PathWhiz

PathWhiz ID	Pathway	Meta Data
PW109254 View Pathway	protein Cadmium Induces DNA Synthesis and Proliferation in Macrophages Bos taurus Cadmium (Cd(2+)) exposure increases the risk of cancer in humans and animals. Humans may come into contact with cadmium when smoking and ingesting contaminated food. This will increase the risk of lung cancer and prostate cancer. In the millimolar range, cadmium will inhibit cell growth. Cadmium induces DNA synthesis and proliferation and affects signal transduction and mobilization in macrophages. At micromolar concentrations, cadmium significantly increased cell division as judged by thymidine uptake and cell counts. Activating this pathway will increase the availability of the transcription factor NF(kappa)B and will activate the early genes c-fos and c-myc. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 12:41 Last Updated: August 31, 2018 at 12:41
PW109282 View Pathway	protein Cadmium Induces DNA Synthesis and Proliferation in Macrophages Rattus norvegicus Cadmium (Cd(2+)) exposure increases the risk of cancer in humans and animals. Humans may come into contact with cadmium when smoking and ingesting contaminated food. This will increase the risk of lung cancer and prostate cancer. In the millimolar range, cadmium will inhibit cell growth. Cadmium induces DNA synthesis and proliferation and affects signal transduction and mobilization in macrophages. At micromolar concentrations, cadmium significantly increased cell division as judged by thymidine uptake and cell counts. Activating this pathway will increase the availability of the transcription factor NF(kappa)B and will activate the early genes c-fos and c-myc. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 12:49 Last Updated: August 31, 2018 at 12:49
PW109207 View Pathway	protein Cadmium Induces DNA Synthesis and Proliferation in Macrophages Mus musculus Cadmium (Cd(2+)) exposure increases the risk of cancer in humans and animals. Humans may come into contact with cadmium when smoking and ingesting contaminated food. This will increase the risk of lung cancer and prostate cancer. In the millimolar range, cadmium will inhibit cell growth. Cadmium induces DNA synthesis and proliferation and affects signal transduction and mobilization in macrophages. At micromolar concentrations, cadmium significantly increased cell division as judged by thymidine uptake and cell counts. Activating this pathway will increase the availability of the transcription factor NF(kappa)B and will activate the early genes c-fos and c-myc. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 12:33 Last Updated: August 31, 2018 at 12:33
PW124249 View Pathway	metabolic Cadena Transportadora y Fosforilación Oxidativa (CV) Homo sapiens Complejos transportadores de electrones (I, II, III y IV) para la generación de gradiente de protones en la mitocondria y fosforilación oxidativa para generar energía (ATP) mediante ATP sintasa. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: October 18, 2020 at 22:02 Last Updated: October 18, 2020 at 22:02
PW124248 View Pathway	metabolic Cadena transportadora de electrones y fosforilación oxidativa (CV) error Homo sapiens Complejos transportadores de electrones (I, II, III y IV) para la generación de gradiente de protones en la mitocondria y fosforilación oxidativa para generar energía (ATP) mediante ATP sintasa. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: October 18, 2020 at 21:57 Last Updated: October 18, 2020 at 21:57
PW175987 View Pathway	metabolic Cabozantinib Predicted Metabolism Pathway new Homo sapiens Metabolites of Cabozantinib are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:02 Last Updated: November 29, 2023 at 13:02
PW145863 View Pathway	drug action Cabozantinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:50 Last Updated: October 07, 2023 at 16:50
PW128518 View Pathway	drug action Cabozantinib Action Pathway Homo sapiens Cabozantinib is a tyrosine kinase inhibitor with broad applications in oncology. Originally approved in 2012 under the brand name Cometriq, it was primarily indicated for metastatic medullary thyroid cancer. Subsequently, a capsule formulation known as Cabometyx gained approval for the treatment of advanced renal cell carcinoma in 2016. In 2019, this same formulation received additional approvals for the treatment of hepatocellular carcinoma in patients who had previously been treated with sorafenib. Cabozantinib's mechanism of action involves inhibiting various receptor tyrosine kinases, effectively suppressing processes such as metastasis, angiogenesis, and oncogenesis, making it a versatile therapeutic option in the management of advanced cancers. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: September 01, 2023 at 12:22 Last Updated: September 01, 2023 at 12:22
PW146443 View Pathway	drug action Cabotegravir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:12 Last Updated: October 07, 2023 at 18:12
PW127486 View Pathway	drug action Cabotegravir Action Pathway Homo sapiens Cabotegravir is an HIV-1 integrase inhibitor used for treatment and pre-exposure prophylaxis of HIV-1 infection. It is prescribed with the non-nucleoside reverse transcriptase inhibitor, rilpivirine. Cabotegravir is transported into the infected cell then transported into the nucleus via importin nuclear transporter. The viral RNA is injected into the cell then transcribed into viral DNA via reverse transcriptase. It is then transported into the nucleus where it is integrated into the host DNA. Cabotegravir inhibits HIV integrase which prevents the viral DNA from being integrated into the host DNA. This prevents viral replication and further progression of the virus. It is used in combination with reverse transcriptase inhibitors which further prevents viral replication and progression of the virus. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: March 15, 2023 at 14:27 Last Updated: March 15, 2023 at 14:27