PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144473 View Pathway	drug action Trimethadione Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:42 Last Updated: October 07, 2023 at 13:42
PW176157 View Pathway	metabolic Trimethadione Predicted Metabolism Pathway new Homo sapiens Metabolites of Trimethadione are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:23 Last Updated: November 29, 2023 at 14:23
PW145205 View Pathway	drug action Trimethaphan Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:18 Last Updated: October 07, 2023 at 15:18
PW144775 View Pathway	drug action Trimethobenzamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:24 Last Updated: October 07, 2023 at 14:24
PW144565 View Pathway	drug action Trimethoprim Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:54 Last Updated: October 07, 2023 at 13:54
PW176444 View Pathway	metabolic Trimethoprim Predicted Metabolism Pathway Homo sapiens Metabolites of Trimethoprim are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 12:55 Last Updated: December 12, 2023 at 12:55
PW145245 View Pathway	drug action Trimetrexate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:24 Last Updated: October 07, 2023 at 15:24
PW127943 View Pathway	drug action Trimipramine Action Pathway Homo sapiens Trimipramine is a tricyclic antidepressant (TCA) used to treat depression accompanied or not by anxiety and agitation or sleep disturbance. It is very similar to imipramine but it has more antihistaminic and sedative properties. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT) in the neurons. By binding to the sodium-dependent serotonin transporter and the sodium-dependent noradrenaline transporter, trimipramine fulfill its functions. Some side effects of its use include agitation, convulsions, irregular heart rate, muscle rigidity, stupor, and some others. This drug is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 21, 2023 at 12:58 Last Updated: June 21, 2023 at 12:58
PW144838 View Pathway	drug action Trimipramine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:32 Last Updated: October 07, 2023 at 14:32
PW147100 View Pathway	drug action Trimipramine H1 Antihistamine Neurological Sleep Action Pathway Homo sapiens Trimipramine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Wakefulness is regulated by histamine in the tuberomammillary nucleus, a part of the hypothalamus. Histidine is decarboxylated into histamine in the neuron. Histamine is transported into synaptic vesicles by a monoamine transporter then released into the synapse. Normally histamine would activate the H1 histamine receptor on the post-synaptic neuron in the tuberomammillary nucleus. Trimipramine inhibits the H1 histamine receptor, preventing the depolarization of the post-synaptic neuron. This prevents the wakefulness signal from being sent to the major areas of the brain, causing sleepiness. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 14:47 Last Updated: October 10, 2023 at 14:47