PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127769 View Pathway	drug action Ciclesonide Action Pathway Homo sapiens Ciclesonide is a glucocorticoid used in the relief of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents. It is also used to treat obstructive airway diseases like asthma, bronchoconstriction, and chronic obstructive pulmonary disease (COPD). Ciclesonide is a pro-drug so it is enzymatically hydrolyzed to C21-desisobutyryl-ciclesonide (des-ciclesonide or RM1), the active metabolite. Des-ciclesonide has anti-inflammatory activity with an affinity for the glucocorticoid receptor that is 120 times higher than ciclesonide. As des-ciclesonide is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) of influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Des-ciclesonide also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Ciclesonide is administered as an inhaler or as a nasal spray. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: May 31, 2023 at 15:47 Last Updated: May 31, 2023 at 15:47
PW145419 View Pathway	drug action Ciclesonide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:47 Last Updated: October 07, 2023 at 15:47
PW123610 View Pathway	signaling ciclic AMP Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 27, 2019 at 13:48 Last Updated: September 27, 2019 at 13:48
PW125997 View Pathway	metabolic Ciclo de Krebs Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: May 18, 2021 at 01:33 Last Updated: May 18, 2021 at 01:33
PW124247 View Pathway	metabolic Ciclo de Krebs y destino del esqueleto carbonado de los aminoácidos (CV) Homo sapiens Ruta metabólica que forma parte de la respiración celular para generar energía a partir de la oxidación de Acetil-CoA. Destino de los esqueletos carbonados de los aminoácidos que pueden alimentar el ciclo de Krebs. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: October 18, 2020 at 21:40 Last Updated: October 18, 2020 at 21:40
PW124278 View Pathway	metabolic Ciclo de la Urea (CV) Homo sapiens Ruta metabólica en la cual se degradan aminoácidos para generar un único producto de excreción, la urea. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: October 25, 2020 at 12:33 Last Updated: October 25, 2020 at 12:33
PW124267 View Pathway	metabolic Ciclo de Urea (CV) error Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: October 23, 2020 at 13:29 Last Updated: October 23, 2020 at 13:29
PW124411 View Pathway	metabolic Ciclo del glutamato Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Paula Created On: January 03, 2021 at 14:27 Last Updated: January 03, 2021 at 14:27
PW132372 View Pathway	metabolic Ciclopirox Drug Metabolism Homo sapiens Ciclopirox is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Ciclopirox passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:18 Last Updated: September 21, 2023 at 21:18
PW145275 View Pathway	drug action Ciclopirox Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:26 Last Updated: October 07, 2023 at 15:26