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Pathways

PathWhiz ID Pathway Meta Data

PW146121

Pw146121 View Pathway
drug action

Chymotrypsin Drug Metabolism Action Pathway

Homo sapiens

PW146749

Pw146749 View Pathway
drug action

Cianidanol Drug Metabolism Action Pathway

Homo sapiens

PW127769

Pw127769 View Pathway
drug action

Ciclesonide Action Pathway

Homo sapiens
Ciclesonide is a glucocorticoid used in the relief of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents. It is also used to treat obstructive airway diseases like asthma, bronchoconstriction, and chronic obstructive pulmonary disease (COPD). Ciclesonide is a pro-drug so it is enzymatically hydrolyzed to C21-desisobutyryl-ciclesonide (des-ciclesonide or RM1), the active metabolite. Des-ciclesonide has anti-inflammatory activity with an affinity for the glucocorticoid receptor that is 120 times higher than ciclesonide. As des-ciclesonide is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) of influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Des-ciclesonide also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Ciclesonide is administered as an inhaler or as a nasal spray.

PW145419

Pw145419 View Pathway
drug action

Ciclesonide Drug Metabolism Action Pathway

Homo sapiens

PW123610

Pw123610 View Pathway
signaling

ciclic AMP

Homo sapiens

PW125997

Pw125997 View Pathway
metabolic

Ciclo de Krebs

Homo sapiens

PW124247

Pw124247 View Pathway
metabolic

Ciclo de Krebs y destino del esqueleto carbonado de los aminoácidos (CV)

Homo sapiens
Ruta metabólica que forma parte de la respiración celular para generar energía a partir de la oxidación de Acetil-CoA. Destino de los esqueletos carbonados de los aminoácidos que pueden alimentar el ciclo de Krebs.

PW124278

Pw124278 View Pathway
metabolic

Ciclo de la Urea (CV)

Homo sapiens
Ruta metabólica en la cual se degradan aminoácidos para generar un único producto de excreción, la urea.

PW124267

Pw124267 View Pathway
metabolic

Ciclo de Urea (CV) error

Homo sapiens

PW124411

Pw124411 View Pathway
metabolic

Ciclo del glutamato

Homo sapiens