PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144670 View Pathway	drug action Methoxsalen Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:10 Last Updated: October 07, 2023 at 14:10
PW176391 View Pathway	metabolic Methoxsalen Predicted Metabolism Pathway Homo sapiens Metabolites of Methoxsalen are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:42 Last Updated: December 07, 2023 at 16:42
PW132296 View Pathway	metabolic Methoxyflurane Drug Metabolism Homo sapiens Methoxyflurane is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Methoxyflurane passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:42 Last Updated: September 21, 2023 at 20:42
PW145125 View Pathway	drug action Methoxyflurane Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:08 Last Updated: October 07, 2023 at 15:08
PW146663 View Pathway	drug action Methoxyphenamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:45 Last Updated: October 07, 2023 at 18:45
PW146348 View Pathway	drug action Methscopolamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:59 Last Updated: October 07, 2023 at 17:59
PW127924 View Pathway	drug action Methsuximide Action Pathway Homo sapiens Methsuximide is a succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures. It can be found under the brand names Celontin and Petinutin. Used in the treatment of epilepsy. Methsuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli. It binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. GABA release is inhibited due to mutations of the SCN1A, SCN1B gene causing enhanced reuptake. Possible side effects of using methsuximide may include nausea, constipation, weight loss, and hiccups. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 20, 2023 at 08:48 Last Updated: June 20, 2023 at 08:48
PW132480 View Pathway	metabolic Methsuximide Drug Metabolism Homo sapiens Methsuximide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Methsuximide passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:59 Last Updated: September 21, 2023 at 21:59
PW145634 View Pathway	drug action Methsuximide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:16 Last Updated: October 07, 2023 at 16:16
PW000327 View Pathway	drug action Methyclothiazide Action Pathway Homo sapiens Methyclothiazide (also known as Enduron or Methyclothiazid) is an organic compound that used for diuretic. It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption. Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount. Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium gradient that will increase the osmolarity in interstitium, which lead to establishment of osmotic gradient for water reabsorption. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45