PathWhiz

PathWhiz ID	Pathway	Meta Data
PW126170 View Pathway	drug action Sildenafil Action Pathway Homo sapiens Sildenafil is a phosphodiesterase-5 inhibitor used for the treatment of erectile dysfunction. Sexual stimulation causes the release of nitric oxide (NO) from nerves and endothelial cells into the penis. NO activates the enzyme guanylate cyclase.2 The activation of this enzyme is followed by the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP), activating a cascade of protein kinase-dependent phosphorylation events in smooth muscles, ultimately resulting in the dephosphorylation of myosin light chains within smooth muscle. This activity causes the relaxation of smooth muscle within blood vessels, resulting in the desired vasodilatory effect. Phosphodiesterase-5 breaks down cGMP to GMP. Sildenafil inhibits phosphodiesterase-5, preventing the breakdown of cGMP. This increases the concentration of cGMP, increasing the vasodilation and improving blood flow leading to penile erection. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: July 28, 2021 at 23:48 Last Updated: July 28, 2021 at 23:48
PW144334 View Pathway	drug action Sildenafil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:25 Last Updated: October 07, 2023 at 13:25
PW175936 View Pathway	metabolic Sildenafil Predicted Metabolism Pathway Homo sapiens Sildenafil PIS1M1, Sildenafil PIS1M2, Sildenafil PIS2M1 are metabolites of Sildenafil predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 16, 2023 at 12:44 Last Updated: November 16, 2023 at 12:44
PW146253 View Pathway	drug action Silicon dioxide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:47 Last Updated: October 07, 2023 at 17:47
PW146576 View Pathway	drug action Silicon Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:33 Last Updated: October 07, 2023 at 18:33
PW145677 View Pathway	drug action Silodosin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:22 Last Updated: October 07, 2023 at 16:22
PW146759 View Pathway	drug action Silodrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:58 Last Updated: October 07, 2023 at 18:58
PW146574 View Pathway	drug action Silver Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:32 Last Updated: October 07, 2023 at 18:32
PW146220 View Pathway	drug action Silver nitrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:42 Last Updated: October 07, 2023 at 17:42
PW132182 View Pathway	metabolic Silver sulfadiazine Drug Metabolism Homo sapiens Silver sulfadiazine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Silver sulfadiazine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 19:58 Last Updated: September 21, 2023 at 19:58