the A site. The P site binds to the tRNA holding the growing polypeptide chain and the E site binds to the uncharged tRNA. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: March 29, 2021 at 22:17 Last Updated: March 29, 2021 at 22:17
PW144677 View Pathway	drug action Tigecycline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:11 Last Updated: October 07, 2023 at 14:11
PW146454 View Pathway	drug action Tilarginine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:14 Last Updated: October 07, 2023 at 18:14
PW132499 View Pathway	metabolic Tilbroquinol Drug Metabolism Homo sapiens Tilbroquinol is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Tilbroquinol passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:07 Last Updated: September 21, 2023 at 22:07