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CHEBI:16015 ChEBI 7722-84-1 CAS C23H38N7O17P3S Acetyl-CoA 809.1258 937 ChemSpider CHEBI:16134 ChEBI L-Aspartic acid SubPathwayInput 1.0 HMDB0003125 HMDB 1.0 439153 PubChem-compound Membrane primary amine oxidase 1.0 50 ChemSpider CHEBI:18323 ChEBI 388363 ChemSpider 1.0 Hydrogen peroxide 1.0 CHEBI:17568 ChEBI Beta-Ala-His dipeptidase 5745 ChemSpider 100482 ChemSpider 1.0 L-ASPARTATE BioCyc 1.0 1141 ChemSpider CHEBI:16474 ChEBI PW000160 PathWhiz 952 ChemSpider Ureidopropionic acid Carbon dioxide Aldehyde dehydrogenase, mitochondrial 74 ChemSpider 64969 PubChem-compound 6274 PubChem-compound C00106 KEGG Compound PW000032 PathWhiz Carbon dioxide C02642 KEGG Compound CHEBI:16240 ChEBI 58494 ChemSpider 1010 ChemSpider C00222 KEGG Compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 1.0 C3H7NO 3-Aminopropionaldehyde 73.052765 PANTOTHENATE BioCyc 3-AMINO-PROPANAL BioCyc Q99259 UniProt 1.0 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial C00007 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound 1.0 C00005 KEGG Compound NADH C00004 KEGG Compound C00003 KEGG Compound NADP Q96KN2 UniProt 3-Aminopropionaldehyde Coenzyme A Malonic semialdehyde SubPathwayInput beta-Alanine SubPathwayOutput 2.0 Q12882 UniProt C21H28N7O14P2 NAD 664.11694 1.0 Beta-Ala-His dipeptidase 44367445 PubChem-compound C00011 KEGG Compound C00010 KEGG Compound Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial HMDB0000902 HMDB C00135 KEGG Compound C00014 KEGG Compound Extracellular Space NAD(P) BioCyc 4-aminobutyrate aminotransferase, mitochondrial 1.0 H Hydrogen Ion 1.007825 C00386 KEGG Compound 53-84-9 CAS C00027 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound false Ureidopropionic acid + Water ↔ Ammonia + Carbon dioxide + beta-Alanine REVERSIBLE Anserine L-Glutamic acid Oxygen 462-88-4 CAS 79-83-4 CAS 504-07-4 CAS 415 ChemSpider Glutamate decarboxylase 1 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES O=C1CCNC(=O)N1 HMDB0001106 HMDB Transport8 false beta-Alanine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 1.0 HYDROGEN-PEROXIDE BioCyc 649 PubChem-compound Dihydrouracil 1.0 1.0 Water C00049 KEGG Compound 4.0 HMDB0000026 HMDB 763 ChemSpider C01262 KEGG Compound HMDB0000148 HMDB Carnosine Membrane primary amine oxidase 784 PubChem-compound 428 PubChem-compound URACIL BioCyc 4-aminobutyrate aminotransferase, mitochondrial 7732-18-5 CAS HMDB0001487 HMDB C01152 KEGG Compound 1.0 926-61-4 CAS AMMONIA BioCyc SMILES N 56-86-0 CAS 1.0 Dihydropyrimidine dehydrogenase [NADP(+)] HMDB0000033 HMDB CHEBI:17053 ChEBI CHEBI:18261 ChEBI false L-Aspartic acid → Carbon dioxide + beta-Alanine LEFT_TO_RIGHT Dihydropyrimidine dehydrogenase [NADP(+)] Beta-Ala-His dipeptidase NAD HMDB0001377 HMDB 1.0 2.0 Dihydropyrimidine dehydrogenase [NADP(+)] Reaction5 false Oxoglutaric acid + beta-Alanine → L-Glutamic acid + Malonic semialdehyde LEFT_TO_RIGHT Ammonia Ammonia SMILES NCCC(O)=O 962 PubChem-compound CO2 Carbon dioxide 43.98983 HMDB0000056 HMDB HMDB0000177 HMDB C00080 KEGG Compound SMILES O=O L-Histidine Water 1.0 Aldehyde dehydrogenase, mitochondrial SMILES OC(=O)CC=O HMDB0000051 HMDB 352-92-1 CAS HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O 3-Methylhistidine C6H9N3O2 L-Histidine 155.06947 Beta-ureidopropionase 1.0 Dihydropyrimidinase Beta-ureidopropionase 845 ChemSpider 963 ChemSpider Uracil SubPathwayInput C4H7NO4 L-Aspartic acid 133.0375 C3H10N2 1,3-Diaminopropane 74.0844 C7H11N3O2 3-Methylhistidine 169.08513 Malonic semialdehyde Aldehyde dehydrogenase, mitochondrial 444493 PubChem-compound 988 PubChem-compound C4H4N2O2 Uracil 112.027275 868 PubChem-compound C00099 KEGG Compound C05665 KEGG Compound 22833512 PubChem-compound 1.0 ACETYL-COA BioCyc CARNOSINE BioCyc H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 Dihydropyrimidinase HMDB0000191 HMDB HMDB0000194 HMDB NADH BioCyc HMDB0000076 HMDB NAD BioCyc 977 PubChem-compound HMDB0059597 HMDB 56-84-8 CAS 629 ChemSpider Acetyl-CoA CHEBI:15901 ChEBI ReactionCatalysis157 ACTIVATION ReactionCatalysis158 ACTIVATION 30572 ChemSpider ReactionCatalysis156 ACTIVATION 17215925 ChemSpider 66-22-8 CAS SMILES O=C1NC=CC(=O)N1 Q02252 UniProt SMILES O SMILES OO H3N Ammonia 17.026548 CHEBI:15971 ChEBI 1.0 4.0 SubPathwayInteraction823 SubPathwayReaction SubPathway823Reaction SubPathwayInteraction820 SubPathway820Reaction SubPathwayReaction 239 PubChem-compound SubPathwayInteraction821 SubPathwayReaction SubPathway821Reaction SubPathwayInteraction824 SubPathwayReaction SubPathway824Reaction 111 PubChem-compound 1.0 1.0 HMDB0000300 HMDB 6816 PubChem-compound Water 51 PubChem-compound CHEBI:15846 ChEBI CHEBI:15725 ChEBI CHEBI:15727 ChEBI C3H7NO2 beta-Alanine 89.047676 Pyrimidine Metabolism SubPathway 53-59-8 CAS C10H16N4O3 Anserine 240.12224 6038 ChemSpider Glutamate decarboxylase 1 1038 PubChem-compound Intestinal Microflora SubPathway CHEBI:18090 ChEBI 274 ChemSpider beta-Alanine C5H6O5 Oxoglutaric acid 146.02153 CHEBI:16908 ChEBI C4H8N2O3 Ureidopropionic acid 132.0535 ReactionCatalysis162 ACTIVATION ReactionCatalysis163 ACTIVATION 109-76-2 CAS C9H17NO5 Pantothenic acid 219.11067 ReactionCatalysis160 ACTIVATION ReactionCatalysis161 ACTIVATION 305-84-0 CAS DI-H-URACIL BioCyc Aspartate Metabolism SubPathway false Dihydrouracil + NADP ↔ NADPH + Uracil REVERSIBLE C21H30N7O17P3 NADPH 745.0911 Membrane primary amine oxidase Reaction666 false Coenzyme A + Malonic semialdehyde + NAD → Acetyl-CoA + Carbon dioxide + NADH LEFT_TO_RIGHT false Anserine + Water → 3-Methylhistidine + beta-Alanine LEFT_TO_RIGHT C9H14N4O3 Carnosine 226.1066 false Carnosine + Water → L-Histidine + beta-Alanine LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 75 PubChem-compound Mitochondrion Q14117 UniProt ReactionCatalysis159 ACTIVATION 1.0 NADPH BioCyc HMDB0000208 HMDB SMILES CN1C=NC=C1C[C@H](NC(=O)CCN)C(O)=O CPD-6641 BioCyc 71-00-1 CAS 217 ChemSpider 1,3-Diaminopropane Q9UBR1 UniProt 58-68-4 CAS HMDB0000210 HMDB HMDB0001423 HMDB SMILES CC(C)(CO)[C@@H](O)C(=O)NCCC(O)=O HMDB0000217 HMDB 1.0 SMILES OC(=O)CCC(=O)C(O)=O GO:0005886 GENE ONTOLOGY ReactionCatalysis8 ACTIVATION 124-38-9 CAS CHEBI:30915 ChEBI ReactionCatalysis6 ACTIVATION SMP0000046 SMPDB SMILES NC(=O)NCCC(O)=O 3-UREIDO-PROPIONATE BioCyc HMDB0011111 HMDB SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GO:0005759 GENE ONTOLOGY SMILES NCCC(=O)N[C@@H](CC1=CN=CN1)C(O)=O 7664-41-7 CAS GLT BioCyc beta-Alanine Metabolism 107-95-9 CAS 53-57-6 CAS CPD-313 BioCyc Dihydropyrimidinase SMILES O=C=O 1.0 2.0 222 PubChem-compound Hydrogen Ion 1.0 234 ChemSpider HMDB0000479 HMDB C21H29N7O14P2 NADH 665.12476 1.0 HMDB0001206 HMDB SMP0000067 SMPDB Propanoate Metabolism SubPathway C4H6N2O2 Dihydrouracil 114.04293 SMILES N[C@@H](CC1=CN=CN1)C(O)=O 109 ChemSpider HMDB0000002 HMDB GO:0005739 GENE ONTOLOGY GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY 1.0 SMILES N[C@@H](CC(O)=O)C(O)=O SMILES NCCCN SMILES CN1C=NC=C1C[C@H](N)C(O)=O CHEBI:16958 ChEBI Pantothenate and CoA Biosynthesis SubPathway SMP0000007 SMPDB false 3-Aminopropionaldehyde + NAD + Water → Hydrogen Ion + NADH + beta-Alanine LEFT_TO_RIGHT SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 5682 ChemSpider CHEBI:1146900 ChEBI false Dihydrouracil + Water ↔ Ureidopropionic acid REVERSIBLE Mitochondrial Matrix CO-A BioCyc SMP0000016 SMPDB Glutamate decarboxylase 1 P05091 UniProt B-ALANINE BioCyc 5675 ChemSpider 3-Aminopropionaldehyde 72-89-9 CAS C21H36N7O16P3S Coenzyme A 767.11523 1.0 Cytoplasm NADPH CHEBI:7916 ChEBI 1.0 584-85-0 CAS 6557 ChemSpider SMP0000027 SMPDB P80404 UniProt 1.0 Homo sapiens SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider CHEBI:17960 ChEBI Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial C3H4O3 Malonic semialdehyde 88.016045 O2 Oxygen 31.98983 Water HIS BioCyc C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound C00986 KEGG Compound 1.0 C00864 KEGG Compound CHEBI:16526 ChEBI 7782-44-7 CAS false 1,3-Diaminopropane + Oxygen + Water → 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxide LEFT_TO_RIGHT 9606 TAXONOMY PW000149 PathWhiz 2-KETOGLUTARATE BioCyc 392413 ChemSpider 1174 PubChem-compound Oxoglutaric acid 5893 PubChem-compound 4.0 4-aminobutyrate aminotransferase, mitochondrial CHEBI:27596 ChEBI CHEBI:15377 ChEBI Cell Membrane 368-16-1 CAS PW000011 PathWhiz CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] 5886 PubChem-compound 439224 PubChem-compound 2.0 280 PubChem-compound PW000002 PathWhiz Pantothenic acid SubPathwayInput SMILES NCCC=O beta-Alanine 2.0 112072 PubChem-compound Q16853 UniProt C00429 KEGG Compound HMDB0001967 HMDB CHEBI:15351 ChEBI SubPathwayInteraction15 SubPathway15Reaction SubPathwayReaction 85-61-0 CAS Beta-Ala-His dipeptidase Beta-Ala-His dipeptidase Glutamate decarboxylase 1 Beta- ureidopropionase Dihydropyrimidinase Dihydropyrimidine dehydrogenase [NADP(+)] 4-aminobutyrate aminotransferase, mitochondrial Methylmalonate- semialdehyde dehydrogenase [acylating], mitochondrial Aldehyde dehydrogenase, mitochondrial Membrane primary amine oxidase Pantothenic acid beta-Alanine L-Aspartic acid Uracil Malonic semialdehyde beta-Alanine Anserine H 2 O 3-Methylhistidine Carnosine H 2 O L-Histidine CO 2 Ureidopropionic acid H 2 O CO 2 NH 3 Dihydrouracil H 2 O NADP NADPH Oxoglutaric acid L-Glutamic acid CoA NAD Acetyl-CoA CO 2 NADH 3-Aminopropionaldehyde NAD H 2 O NADH H + 1,3-Diaminopropane O 2 H 2 O NH 3 H 2 O 2 Zinc (II) ion Zinc (II) ion Pyridoxal 5'-phosphate Zinc (II) ion Zinc (II) ion FAD Flavin Mononucleotide Pyridoxal 5'-phosphate Copper Calcium Topaquinone Pantothenate and CoA Biosynthesis Aspartate Metabolism Pyrimidine Metabolism Propanoate Metabolism Extracellular Space Intracellular Space Mitochondria