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C00315 KEGG Compound 6022 PubChem-compound 23656-67-9 CAS C23H38N7O17P3S Acetyl-CoA 809.1258 1.0 937 ChemSpider Spermidine synthase Spermidine HMDB00250 HMDB 5-Methylthioribose HMDB01341 HMDB Spermidine synthase SMILES O adenosylmethionine decarboxylase 13837702 ChemSpider 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Pyrophosphate 2.0 1.0 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase SMP00834 SMPDB 2.0 ATP BioCyc 6137 PubChem-compound 1.0 S-ADENOSYLMETHIONINAMINE BioCyc D-methionine-binding lipoprotein metQ 1.0 methionine adenosyltransferase 6816 PubChem-compound 124-20-9 CAS Water 559142 ChemSpider 4.1.1.50 false 4.1.1.50 Hydrogen Ion + S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine LEFT_TO_RIGHT ADP BioCyc 2.5.1.- false 2.5.1.- Putrescine + S-Adenosylmethioninamine → 5'-S-methyl-5'-thioadenosine + Hydrogen Ion + Spermidine LEFT_TO_RIGHT S-adenosyl-L-methionine biosynthesis 3.2.2.9 false 3.2.2.9 5'-S-methyl-5'-thioadenosine + Water → 5-Methylthioribose + Adenine LEFT_TO_RIGHT ReactionCatalysis5138 ACTIVATION ReactionCatalysis5136 ACTIVATION ReactionCatalysis5137 ACTIVATION C15H23N6O5S S-Adenosylmethionine 399.14505 HMDB01206 HMDB 1.0 5742 ChemSpider 1038 PubChem-compound 1.0 Spermidine N(1)-acetyltransferase SMILES CSCC[C@H](N)C(O)=O HMDB59597 HMDB 274 ChemSpider D-methionine transport system permease protein metI PW000837 PathWhiz Pyrophosphate PW000836 PathWhiz Adenosine diphosphate SMP00856 SMPDB SMP00857 SMPDB SMILES CSCC1OC(C(O)C1O)N1C=NC2=C(N)N=CN=C12 O4P Phosphate 94.95342 Acetyl-CoA P31547 UniProt 1010 ChemSpider GO:0070258 GENE ONTOLOGY 1.0 Methionine import ATP-binding protein MetN Adenosine triphosphate SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS N8-Acetylspermidine Adenine C9H21N3O N8-Acetylspermidine 187.16846 PPI BioCyc SMILES NCCCCN C5H5N5 Adenine 135.05449 2.3.1.57 false 2.3.1.57 Acetyl-CoA + Spermidine → Coenzyme A + Hydrogen Ion + N8-Acetylspermidine LEFT_TO_RIGHT ReactionCatalysis5154 ACTIVATION L-Methionine BiologicalState109 HMDB00696 HMDB HMDB01423 HMDB CHEBI:17148 ChEBI CHEBI:16610 ChEBI Hydrogen Ion SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 1.0 Adenosine triphosphate L-methionine / D-methionine ABC transporter S-adenosylmethionine decarboxylase proenzyme SMILES [O-]P([O-])([O-])=O 124-38-9 CAS 3.6.3.- false 3.6.3.- Adenosine triphosphate + L-Methionine + Water → Adenosine diphosphate + Hydrogen Ion + L-Methionine + Phosphate LEFT_TO_RIGHT Hydrogen Ion 110264 ChemSpider P30750 UniProt C00009 KEGG Compound C00008 KEGG Compound 110-60-1 CAS Quorum Sensing SubPathway CHEBI:15414 ChEBI Spermidine synthase C11H15N5O3S 5'-S-methyl-5'-thioadenosine 297.08957 ADENINE BioCyc ReactionCoupledTransportCatalysis145 ACTIVATION C00001 KEGG Compound CHEBI:18361 ChEBI CHEBI:18367 ChEBI Inner Membrane 1032 ChemSpider C00002 KEGG Compound 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase SMILES NC1=C2NC=NC2=NC=N1 123689 PubChem-compound SMILES CC(=O)NCCCCNCCCN HMDB01429 HMDB 1.0 S-adenosylmethionine synthase C00019 KEGG Compound D-methionine transport system permease protein metI ReactionCoupledTransportCatalysis159 ACTIVATION CHEBI:15625 ChEBI S-ADENOSYLMETHIONINE BioCyc C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound HMDB01087 HMDB C03089 KEGG Compound SubPathwayInteraction1660 SubPathway1660Reaction SubPathwayReaction C00013 KEGG Compound C00134 KEGG Compound O7P2 Pyrophosphate 173.91193 5957 PubChem-compound ReactionCatalysis3044 ACTIVATION C7H19N3 Spermidine 145.1579 439415 PubChem-compound CHEBI:16708 ChEBI 562 TAXONOMY H Hydrogen Ion 1.007825 22365-13-5 CAS C6H12O4S 5-Methylthioribose 180.04562 HMDB01414 HMDB P09158 UniProt Methionine import ATP-binding protein MetN L-Methionine 1102 PubChem-compound MET BioCyc 56-65-5 CAS CPD-560 BioCyc C00147 KEGG Compound 2.0 HMDB02189 HMDB BiologicalState139 C00024 KEGG Compound C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 ReactionCoupledTransport125 false Adenosine triphosphate + L-Methionine + Water → Adenosine diphosphate + Hydrogen Ion + L-Methionine + Pyrophosphate LEFT_TO_RIGHT 1.0 1.0 73-24-5 CAS CHEBI:16895 ChEBI C5H11NO2S L-Methionine 149.05106 Hydrogen Ion PUTRESCINE BioCyc L-methionine / D-methionine ABC transporter Adenosine triphosphate CPD-8587 BioCyc HMDB01185 HMDB CHEBI:1146900 ChEBI Water Outer Membrane GO:0043165 GENE ONTOLOGY 1.0 4.0 SMILES NCCCCNCCCN SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS Phosphate methionine biosynthesis SubPathway P0AF12 UniProt CO-A BioCyc 1.0 SMILES CSC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O 1.0 1071 ChemSpider 72-89-9 CAS C01137 KEGG Compound CPD-3462 BioCyc S-adenosylmethionine decarboxylase proenzyme SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Coenzyme A S-adenosylmethionine synthase 1.0 C21H36N7O16P3S Coenzyme A 767.11523 P28635 UniProt HMDB00538 HMDB Putrescine 388529 ChemSpider C4H12N2 Putrescine 88.10005 Water 5'-S-methyl-5'-thioadenosine CHEBI:15422 ChEBI 1.0 C01029 KEGG Compound 1.0 D-methionine transport system permease protein metI 6557 ChemSpider D-methionine-binding lipoprotein metQ SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 7732-18-5 CAS SubPathwayInteraction1186 SubPathway1186Reaction SubPathwayReaction 1.0 1.0 HMDB00988 HMDB 63-68-3 CAS 2.0 5907 ChemSpider CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 P0A7F6 UniProt 1.0 CHEBI:16526 ChEBI L-Methionine CHEBI:16761 ChEBI 1.0 S-Adenosylmethioninamine C00073 KEGG Compound HMDB01967 HMDB C14H23N6O3S S-Adenosylmethioninamine 355.15524 962 PubChem-compound 31983 ChemSpider 8.0 5800 ChemSpider 392413 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate 1.0 HMDB02111 HMDB C00080 KEGG Compound 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine LEFT_TO_RIGHT CHEBI:27911 ChEBI PW000814 PathWhiz CHEBI:15377 ChEBI 1.0 14265-44-2 CAS CHEBI:15378 ChEBI SMILES [H+] 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O S-Adenosylmethionine 1045 PubChem-compound Spermidine N(1)-acetyltransferase 1.0 Methionine import ATP-binding protein MetN 1.0 280 PubChem-compound SMILES C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N P0A817 UniProt 439904 PubChem-compound HMDB00034 HMDB D-methionine-binding lipoprotein metQ 4.0 644102 PubChem-compound 444493 PubChem-compound spermidine acetyltransferase ACETYL-COA BioCyc H2O Water 18.010565 190 PubChem-compound 388938 ChemSpider 29908-03-0 CAS 1061 PubChem-compound HMDB01257 HMDB SPERMIDINE BioCyc Carbon dioxide 1.0 CHEBI:15351 ChEBI 1.0 24762165 PubChem-compound P0A951 UniProt 13431-24-8 CAS 185 ChemSpider Adenosine diphosphate 85-61-0 CAS 1.0 S- adenosylmethionine synthase S- adenosylmethionine decarboxylase proenzyme Spermidine synthase 5'- methylthioadenosine/S- adenosylhomocysteine nucleosidase Spermidine N(1)- acetyltransferase Methionine import ATP-binding protein MetN D-methionine transport system permease protein metI D-methionine- binding lipoprotein metQ Methionine import ATP-binding protein MetN D-methionine transport system permease protein metI D-methionine- binding lipoprotein metQ L-Methionine H 2 O ATP P i PP i S- Adenosylmethionine H + CO 2 S- Adenosylmethioninamine Putrescine Spermidine H + 5'-S-methyl- 5'- thioadenosine H 2 O 5- Methylthioribose Adenine Acetyl-CoA N8- Acetylspermidine CoA H + L-Methionine ATP H 2 O ADP P i H + L-Methionine L-Methionine ATP H 2 O ADP PP i H + L-Methionine Pyruvic acid Magnesium methionine biosynthesis
C00315 KEGG Compound 6022 PubChem-compound 23656-67-9 CAS C23H38N7O17P3S Acetyl-CoA 809.1258 1.0 937 ChemSpider Spermidine synthase Spermidine HMDB00250 HMDB 5-Methylthioribose HMDB01341 HMDB Spermidine synthase SMILES O adenosylmethionine decarboxylase 13837702 ChemSpider 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Pyrophosphate 2.0 1.0 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase http://identifiers.org/smpdb/SMP00834 SMPDB 2.0 ATP BioCyc 6137 PubChem-compound 1.0 S-ADENOSYLMETHIONINAMINE BioCyc D-methionine-binding lipoprotein metQ 1.0 methionine adenosyltransferase 6816 PubChem-compound 124-20-9 CAS Water 559142 ChemSpider 4.1.1.50 false 4.1.1.50 Hydrogen Ion + S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine LEFT_TO_RIGHT ADP BioCyc 2.5.1.- false 2.5.1.- Putrescine + S-Adenosylmethioninamine → 5'-S-methyl-5'-thioadenosine + Hydrogen Ion + Spermidine LEFT_TO_RIGHT S-adenosyl-L-methionine biosynthesis 3.2.2.9 false 3.2.2.9 5'-S-methyl-5'-thioadenosine + Water → 5-Methylthioribose + Adenine LEFT_TO_RIGHT ReactionCatalysis5138 ACTIVATION ReactionCatalysis5136 ACTIVATION ReactionCatalysis5137 ACTIVATION C15H23N6O5S S-Adenosylmethionine 399.14505 HMDB01206 HMDB 1.0 5742 ChemSpider 1038 PubChem-compound 1.0 Spermidine N(1)-acetyltransferase SMILES CSCC[C@H](N)C(O)=O HMDB59597 HMDB 274 ChemSpider D-methionine transport system permease protein metI PW000837 PathWhiz Pyrophosphate PW000836 PathWhiz Adenosine diphosphate http://identifiers.org/smpdb/SMP00856 SMPDB http://identifiers.org/smpdb/SMP00857 SMPDB SMILES CSCC1OC(C(O)C1O)N1C=NC2=C(N)N=CN=C12 O4P Phosphate 94.95342 Acetyl-CoA P31547 UniProt 1010 ChemSpider GO:0070258 GENE ONTOLOGY 1.0 Methionine import ATP-binding protein MetN Adenosine triphosphate SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS N8-Acetylspermidine Adenine C9H21N3O N8-Acetylspermidine 187.16846 PPI BioCyc SMILES NCCCCN C5H5N5 Adenine 135.05449 2.3.1.57 false 2.3.1.57 Acetyl-CoA + Spermidine → Coenzyme A + Hydrogen Ion + N8-Acetylspermidine LEFT_TO_RIGHT ReactionCatalysis5154 ACTIVATION L-Methionine BiologicalState109 Escherichia coli, Inner Membrane HMDB00696 HMDB HMDB01423 HMDB CHEBI:17148 ChEBI CHEBI:16610 ChEBI Quorum Sensing SubPathway Hydrogen Ion SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 1.0 Adenosine triphosphate L-methionine / D-methionine ABC transporter S-adenosylmethionine decarboxylase proenzyme SMILES [O-]P([O-])([O-])=O 124-38-9 CAS 3.6.3.- false 3.6.3.- Adenosine triphosphate + L-Methionine + Water → Adenosine diphosphate + Hydrogen Ion + L-Methionine + Phosphate LEFT_TO_RIGHT Hydrogen Ion 110264 ChemSpider P30750 UniProt C00009 KEGG Compound C00008 KEGG Compound 110-60-1 CAS CHEBI:15414 ChEBI Spermidine synthase C11H15N5O3S 5'-S-methyl-5'-thioadenosine 297.08957 ADENINE BioCyc ReactionCoupledTransportCatalysis145 ACTIVATION C00001 KEGG Compound CHEBI:18361 ChEBI CHEBI:18367 ChEBI Inner Membrane 1032 ChemSpider C00002 KEGG Compound 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase SMILES NC1=C2NC=NC2=NC=N1 123689 PubChem-compound SMILES CC(=O)NCCCCNCCCN HMDB01429 HMDB 1.0 S-adenosylmethionine synthase C00019 KEGG Compound D-methionine transport system permease protein metI ReactionCoupledTransportCatalysis159 ACTIVATION CHEBI:15625 ChEBI S-ADENOSYLMETHIONINE BioCyc C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound HMDB01087 HMDB C03089 KEGG Compound SubPathwayInteraction1660 SubPathway1660Reaction SubPathwayReaction C00013 KEGG Compound C00134 KEGG Compound O7P2 Pyrophosphate 173.91193 5957 PubChem-compound ReactionCatalysis3044 ACTIVATION C7H19N3 Spermidine 145.1579 439415 PubChem-compound CHEBI:16708 ChEBI 562 TAXONOMY H Hydrogen Ion 1.007825 22365-13-5 CAS C6H12O4S 5-Methylthioribose 180.04562 HMDB01414 HMDB P09158 UniProt Methionine import ATP-binding protein MetN L-Methionine 1102 PubChem-compound MET BioCyc 56-65-5 CAS CPD-560 BioCyc C00147 KEGG Compound 2.0 HMDB02189 HMDB BiologicalState139 Escherichia coli, Outer Membrane C00024 KEGG Compound C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 ReactionCoupledTransport125 false Adenosine triphosphate + L-Methionine + Water → Adenosine diphosphate + Hydrogen Ion + L-Methionine + Pyrophosphate LEFT_TO_RIGHT 1.0 1.0 73-24-5 CAS CHEBI:16895 ChEBI C5H11NO2S L-Methionine 149.05106 Hydrogen Ion PUTRESCINE BioCyc L-methionine / D-methionine ABC transporter Adenosine triphosphate CPD-8587 BioCyc HMDB01185 HMDB CHEBI:1146900 ChEBI Water Outer Membrane GO:0043165 GENE ONTOLOGY 1.0 4.0 SMILES NCCCCNCCCN SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS Phosphate P0AF12 UniProt CO-A BioCyc 1.0 SMILES CSC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O 1.0 1071 ChemSpider 72-89-9 CAS C01137 KEGG Compound CPD-3462 BioCyc S-adenosylmethionine decarboxylase proenzyme SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Coenzyme A S-adenosylmethionine synthase 1.0 C21H36N7O16P3S Coenzyme A 767.11523 P28635 UniProt HMDB00538 HMDB Putrescine 388529 ChemSpider C4H12N2 Putrescine 88.10005 Water 5'-S-methyl-5'-thioadenosine CHEBI:15422 ChEBI 1.0 C01029 KEGG Compound methionine biosynthesis SubPathway 1.0 D-methionine transport system permease protein metI 6557 ChemSpider D-methionine-binding lipoprotein metQ SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 7732-18-5 CAS SubPathwayInteraction1186 SubPathway1186Reaction SubPathwayReaction 1.0 1.0 HMDB00988 HMDB 63-68-3 CAS 2.0 5907 ChemSpider CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 P0A7F6 UniProt 1.0 CHEBI:16526 ChEBI L-Methionine CHEBI:16761 ChEBI 1.0 S-Adenosylmethioninamine C00073 KEGG Compound HMDB01967 HMDB C14H23N6O3S S-Adenosylmethioninamine 355.15524 962 PubChem-compound 31983 ChemSpider 8.0 5800 ChemSpider 392413 ChemSpider CO2 Carbon dioxide 43.98983 Phosphate 1.0 HMDB02111 HMDB C00080 KEGG Compound 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine LEFT_TO_RIGHT CHEBI:27911 ChEBI PW000814 PathWhiz CHEBI:15377 ChEBI 1.0 14265-44-2 CAS CHEBI:15378 ChEBI SMILES [H+] 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O S-Adenosylmethionine 1045 PubChem-compound Spermidine N(1)-acetyltransferase 1.0 Methionine import ATP-binding protein MetN 1.0 280 PubChem-compound SMILES C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N P0A817 UniProt 439904 PubChem-compound HMDB00034 HMDB D-methionine-binding lipoprotein metQ 4.0 644102 PubChem-compound 444493 PubChem-compound spermidine acetyltransferase ACETYL-COA BioCyc H2O Water 18.010565 190 PubChem-compound 388938 ChemSpider 29908-03-0 CAS 1061 PubChem-compound HMDB01257 HMDB SPERMIDINE BioCyc Carbon dioxide 1.0 CHEBI:15351 ChEBI 1.0 24762165 PubChem-compound P0A951 UniProt 13431-24-8 CAS 185 ChemSpider Adenosine diphosphate 85-61-0 CAS 1.0 metK speD speE mtn speG metN metI metQ metN metI metQ L-Methionine Water Adenosine triphosphate Phosphate Pyrophosphate S- Adenosylmethionine Hydrogen Ion Carbon dioxide S- Adenosylmethioninamine Putrescine Spermidine Hydrogen Ion 5'-S-methyl- 5'- thioadenosine Water 5- Methylthioribose Adenine Acetyl-CoA N8- Acetylspermidine Coenzyme A Hydrogen Ion L-Methionine Adenosine triphosphate Water Adenosine diphosphate Phosphate Hydrogen Ion L-Methionine L-Methionine Adenosine triphosphate Water Adenosine diphosphate Pyrophosphate Hydrogen Ion L-Methionine methionine biosynthesis