PathWhiz

PathWhiz ID	Pathway	Meta Data
PW088423 View Pathway	metabolic Pterine Biosynthesis Drosophila melanogaster Folates are very important cofactors that provide support for many biosynthetic reactions. The reactions depicted in this pathway include reactions that are paired with transports, within the cell, travelling intracellularly, which allows folate to be absorbed by cells, as well as the synthesis of pterines, which are used in folate synthesis. Two branches are depicted: Pterin synthesis and Folate biosynthesis. In pterin synthesis, GTP is the precursor for pterin biosynthesis. In the first reaction, GTP cyclohydrolase acts to create formamidopyrimidine nucleoside triphosphate from guanosine triphosphate, which is provided from the purine metabolism pathway. Formamidopyrimidine nucleoside triphosphate then uses GTP cyclohydrolase again to create 2,5-diaminopyrimidine nucleoside triphosphate. GTP cyclohydrolase then works with 2,5-diaminopyrimidine nucleoside triphosphate to produce 2,3-diamino-6-(5’-triphosphoryl-3’,4’-trihydroxy-2’-oxopentyl)-amino-4-oxopyrimidine, which is then converted by GTP cyclohydrolase to dihydroneopterin triphosphate. Dihydroneopterin is then transported to the mitochondria and subsequently catalyzed into dyspropterin, which then exits the mitochondria to continue pterin biosynthesis. Once having been transported from the mitochondria, dyspropterin uses sepiapterin reductase, aldose reductase and carbonyl reductase [NADPH] 1 to create 6-lactoyltetrahydropterin. This compound then undergoes 2 reactions, the first being sepiapterin reductase converting 6-lactoyltetrahydropterin into tetrahydrobiopterin, the second being 6-lactoyltetrahydropterin being converted to sepiapterin. Both branches of pterin reactions then respectively end in the creation of neopterin and dihydrobiopterin. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 16:17 Last Updated: August 10, 2018 at 16:17
PW000140 View Pathway	metabolic Pterine Biosynthesis Homo sapiens Folates are very important cofactors that provide support for many biosynthetic reactions. The reactions depicted in this pathway include reactions that are paired with transports, within the cell, travelling intracellularly, which allows folate to be absorbed by cells, as well as the synthesis of pterines, which are used in folate synthesis. Two branches are depicted: Pterin synthesis and Folate biosynthesis. In pterin synthesis, GTP is the precursor for pterin biosynthesis. In the first reaction, GTP cyclohydrolase acts to create formamidopyrimidine nucleoside triphosphate from guanosine triphosphate, which is provided from the purine metabolism pathway. Formamidopyrimidine nucleoside triphosphate then uses GTP cyclohydrolase again to create 2,5-diaminopyrimidine nucleoside triphosphate. GTP cyclohydrolase then works with 2,5-diaminopyrimidine nucleoside triphosphate to produce 2,3-diamino-6-(5’-triphosphoryl-3’,4’-trihydroxy-2’-oxopentyl)-amino-4-oxopyrimidine, which is then converted by GTP cyclohydrolase to dihydroneopterin triphosphate. Dihydroneopterin is then transported to the mitochondria and subsequently catalyzed into dyspropterin, which then exits the mitochondria to continue pterin biosynthesis. Once having been transported from the mitochondria, dyspropterin uses sepiapterin reductase, aldose reductase and carbonyl reductase [NADPH] 1 to create 6-lactoyltetrahydropterin. This compound then undergoes 2 reactions, the first being sepiapterin reductase converting 6-lactoyltetrahydropterin into tetrahydrobiopterin, the second being 6-lactoyltetrahydropterin being converted to sepiapterin. Both branches of pterin reactions then respectively end in the creation of neopterin and dihydrobiopterin. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 16, 2013 at 12:55 Last Updated: August 16, 2013 at 12:55
PW088362 View Pathway	metabolic Pterine Biosynthesis Rattus norvegicus Folates are very important cofactors that provide support for many biosynthetic reactions. The reactions depicted in this pathway include reactions that are paired with transports, within the cell, travelling intracellularly, which allows folate to be absorbed by cells, as well as the synthesis of pterines, which are used in folate synthesis. Two branches are depicted: Pterin synthesis and Folate biosynthesis. In pterin synthesis, GTP is the precursor for pterin biosynthesis. In the first reaction, GTP cyclohydrolase acts to create formamidopyrimidine nucleoside triphosphate from guanosine triphosphate, which is provided from the purine metabolism pathway. Formamidopyrimidine nucleoside triphosphate then uses GTP cyclohydrolase again to create 2,5-diaminopyrimidine nucleoside triphosphate. GTP cyclohydrolase then works with 2,5-diaminopyrimidine nucleoside triphosphate to produce 2,3-diamino-6-(5’-triphosphoryl-3’,4’-trihydroxy-2’-oxopentyl)-amino-4-oxopyrimidine, which is then converted by GTP cyclohydrolase to dihydroneopterin triphosphate. Dihydroneopterin is then transported to the mitochondria and subsequently catalyzed into dyspropterin, which then exits the mitochondria to continue pterin biosynthesis. Once having been transported from the mitochondria, dyspropterin uses sepiapterin reductase, aldose reductase and carbonyl reductase [NADPH] 1 to create 6-lactoyltetrahydropterin. This compound then undergoes 2 reactions, the first being sepiapterin reductase converting 6-lactoyltetrahydropterin into tetrahydrobiopterin, the second being 6-lactoyltetrahydropterin being converted to sepiapterin. Both branches of pterin reactions then respectively end in the creation of neopterin and dihydrobiopterin. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 14:59 Last Updated: August 10, 2018 at 14:59
PW123847 View Pathway	drug action punicaligin Action Pathway Candida albicans BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: March 30, 2020 at 08:26 Last Updated: March 30, 2020 at 08:26
PW124215 View Pathway	metabolic Purina Homo sapiens RUTAS Y TODO ASI MAMALON BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Saul Created On: October 13, 2020 at 17:31 Last Updated: October 13, 2020 at 17:31
PW124216 View Pathway	metabolic PurinaA Homo sapiens ASI MAMALON BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Saul Created On: October 13, 2020 at 17:33 Last Updated: October 13, 2020 at 17:33
PW124254 View Pathway	metabolic Purine human BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: luis Created On: October 19, 2020 at 18:01 Last Updated: October 19, 2020 at 18:01
PW124284 View Pathway	metabolic Purine Catabolism Homo sapiens Purines Catabolism. Focusing on definciency of ADA, causing SCID. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 26, 2020 at 22:09 Last Updated: October 26, 2020 at 22:09
PW001887 View Pathway	metabolic Purine Degradation Escherichia coli Pseudouridine is phosphorylated by interacting with atp and a psuK resulting in the release of an ADP, a hydrogen ion and a pseudouridine 5'-phosphate. The latter compound then reacts with water through a pseudouridine 5'-phosphate glycosidase resulting in the release of a uracil and D-ribofuranose 5-phosphate BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: September 09, 2015 at 16:20 Last Updated: September 09, 2015 at 16:20
PW002077 View Pathway	metabolic Purine Deoxyribonucleosides Degradation Escherichia coli The purine deoxyribonucleosides degradation starts with deoxyadenosine reacting with a water molecule and a hydrogen in through a deoxyadenosune deaminase resulting in the release of ammonium and a deoxyinosine. Deoxyinosine reacts in a reversible manner with phosphate through a deoxyinosine phosphorylase resulting in the release of a hypoxanthine and a 2-deoxy-alpha-D-ribose-1-phosphate. Deoxyadenosine reacts with a phosphate through a deoxyadenosine phosphorylase resulting in the release of adenine and a 2-deoxy-alpha-D-ribose-1-phosphate. This compound in turn reacts with guanine through a deoxyguanosine phosphorylase resulting in the release of a phosphate and a deoxyguanosine. Deoxy-alpha-D-ribose 1-phosphate reacts with a deoxyribose 1,5-phosphomutase resulting in the release of a 2-deoxy-D-ribose 5 phosphate. This compound in turn reacts with deoxyribose-phosphate aldolase resulting in the release of an acetaldehyde and a a D-glyceraldehyde 3-phosphate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: October 13, 2015 at 11:30 Last Updated: October 13, 2015 at 11:30