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PW132375

Pw132375 View Pathway
metabolic

2-mercaptobenzothiazole Drug Metabolism

Homo sapiens
2-mercaptobenzothiazole is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. 2-mercaptobenzothiazole passes through the liver and is then excreted from the body mainly through the kidney.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ray Kruger

Created On: September 21, 2023 at 21:19

Last Updated: September 21, 2023 at 21:19

PW000525

Pw000525 View Pathway
disease

2-Ketoglutarate Dehydrogenase Complex Deficiency

Homo sapiens
2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective oxoglutarate dehydrogenase complex (OGDC). OGDC catalyzes the conversion of 2-ketoglutarate into succinyl-CoA. This disorder is characterized by a large accumulation of 2-ketoglutarate in the urine. Symptoms of the disorder include opisthotonus, ataxia, developmental delay, and seizures.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: WishartLab

Created On: August 29, 2013 at 10:39

Last Updated: August 29, 2013 at 10:39

PW122093

Pw122093 View Pathway
disease

2-Ketoglutarate Dehydrogenase Complex Deficiency

Rattus norvegicus
2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective oxoglutarate dehydrogenase complex (OGDC). OGDC catalyzes the conversion of 2-ketoglutarate into succinyl-CoA. This disorder is characterized by a large accumulation of 2-ketoglutarate in the urine. Symptoms of the disorder include opisthotonus, ataxia, developmental delay, and seizures.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: September 10, 2018 at 15:52

Last Updated: September 10, 2018 at 15:52

PW127322

Pw127322 View Pathway
disease

2-Ketoglutarate Dehydrogenase Complex Deficiency

Homo sapiens
2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective oxoglutarate dehydrogenase complex (OGDC). OGDC catalyzes the conversion of 2-ketoglutarate into succinyl-CoA. This disorder is characterized by a large accumulation of 2-ketoglutarate in the urine. Symptoms of the disorder include opisthotonus, ataxia, developmental delay, and seizures.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ray Kruger

Created On: December 08, 2022 at 17:05

Last Updated: December 08, 2022 at 17:05

PW121869

Pw121869 View Pathway
disease

2-Ketoglutarate Dehydrogenase Complex Deficiency

Mus musculus
2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective oxoglutarate dehydrogenase complex (OGDC). OGDC catalyzes the conversion of 2-ketoglutarate into succinyl-CoA. This disorder is characterized by a large accumulation of 2-ketoglutarate in the urine. Symptoms of the disorder include opisthotonus, ataxia, developmental delay, and seizures.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: September 10, 2018 at 15:50

Last Updated: September 10, 2018 at 15:50

PW124243

Pw124243 View Pathway
metabolic

2-Keto acid

Corynebacterium atypicum
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Belen Maldonado

Created On: October 18, 2020 at 15:48

Last Updated: October 18, 2020 at 15:48

PW121689

Pw121689 View Pathway
disease

2-Hydroxyglutric Aciduria (D and L Form)

Mus musculus
L-2-Hydroxyglutaric Aciduria (D-2-Hydroxyglutaric Aciduria ) is an autosomal recessive disease caused by a mutation in the L2HGDH gene which codes for L-2-Hydroxygluarate dehydrogenase. A deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid. Symptoms, which present at birth, include ataxia, hypotonia, mental retardation, and seizures. Premature death often results. D-2-Hydroxyglutaric Aciduria is an autosomal recessive disease caused by a mutation in the D2HGDH gene which does for D-2-Hydroxygluarate dehydrogenase. A deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid. Symptoms, which present at birth, include ataxia, hypotonia, mental retardation, and seizures. Premature death often results.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: September 10, 2018 at 15:49

Last Updated: September 10, 2018 at 15:49

PW121915

Pw121915 View Pathway
disease

2-Hydroxyglutric Aciduria (D and L Form)

Rattus norvegicus
L-2-Hydroxyglutaric Aciduria (D-2-Hydroxyglutaric Aciduria ) is an autosomal recessive disease caused by a mutation in the L2HGDH gene which codes for L-2-Hydroxygluarate dehydrogenase. A deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid. Symptoms, which present at birth, include ataxia, hypotonia, mental retardation, and seizures. Premature death often results. D-2-Hydroxyglutaric Aciduria is an autosomal recessive disease caused by a mutation in the D2HGDH gene which does for D-2-Hydroxygluarate dehydrogenase. A deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid. Symptoms, which present at birth, include ataxia, hypotonia, mental retardation, and seizures. Premature death often results.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: September 10, 2018 at 15:50

Last Updated: September 10, 2018 at 15:50

PW000212

Pw000212 View Pathway
disease

2-Hydroxyglutric Aciduria (D and L Form)

Homo sapiens
L-2-Hydroxyglutaric Aciduria (D-2-Hydroxyglutaric Aciduria ) is an autosomal recessive disease caused by a mutation in the L2HGDH gene which codes for L-2-Hydroxygluarate dehydrogenase. A deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid. Symptoms, which present at birth, include ataxia, hypotonia, mental retardation, and seizures. Premature death often results. D-2-Hydroxyglutaric Aciduria is an autosomal recessive disease caused by a mutation in the D2HGDH gene which does for D-2-Hydroxygluarate dehydrogenase. A deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid. Symptoms, which present at birth, include ataxia, hypotonia, mental retardation, and seizures. Premature death often results.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: WishartLab

Created On: August 20, 2013 at 13:00

Last Updated: August 20, 2013 at 13:00

PW127064

Pw127064 View Pathway
disease

2-HG (updated)

Homo sapiens
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Nitya Khetarpal

Created On: August 04, 2022 at 13:04

Last Updated: August 04, 2022 at 13:04