Loader

Pathways

PathWhiz ID Pathway Meta Data

PW127165

Pw127165 View Pathway
metabolic

Warfarin Metabolism

Homo sapiens

PW146013

Pw146013 View Pathway
drug action

Water Drug Metabolism Action Pathway

Homo sapiens

PW123688

Pw123688 View Pathway
physiological

WDR92-mediated gene silencing

Homo sapiens

PW124387

Pw124387 View Pathway
disease

Wilson disease

Homo sapiens
Wilson disaease

PW000842

Pw000842 View Pathway
signaling

Wnt

Homo sapiens

PW123854

Pw123854 View Pathway
signaling

Wnt 1586270741

Homo sapiens
WNT MTOR

PW002348

Pw002348 View Pathway
signaling

Wnt pathway

Homo sapiens

PW078607

Pw078607 View Pathway
signaling

WNT Signaling Pathway

Homo sapiens
The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities.The Wnts are secreted glycoproteins and comprise a large family of nineteen proteins in humans hinting to a daunting complexity of signaling regulation, function and biological output. To date major signaling branches downstream of the Fz receptor have been identified including a canonical or Wnt/β-catenin dependent pathway and the non-canonical or β-catenin-independent pathway which can be further divided into the Planar Cell Polarity and the Wnt/Ca2+ pathways, and these branches are being actively dissected at the molecular and biochemical levels.

PW122507

Pw122507 View Pathway
signaling

Wnt-PCP pathway

Mus musculus

PW090973

Pw090973 View Pathway
signaling

Wnt/LRP6 Signalling

Homo sapiens
Canonical Wnt/β-catenin signaling has central roles in development and diseases, and is initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3) initiates Wnt/β-catenin signaling. Both Fz and Dvl functions are critical for Wnt-induced Lrp6 phosphorylation through Fz-Lrp6 interaction.