PathWhiz

PathWhiz ID	Pathway	Meta Data
PW132600 View Pathway	metabolic Oteracil Drug Metabolism Homo sapiens Oteracil is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Oteracil passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:34 Last Updated: September 21, 2023 at 22:34
PW145529 View Pathway	drug action Oteracil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:00 Last Updated: October 07, 2023 at 16:00
PW127398 View Pathway	drug action Oteseconazole Action Pathway Homo sapiens Oteseconazole is an azole antifungal used to prevent recurrent vulvovaginal candidiasis in females who are not of reproductive potential. By binding and inhibiting CYP51, oteseconazole is active against most microorganisms associated with recurrent vulvovaginal candidiasis (RVVC). Oteseconazole has demonstrated activity against Candida albicans, Candida glabrata, Candida krusei, Candida parapsilosis, Candida tropicalis, Candida lusitaniae and Candida dubliniensis. Unlike previous-generation azole antifungals, oteseconazole has a high selectivity for CYP51 and little interaction with human cytochrome P450s. Oteseconazole inhibits the enzyme lanosterol 14-alpha demethylase. Lanosterol 14-alpha demethylase is the enzyme that catalyzes the synthesis of 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol from lanosterol. With this enzyme inhibited ergosterol synthesis cannot occur which causes a significant low concentration of ergosterol in the fungal cell. Ergosterol is essential in maintaining membrane integrity in fungi. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die.Because of its ability to bind and inhibit CYP51, oteseconazole is active against most microorganisms associated with recurrent vulvovaginal candidiasis (RVVC). Besides blocking the formation of ergosterol, oteseconazole also promotes the accumulation of 14-methylated sterols that lead to fungal cell death. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: January 05, 2023 at 09:16 Last Updated: January 05, 2023 at 09:16
PW146577 View Pathway	drug action Oteseconazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:33 Last Updated: October 07, 2023 at 18:33
PW176109 View Pathway	metabolic Oteseconazole Predicted Metabolism Pathway new Homo sapiens Metabolites of Oteseconazole are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:01 Last Updated: November 29, 2023 at 14:01
PW145183 View Pathway	drug action Ouabain Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:15 Last Updated: October 07, 2023 at 15:15
PW123588 View Pathway	disease Ovarian Cancer Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 04, 2019 at 18:10 Last Updated: September 04, 2019 at 18:10
PW120522 View Pathway	signaling OX40 Signaling Pathway Homo sapiens OX40 is a type 1 transmembrane glycoprotein, reported nearly 30 years ago as a cell surface antigen expressed on activated T cells. Since its discovery, it has been validated as a bone fide costimulatory molecule for T cells and member of the TNF receptor family. Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a fellow of the TNFR-superfamily of receptors. It is a protein which in humans is encoded by the TNFRSF4 gene which contains 9 exons. It also has been demonstrated to have a key role in the survival and homeostasis of effector and memory T cells in transplantation and autoimmunity. OX40 is not constitutively expressed on resting naive T cells, unlike CD28. As a secondary co-stimulatory immune checkpoint molecule, it expresses after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells and resting naive T cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell and the expression of CD28; without CD28, expression of OX40 is delayed and of fourfold lower levels. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aidin Foroutannaddafi Created On: September 07, 2018 at 19:53 Last Updated: September 07, 2018 at 19:53
PW127494 View Pathway	drug action Oxacillin Action Pathway Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Oxacillin is a penicillin antibiotic used to treat a number of susceptible bacterial infections. Oxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Oxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacillin interferes with an autolysin inhibitor. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: March 20, 2023 at 03:22 Last Updated: March 20, 2023 at 03:22
PW144825 View Pathway	drug action Oxacillin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:30 Last Updated: October 07, 2023 at 14:30