PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146127 View Pathway	drug action Iodohippurate sodium I-131 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:28 Last Updated: October 07, 2023 at 17:28
PW146164 View Pathway	drug action Iofetamine I-123 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:33 Last Updated: October 07, 2023 at 17:33
PW145847 View Pathway	drug action Ioflupane I-123 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:48 Last Updated: October 07, 2023 at 16:48
PW176262 View Pathway	metabolic Ioflupane I-123 Predicted Metabolism Pathway Homo sapiens Metabolites of Ioflupane I-123 are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:16 Last Updated: December 04, 2023 at 14:16
PW145395 View Pathway	drug action Iohexol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:44 Last Updated: October 07, 2023 at 15:44
PW146433 View Pathway	drug action Iomeprol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:11 Last Updated: October 07, 2023 at 18:11
PW176071 View Pathway	metabolic Iomeprol Predicted Metabolism Pathway new Homo sapiens Metabolites of Iomeprol are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:43 Last Updated: November 29, 2023 at 13:43
PW091052 View Pathway	protein Ion Channel and Phorbal Esters Signaling Pathway Homo sapiens Ionomycin is an ionophore, a compound that binds calcium ions reversibly, and is used to transport calcium ions across the cell’s plasma membrane, increasing cellular calcium concentration. This increased concentration activates the protein-tyrosine kinase 2-beta, which is responsible for regulation of actin in the cell’s cytoskeleton, as well as cell movement, polarization, adhesion and spreading. It is also important for B-cells and T-cells to migrate and spread. When the P2Y purinoceptor 2 is activated on the cell surface, it activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1), an enzyme that is responsible for regulating the conversion of phosphatidylinositol (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DG). IP3 then activates an IP3 sensitive calcium channel, increasing the concentration of intracellular calcium. The calcium can activate protein-tyrosine kinase 2-beta, and can also activate protein kinase C. DG also works to activate protein kinase C in the cell. Phorbal esters are compounds found in certain families of plants, and are found to promote tumor growth. As such, they are commonly used in research. In this pathway, they are shown to activate protein kinase C in the same way as calcium does, as well as mimicking the action of DG. Phorbal esters, in conjunction with ionomycin, are used in this case to study the cellular response to DAG and calcium signalling without needing the cells to undergo other stimulation, mimicking things like T-cell activation easily. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Jonas Patron Created On: August 14, 2018 at 15:04 Last Updated: August 14, 2018 at 15:04
PW122232 View Pathway	protein Ion Channel and Phorbal Esters Signaling Pathway Rattus norvegicus Molecules transmitting signals into cells often act through receptors in the plasma membrane that stimulate production of second messengers. When activated by a plasma membrane receptor, the enzyme phospholipase C (PLCg) hydrolyzes the membrane lipid phosphatidylinositol (PIP2) into the second messengers diacylglycerol (DAG) and IP3. IP3 releases calcium from intracellular stores into the cytoplasm where calcium alters many cellular activities, including activating protein kinase C. DAG also activates protein kinase C. Biologists often study signaling by artificially manipulating pathways using molecules like ionomycin and phorbol esters as research tools. Ionomycin is a molecule that carries calcium through the plasma membrane to increase the calcium concentration in the cytoplasm and activate protein kinase C without activating phospholipase C. Phorbol esters are molecules that mimic the action of DAG in the activation of protein kinase C, and were originally identified as tumor-promoting agents. The combination of ionomycin and phorbol esters is often used experimentally to study the effect of calcium and DAG signaling in cellular responses like T cell activation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 15:08 Last Updated: September 20, 2018 at 15:08
PW122208 View Pathway	protein Ion Channel and Phorbal Esters Signaling Pathway Bos taurus Molecules transmitting signals into cells often act through receptors in the plasma membrane that stimulate production of second messengers. When activated by a plasma membrane receptor, the enzyme phospholipase C (PLCg) hydrolyzes the membrane lipid phosphatidylinositol (PIP2) into the second messengers diacylglycerol (DAG) and IP3. IP3 releases calcium from intracellular stores into the cytoplasm where calcium alters many cellular activities, including activating protein kinase C. DAG also activates protein kinase C. Biologists often study signaling by artificially manipulating pathways using molecules like ionomycin and phorbol esters as research tools. Ionomycin is a molecule that carries calcium through the plasma membrane to increase the calcium concentration in the cytoplasm and activate protein kinase C without activating phospholipase C. Phorbol esters are molecules that mimic the action of DAG in the activation of protein kinase C, and were originally identified as tumor-promoting agents. The combination of ionomycin and phorbol esters is often used experimentally to study the effect of calcium and DAG signaling in cellular responses like T cell activation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:59 Last Updated: September 20, 2018 at 14:59