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CHEBI:16015 ChEBI 30572 ChemSpider Phenylpyruvic acid 7722-84-1 CAS Homogentisic acid 6140 PubChem-compound Q96RQ9 UniProt 937 ChemSpider CHEBI:16134 ChEBI 63-91-2 CAS P-HYDROXY-PHENYLPYRUVATE BioCyc HMDB0003125 HMDB Phenylalanine--tRNA ligase alpha subunit P16930 UniProt 110-17-8 CAS 21883788 PubChem-compound SMILES CC(O)C(O)C1CNC2=NC(N)=NC(=O)C2(O)N1 SMILES O SMILES OO H3N Ammonia 17.026548 L-Phenylalanine C10H14N5O7P Adenosine monophosphate 347.06308 50 ChemSpider 1.0 1.0 CHEBI:16027 ChEBI L-amino-acid oxidase 5833 ChemSpider HMDB0000538 HMDB Phenylalanine--tRNA ligase beta subunit ATP BioCyc Aspartate aminotransferase, cytoplasmic Phenylalanine--tRNA ligase SMILES N[C@@H](CC1=CC=C(O)C=C1)C(O)=O 51 PubChem-compound C8H8O6 Maleylacetoacetic acid 200.03209 Water 1.0 Phenylalanine-4-hydroxylase Hydrogen peroxide 559142 ChemSpider 1.0 Tyrosine aminotransferase HMDB0002281 HMDB C4H6O3 Acetoacetic acid 102.03169 1.0 2.0 Q9Y285 UniProt Lysosome CHEBI:59560 ChEBI 1.0 CHEBI:44747 ChEBI 5742 ChemSpider tRNA(Tyr) PW000042 PathWhiz 954 ChemSpider 952 ChemSpider Carbon dioxide Phenylalanine-4-hydroxylase 4-Fumarylacetoacetic acid 274 ChemSpider HMDB0002052 HMDB C5H6O5 Oxoglutaric acid 146.02153 TYR BioCyc C9H8O3 Phenylpyruvic acid 164.04735 Citric Acid Cycle SubPathway 5858 ChemSpider CHEBI:47904 ChEBI P32754 UniProt Adenosine monophosphate SMILES OC(=O)C(=O)CC1=CC=C(O)C=C1 Maleylacetoacetate isomerase CHEBI:16240 ChEBI O43708 UniProt HMDB0000205 HMDB PPI BioCyc 1.0 4444078 ChemSpider Reaction79 false L-Phenylalanine + Oxoglutaric acid ↔ L-Glutamic acid + Phenylpyruvic acid REVERSIBLE HMDB0000208 HMDB L-Glutamic acid SubPathwayInteraction90 SubPathwayReaction SubPathway90Reaction CPD-6641 BioCyc 217 ChemSpider P00439 UniProt SubPathwayInteraction89 SubPathway89Reaction SubPathwayReaction SMILES OC(=O)C(=O)CC1=CC=CC=C1 Acetoacetic acid SubPathwayInput SubPathwayInteraction88 SubPathwayReaction SubPathway88Reaction 2.6.1.5 false 2.6.1.5 L-Tyrosine + Oxoglutaric acid ↔ 4-Hydroxyphenylpyruvic acid + L-Glutamic acid REVERSIBLE Fumarylacetoacetase SMILES OC(=O)CCC(=O)C(O)=O Tyrosine aminotransferase CHEBI:30915 ChEBI 124-38-9 CAS GO:0005764 GENE ONTOLOGY 94 ChemSpider 1.0 C00007 KEGG Compound 451-13-8 CAS Aspartate aminotransferase, cytoplasmic 4-hydroxyphenylpyruvate dioxygenase C00001 KEGG Compound C00122 KEGG Compound CHEBI:18361 ChEBI 4-Hydroxyphenylpyruvic acid HMDB0059658 HMDB 1.0 C00002 KEGG Compound L-Phenylalanine 4-FUMARYL-ACETOACETATE BioCyc Fumaric acid SubPathwayInput PHENYL-PYRUVATE BioCyc 4-Hydroxyphenylpyruvic acid 2.0 Phenylalanine and Tyrosine Metabolism GLT BioCyc 7664-41-7 CAS 1.0 C4H4O4 Fumaric acid 116.010956 Tyrosine Metabolism SubPathway SMP0000057 SMPDB CHEBI:30907 ChEBI C8H8O4 Homogentisic acid 168.04225 Oxygen Homogentisate 1,2-dioxygenase Maleylacetoacetic acid 1.0 Adenosine triphosphate C00011 KEGG Compound SMILES O=C=O 1.0 SMILES N[C@@H](CC1=CC=CC=C1)C(O)=O L-Tyrosine SubPathwayInput 222 PubChem-compound C00014 KEGG Compound C00013 KEGG Compound Catecholamine Biosynthesis SubPathway O7P2 Pyrophosphate 173.91193 40270 ChemSpider 1.0 5957 PubChem-compound 4-hydroxyphenylpyruvate dioxygenase 6.1.1.1 false 6.1.1.1 Adenosine triphosphate + L-Tyrosine + tRNA(Tyr) → Adenosine monophosphate + L-tyrosyl-tRNA(Tyr) + Pyrophosphate LEFT_TO_RIGHT CHEBI:15999 ChEBI 6.1.1.20 false 6.1.1.20 Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) → Adenosine monophosphate + L-phenylalanyl-tRNA(Phe) + Pyrophosphate LEFT_TO_RIGHT 56-65-5 CAS C00020 KEGG Compound C00027 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound 2.0 L-tyrosyl-tRNA(Tyr) 2.0 Phenylalanine--tRNA ligase beta subunit 1.0 C00272 KEGG Compound GO:0005737 GENE ONTOLOGY Aspartate aminotransferase, cytoplasmic C8H8O6 4-Fumarylacetoacetic acid 200.03209 1.0 Tyrosine--tRNA ligase, cytoplasmic SMP0000008 SMPDB SMP0000006 SMPDB 3-KETOBUTYRATE BioCyc Homogentisate 1,2-dioxygenase 4-hydroxyphenylpyruvate dioxygenase 328-50-7 CAS HMDB0000134 HMDB Phenylpyruvic acid AMP BioCyc HYDROGEN-PEROXIDE BioCyc 1.0 C15522 KEGG Compound Phenylalanine-4-hydroxylase Q9NSD9 UniProt 44257 PubChem-compound HMDB0000130 HMDB HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O tRNA(Phe) 14000-31-8 CAS L-erythro-tetrahydrobiopterin C9H8O4 4-Hydroxyphenylpyruvic acid 180.04225 997 PubChem-compound CHEBI:29161 ChEBI 2.0 C00166 KEGG Compound C00164 KEGG Compound L-Tyrosine Fumarylacetoacetase 763 ChemSpider L-phenylalanyl-tRNA(Phe) HMDB0000148 HMDB L-tyrosyl-tRNA(Tyr) SMILES OC(=O)CC(=O)CC(=O)\C=C\C(O)=O tRNA(Tyr) Cytoplasm SMP0000012 SMPDB Tyrosine--tRNA ligase, cytoplasmic 784 PubChem-compound 10197150 ChemSpider CHEBI:15422 ChEBI 1.0 Homo sapiens FUM BioCyc 62989-33-7 CAS HMDB0000707 HMDB 7732-18-5 CAS 780 PubChem-compound CHEBI:18012 ChEBI 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 O2 Oxygen 31.98983 HMDB0000158 HMDB HMDB0000159 HMDB AMMONIA BioCyc SMILES N 56-86-0 CAS SMILES [H][C@@]1(CNC2=C(N1)C(=O)NC(N)=N2)[C@@H](O)[C@H](C)O 2.0 CHEBI:29153 ChEBI ReactionCatalysis447 ACTIVATION ReactionCatalysis445 ACTIVATION C5H9NO4 L-Glutamic acid 147.05316 Phenylalanine--tRNA ligase alpha subunit ReactionCatalysis446 ACTIVATION 156-06-9 CAS 33032 PubChem-compound ReactionCatalysis443 ACTIVATION 60-18-4 CAS ReactionCatalysis444 ACTIVATION ReactionCatalysis441 ACTIVATION Water ReactionCatalysis442 ACTIVATION 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 ReactionCatalysis440 ACTIVATION 1.0 129803 PubChem-compound CHEBI:16526 ChEBI CHEBI:17295 ChEBI 4444081 ChemSpider 4a-Hydroxytetrahydrobiopterin 7782-44-7 CAS Pyrophosphate C01036 KEGG Compound HMDB0001377 HMDB Tyrosine--tRNA ligase, cytoplasmic HMDB0000045 HMDB SMILES CC(=O)CC(O)=O 1.0 SMILES OC(=O)CC(=O)CC(=O)\C=C/C(O)=O ReactionCatalysis438 ACTIVATION PHE BioCyc ReactionCatalysis436 ACTIVATION Reaction386 false Maleylacetoacetic acid → 4-Fumarylacetoacetic acid LEFT_TO_RIGHT ReactionCatalysis437 ACTIVATION 3.7.1.2 false 3.7.1.2 4-Fumarylacetoacetic acid + Water → Acetoacetic acid + Fumaric acid LEFT_TO_RIGHT ReactionCatalysis435 ACTIVATION 9606 TAXONOMY 962 PubChem-compound PW000142 PathWhiz 70110-58-6 CAS 1.0 P54577 UniProt C9H11NO2 L-Phenylalanine 165.07898 2-KETOGLUTARATE BioCyc tRNA(Phe) C9H11NO3 L-Tyrosine 181.0739 114908 ChemSpider CO2 Carbon dioxide 43.98983 C00079 KEGG Compound Fumarylacetoacetase 972 ChemSpider SMILES O=O 1.0 HMDB0001268 HMDB Maleylacetoacetate isomerase C00082 KEGG Compound Oxoglutaric acid HMDB0000051 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O C9H15N5O3 L-erythro-tetrahydrobiopterin 241.1175 HMDB0002111 HMDB 1.4.3.2 false 1.4.3.2 L-Phenylalanine + Oxygen + Water → Ammonia + Hydrogen peroxide + Phenylpyruvic acid LEFT_TO_RIGHT 1.4.3.2 false 1.4.3.2 L-Tyrosine + Oxygen + Water → 4-Hydroxyphenylpyruvic acid + Ammonia + Hydrogen peroxide LEFT_TO_RIGHT 1.13.11.5 false 1.13.11.5 Homogentisic acid + Oxygen → Maleylacetoacetic acid LEFT_TO_RIGHT 1.0 CHEBI:15377 ChEBI 6057 PubChem-compound CHEBI:15379 ChEBI PW000017 PathWhiz 5910 ChemSpider 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5280393 PubChem-compound 1.0 Q93099 UniProt CHEBI:15374 ChEBI C01179 KEGG Compound 5280398 PubChem-compound L-phenylalanyl-tRNA(Phe) 280 PubChem-compound C01061 KEGG Compound HMDB0000060 HMDB 96 PubChem-compound 2.0 1.13.11.27 false 1.13.11.27 4-Hydroxyphenylpyruvic acid + Oxygen → Carbon dioxide + Homogentisic acid LEFT_TO_RIGHT 28613-33-4 CAS 1.0 CHEBI:15344 ChEBI 156-39-8 CAS 644102 PubChem-compound PW000005 PathWhiz 6083 PubChem-compound 759 ChemSpider 2.0 2.0 CHEBI:30851 ChEBI Maleylacetoacetate isomerase C9H15N5O4 4a-Hydroxytetrahydrobiopterin 257.1124 H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 Oxygen 1.14.16.1 false 1.14.16.1 L-Phenylalanine + L-erythro-tetrahydrobiopterin + Oxygen → 4a-Hydroxytetrahydrobiopterin + L-Tyrosine LEFT_TO_RIGHT L-amino-acid oxidase Ammonia 541-50-4 CAS CHEBI:17895 ChEBI 1.0 977 PubChem-compound 5698-52-2 CAS 1.0 CHEBI:29182 ChEBI HMDB0001967 HMDB P17735 UniProt C00544 KEGG Compound 1.0 Tyrosine aminotransferase SMILES OC(=O)\C=C\C(O)=O 1.0 1.0 CHEBI:29184 ChEBI 979 PubChem-compound P17174 UniProt SMILES OC(=O)CC1=C(O)C=CC(O)=C1 4-MALEYL-ACETOACETATE BioCyc Aspartate aminotransferase, cytoplasmic L-amino-acid oxidase Tyrosine aminotransferase Phenylalanine- 4-hydroxylase Aspartate aminotransferase, cytoplasmic Tyrosine aminotransferase L-amino-acid oxidase Tyrosine--tRNA ligase, cytoplasmic Phenylalanine- -tRNA ligase 4- hydroxyphenylpyruvate dioxygenase Homogentisate 1,2-dioxygenase Maleylacetoacetate isomerase Fumarylacetoacetase L-Tyrosine Fumaric acid Acetoacetic acid L-Phenylalanine Oxoglutaric acid Phenylpyruvic acid L-Glutamic acid H 2 O O 2 NH 3 H 2 O 2 Oxoglutaric acid L-Glutamic acid L-erythro-tetrahydrobiopterin O 2 4a-Hydroxytetrahydrobiopterin Oxoglutaric acid 4-Hydroxyphenylpyruvic acid L-Glutamic acid Oxoglutaric acid L-Glutamic acid H 2 O O 2 NH 3 H 2 O 2 ATP AMP PP i ATP AMP PP i O 2 Homogentisic acid CO 2 O 2 Maleylacetoacetic acid 4-Fumarylacetoacetic acid H 2 O Pyridoxal 5'-phosphate FAD Pyridoxal 5'-phosphate Fe2+ Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate FAD Fe3+ Iron Calcium Magnesium tRNA(Tyr) L-tyrosyl- tRNA(Tyr) tRNA(Phe) L- phenylalanyl- tRNA(Phe) Catecholamine Biosynthesis Tyrosine Metabolism Citric Acid Cycle Intracellular Space Extracellular Space Liver
CHEBI:16015 ChEBI 30572 ChemSpider Phenylpyruvic acid 7722-84-1 CAS Homogentisic acid 6140 PubChem-compound Q96RQ9 UniProt 937 ChemSpider CHEBI:16134 ChEBI 63-91-2 CAS P-HYDROXY-PHENYLPYRUVATE BioCyc HMDB0003125 HMDB Phenylalanine--tRNA ligase alpha subunit P16930 UniProt 110-17-8 CAS 21883788 PubChem-compound SMILES CC(O)C(O)C1CNC2=NC(N)=NC(=O)C2(O)N1 SMILES O SMILES OO H3N Ammonia 17.026548 L-Phenylalanine C10H14N5O7P Adenosine monophosphate 347.06308 50 ChemSpider 1.0 1.0 CHEBI:16027 ChEBI L-amino-acid oxidase 5833 ChemSpider HMDB0000538 HMDB Phenylalanine--tRNA ligase beta subunit ATP BioCyc Aspartate aminotransferase, cytoplasmic Phenylalanine--tRNA ligase SMILES N[C@@H](CC1=CC=C(O)C=C1)C(O)=O 51 PubChem-compound C8H8O6 Maleylacetoacetic acid 200.03209 Water 1.0 Phenylalanine-4-hydroxylase Hydrogen peroxide 559142 ChemSpider 1.0 Tyrosine aminotransferase HMDB0002281 HMDB C4H6O3 Acetoacetic acid 102.03169 1.0 2.0 Q9Y285 UniProt Lysosome CHEBI:59560 ChEBI 1.0 CHEBI:44747 ChEBI 5742 ChemSpider tRNA(Tyr) PW000042 PathWhiz 954 ChemSpider 952 ChemSpider Carbon dioxide Phenylalanine-4-hydroxylase 4-Fumarylacetoacetic acid 274 ChemSpider HMDB0002052 HMDB C5H6O5 Oxoglutaric acid 146.02153 TYR BioCyc C9H8O3 Phenylpyruvic acid 164.04735 Citric Acid Cycle SubPathway 5858 ChemSpider CHEBI:47904 ChEBI P32754 UniProt Adenosine monophosphate SMILES OC(=O)C(=O)CC1=CC=C(O)C=C1 Maleylacetoacetate isomerase CHEBI:16240 ChEBI O43708 UniProt HMDB0000205 HMDB PPI BioCyc 1.0 4444078 ChemSpider Reaction79 false L-Phenylalanine + Oxoglutaric acid ↔ L-Glutamic acid + Phenylpyruvic acid REVERSIBLE HMDB0000208 HMDB L-Glutamic acid SubPathwayInteraction90 SubPathwayReaction SubPathway90Reaction CPD-6641 BioCyc 217 ChemSpider P00439 UniProt SubPathwayInteraction89 SubPathway89Reaction SubPathwayReaction SMILES OC(=O)C(=O)CC1=CC=CC=C1 Acetoacetic acid SubPathwayInput SubPathwayInteraction88 SubPathwayReaction SubPathway88Reaction 2.6.1.5 false 2.6.1.5 L-Tyrosine + Oxoglutaric acid ↔ 4-Hydroxyphenylpyruvic acid + L-Glutamic acid REVERSIBLE Fumarylacetoacetase SMILES OC(=O)CCC(=O)C(O)=O Tyrosine aminotransferase CHEBI:30915 ChEBI 124-38-9 CAS GO:0005764 GENE ONTOLOGY 94 ChemSpider 1.0 C00007 KEGG Compound 451-13-8 CAS Aspartate aminotransferase, cytoplasmic 4-hydroxyphenylpyruvate dioxygenase C00001 KEGG Compound C00122 KEGG Compound CHEBI:18361 ChEBI 4-Hydroxyphenylpyruvic acid HMDB0059658 HMDB 1.0 C00002 KEGG Compound L-Phenylalanine 4-FUMARYL-ACETOACETATE BioCyc Fumaric acid SubPathwayInput PHENYL-PYRUVATE BioCyc 4-Hydroxyphenylpyruvic acid 2.0 Phenylalanine and Tyrosine Metabolism GLT BioCyc 7664-41-7 CAS 1.0 C4H4O4 Fumaric acid 116.010956 Tyrosine Metabolism SubPathway SMP0000057 SMPDB CHEBI:30907 ChEBI C8H8O4 Homogentisic acid 168.04225 Oxygen Homogentisate 1,2-dioxygenase Maleylacetoacetic acid 1.0 Adenosine triphosphate C00011 KEGG Compound SMILES O=C=O 1.0 SMILES N[C@@H](CC1=CC=CC=C1)C(O)=O L-Tyrosine SubPathwayInput 222 PubChem-compound C00014 KEGG Compound C00013 KEGG Compound Catecholamine Biosynthesis SubPathway O7P2 Pyrophosphate 173.91193 40270 ChemSpider 1.0 5957 PubChem-compound 4-hydroxyphenylpyruvate dioxygenase 6.1.1.1 false 6.1.1.1 Adenosine triphosphate + L-Tyrosine + tRNA(Tyr) → Adenosine monophosphate + L-tyrosyl-tRNA(Tyr) + Pyrophosphate LEFT_TO_RIGHT CHEBI:15999 ChEBI 6.1.1.20 false 6.1.1.20 Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) → Adenosine monophosphate + L-phenylalanyl-tRNA(Phe) + Pyrophosphate LEFT_TO_RIGHT 56-65-5 CAS C00020 KEGG Compound C00027 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound 2.0 L-tyrosyl-tRNA(Tyr) 2.0 Phenylalanine--tRNA ligase beta subunit 1.0 C00272 KEGG Compound GO:0005737 GENE ONTOLOGY Aspartate aminotransferase, cytoplasmic C8H8O6 4-Fumarylacetoacetic acid 200.03209 1.0 Tyrosine--tRNA ligase, cytoplasmic SMP0000008 SMPDB SMP0000006 SMPDB 3-KETOBUTYRATE BioCyc Homogentisate 1,2-dioxygenase 4-hydroxyphenylpyruvate dioxygenase 328-50-7 CAS HMDB0000134 HMDB Phenylpyruvic acid AMP BioCyc HYDROGEN-PEROXIDE BioCyc 1.0 C15522 KEGG Compound Phenylalanine-4-hydroxylase Q9NSD9 UniProt 44257 PubChem-compound HMDB0000130 HMDB HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O tRNA(Phe) 14000-31-8 CAS L-erythro-tetrahydrobiopterin C9H8O4 4-Hydroxyphenylpyruvic acid 180.04225 997 PubChem-compound CHEBI:29161 ChEBI 2.0 C00166 KEGG Compound C00164 KEGG Compound L-Tyrosine Fumarylacetoacetase 763 ChemSpider L-phenylalanyl-tRNA(Phe) HMDB0000148 HMDB L-tyrosyl-tRNA(Tyr) SMILES OC(=O)CC(=O)CC(=O)\C=C\C(O)=O tRNA(Tyr) Cytoplasm SMP0000012 SMPDB Tyrosine--tRNA ligase, cytoplasmic 784 PubChem-compound 10197150 ChemSpider CHEBI:15422 ChEBI 1.0 Homo sapiens FUM BioCyc 62989-33-7 CAS HMDB0000707 HMDB 7732-18-5 CAS 780 PubChem-compound CHEBI:18012 ChEBI 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 O2 Oxygen 31.98983 HMDB0000158 HMDB HMDB0000159 HMDB AMMONIA BioCyc SMILES N 56-86-0 CAS SMILES [H][C@@]1(CNC2=C(N1)C(=O)NC(N)=N2)[C@@H](O)[C@H](C)O 2.0 CHEBI:29153 ChEBI ReactionCatalysis447 ACTIVATION ReactionCatalysis445 ACTIVATION C5H9NO4 L-Glutamic acid 147.05316 Phenylalanine--tRNA ligase alpha subunit ReactionCatalysis446 ACTIVATION 156-06-9 CAS 33032 PubChem-compound ReactionCatalysis443 ACTIVATION 60-18-4 CAS ReactionCatalysis444 ACTIVATION ReactionCatalysis441 ACTIVATION Water ReactionCatalysis442 ACTIVATION 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 ReactionCatalysis440 ACTIVATION 1.0 129803 PubChem-compound CHEBI:16526 ChEBI CHEBI:17295 ChEBI 4444081 ChemSpider 4a-Hydroxytetrahydrobiopterin 7782-44-7 CAS Pyrophosphate C01036 KEGG Compound HMDB0001377 HMDB Tyrosine--tRNA ligase, cytoplasmic HMDB0000045 HMDB SMILES CC(=O)CC(O)=O 1.0 SMILES OC(=O)CC(=O)CC(=O)\C=C/C(O)=O ReactionCatalysis438 ACTIVATION PHE BioCyc ReactionCatalysis436 ACTIVATION Reaction386 false Maleylacetoacetic acid → 4-Fumarylacetoacetic acid LEFT_TO_RIGHT ReactionCatalysis437 ACTIVATION 3.7.1.2 false 3.7.1.2 4-Fumarylacetoacetic acid + Water → Acetoacetic acid + Fumaric acid LEFT_TO_RIGHT ReactionCatalysis435 ACTIVATION 9606 TAXONOMY 962 PubChem-compound PW000142 PathWhiz 70110-58-6 CAS 1.0 P54577 UniProt C9H11NO2 L-Phenylalanine 165.07898 2-KETOGLUTARATE BioCyc tRNA(Phe) C9H11NO3 L-Tyrosine 181.0739 114908 ChemSpider CO2 Carbon dioxide 43.98983 C00079 KEGG Compound Fumarylacetoacetase 972 ChemSpider SMILES O=O 1.0 HMDB0001268 HMDB Maleylacetoacetate isomerase C00082 KEGG Compound Oxoglutaric acid HMDB0000051 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O C9H15N5O3 L-erythro-tetrahydrobiopterin 241.1175 HMDB0002111 HMDB 1.4.3.2 false 1.4.3.2 L-Phenylalanine + Oxygen + Water → Ammonia + Hydrogen peroxide + Phenylpyruvic acid LEFT_TO_RIGHT 1.4.3.2 false 1.4.3.2 L-Tyrosine + Oxygen + Water → 4-Hydroxyphenylpyruvic acid + Ammonia + Hydrogen peroxide LEFT_TO_RIGHT 1.13.11.5 false 1.13.11.5 Homogentisic acid + Oxygen → Maleylacetoacetic acid LEFT_TO_RIGHT 1.0 CHEBI:15377 ChEBI 6057 PubChem-compound CHEBI:15379 ChEBI PW000017 PathWhiz 5910 ChemSpider 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5280393 PubChem-compound 1.0 Q93099 UniProt CHEBI:15374 ChEBI C01179 KEGG Compound 5280398 PubChem-compound L-phenylalanyl-tRNA(Phe) 280 PubChem-compound C01061 KEGG Compound HMDB0000060 HMDB 96 PubChem-compound 2.0 1.13.11.27 false 1.13.11.27 4-Hydroxyphenylpyruvic acid + Oxygen → Carbon dioxide + Homogentisic acid LEFT_TO_RIGHT 28613-33-4 CAS 1.0 CHEBI:15344 ChEBI 156-39-8 CAS 644102 PubChem-compound PW000005 PathWhiz 6083 PubChem-compound 759 ChemSpider 2.0 2.0 CHEBI:30851 ChEBI Maleylacetoacetate isomerase C9H15N5O4 4a-Hydroxytetrahydrobiopterin 257.1124 H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 Oxygen 1.14.16.1 false 1.14.16.1 L-Phenylalanine + L-erythro-tetrahydrobiopterin + Oxygen → 4a-Hydroxytetrahydrobiopterin + L-Tyrosine LEFT_TO_RIGHT L-amino-acid oxidase Ammonia 541-50-4 CAS CHEBI:17895 ChEBI 1.0 977 PubChem-compound 5698-52-2 CAS 1.0 CHEBI:29182 ChEBI HMDB0001967 HMDB P17735 UniProt C00544 KEGG Compound 1.0 Tyrosine aminotransferase SMILES OC(=O)\C=C\C(O)=O 1.0 1.0 CHEBI:29184 ChEBI 979 PubChem-compound P17174 UniProt SMILES OC(=O)CC1=C(O)C=CC(O)=C1 4-MALEYL-ACETOACETATE BioCyc GOT1 IL4I1 TAT PAH GOT1 TAT IL4I1 YARS FARSA FARSB HPD HGD GSTZ1 FAH L-Tyrosine Fumaric acid Acetoacetic acid L-Phenylalanine Oxoglutaric acid Phenylpyruvic acid L-Glutamic acid Water Oxygen Ammonia Hydrogen peroxide Oxoglutaric acid L-Glutamic acid L-erythro- tetrahydrobiopterin Oxygen 4a- Hydroxytetrahydrobiopterin Oxoglutaric acid 4- Hydroxyphenylpyruvic acid L-Glutamic acid Oxoglutaric acid L-Glutamic acid Water Oxygen Ammonia Hydrogen peroxide Adenosine triphosphate Adenosine monophosphate Pyrophosphate Adenosine triphosphate Adenosine monophosphate Pyrophosphate Oxygen Homogentisic acid Carbon dioxide Oxygen Maleylacetoacetic acid 4- Fumarylacetoacetic acid Water tRNA(Tyr) L-tyrosyl- tRNA(Tyr) tRNA(Phe) L- phenylalanyl- tRNA(Phe) Catecholamine Biosynthesis Tyrosine Metabolism Citric Acid Cycle