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Dihydrodipicolinate synthase Lysine- sensitive aspartokinase 3 Putative sulfate transporter ychM Anaerobic C4- dicarboxylate transporter dcuC Anaerobic C4- dicarboxylate transporter dcuB Proton glutamate symport protein Aerobic C4- dicarboxylate transport protein Diaminopimelate decarboxylase Aspartate- semialdehyde dehydrogenase Dihydrodipicolinate reductase 2,3,4,5- tetrahydropyridine- 2,6- dicarboxylate N- succinyltransferase Acetylornithine/succinyldiaminopimelate aminotransferase Succinyl- diaminopimelate desuccinylase Diaminopimelate epimerase Glutamate/aspartate transport ATP-binding protein gltL Glutamate/aspartate transport system permease protein gltK Glutamate/aspartate transport system permease protein gltJ Glutamate/aspartate periplasmic- binding protein Anaerobic C4- dicarboxylate transporter dcuA L-Lysine meso- diaminopimelate L-Aspartic acid L-Aspartic acid L-Aspartic acid Succinic acid Succinic acid L-Aspartic acid H + H + L-Aspartic acid H + H + H + CO 2 ATP ADP L-Aspartyl-4- phosphate NADPH H + P i NADP L-aspartic 4-semialdehyde Pyruvic acid H + H 2 O (2S,4S)-4- hydroxy- 2,3,4,5- tetrahydrodipicolinate H + NADPH H 2 O NADP (S)-2,3,4,5- tetrahydrodipicolinate Succinyl-CoA H 2 O CoA N-Succinyl-2- amino-6- ketopimelate L-Glutamic acid N-Succinyl- L,L-2,6- diaminopimelate Oxoglutaric acid H 2 O Succinic acid L,L- diaminopimelate L-Aspartic acid ATP H 2 O ADP P i H + Methionine Biosynthesis Peptidoglycan Biosynthesis I Lysine Degradation I
dapA lysC ychM dcuC dcuB gltP dctA lysA asd dapB dapD argD dapE dapF gltL gltK gltJ gltI dcuA L-Lysine meso- diaminopimelate L-Aspartic acid L-Aspartic acid L-Aspartic acid Succinic acid Succinic acid L-Aspartic acid Hydrogen Ion Hydrogen Ion L-Aspartic acid Hydrogen Ion Hydrogen Ion Hydrogen Ion Carbon dioxide Adenosine triphosphate Adenosine diphosphate L-Aspartyl-4- phosphate NADPH Hydrogen Ion Phosphate NADP L-aspartic 4-semialdehyde Pyruvic acid Hydrogen Ion Water (2S,4S)-4- hydroxy- 2,3,4,5- tetrahydrodipicolinate Hydrogen Ion NADPH Water NADP (S)-2,3,4,5- tetrahydrodipicolinate Succinyl-CoA Water Coenzyme A N-Succinyl-2- amino-6- ketopimelate L-Glutamic acid N-Succinyl- L,L-2,6- diaminopimelate Oxoglutaric acid Water Succinic acid L,L- diaminopimelate L-Aspartic acid Adenosine triphosphate Water Adenosine diphosphate Phosphate Hydrogen Ion Methionine Biosynthesis Peptidoglycan Biosynthesis I Lysine Degradation I