PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146706 View Pathway	drug action Testosterone undecanoate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:50 Last Updated: October 07, 2023 at 18:50
PW124220 View Pathway	metabolic Testpeterpath Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 13, 2020 at 19:45 Last Updated: October 13, 2020 at 19:45
PW145594 View Pathway	drug action Tetrabenazine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:09 Last Updated: October 07, 2023 at 16:09
PW176409 View Pathway	metabolic Tetrabenazine Predicted Metabolism Pathway Homo sapiens Metabolites of Tetrabenazine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:57 Last Updated: December 07, 2023 at 16:57
PW145965 View Pathway	drug action Tetracaine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:05 Last Updated: October 07, 2023 at 17:05
PW145643 View Pathway	drug action Tetrachlorodecaoxide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:17 Last Updated: October 07, 2023 at 16:17
PW145359 View Pathway	drug action Tetracosactide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:39 Last Updated: October 07, 2023 at 15:39
PW124338 View Pathway	drug action Tetracycline Homo sapiens Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells. This drug is used to Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: November 12, 2020 at 13:20 Last Updated: November 12, 2020 at 13:20
PW000362 View Pathway	drug action Tetracycline Action Pathway Homo sapiens Tetracycline is a short-acting antibiotic that is semi-synthetically produced from chlortetracycline, a compound derived from Streptomyces aureofaciens. Tetracycline enters bacterial cells by passively diffusing through membrane porin channels. Once inside the cell, tetracycline reversibly binds to the 30S subunit just above the binding site for aminoacyl tRNA. At its primary binding site, interactions with the sugar phosphate backbone of residues in helices 31 and 34 via hydrogen bonds with oxygen atoms and hydroxyl groups on the hydrophilic side of the tetracycline help anchor the drug in position. Salt bridge interactions between the backbone of 16S rRNA and tetracycline are mediated by a magnesium ion in the binding site. Tetracycline prevents incoming aminoacyl tRNA from binding to the A site on the ribosome-RNA complex via steric hindrance. This causes inhibition of protein synthesis and hence bacterial cell growth. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW128349 View Pathway	drug action Tetracycline Action Pathway Homo sapiens Tetracycline is a broad-use antibiotic that is produced by Streptomyces and used to treat bacterial infections such as rocky mountain spotted fever, typhus fever and tick fevers. it is most effectively administered orally but can also be administered via intramuscular injection. It has a half-life of 6-12 hours and is concentrated by the liver and excreted through the urine and feces. Tetracycline can passively transport itself through the bacterial membrane and goes on to inhibit bacterial growth. It stops bacterial growth by binding to the 30S subunits that inhibit the transfer of amino-acyl tRNA to site A of the ribosome. Thus halting protein synthesis and stopping bacterial growth. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 23, 2023 at 11:01 Last Updated: August 23, 2023 at 11:01