PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145775 View Pathway	drug action Alcaftadine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:37 Last Updated: October 07, 2023 at 16:37
PW144637 View Pathway	drug action Albendazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:05 Last Updated: October 07, 2023 at 14:05
PW127418 View Pathway	drug action Albendazole Action Pathway Homo sapiens Albendazole is a broad-spectrum benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by diminishing its energy production, ultimately leading to immobilization and death of the parasite. It works by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. As cytoplasmic microtubules are critical in promoting glucose uptake in larval and adult stages of the susceptible parasites, the glycogen stores of the parasites are depleted. Cellular glucose dissipates which results in decreased production and dissipation of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes also result in decreased production of adenosine triphosphate (ATP), BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: January 25, 2023 at 10:39 Last Updated: January 25, 2023 at 10:39
PW146097 View Pathway	drug action Alatrofloxacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:24 Last Updated: October 07, 2023 at 17:24
PW124410 View Pathway	metabolic Alanine metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: January 03, 2021 at 04:56 Last Updated: January 03, 2021 at 04:56
PW064560 View Pathway	metabolic Alanine Metabolism Mus musculus Alanine (L-Alanine) is an α-amino acid that is used for protein biosynthesis. Approximately 8% of human proteins have alanine in their structures. The reductive lamination of pyruvate is effected by alanine transaminase. L-Alanine can be converted to pyruvic acid by alanine aminotransferase 1 reversibly coupled with interconversion of oxoglutaric acid and L-glutamic acid. L-Alanine can also be produced by alanine-glyoxylate transaminase with coupled interconversion of glyoxylate and glycine. L-Alanine will be coupled with alanyl tRNA by alanyl-tRNA synthetase to perform protein biosynthesis. Alanine can also be used to provide energy under fasting conditions. There are two pathways that can facilitate this: (1) alanine is converted to pyruvate to synthesize glucose via the gluconeogenesis pathway in liver tissue or (2) alanine converted into pyruvate moves into the TCA cycle to be oxidized in other tissues. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: January 21, 2018 at 16:17 Last Updated: January 21, 2018 at 16:17
PW088294 View Pathway	metabolic Alanine Metabolism Rattus norvegicus Alanine (L-Alanine) is an α-amino acid that is used for protein biosynthesis. Approximately 8% of human proteins have alanine in their structures. The reductive lamination of pyruvate is effected by alanine transaminase. L-Alanine can be converted to pyruvic acid by alanine aminotransferase 1 reversibly coupled with interconversion of oxoglutaric acid and L-glutamic acid. L-Alanine can also be produced by alanine-glyoxylate transaminase with coupled interconversion of glyoxylate and glycine. L-Alanine will be coupled with alanyl tRNA by alanyl-tRNA synthetase to perform protein biosynthesis. Alanine can also be used to provide energy under fasting conditions. There are two pathways that can facilitate this: (1) alanine is converted to pyruvate to synthesize glucose via the gluconeogenesis pathway in liver tissue or (2) alanine converted into pyruvate moves into the TCA cycle to be oxidized in other tissues. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 13:17 Last Updated: August 10, 2018 at 13:17
PW123811 View Pathway	metabolic alanine metabolism Escherichia coli BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Sabnam Rahman Created On: February 16, 2020 at 04:52 Last Updated: February 16, 2020 at 04:52
PW002521 View Pathway	metabolic Alanine Metabolism Arabidopsis thaliana The alanine biosynthesis starts with hypoxic conditions leading to large amounts of alanine being produced either through reactions in chloroplast, mitochondrion or cytoplasm Alanine concentration decreases after the plants return to normal oxygen conditions. Alanine production can be used by plants to conserve nitrogen and carbon atoms during anaerobic fermentation, otherwise, nitrogen and carbon atoms may be lost. Alanine is degraded and the nitrogen stored is released. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: April 08, 2016 at 11:14 Last Updated: April 08, 2016 at 11:14
PW088183 View Pathway	metabolic Alanine Metabolism Bos taurus Alanine (L-Alanine) is an α-amino acid that is used for protein biosynthesis. Approximately 8% of human proteins have alanine in their structures. The reductive lamination of pyruvate is effected by alanine transaminase. L-Alanine can be converted to pyruvic acid by alanine aminotransferase 1 reversibly coupled with interconversion of oxoglutaric acid and L-glutamic acid. L-Alanine can also be produced by alanine-glyoxylate transaminase with coupled interconversion of glyoxylate and glycine. L-Alanine will be coupled with alanyl tRNA by alanyl-tRNA synthetase to perform protein biosynthesis. Alanine can also be used to provide energy under fasting conditions. There are two pathways that can facilitate this: (1) alanine is converted to pyruvate to synthesize glucose via the gluconeogenesis pathway in liver tissue or (2) alanine converted into pyruvate moves into the TCA cycle to be oxidized in other tissues. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 10:38 Last Updated: August 10, 2018 at 10:38