PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144313 View Pathway	drug action Amphetamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:22 Last Updated: October 07, 2023 at 13:22
PW012914 View Pathway	metabolic AMP Degradation (Hypoxanthine Route) Arabidopsis thaliana Purine nucleotides are eventually degraded to ammonia and carbon dioxide. This pathway follows the degradation of AMP to a urate intermediate in the cytosol via xanthine conversion from hypoxanthine. First, AMP deaminase catalyzes the conversion of AMP is into IMP. Second, the predicted enzyme 5′-nucleotidase (coloured orange in the image) is theorized to convert IMP into inosine. Third, ribonucleoside hydrolase converts inosine into hypoxanthine. Fourth, xanthine dehydrogenase is an enzyme that requires [2Fe-2S] cluster, FAD, and Moco as cofactors for catalyzing two subsequent reaction in the AMP degradation pathway: the conversion of hypoxanthine into xanthine and the conversion of xanthine into urate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 24, 2017 at 15:38 Last Updated: February 24, 2017 at 15:38
PW145152 View Pathway	drug action Amoxicillin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:11 Last Updated: October 07, 2023 at 15:11
PW127465 View Pathway	drug action Amoxicillin Action Pathway Helicobacter pylori Amoxicillin is a penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections. Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection. Amoxicillin competitively inhibits penicillin-binding protein 1 and other high molecular weight penicillin binding proteins. Penicillin bind proteins are responsible for glycosyltransferase and transpeptidase reactions that lead to cross-linking of D-alanine and D-aspartic acid in bacterial cell walls. Without the action of penicillin binding proteins, bacteria upregulate autolytic enzymes and are unable to build and repair the cell wall, leading to bacteriocidal action. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: March 06, 2023 at 13:44 Last Updated: March 06, 2023 at 13:44
PW128101 View Pathway	drug action Amoxapine SSRI Action Pathway Homo sapiens Amoxapine is a second-generation tricyclic dibenzoxazepine antidepressant, chemically distinct from the dibenzodiazepines, dibenzocycloheptenes, and dibenzoxepines. It has a mild sedative component to its action. The mechanism of its clinical action in man is not well understood. In animals, amoxapine reduced the uptake of norepinephirine and serotonin and blocked the response of dopamine receptors to dopamine. Amoxapine is not a monoamine oxidase inhibitor. Clinical studies have demonstrated that amoxapine has a more rapid onset of action than either amitriptyline or imipramine. Amoxapine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 17, 2023 at 16:13 Last Updated: July 17, 2023 at 16:13
PW144661 View Pathway	drug action Amoxapine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:09 Last Updated: October 07, 2023 at 14:09
PW145942 View Pathway	drug action Amorolfine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:01 Last Updated: October 07, 2023 at 17:01
PW176320 View Pathway	metabolic Amodiaquine Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:02 Last Updated: December 07, 2023 at 15:02
PW144729 View Pathway	drug action Amodiaquine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:18 Last Updated: October 07, 2023 at 14:18
PW127424 View Pathway	drug action Amodiaquine Action Pathway Homo sapiens Amodiaquine, a 4-aminoquinoline similar to chloroquine in structure and activity, is an antimalarial drug. It has also been used as an anti-inflammatory agent. Amodiaquine is at least as effective as chloroquine, and is effective against some chloroquine-resistant strains, although resistance to amodiaquine has been reported. 4-Aminoquinolines depress cardiac muscle, impair cardiac conductivity, and produce vasodilatation with resultant hypotension. They depress respiration and cause diplopia, dizziness and nausea. The mechanism of action of Amodiaquine is not certain, but like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in the accumulation of free heme, which is toxic to the parasite. The drug binds to the heme which prevents the parasite from converting it to a less toxic form. This complex is toxic and disrupts membrane function. This eventually causes parasite death. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: January 26, 2023 at 15:01 Last Updated: January 26, 2023 at 15:01