PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145010 View Pathway	drug action Zonisamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:55 Last Updated: October 07, 2023 at 14:55
PW176168 View Pathway	metabolic Zonisamide Predicted Metabolism Pathway new Homo sapiens Metabolites of Zonisamide are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:29 Last Updated: November 29, 2023 at 14:29
PW128437 View Pathway	drug action Zopiclone Action Pathway Homo sapiens Zopiclone, a nonbenzodiazepine hypnotic belonging to the pyrazolopyrimidine class, is employed for the short-term management of insomnia. Operating outside the benzodiazepine and barbiturate realms, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABABZ) receptor complex, demonstrating both benzodiazepine-like and some barbiturate-like properties. By selectively binding to the brain alpha subunit of the GABA A omega-1 receptor, zopiclone's action unfolds through engagement with the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Its effects align with those of benzodiazepines, acting as full agonists on various GABAA receptor subunits (α1, α2, α3, α5), amplifying GABA's inhibitory actions to produce therapeutic (hypnotic and anxiolytic) and adverse outcomes. Primarily metabolized through processes like decarboxylation, demethylation, and side chain oxidation in the liver, zopiclone undergoes substantial metabolic transformation. This results in the formation of metabolites such as a weakly active N-oxide derivative (constituting around 12% of the dose) and an inactive N-desmethyl metabolite (approximately 16% of the dose). Moreover, nearly 50% of the dose is converted to additional inactive metabolites via decarboxylation, with hepatic microsomal enzymes seemingly playing no significant role in zopiclone clearance. Renowned for its distinct mechanism within the realm of nonbenzodiazepine hypnotics, zopiclone effectively addresses short-term insomnia management. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: August 28, 2023 at 20:41 Last Updated: August 28, 2023 at 20:41
PW145285 View Pathway	drug action Zopiclone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:28 Last Updated: October 07, 2023 at 15:28
PW176169 View Pathway	metabolic Zopiclone Predicted Metabolism Pathway new Homo sapiens Metabolites of Zopiclone are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:29 Last Updated: November 29, 2023 at 14:29
PW146043 View Pathway	drug action Zotepine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:16 Last Updated: October 07, 2023 at 17:16
PW145992 View Pathway	drug action Zucapsaicin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:09 Last Updated: October 07, 2023 at 17:09
PW128180 View Pathway	drug action Zuclopenthixol Dopamine Antagonist Action Pathway Homo sapiens Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. Zuclopenthixol is a typical antipsychotic neuroleptic drug of the thioxanthene class. It mainly acts by antagonism of D1 and D2 dopamine receptors. Zuclopenthixol also has high affinity for alpha1-adrenergic and 5-HT2 receptors. It has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and alpha2-adrenergic receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 28, 2023 at 11:55 Last Updated: July 28, 2023 at 11:55
PW145487 View Pathway	drug action Zuclopenthixol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:55 Last Updated: October 07, 2023 at 15:55
PW147102 View Pathway	drug action Zuclopenthixol H1 Antihistamine Neurological Sleep Action Pathway Homo sapiens Zuclopenthixol is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Wakefulness is regulated by histamine in the tuberomammillary nucleus, a part of the hypothalamus. Histidine is decarboxylated into histamine in the neuron. Histamine is transported into synaptic vesicles by a monoamine transporter then released into the synapse. Normally histamine would activate the H1 histamine receptor on the post-synaptic neuron in the tuberomammillary nucleus. Zuclopenthixol inhibits the H1 histamine receptor, preventing the depolarization of the post-synaptic neuron. This prevents the wakefulness signal from being sent to the major areas of the brain, causing sleepiness. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 14:47 Last Updated: October 10, 2023 at 14:47