PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145950 View Pathway	drug action Trimetazidine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:02 Last Updated: October 07, 2023 at 17:02
PW127933 View Pathway	drug action Trimethadione Action Pathway Homo sapiens Trimethadione is an anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures. Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened. GABA release is inhibited due to mutations of the SCN1A, SCN1B gene causing enhanced reuptake. Possible side effects of using trimethadione may include tiredness, changes in weight, hiccups, and headache. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 20, 2023 at 14:03 Last Updated: June 20, 2023 at 14:03
PW144473 View Pathway	drug action Trimethadione Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:42 Last Updated: October 07, 2023 at 13:42
PW176157 View Pathway	metabolic Trimethadione Predicted Metabolism Pathway new Homo sapiens Metabolites of Trimethadione are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:23 Last Updated: November 29, 2023 at 14:23
PW145205 View Pathway	drug action Trimethaphan Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:18 Last Updated: October 07, 2023 at 15:18
PW144775 View Pathway	drug action Trimethobenzamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:24 Last Updated: October 07, 2023 at 14:24
PW144565 View Pathway	drug action Trimethoprim Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:54 Last Updated: October 07, 2023 at 13:54
PW176444 View Pathway	metabolic Trimethoprim Predicted Metabolism Pathway Homo sapiens Metabolites of Trimethoprim are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 12:55 Last Updated: December 12, 2023 at 12:55
PW145245 View Pathway	drug action Trimetrexate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:24 Last Updated: October 07, 2023 at 15:24
PW127943 View Pathway	drug action Trimipramine Action Pathway Homo sapiens Trimipramine is a tricyclic antidepressant (TCA) used to treat depression accompanied or not by anxiety and agitation or sleep disturbance. It is very similar to imipramine but it has more antihistaminic and sedative properties. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT) in the neurons. By binding to the sodium-dependent serotonin transporter and the sodium-dependent noradrenaline transporter, trimipramine fulfill its functions. Some side effects of its use include agitation, convulsions, irregular heart rate, muscle rigidity, stupor, and some others. This drug is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 21, 2023 at 12:58 Last Updated: June 21, 2023 at 12:58