PathWhiz

PathWhiz ID	Pathway	Meta Data
PW124480 View Pathway	metabolic Acetonitrile Metabolism Homo sapiens Methyl cyanide (acetonitrile) is metabolized to citrate, succinate, fumarate, malate, glutamate, pyrrolidonecarboxylic acid and aspartate. Non-radioactive acetamide and acetate compete with 14C from methyl cyanide, and [2-14C]acetate and [2-14C]methyl cyanide are metabolized at similar rates, giving identical products. This evidence, combined with the inhibitory effect of fluoroacetate and arsenite on methyl cyanide metabolism, indicates that the pathway is: methyl cyanide leads to acetamide leads to acetate leads to tricarboxylic acid-cycle intermediates. The pathway was investigated in a species of Pseudomonas (group III; N.C.I.B. 10477), but comparison of labelling patterns suggests that it also exists in several higher plants. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Anastasija Petrovic Created On: January 25, 2021 at 21:30 Last Updated: January 25, 2021 at 21:30
PW145155 View Pathway	drug action Acetophenazine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:11 Last Updated: October 07, 2023 at 15:11
PW124173 View Pathway	metabolic acetyl CoA production by PDH and Krebs cycle human metabolic pathway of acetyl CoA production by PDH and Krebs cycle BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 22, 2020 at 15:42 Last Updated: September 22, 2020 at 15:42
PW128457 View Pathway	drug action Acetyl sulfisoxazole Action Pathway Escherichia coli (strain K12) Acetyl sulfisoxazole is an antibacterial from the sulfanilamide drug class. It is a broad-spectrum antibiotic indicated against urinary tract infections, meningococcal meningitis, acute otitis media, inclusion conjunctivitis, toxoplasmosis, and many others. Acetyl sulfisoxazole is a synthetic bacteriostatic, meaning that it stops the bacteria from growing. This drug binds competitively to the dihydropteroate synthase enzyme. This enzyme is essential to produce dihydrofolic acid in bacteria, when it is inhibited, the bacteria cannot grow anymore because they cannot produce DNA with the folic acid. Thus drug is administered as an oral tablet. N1-acetyl sulfisoxazole is metabolized to sulfisoxazole by digestive enzymes in the gastrointestinal tract and is absorbed as sulfisoxazole (the active compound). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 29, 2023 at 12:52 Last Updated: August 29, 2023 at 12:52
PW132441 View Pathway	metabolic Acetyl sulfisoxazole Drug Metabolism Homo sapiens Acetyl sulfisoxazole is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Acetyl sulfisoxazole passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:48 Last Updated: September 21, 2023 at 21:48
PW146741 View Pathway	drug action Acetyl sulfisoxazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:56 Last Updated: October 07, 2023 at 18:56
PW120684 View Pathway	protein Acetylation and Deacetylation of RelA in The Nucleus Homo sapiens NF-kB transcription factor plays a role in the inflammatory and immune response of mammals. Acetylation of RelA regulates NF-kB activity. Tumor necrosis factor activates tumor necrosis factor receptor, recruiting proteins FADD, TRADD, RIP and TRAF6 to activate the NF-kB pathway. Activation of IKK complex causes the phosphorylation of I-kappa-B-alpha and triggers its degradation. I-kappa-B-alpha normally sequesters KF-kB in the cytoplasm, following its degradation, RELA and p50 (subunits of NF-kB) are liberated can translocate to the nucleus to activate gene expression. RelA and p50 associate with p300 and CREB transcriptional co-activators causing the acetylation of RelA and increase in transcriptional activity. Acetylated RelaA is targeted for deacetylation by transcriptional co-repressor Histone deacetylation 3 (HDAC3). This promotes its binding to I-kappa-B-alpha causing NF-kB's transport out of the nucleus and reduces its activity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Debra Lipton Created On: September 10, 2018 at 14:46 Last Updated: September 10, 2018 at 14:46
PW145852 View Pathway	drug action Acetylcarnitine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:49 Last Updated: October 07, 2023 at 16:49
PW145524 View Pathway	drug action Acetylcholine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:00 Last Updated: October 07, 2023 at 16:00
PW123915 View Pathway	signaling acetylcholine signaling Rattus norvegicus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Naveen Singh Created On: June 04, 2020 at 01:23 Last Updated: June 04, 2020 at 01:23