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CHEBI:16015 ChEBI HMDB00254 HMDB Glutamate/aspartate transport system permease protein gltK 6022 PubChem-compound P04036 UniProt 439161 PubChem-compound 937 ChemSpider 22138-53-0 CAS HMDB01341 HMDB 50 ChemSpider 1.0 HMDB00148 HMDB 809 ChemSpider ATP BioCyc Glutamate/aspartate periplasmic-binding protein 1.0 5747 ChemSpider 1.0 5745 ChemSpider Dihydrodipicolinate reductase CHEBI:15380 ChEBI 5742 ChemSpider C25H40N7O19P3S Succinyl-CoA 867.1312 L-ASPARTATE BioCyc Glutamate/aspartate transport system permease protein gltJ CHEBI:16474 ChEBI HMDB59597 HMDB P18335 UniProt HMDB00243 HMDB 389314 ChemSpider 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase P08660 UniProt Diaminopimelate epimerase Aerobic C4-dicarboxylate transport protein Proton glutamate symport protein Succinyl-diaminopimelate desuccinylase 1010 ChemSpider 4.0 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Glutamate/aspartate transport ATP-binding protein gltL 4.0 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O BiologicalState109 1.0 HMDB01423 HMDB Hydrogen Ion SubPathwayInteraction1648 SubPathway1648Reaction SubPathwayReaction HMDB00217 HMDB Cytosol Dihydrodipicolinate synthase Adenosine triphosphate SUC BioCyc Acetylornithine/succinyldiaminopimelate aminotransferase 56-87-1 CAS HMDB00208 HMDB 1.0 HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI Hydrogen Ion P0ABN5 UniProt C00001 KEGG Compound Aspartate-semialdehyde dehydrogenase ReactionCoupledTransportCatalysis142 ACTIVATION C00005 KEGG Compound Glutamate/aspartate transport ATP-binding protein gltL CHEBI:18367 ChEBI 1032 ChemSpider 1.0 C00002 KEGG Compound 1031 ChemSpider L-Aspartic acid ReactionCoupledTransport108 false Adenosine triphosphate + L-Aspartic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Aspartic acid + Phosphate LEFT_TO_RIGHT Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB HMDB01429 HMDB L-Aspartic acid 44367445 PubChem-compound C00011 KEGG Compound C00010 KEGG Compound NAD(P) BioCyc 562 TAXONOMY P0ABP1 UniProt H Hydrogen Ion 1.007825 P0ABP4 UniProt 388307 ChemSpider C00022 KEGG Compound 56-65-5 CAS Glutamate/aspartate periplasmic-binding protein C00026 KEGG Compound C00025 KEGG Compound SMILES NC(CC(=O)OP(O)(O)=O)C(O)=O 1.0 P0AAG3 UniProt 328-50-7 CAS Water SMILES OC(=O)CCC(O)=O P0AFR2 UniProt C00042 KEGG Compound C00049 KEGG Compound C00047 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 SMILES NC(CCC[C@H](NC(=O)CCC(O)=O)C(O)=O)C(O)=O 604-98-8 CAS Anaerobic C4-dicarboxylate transporter dcuA SMILES OC(=O)CCC(=O)N[C@@H](CCCC(=O)C(O)=O)C(O)=O SMP00794 SMPDB HMDB00538 HMDB SMP00795 SMPDB CHEBI:18019 ChEBI 1.0 7732-18-5 CAS L-BETA-ASPARTYL-P BioCyc 56-86-0 CAS 4.0 2.0 P0AER3 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:57791 ChEBI P0AER5 UniProt CHEBI:17053 ChEBI 1.0 C04421 KEGG Compound Glutamate/aspartate transport system permease protein gltK Glutamate/aspartate transport system permease protein gltJ SMILES CC(=O)C(O)=O HMDB01967 HMDB 962 PubChem-compound 5800 ChemSpider 4.0 CO2 Carbon dioxide 43.98983 Phosphate C00080 KEGG Compound Periplasmic Space Oxoglutaric acid 1.0 CHEBI:537519 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000814 PathWhiz 14265-44-2 CAS C6H14N2O2 L-Lysine 146.10553 PYRUVATE BioCyc 832 PubChem-compound 58-64-0 CAS SMILES N[C@@H](CC=O)C(O)=O SMILES [O-]C(=O)C1CCCC(=N1)C([O-])=O Putative sulfate transporter ychM SMILES OC1CC(N=C(C1)C([O-])=O)C([O-])=O C00091 KEGG Compound L-Aspartic acid 1.0 CHEBI:57609 ChEBI C4H7NO4 L-Aspartic acid 133.0375 SMILES N[C@@H](CCC[C@H](N)C(O)=O)C(O)=O Transport453 false L-Aspartic acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT Transport452 false L-Aspartic acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT SMILES [H][C@](N)(CCC[C@@]([H])(N)C(O)=O)C(O)=O L-Lysine 2.0 22833512 PubChem-compound Succinyl-diaminopimelate desuccinylase L-Aspartic acid C04462 KEGG Compound H2O Water 18.010565 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase Proton glutamate symport protein Aerobic C4-dicarboxylate transport protein Transport455 false L-Aspartic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT Transport454 false L-Aspartic acid (→), Succinic acid (←) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 1.0 Carbon dioxide 56-84-8 CAS Dihydrodipicolinate synthase P0A830 UniProt PW000906 PathWhiz Adenosine diphosphate 1.0 30572 ChemSpider 17215925 ChemSpider C7H14N2O4 L,L-diaminopimelate 190.09535 C7H14N2O4 meso-diaminopimelate 190.09535 4-hydroxy-tetrahydrodipicolinate reductase N-succinyldiaminopimelate aminotransferase tetrahydrodipicolinate succinylase Aspartate kinase Succinic acid 4-hydroxy-tetrahydrodipicolinate synthase dicarboxylate transporter aspartate semialdehyde dehydrogenase Aspartate-semialdehyde dehydrogenase SMILES O Acetylornithine/succinyldiaminopimelate aminotransferase SMP00834 SMPDB 5962 PubChem-compound 1.0 1.0 25202447 PubChem-compound 6816 PubChem-compound diaminopimelate epimerase 51 PubChem-compound N-succinyl-L-diaminopimelate desuccinylase Pyruvic acid diaminopimelate decarboxylase Succinic acid ADP BioCyc C3H4O3 Pyruvic acid 88.016045 53-59-8 CAS 1.0 1038 PubChem-compound glutamate / aspartate ABC transporter LYS BioCyc GO:0005829 GENE ONTOLOGY 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 P0A6K1 UniProt 2.0 P0A9Q9 UniProt O4P Phosphate 94.95342 NADPH GO:0070258 GENE ONTOLOGY NADP C21H30N7O17P3 NADPH 745.0911 P0A6L2 UniProt C21H29N7O17P3 NADP 744.08325 NADPH BioCyc Diaminopimelate decarboxylase Lysine-sensitive aspartokinase 3 L-aspartic 4-semialdehyde (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate (S)-2,3,4,5-tetrahydrodipicolinate L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O CHEBI:30915 ChEBI 124-38-9 CAS Hydrogen Ion PW000772 PathWhiz PW000771 PathWhiz 2.0 1.0 Inner Membrane SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O ReactionCatalysis2500 ACTIVATION 1.0 C03082 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLT BioCyc 1.0 Anaerobic C4-dicarboxylate transporter dcuA 53-57-6 CAS 1.0 SMP00924 SMPDB CHEBI:15741 ChEBI 1.0 1.0 SMILES O=C=O 1110 PubChem-compound P0AED7 UniProt 5957 PubChem-compound GO:0005620 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 CHEBI:67139 ChEBI 1.0 L,L-diaminopimelate meso-diaminopimelate TransportCatalysis390 ACTIVATION Lysine Biosynthesis Dihydrodipicolinate reductase CHEBI:16845 ChEBI SMILES NCCCC[C@H](N)C(O)=O C4H7NO3 L-aspartic 4-semialdehyde 117.042595 C7H7NO5 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate 185.03352 C7H7NO4 (S)-2,3,4,5-tetrahydrodipicolinate 169.0386 N-Succinyl-L,L-2,6-diaminopimelate Adenosine diphosphate N-Succinyl-2-amino-6-ketopimelate C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CC(O)=O)C(O)=O C11H18N2O7 N-Succinyl-L,L-2,6-diaminopimelate 290.1114 C11H15NO8 N-Succinyl-2-amino-6-ketopimelate 289.07977 TransportCatalysis389 ACTIVATION TransportCatalysis388 ACTIVATION TransportCatalysis387 ACTIVATION 1.0 Diaminopimelate epimerase Adenosine triphosphate CPD-8587 BioCyc 2.0 Putative sulfate transporter ychM CHEBI:1146900 ChEBI Lysine Degradation I SubPathway peptidoglycan biosynthesis I SubPathway ReactionCatalysis2493 ACTIVATION ReactionCatalysis2492 ACTIVATION ReactionCatalysis2495 ACTIVATION ReactionCatalysis2494 ACTIVATION ReactionCatalysis2497 ACTIVATION ReactionCatalysis2496 ACTIVATION ReactionCatalysis2499 ACTIVATION ReactionCatalysis2498 ACTIVATION SubPathwayInteraction1617 SubPathwayReaction SubPathway1617Reaction Phosphate P37902 UniProt SubPathwayInteraction1618 SubPathway1618Reaction SubPathwayReaction CO-A BioCyc 1.0 5675 ChemSpider 1078 ChemSpider Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 2.0 2.0 Water CHEBI:15422 ChEBI 1.17.1.8 false 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen Ion + NADPH → (S)-2,3,4,5-tetrahydrodipicolinate + NADP + Water LEFT_TO_RIGHT 6557 ChemSpider 2.3.1.117 false 2.3.1.117 (S)-2,3,4,5-tetrahydrodipicolinate + Succinyl-CoA + Water → Coenzyme A + N-Succinyl-2-amino-6-ketopimelate LEFT_TO_RIGHT HMDB00191 HMDB Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB 127-17-3 CAS 1.0 1.2.1.11 false 1.2.1.11 Hydrogen Ion + L-Aspartyl-4-phosphate + NADPH → L-aspartic 4-semialdehyde + NADP + Phosphate LEFT_TO_RIGHT 4.3.3.7 false 4.3.3.7 L-aspartic 4-semialdehyde + Pyruvic acid → (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen Ion + Water LEFT_TO_RIGHT 2.7.2.4 false 2.7.2.4 Adenosine triphosphate + L-Aspartic acid → Adenosine diphosphate + L-Aspartyl-4-phosphate LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 1.0 CHEBI:16526 ChEBI 1.0 CHEBI:16761 ChEBI CHEBI:35266 ChEBI methionine biosynthesis SubPathway P21345 UniProt Succinic acid 1.0 26605-36-7 CAS 2-KETOGLUTARATE BioCyc 1.0 440349 PubChem-compound 1.0 HMDB02111 HMDB HMDB01022 HMDB 110-15-6 CAS N-SUCCINYL-2-AMINO-6-KETOPIMELATE BioCyc CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] Succinyl-CoA SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound P0A9D8 UniProt HMDB00182 HMDB Reaction2530 false L-Glutamic acid + N-Succinyl-2-amino-6-ketopimelate → N-Succinyl-L,L-2,6-diaminopimelate + Oxoglutaric acid LEFT_TO_RIGHT 1.0 C4H8NO7P L-Aspartyl-4-phosphate 213.00385 280 PubChem-compound L-Aspartyl-4-phosphate 4.1.1.20 false 4.1.1.20 Hydrogen Ion + meso-diaminopimelate → Carbon dioxide + L-Lysine LEFT_TO_RIGHT 3.5.1.18 false 3.5.1.18 N-Succinyl-L,L-2,6-diaminopimelate + Water → L,L-diaminopimelate + Succinic acid LEFT_TO_RIGHT 5.1.1.7 false 5.1.1.7 L,L-diaminopimelate → meso-diaminopimelate LEFT_TO_RIGHT 3-METHYLBENZYLSUCCINYL-COA BioCyc HMDB12267 HMDB HMDB12266 HMDB 1060 PubChem-compound N-SUCCINYLLL-2-6-DIAMINOPIMELATE BioCyc 1061 PubChem-compound Hydrogen Ion Diaminopimelate decarboxylase 1.0 1.0 HMDB12250 HMDB Lysine-sensitive aspartokinase 3 1.0 85-61-0 CAS P00861 UniProt Aerobic C4- dicarboxylate transport protein Proton glutamate symport protein Anaerobic C4- dicarboxylate transporter dcuC Anaerobic C4- dicarboxylate transporter dcuB Putative sulfate transporter ychM Lysine- sensitive aspartokinase 3 Aspartate- semialdehyde dehydrogenase Dihydrodipicolinate synthase Dihydrodipicolinate reductase 2,3,4,5- tetrahydropyridine- 2,6- dicarboxylate N- succinyltransferase Acetylornithine/succinyldiaminopimelate aminotransferase Succinyl- diaminopimelate desuccinylase Diaminopimelate epimerase Diaminopimelate decarboxylase Glutamate/aspartate transport ATP-binding protein gltL Glutamate/aspartate transport system permease protein gltK Glutamate/aspartate transport system permease protein gltJ Glutamate/aspartate periplasmic- binding protein Anaerobic C4- dicarboxylate transporter dcuA L-Aspartic acid L-Aspartic acid H + H + L-Aspartic acid L-Aspartic acid H + H + L-Aspartic acid L-Aspartic acid Succinic acid Succinic acid L-Aspartic acid L-Aspartic acid L-Aspartic acid ATP ADP L-Aspartyl-4- phosphate L-Aspartyl-4- phosphate NADPH H + P i NADP L-aspartic 4-semialdehyde L-aspartic 4-semialdehyde Pyruvic acid H + H 2 O (2S,4S)-4- hydroxy- 2,3,4,5- tetrahydrodipicolinate (2S,4S)-4- hydroxy- 2,3,4,5- tetrahydrodipicolinate H + NADPH H 2 O NADP (S)-2,3,4,5- tetrahydrodipicolinate (S)-2,3,4,5- tetrahydrodipicolinate Succinyl-CoA H 2 O CoA N-Succinyl-2- amino-6- ketopimelate N-Succinyl-2- amino-6- ketopimelate L-Glutamic acid N-Succinyl- L,L-2,6- diaminopimelate Oxoglutaric acid N-Succinyl- L,L-2,6- diaminopimelate H 2 O Succinic acid L,L- diaminopimelate L,L- diaminopimelate meso- diaminopimelate meso- diaminopimelate H + L-Lysine CO 2 L-Aspartic acid ATP H 2 O ADP P i H + L-Aspartic acid peptidoglycan biosynthesis I Lysine Degradation I methionine biosynthesis
CHEBI:16015 ChEBI HMDB00254 HMDB Glutamate/aspartate transport system permease protein gltK 6022 PubChem-compound P04036 UniProt 439161 PubChem-compound 937 ChemSpider 22138-53-0 CAS HMDB01341 HMDB 50 ChemSpider 1.0 HMDB00148 HMDB 809 ChemSpider ATP BioCyc Glutamate/aspartate periplasmic-binding protein 1.0 5747 ChemSpider 1.0 5745 ChemSpider Dihydrodipicolinate reductase CHEBI:15380 ChEBI 5742 ChemSpider C25H40N7O19P3S Succinyl-CoA 867.1312 L-ASPARTATE BioCyc Glutamate/aspartate transport system permease protein gltJ CHEBI:16474 ChEBI HMDB59597 HMDB P18335 UniProt HMDB00243 HMDB 389314 ChemSpider 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase P08660 UniProt Diaminopimelate epimerase Aerobic C4-dicarboxylate transport protein Proton glutamate symport protein Succinyl-diaminopimelate desuccinylase 1010 ChemSpider 4.0 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Glutamate/aspartate transport ATP-binding protein gltL 4.0 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O BiologicalState109 Escherichia coli, Inner Membrane 1.0 HMDB01423 HMDB Hydrogen Ion SubPathwayInteraction1648 SubPathway1648Reaction SubPathwayReaction HMDB00217 HMDB Cytosol Dihydrodipicolinate synthase Adenosine triphosphate SUC BioCyc Acetylornithine/succinyldiaminopimelate aminotransferase 56-87-1 CAS HMDB00208 HMDB 1.0 HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI Hydrogen Ion P0ABN5 UniProt C00001 KEGG Compound Aspartate-semialdehyde dehydrogenase ReactionCoupledTransportCatalysis142 ACTIVATION C00005 KEGG Compound Glutamate/aspartate transport ATP-binding protein gltL CHEBI:18367 ChEBI 1032 ChemSpider 1.0 C00002 KEGG Compound 1031 ChemSpider L-Aspartic acid ReactionCoupledTransport108 false Adenosine triphosphate + L-Aspartic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Aspartic acid + Phosphate LEFT_TO_RIGHT Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB HMDB01429 HMDB L-Aspartic acid 44367445 PubChem-compound C00011 KEGG Compound C00010 KEGG Compound NAD(P) BioCyc 562 TAXONOMY P0ABP1 UniProt H Hydrogen Ion 1.007825 P0ABP4 UniProt 388307 ChemSpider C00022 KEGG Compound 56-65-5 CAS Glutamate/aspartate periplasmic-binding protein C00026 KEGG Compound C00025 KEGG Compound SMILES NC(CC(=O)OP(O)(O)=O)C(O)=O 1.0 P0AAG3 UniProt 328-50-7 CAS Water SMILES OC(=O)CCC(O)=O P0AFR2 UniProt C00042 KEGG Compound C00049 KEGG Compound C00047 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 SMILES NC(CCC[C@H](NC(=O)CCC(O)=O)C(O)=O)C(O)=O 604-98-8 CAS Anaerobic C4-dicarboxylate transporter dcuA SMILES OC(=O)CCC(=O)N[C@@H](CCCC(=O)C(O)=O)C(O)=O http://identifiers.org/smpdb/SMP00794 SMPDB HMDB00538 HMDB http://identifiers.org/smpdb/SMP00795 SMPDB CHEBI:18019 ChEBI 1.0 7732-18-5 CAS L-BETA-ASPARTYL-P BioCyc 56-86-0 CAS 4.0 2.0 P0AER3 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:57791 ChEBI P0AER5 UniProt CHEBI:17053 ChEBI 1.0 C04421 KEGG Compound Glutamate/aspartate transport system permease protein gltK Glutamate/aspartate transport system permease protein gltJ SMILES CC(=O)C(O)=O HMDB01967 HMDB 962 PubChem-compound 5800 ChemSpider 4.0 CO2 Carbon dioxide 43.98983 Phosphate C00080 KEGG Compound Periplasmic Space Oxoglutaric acid 1.0 CHEBI:537519 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000814 PathWhiz 14265-44-2 CAS C6H14N2O2 L-Lysine 146.10553 PYRUVATE BioCyc 832 PubChem-compound 58-64-0 CAS SMILES N[C@@H](CC=O)C(O)=O SMILES [O-]C(=O)C1CCCC(=N1)C([O-])=O Putative sulfate transporter ychM SMILES OC1CC(N=C(C1)C([O-])=O)C([O-])=O C00091 KEGG Compound L-Aspartic acid 1.0 CHEBI:57609 ChEBI C4H7NO4 L-Aspartic acid 133.0375 SMILES N[C@@H](CCC[C@H](N)C(O)=O)C(O)=O Transport453 false L-Aspartic acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT Transport452 false L-Aspartic acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT SMILES [H][C@](N)(CCC[C@@]([H])(N)C(O)=O)C(O)=O L-Lysine 2.0 22833512 PubChem-compound Succinyl-diaminopimelate desuccinylase L-Aspartic acid C04462 KEGG Compound H2O Water 18.010565 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase Proton glutamate symport protein Aerobic C4-dicarboxylate transport protein Transport455 false L-Aspartic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT Transport454 false L-Aspartic acid (→), Succinic acid (←) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 1.0 Carbon dioxide 56-84-8 CAS Dihydrodipicolinate synthase P0A830 UniProt PW000906 PathWhiz Adenosine diphosphate 1.0 30572 ChemSpider 17215925 ChemSpider C7H14N2O4 L,L-diaminopimelate 190.09535 C7H14N2O4 meso-diaminopimelate 190.09535 4-hydroxy-tetrahydrodipicolinate reductase N-succinyldiaminopimelate aminotransferase tetrahydrodipicolinate succinylase Aspartate kinase Succinic acid 4-hydroxy-tetrahydrodipicolinate synthase dicarboxylate transporter aspartate semialdehyde dehydrogenase Aspartate-semialdehyde dehydrogenase SMILES O Acetylornithine/succinyldiaminopimelate aminotransferase http://identifiers.org/smpdb/SMP00834 SMPDB 5962 PubChem-compound 1.0 1.0 25202447 PubChem-compound 6816 PubChem-compound diaminopimelate epimerase 51 PubChem-compound N-succinyl-L-diaminopimelate desuccinylase Pyruvic acid diaminopimelate decarboxylase Succinic acid ADP BioCyc C3H4O3 Pyruvic acid 88.016045 53-59-8 CAS 1.0 1038 PubChem-compound glutamate / aspartate ABC transporter LYS BioCyc GO:0005829 GENE ONTOLOGY 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 P0A6K1 UniProt Lysine Degradation I SubPathway 2.0 P0A9Q9 UniProt O4P Phosphate 94.95342 NADPH GO:0070258 GENE ONTOLOGY NADP C21H30N7O17P3 NADPH 745.0911 P0A6L2 UniProt C21H29N7O17P3 NADP 744.08325 NADPH BioCyc Diaminopimelate decarboxylase Lysine-sensitive aspartokinase 3 L-aspartic 4-semialdehyde (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate (S)-2,3,4,5-tetrahydrodipicolinate L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O CHEBI:30915 ChEBI 124-38-9 CAS Hydrogen Ion PW000772 PathWhiz PW000771 PathWhiz 2.0 1.0 Inner Membrane SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O ReactionCatalysis2500 ACTIVATION 1.0 C03082 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLT BioCyc 1.0 Anaerobic C4-dicarboxylate transporter dcuA 53-57-6 CAS 1.0 http://identifiers.org/smpdb/SMP00924 SMPDB CHEBI:15741 ChEBI 1.0 1.0 SMILES O=C=O 1110 PubChem-compound P0AED7 UniProt 5957 PubChem-compound GO:0005620 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 CHEBI:67139 ChEBI 1.0 L,L-diaminopimelate meso-diaminopimelate TransportCatalysis390 ACTIVATION Lysine Biosynthesis Dihydrodipicolinate reductase CHEBI:16845 ChEBI SMILES NCCCC[C@H](N)C(O)=O C4H7NO3 L-aspartic 4-semialdehyde 117.042595 C7H7NO5 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate 185.03352 C7H7NO4 (S)-2,3,4,5-tetrahydrodipicolinate 169.0386 N-Succinyl-L,L-2,6-diaminopimelate Adenosine diphosphate N-Succinyl-2-amino-6-ketopimelate C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CC(O)=O)C(O)=O C11H18N2O7 N-Succinyl-L,L-2,6-diaminopimelate 290.1114 C11H15NO8 N-Succinyl-2-amino-6-ketopimelate 289.07977 TransportCatalysis389 ACTIVATION TransportCatalysis388 ACTIVATION TransportCatalysis387 ACTIVATION 1.0 Diaminopimelate epimerase Adenosine triphosphate CPD-8587 BioCyc 2.0 Putative sulfate transporter ychM CHEBI:1146900 ChEBI ReactionCatalysis2493 ACTIVATION ReactionCatalysis2492 ACTIVATION ReactionCatalysis2495 ACTIVATION ReactionCatalysis2494 ACTIVATION ReactionCatalysis2497 ACTIVATION ReactionCatalysis2496 ACTIVATION ReactionCatalysis2499 ACTIVATION ReactionCatalysis2498 ACTIVATION SubPathwayInteraction1617 SubPathwayReaction SubPathway1617Reaction Phosphate P37902 UniProt SubPathwayInteraction1618 SubPathway1618Reaction SubPathwayReaction CO-A BioCyc 1.0 5675 ChemSpider 1078 ChemSpider Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 2.0 2.0 Water CHEBI:15422 ChEBI methionine biosynthesis SubPathway 1.17.1.8 false 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen Ion + NADPH → (S)-2,3,4,5-tetrahydrodipicolinate + NADP + Water LEFT_TO_RIGHT 6557 ChemSpider 2.3.1.117 false 2.3.1.117 (S)-2,3,4,5-tetrahydrodipicolinate + Succinyl-CoA + Water → Coenzyme A + N-Succinyl-2-amino-6-ketopimelate LEFT_TO_RIGHT HMDB00191 HMDB Anaerobic C4-dicarboxylate transporter dcuC Anaerobic C4-dicarboxylate transporter dcuB 127-17-3 CAS 1.0 1.2.1.11 false 1.2.1.11 Hydrogen Ion + L-Aspartyl-4-phosphate + NADPH → L-aspartic 4-semialdehyde + NADP + Phosphate LEFT_TO_RIGHT 4.3.3.7 false 4.3.3.7 L-aspartic 4-semialdehyde + Pyruvic acid → (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen Ion + Water LEFT_TO_RIGHT 2.7.2.4 false 2.7.2.4 Adenosine triphosphate + L-Aspartic acid → Adenosine diphosphate + L-Aspartyl-4-phosphate LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 1.0 CHEBI:16526 ChEBI 1.0 CHEBI:16761 ChEBI CHEBI:35266 ChEBI P21345 UniProt Succinic acid 1.0 26605-36-7 CAS 2-KETOGLUTARATE BioCyc 1.0 440349 PubChem-compound 1.0 HMDB02111 HMDB HMDB01022 HMDB 110-15-6 CAS N-SUCCINYL-2-AMINO-6-KETOPIMELATE BioCyc CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] Succinyl-CoA SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound P0A9D8 UniProt HMDB00182 HMDB Reaction2530 false L-Glutamic acid + N-Succinyl-2-amino-6-ketopimelate → N-Succinyl-L,L-2,6-diaminopimelate + Oxoglutaric acid LEFT_TO_RIGHT 1.0 C4H8NO7P L-Aspartyl-4-phosphate 213.00385 280 PubChem-compound L-Aspartyl-4-phosphate 4.1.1.20 false 4.1.1.20 Hydrogen Ion + meso-diaminopimelate → Carbon dioxide + L-Lysine LEFT_TO_RIGHT 3.5.1.18 false 3.5.1.18 N-Succinyl-L,L-2,6-diaminopimelate + Water → L,L-diaminopimelate + Succinic acid LEFT_TO_RIGHT 5.1.1.7 false 5.1.1.7 L,L-diaminopimelate → meso-diaminopimelate LEFT_TO_RIGHT 3-METHYLBENZYLSUCCINYL-COA BioCyc HMDB12267 HMDB HMDB12266 HMDB 1060 PubChem-compound N-SUCCINYLLL-2-6-DIAMINOPIMELATE BioCyc 1061 PubChem-compound Hydrogen Ion peptidoglycan biosynthesis I SubPathway Diaminopimelate decarboxylase 1.0 1.0 HMDB12250 HMDB Lysine-sensitive aspartokinase 3 1.0 85-61-0 CAS P00861 UniProt