PathWhiz

PathWhiz ID	Pathway	Meta Data
PW122570 View Pathway	metabolic Biosynthesis of Siderophore Group Nonribosomal Peptides Pseudomonas aeruginosa 2,3-Dihydroxybenzoate is synthesized from chorismate via isochorismate and 2,3-dihydroxy-2,3-dihydrobenzoate. The biosynthesis of 2,3-dihydroxybenzoate starts from chorismate being synthesized into isochorismate through isochorismate synthase entC. The N-terminal isochorismate lyase domain of EntB hydrolyzes the pyruvate group of isochorismate to produce 2,3-dihydro-2,3-dihydroxybenzoate. The conversion of this latter compound to 2,3-dihydroxybenzoate is catalyzed by the EntA dehydrogenase. This compound then interacts with L-serine and ATP through the enterobactin synthase protein complex resulting in the production of enterobactin. Enterobactin is exported into the periplasmic space through the enterobactin exporter entS. Enterobactin is then exported into the environment through the outer membrane protein TolC. In the environment, enterobactin reacts with iron to produce ferric enterobactin. It is then imported into the periplasmic space through a ferric enterobactin outer membrane transport complex. Ferric enterobactin continues it's journey and enters the cytoplasm via a ferric enterobactin ABC transporter. Once inside the cytoplasm, ferric enterobactin spontaneously releases the iron ion from the enterobactin. Alternatively, it can react with water through an enterochelin esterase resulting in the release of 2,3-dihydroxybenzoylserine, Fe3+, and hydrogen ions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 16:58 Last Updated: August 12, 2019 at 16:58
PW122264 View Pathway	metabolic Biosynthesis of type II polyketide backbone Bacteria Polyketide synthases (PKSs) are large (Mr 100- to 10,000-kDa) multienzyme systems that are responsible for the stepwise biosynthesis of extraordinarily complex natural products from simple 2-, 3-, and 4-carbon building blocks such as acetyl-CoA, propionyl-CoA, butyryl-CoA, and their activated derivatives, malonyl-, methylmalonyl-, and ethylmalonyl-CoA. These polyketide natural products are known to possess a wealth of pharmacologically important activities, including antimicrobial, antifungal, antiparasitic, antitumor, and immunosuppressive properties. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ng Ngashangva Created On: October 23, 2018 at 01:31 Last Updated: October 23, 2018 at 01:31
PW124142 View Pathway	metabolic Biosynthesis of type II polyketide backbone Paenibacillus peoriae IBSD35 Polyketide synthases (PKSs) are large (Mr 100- to 10,000-kDa) multienzyme systems that are responsible for the stepwise biosynthesis of extraordinarily complex natural products from simple 2-, 3-, and 4-carbon building blocks such as acetyl-CoA, propionyl-CoA, butyryl-CoA, and their activated derivatives, malonyl-, methylmalonyl-, and ethylmalonyl-CoA. These polyketide natural products are known to possess a wealth of pharmacologically important activities, including antimicrobial, antifungal, antiparasitic, antitumor, and immunosuppressive properties. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ng Ngashangva Created On: September 03, 2020 at 23:48 Last Updated: September 03, 2020 at 23:48
PW127014 View Pathway	metabolic Biosynthesis of type II polyketide backbone 1655806275 Bacteria BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ng Ngashangva Created On: June 21, 2022 at 04:11 Last Updated: June 21, 2022 at 04:11
PW127015 View Pathway	metabolic Biosynthesis of type II polyketide backbone 1655806835 Bacteria BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ng Ngashangva Created On: June 21, 2022 at 04:21 Last Updated: June 21, 2022 at 04:21
PW127016 View Pathway	metabolic Biosynthesis of type II polyketide backbone 1655806835 Paenibacillus peoriae IBSD35 BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ng Ngashangva Created On: June 21, 2022 at 04:22 Last Updated: June 21, 2022 at 04:22
PW123902 View Pathway	metabolic Biosynthesis of Type II Polyketide Products Streptomyces glaucescens Polyketides are a large group of bioactive secondary metabolites with various biological activities that arise from the diversity in its structures from the precursors of alternating groups like carbonyl and methylene. For this reason, they have a high value in pharmaceutical properties. They are primarily divided into three types: type I, type II and type III polyketides. This pathway focuses on the biosynthesis of type II polyketide products (from the biosynthesis of type II polyketide backbone) which are often based on aromatic molecules produced iteratively by the action of dissociated enzymes in the bacterial species Streptomyces glaucescens. This pathway shows the production of tetracenomycin C and 8-demethyl-tetracenomycin starting from 9,14-decaketides by the action of tcmI, tcmH, tcmN, tcmP, tcmG and tcmO gene proteins. Via a series of reactions using polyketide-synthase, hydroxylase and other enzymes shown in this illustration, the formation of tetracenomycin C occurs. It must be noted that 8-demethyl-tetracenomycin is a derivative of tetracenomycin-C (both shown to be stemming from tetracenomycin-B3) and acts as a teracenomycin having the similar bacterial metabolite role as tetracenomycin-C. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aadhavya Sivakumaran Created On: May 29, 2020 at 11:35 Last Updated: May 29, 2020 at 11:35
PW002403 View Pathway	metabolic Biosynthesis of Unsaturated Fatty Acids Saccharomyces cerevisiae The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and an NADPH through an enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long-chain fatty acids are then incorporated into the sphingolipid pathway. The long-chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A, and an N-acyl-phytosphinganine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 07, 2016 at 16:14 Last Updated: January 07, 2016 at 16:14
PW002408 View Pathway	metabolic Biosynthesis of Unsaturated Fatty Acids (Docosanoyl-CoA) Saccharomyces cerevisiae The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 13, 2016 at 10:43 Last Updated: January 13, 2016 at 10:43
PW002434 View Pathway	metabolic Biosynthesis of Unsaturated Fatty Acids (Icosanoyl-CoA) Saccharomyces cerevisiae The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 28, 2016 at 10:17 Last Updated: January 28, 2016 at 10:17