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2- isopropylmalate synthase isopropylmalate isomerase isopropylmalate isomerase isopropylmalate isomerase isopropylmalate isomerase D-malate / 3- isopropylmalate dehydrogenase (decarboxylating) tyrosine aminotransferase 3-Methyl-2- oxovaleric acid H 2 O Acetyl-CoA CoA H + 2- Isopropylmalic acid H 2 O Isopropylmaleate H 2 O 3- Isopropylmalate NAD NADH H + 2-Isopropyl- 3- oxosuccinate H + CO 2 Ketoleucine L-Glutamic acid Oxoglutaric acid L-Leucine Isoleucine Biosynthesis 3- isopropylmalate dehydrogenase branched-chain amino-acid aminotransferase
Unknown Unknown Unknown Unknown Unknown Unknown Unknown 3-Methyl-2- oxovaleric acid Water Acetyl-CoA Coenzyme A Hydrogen Ion 2- Isopropylmalic acid Water Isopropylmaleate Water 3- Isopropylmalate NAD NADH Hydrogen Ion 2-Isopropyl- 3- oxosuccinate Hydrogen Ion Carbon dioxide Ketoleucine L-Glutamic acid Oxoglutaric acid L-Leucine Isoleucine Biosynthesis Unknown Unknown