PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144696 View Pathway	drug action Mazindol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:14 Last Updated: October 07, 2023 at 14:14
PW064691 View Pathway	signaling MBP Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: February 24, 2018 at 04:41 Last Updated: February 24, 2018 at 04:41
PW128003 View Pathway	drug action Mebendazole Action Pathway Homo sapiens Mebendazole is a synthetic benzimidazole anthelmintic used to treat helminth infections. This drug is used for the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenal (common hookworm), Necator americanus (American hookworm) infections. Mebendazole causes degenerative alterations in the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP). Due to diminished concentration in ATP, the parasite eventually dies. Mebendazole is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 28, 2023 at 12:55 Last Updated: June 28, 2023 at 12:55
PW144756 View Pathway	drug action Mebendazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:21 Last Updated: October 07, 2023 at 14:21
PW146543 View Pathway	drug action Mebeverine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:28 Last Updated: October 07, 2023 at 18:28
PW062003 View Pathway	drug action Mebhydrolin H1-Antihistamine Action Homo sapiens Mebhydrolin is a first-generation H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release. First-generation antihistamines readily cross the blood-brain barrier and cause sedation and other adverse central nervous system (CNS) effects (e.g. nervousness and insomnia). Second-generation antihistamines are more selective for H1-receptors of the peripheral nervous system (PNS) and do not cross the blood-brain barrier. Consequently, these newer drugs elicit fewer adverse drug reactions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: September 20, 2017 at 23:34 Last Updated: September 20, 2017 at 23:34
PW146939 View Pathway	drug action Mebrofenin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:24 Last Updated: October 07, 2023 at 19:24
PW176269 View Pathway	metabolic Mebrofenin Predicted Metabolism Pathway Homo sapiens Metabolites of Mebrofenin are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:24 Last Updated: December 04, 2023 at 14:24
PW145803 View Pathway	drug action Mebutamate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:42 Last Updated: October 07, 2023 at 16:42
PW132529 View Pathway	metabolic Mecamylamine Drug Metabolism Homo sapiens Mecamylamine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Mecamylamine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:16 Last Updated: September 21, 2023 at 22:16