PathWhiz

PathWhiz ID	Pathway	Meta Data
PW000228 View Pathway	drug action Lisinopril Action Pathway Homo sapiens Benazepril, brand name Lotensin, belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can also be used in the treatment of congestive heart failure and type II diabetes. Benazepril is a prodrug which, following oral administration, undergoes biotransformation in vivo into its active form benazeprilat via cleavage of its ester group by the liver. Angiotensin-converting enzyme (ACE) is a component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I into the active vasoconstrictor angiotensin II. ACE (or kininase II) also degrades the potent vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW144834 View Pathway	drug action Lisinopril Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:31 Last Updated: October 07, 2023 at 14:31
PW123951 View Pathway	signaling Listeria monocytogenes pathway Homo sapiens LAP from L. monocytogenes interact with human intestinal epithelial cells HSP60 BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 29, 2020 at 13:37 Last Updated: June 29, 2020 at 13:37
PW128257 View Pathway	drug action Lisuride Dopamine Agonist Action Pathway Homo sapiens Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. Lisuride is an ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 10, 2023 at 12:29 Last Updated: August 10, 2023 at 12:29
PW132580 View Pathway	metabolic Lisuride Drug Metabolism Homo sapiens Lisuride is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Lisuride passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:29 Last Updated: September 21, 2023 at 22:29
PW144705 View Pathway	drug action Lisuride Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:16 Last Updated: October 07, 2023 at 14:16
PW128475 View Pathway	drug action Lisuride Serotonin agonist Action Pathway Homo sapiens Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. Lisuride is an ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 30, 2023 at 11:30 Last Updated: August 30, 2023 at 11:30
PW132243 View Pathway	metabolic Lithium carbonate Drug Metabolism Homo sapiens Lithium carbonate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Lithium carbonate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:22 Last Updated: September 21, 2023 at 20:22
PW146830 View Pathway	drug action Lithium carbonate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:08 Last Updated: October 07, 2023 at 19:08
PW132236 View Pathway	metabolic Lithium citrate Drug Metabolism Homo sapiens Lithium citrate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Lithium citrate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:19 Last Updated: September 21, 2023 at 20:19