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6022 PubChem-compound 392615 ChemSpider ReactionCatalysis2093 ACTIVATION HMDB0061361 HMDB 74465-19-3 CAS HMDB0061362 HMDB 937 ChemSpider 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate C6H17O21P5 Inositol 1,3,4,5,6-pentakisphosphate 579.895 3.1.3.56 false 3.1.3.56 Inositol 1,3,4,5-tetraphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Phosphate LEFT_TO_RIGHT Reaction1372 false 1D-myo-Inositol 3-phosphate + Water → Phosphate + myo-Inositol LEFT_TO_RIGHT GLUCURONATE BioCyc 1.13.99.1 false 1.13.99.1 Oxygen + myo-Inositol → D-Glucuronic acid + Water LEFT_TO_RIGHT 1-phosphatidyl-1D-myo-inositol 4-phosphate P29218 UniProt ReactionCatalysis2096 ACTIVATION 2.7.1.158 false 2.7.1.158 Adenosine triphosphate + Inositol 1,3,4,5,6-pentakisphosphate → Adenosine diphosphate + Myo-inositol hexakisphosphate LEFT_TO_RIGHT 391520 ChemSpider 2.7.1.127 false 2.7.1.127 Adenosine triphosphate + Inositol 1,4,5-trisphosphate → Adenosine diphosphate + Inositol 1,3,4,5-tetraphosphate LEFT_TO_RIGHT 5.5.1.4 false 5.5.1.4 Glucose 6-phosphate → Myo-inositol 1-phosphate LEFT_TO_RIGHT Reaction1137 false Adenosine diphosphate + Inositol 1,3,4,5,6-pentakisphosphate → Adenosine triphosphate + D-Myo-inositol 3,4,5,6-tetrakisphosphate LEFT_TO_RIGHT 6556-12-3 CAS Reaction1377 false Myo-inositol 1-phosphate + Water → Phosphate + myo-Inositol LEFT_TO_RIGHT HMDB0001187 HMDB C6H16O18P4 Inositol 1,3,4,5-tetraphosphate 499.9287 ATP BioCyc Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 1.0 559142 ChemSpider Adenosine diphosphate 17216102 ChemSpider C6H16O18P4 1D-Myo-inositol 1,3,4,6-tetrakisphosphate 499.9287 HMDB0061341 HMDB 5743 ChemSpider Inositol monophosphatase 1 5742 ChemSpider 1.0 CHEBI:16595 ChEBI 952 ChemSpider 2.7.1.67 false 2.7.1.67 1-Phosphatidyl-D-myo-inositol + Adenosine triphosphate → 1-phosphatidyl-1D-myo-inositol 4-phosphate + Adenosine diphosphate LEFT_TO_RIGHT Reaction2244 false 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Adenosine triphosphate → Adenosine diphosphate + Phosphatidylinositol-3,4,5-trisphosphate LEFT_TO_RIGHT 3.1.4.11 false 3.1.4.11 Inositol 1,4,5-trisphosphate + Water → 1,2-diacylglycerol + 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate LEFT_TO_RIGHT 2.7.1.150 false 2.7.1.150 1-phosphatidyl-1D-myo-inositol 4-phosphate + Adenosine triphosphate → 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Adenosine diphosphate LEFT_TO_RIGHT MYO-INOSITOL BioCyc SMILES OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Reaction2245 false Adenosine diphosphate + Phosphatidylinositol-3,4,5-trisphosphate → 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Adenosine triphosphate LEFT_TO_RIGHT ReactionCatalysis842 ACTIVATION Reaction2246 false 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Water → 1-phosphatidyl-1D-myo-inositol 4-phosphate + Phosphate LEFT_TO_RIGHT C6H18O24P6 Myo-inositol hexakisphosphate 659.8614 Q9H8X2 UniProt 1D-myo-Inositol 3-phosphate 2.0 Reaction1385 true 1-Phosphatidyl-1D-myo-inositol 3-phosphate → Phosphatidylinositol-3,4,5-trisphosphate LEFT_TO_RIGHT 3.1.3.56 false 3.1.3.56 Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,3,4-trisphosphate + Phosphate LEFT_TO_RIGHT HMDB0004249 HMDB 1.0 Reaction1140 false Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,4,5-trisphosphate + Phosphate LEFT_TO_RIGHT ReactionCatalysis838 ACTIVATION ReactionCatalysis839 ACTIVATION PPI BioCyc 1.0 ReactionCatalysis834 ACTIVATION ReactionCatalysis832 ACTIVATION Reaction1147 false 1D-Myo-inositol 1,3,4,6-tetrakisphosphate + Water → 1D-Myo-inositol 3,4-bisphosphate + Pyrophosphate LEFT_TO_RIGHT ReactionCatalysis833 ACTIVATION 3.1.3.66 false 3.1.3.66 1D-Myo-inositol 3,4-bisphosphate + Water → 1D-myo-Inositol 3-phosphate + Phosphate LEFT_TO_RIGHT Reaction1145 false Adenosine triphosphate + Inositol 1,3,4-trisphosphate → Adenosine diphosphate + Inositol 1,3,4,5-tetraphosphate LEFT_TO_RIGHT ReactionCatalysis831 ACTIVATION 1.0 CHEBI:17268 ChEBI 10239179 ChemSpider 1.0 444791 PubChem-compound Cytosol C01204 KEGG Compound 1.0 SMILES O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O 1-PHOSPHATIDYL-MYO-INOSITOL BioCyc Phosphoinositide 3-kinase regulatory subunit 4 1D-Myo-inositol 1,3,4,6-tetrakisphosphate 7664-38-2 CAS 1-L-MYO-INOSITOL-1-P BioCyc ReactionCatalysis1084 ACTIVATION inositol_1,4,5-trisphosphate BioCyc ReactionCatalysis1089 ACTIVATION SMILES OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O C00009 KEGG Compound C00008 KEGG Compound C00007 KEGG Compound ReactionCatalysis1092 ACTIVATION 1D-Myo-inositol 1,4,5,6-tetrakisphosphate ReactionCatalysis1094 ACTIVATION ReactionCatalysis1093 ACTIVATION C00001 KEGG Compound CHEBI:18361 ChEBI 1.0 CHEBI:18367 ChEBI 1032 ChemSpider 388561 ChemSpider C00002 KEGG Compound 388562 ChemSpider CHEBI:16067 ChEBI Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A Inositol polyphosphate 1-phosphatase Type I inositol 3,4-bisphosphate 4-phosphatase Phosphate ReactionCatalysis1098 ACTIVATION ReactionCatalysis1097 ACTIVATION SMILES CC(=O)OCC(CO)OC(C)=O 1.0 SMILES OC1C(O)C(OP(O)(=O)OCCOC(=O)COC=O)C(O)C(O)C1OP(O)(O)=O C01220 KEGG Compound C00137 KEGG Compound PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT BioCyc CHEBI:16155 ChEBI C00013 KEGG Compound 2.0 83-86-3 CAS CHEBI:18348 ChEBI CHEBI:18228 ChEBI 1.0 1.0 56-65-5 CAS 102850-29-3 CAS CHEBI:26078 ChEBI 1.0 440194 PubChem-compound 1.0 110298-84-5 CAS C01243 KEGG Compound C03546 KEGG Compound 443266 PubChem-compound Q99570 UniProt SMILES CC(=O)OC(COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(C)=O C01245 KEGG Compound Phosphatidylinositol-3,4,5-trisphosphate Inositol oxygenase 1.0 Adenosine diphosphate Inositol polyphosphate 1-phosphatase HMDB0000250 HMDB Myo-inositol 1-phosphate SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB 1.0 SubPathwayInteraction786 SubPathway786Reaction SubPathwayReaction Q9UNW1 UniProt HMDB0003529 HMDB C04520 KEGG Compound CHEBI:18169 ChEBI 1-phosphatidylinositol-3-phosphate 5-kinase SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 1D-Myo-inositol 3,4-bisphosphate Q8NFU5 UniProt C05981 KEGG Compound 1,2-diacylglycerol 46495-39-0 CAS SMILES OC1C(O)C(O)C(OP(O)(=O)OCCOC(=O)COC=O)C(O)C1O C6H13O9P 1D-myo-Inositol 3-phosphate 260.02972 CHEBI:17283 ChEBI 7732-18-5 CAS CHEBI:4170 ChEBI P49441 UniProt HMDB0006814 HMDB C6H16O18P4 D-Myo-inositol 3,4,5,6-tetrakisphosphate 499.9287 C01272 KEGG Compound C11H20O16P2 1-Phosphatidyl-1D-myo-inositol 3-phosphate 470.02264 C6H14O12P2 1D-Myo-inositol 1,4-bisphosphate 339.99606 C6H15O15P3 Inositol 1,3,4-trisphosphate 419.96237 C10H16N5O13P3 Adenosine triphosphate 506.99576 Phosphoric acid C04549 KEGG Compound CHEBI:18384 ChEBI Inositol oxygenase 6857403 PubChem-compound 892 PubChem-compound 890 PubChem-compound HMDB0001498 HMDB SMILES O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1O HMDB0001377 HMDB C00191 KEGG Compound C01284 KEGG Compound HMDB0004527 HMDB 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate 1.0 1.0 1.0 Inositol-trisphosphate 3-kinase A 962 PubChem-compound Protein VAC14 homolog 5800 ChemSpider CPD-177 BioCyc 979 ChemSpider Phosphatidylinositol 3-kinase catalytic subunit type 3 1.0 SMILES O=O H3O4P Phosphoric acid 97.9769 HMDB0006953 HMDB HMDB0002111 HMDB Phosphatidylinositol-3,4,5-trisphosphate HMDB0001143 HMDB 14265-44-2 CAS 58-64-0 CAS C00092 KEGG Compound SMILES OC1C(O)[C@H](O)C(OP(O)(=O)OCC(COC=O)OC=O)[C@H](O)[C@H]1O 1.0 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 644102 PubChem-compound Myo-inositol hexakisphosphate Inositol-tetrakisphosphate 1-kinase Multiple inositol polyphosphate phosphatase 1 Q9NPH2 UniProt 56-73-5 CAS Q9UGB7 UniProt Polyphosphoinositide phosphatase 1.0 H2O Water 18.010565 C01194 KEGG Compound Nucleus Q08AM6 UniProt 977 PubChem-compound Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A 53477912 PubChem-compound 1-phosphatidylinositol 3-phosphate 5-kinase 1.0 866 ChemSpider Adenosine triphosphate SMILES O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O HMDB0001059 HMDB Inositol 1,4,5-trisphosphate HMDB0002142 HMDB SMILES O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O 1.0 17215924 ChemSpider 1.0 Phosphatidylinositol 4-kinase alpha Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEBI:15844 ChEBI C04477 KEGG Compound D-Myo-inositol 4-phosphate SMILES O Glycerolipid Metabolism SubPathway Inositol polyphosphate multikinase 1.0 Inositol polyphosphate multikinase HMDB0000538 HMDB 1.0 C04006 KEGG Compound D-Glucuronic acid 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 1004 PubChem-compound Multiple inositol polyphosphate phosphatase 1 1.0 Inositol 1,3,4-trisphosphate C6H13O9P D-Myo-inositol 4-phosphate 260.02972 ADP BioCyc 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 1-Phosphatidyl-1D-myo-inositol 3-phosphate SubPathwayOutput INOSITOL-1-3-4-TRIPHOSPHATE BioCyc GO:0005829 GENE ONTOLOGY HMDB0001401 HMDB Q9Y2I7 UniProt 108765 ChemSpider 85166-31-0 CAS Inositol 1,3,4,5-tetraphosphate C6H13O9P Myo-inositol 1-phosphate 260.02972 C6H12O6 myo-Inositol 180.06339 Pyrophosphate O4P Phosphate 94.95342 C6H14O12P2 1D-Myo-inositol 3,4-bisphosphate 339.99606 Phosphoinositide 3-kinase regulatory subunit 4 Adenosine triphosphate ReactionCatalysis1118 ACTIVATION 1.0 121920 PubChem-compound 10333900 ChemSpider 87-89-8 CAS Mitochondrion 1-Phosphatidyl-D-myo-inositol Activating molecule in BECN1-regulated autophagy protein 1 Polyphosphoinositide phosphatase Beclin-1 1.0 myo-Inositol CPD-6641 BioCyc HMDB0000211 HMDB HMDB0000213 HMDB Water Activating molecule in BECN1-regulated autophagy protein 1 SMILES [O-]P([O-])([O-])=O P23677 UniProt CHEBI:17816 ChEBI Inositol-pentakisphosphate 2-kinase Inositol 1,3,4,5,6-pentakisphosphate 2831-74-5 CAS HMDB0001429 HMDB SMILES O[C@H]1[C@H](O)[C@H](O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1O HMDB0003848 HMDB SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O Protein VAC14 homolog D-MYO-INOSITOL-4-PHOSPHATE BioCyc SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O C6H10O7 D-Glucuronic acid 194.04265 HMDB0001313 HMDB C6H16O18P4 1D-Myo-inositol 1,4,5,6-tetrakisphosphate 499.9287 121010-58-0 CAS GO:0005634 GENE ONTOLOGY 1.0 CHEBI:16618 ChEBI HMDB0003850 HMDB 1.0 PHOSPHATIDYLINOSITOL-345-TRIPHOSPHATE BioCyc Inositol monophosphatase 1 Inositol-trisphosphate 3-kinase A 1.0 Inositol-3-phosphate synthase 1 C12H24O22P4 Phosphatidylinositol-3,4,5-trisphosphate 643.97095 1.0 1.0 SMILES OP(O)(O)=O Inositol Metabolism HMDB0003502 HMDB O7P2 Pyrophosphate 173.91193 5958 PubChem-compound C04063 KEGG Compound 5957 PubChem-compound 98102-63-7 CAS 5256742 ChemSpider 389196 ChemSpider 1.0 Type I inositol 3,4-bisphosphate 4-phosphatase Q8N3E9 UniProt Q9C0C7 UniProt Adenosine triphosphate GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 Inositol 1,4,5-trisphosphate HMDB0000127 HMDB GO:0005737 GENE ONTOLOGY 1.0 C7H12O5 1,2-diacylglycerol 176.06847 Q96PE3 UniProt C11H20O16P2 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate 470.02264 Phosphatidylinositol 4-kinase alpha CPD-8587 BioCyc 1.0 D-Myo-inositol 3,4,5,6-tetrakisphosphate Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1.0 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform HMDB0006235 HMDB Q15735 UniProt C6H13O9P Glucose 6-phosphate 260.02972 14000-31-8 CAS CHEBI:42717 ChEBI CHEBI:16783 ChEBI Adenosine diphosphate 389182 ChemSpider Myo-inositol 1-phosphate 96919 ChemSpider Q8WUK0 UniProt Cytoplasm 2.7.1.137 false 2.7.1.137 1-Phosphatidyl-D-myo-inositol + Adenosine triphosphate → 1-Phosphatidyl-1D-myo-inositol 3-phosphate + Adenosine diphosphate LEFT_TO_RIGHT SMP0000011 SMPDB Q8NEB9 UniProt CHEBI:15422 ChEBI Homo sapiens 1.0 Inositol-pentakisphosphate 2-kinase SMILES O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O 439455 PubChem-compound O2 Oxygen 31.98983 Phosphatidylinositol 3-kinase catalytic subunit type 3 439456 PubChem-compound Beclin-1 CHEBI:16749 ChEBI Water 107758 PubChem-compound 1.0 Phosphatidylinositol 3-kinase catalytic subunit type 3 1-phosphatidyl-1D-myo-inositol 4-phosphate SMP0000039 SMPDB CHEBI:16761 ChEBI SMILES O[C@H]1C(OP(O)(O)=O)[C@H](O)[C@@H](OP(O)(O)=O)C(OP(O)(O)=O)[C@H]1OP(O)(O)=O 7782-44-7 CAS GLC-6-P BioCyc 17216082 ChemSpider 1.0 C11H19O13P 1-Phosphatidyl-D-myo-inositol 390.05634 CHEBI:28858 ChEBI 1.0 9606 TAXONOMY PW000144 PathWhiz PW000143 PathWhiz 1.0 C11H19O13P 1-phosphatidyl-1D-myo-inositol 4-phosphate 390.05634 HMDB0000968 HMDB SMILES OC1[C@H](O)[C@H](O)C(OP(O)(O)=O)[C@@H](O)[C@@H]1O 1-phosphatidylinositol-3-phosphate 5-kinase SMILES O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O Inositol-tetrakisphosphate 1-kinase SMILES O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1OP(O)(O)=O P42356 UniProt SMILES O[C@@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@H]1OP(O)(O)=O SMILES O[C@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@@H](OP(O)(=O)OC[C@@H](CC(O)=O)C(O)=O)[C@@H]1O ReactionCatalysis1121 ACTIVATION CHEBI:15377 ChEBI CHEBI:15379 ChEBI Q92562 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Phosphate ReactionCatalysis2105 ACTIVATION Oxygen 20298-95-7 CAS 440211 PubChem-compound ReactionCatalysis2107 ACTIVATION ReactionCatalysis2106 ACTIVATION ReactionCatalysis2109 ACTIVATION Q14457 UniProt Inositol 1,3,4,5,6-pentakisphosphate CPD-505 BioCyc CPD-506 BioCyc CHEBI:17401 ChEBI Q13572 UniProt Reaction337 false D-Myo-inositol 4-phosphate + Water → Phosphoric acid + myo-Inositol LEFT_TO_RIGHT CHEBI:17526 ChEBI 1D-Myo-inositol 1,4-bisphosphate MI-HEXAKISPHOSPHATE BioCyc 1.0 1.0 P42336 UniProt 17216032 ChemSpider 69256-53-7 CAS ReactionCatalysis2110 ACTIVATION ReactionCatalysis2111 ACTIVATION CHEBI:16322 ChEBI 1061 PubChem-compound Glucose 6-phosphate Reaction349 false Adenosine triphosphate + Inositol 1,3,4-trisphosphate → 1D-Myo-inositol 1,3,4,6-tetrakisphosphate + Adenosine diphosphate LEFT_TO_RIGHT 1.0 Inositol-3-phosphate synthase 1 INOSITOL-1,4-BISPHOSPHATE BioCyc 2.7.1.151 false 2.7.1.151 2 Adenosine triphosphate + Inositol 1,4,5-trisphosphate → 1D-Myo-inositol 1,4,5,6-tetrakisphosphate + 2 Adenosine diphosphate LEFT_TO_RIGHT 2.7.1.151 false 2.7.1.151 1D-Myo-inositol 1,4,5,6-tetrakisphosphate + 2 Adenosine triphosphate → 2 Adenosine diphosphate + Inositol 1,3,4,5,6-pentakisphosphate LEFT_TO_RIGHT 3.1.3.57 false 3.1.3.57 1D-Myo-inositol 1,4-bisphosphate + Water → D-Myo-inositol 4-phosphate + Phosphoric acid LEFT_TO_RIGHT C11555 KEGG Compound 112791-61-4 CAS Inositol-3- phosphate synthase 1 Inositol polyphosphate multikinase Inositol polyphosphate multikinase Inositol- tetrakisphosphate 1-kinase Inositol- pentakisphosphate 2-kinase Multiple inositol polyphosphate phosphatase 1 Inositol- trisphosphate 3-kinase A Phosphatidylinositol 4,5- bisphosphate 5-phosphatase A Inositol polyphosphate 1-phosphatase Inositol monophosphatase 1 Inositol monophosphatase 1 Inositol monophosphatase 1 Inositol oxygenase Type I inositol 3,4- bisphosphate 4-phosphatase Inositol- tetrakisphosphate 1-kinase Inositol- tetrakisphosphate 1-kinase Phosphatidylinositol 4,5- bisphosphate 5-phosphatase A Inositol polyphosphate 1-phosphatase 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase delta-3 1- phosphatidylinositol 3-phosphate 5-kinase Phosphatidylinositol 4-kinase alpha Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylglycerophosphatase and protein- tyrosine phosphatase 1 1-Phosphatidyl-1D-myo-inositol 3-phosphate Glucose 6-phosphate Myo-inositol 1-phosphate Phosphatidylinositol-3,4,5- trisphosphate ATP Inositol 1,4,5-trisphosphate ADP 1D-Myo-inositol 1,4,5,6-tetrakisphosphate ATP ADP Inositol 1,3,4,5,6-pentakisphosphate ADP D-Myo-inositol 3,4,5,6-tetrakisphosphate ATP ATP Myo-inositol hexakisphosphate ADP Inositol 1,3,4,5-tetraphosphate H 2 O P i ATP ADP H 2 O 1D-Myo-inositol 1,4-bisphosphate P i H 2 O D-Myo-inositol 4-phosphate P i H 2 O myo-Inositol P i H 2 O P i 1D-myo-Inositol 3-phosphate H 2 O P i O 2 D-Glucuronic acid H 2 O 1D-Myo-inositol 3,4- bisphosphate H 2 O P i ATP Inositol 1,3,4- trisphosphate ADP 1D-Myo-inositol 1,3,4,6- tetrakisphosphate ATP ADP H 2 O P i H 2 O PP i H 2 O 1,2- diacylglycerol 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate 1-phosphatidyl-1D-myo-inositol 4-phosphate ATP ADP 1-Phosphatidyl-D-myo-inositol ATP ADP ATP ADP ATP ADP ADP ATP H 2 O P i NAD Magnesium Magnesium Magnesium Magnesium Magnesium Fe2+ Magnesium Magnesium Magnesium Calcium Manganese Glycerolipid Metabolism Intracellular Space Nucleus Mitochondria
6022 PubChem-compound 392615 ChemSpider ReactionCatalysis2093 ACTIVATION HMDB0061361 HMDB 74465-19-3 CAS HMDB0061362 HMDB 937 ChemSpider 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate C6H17O21P5 Inositol 1,3,4,5,6-pentakisphosphate 579.895 3.1.3.56 false 3.1.3.56 Inositol 1,3,4,5-tetraphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Phosphate LEFT_TO_RIGHT Reaction1372 false 1D-myo-Inositol 3-phosphate + Water → Phosphate + myo-Inositol LEFT_TO_RIGHT GLUCURONATE BioCyc 1.13.99.1 false 1.13.99.1 Oxygen + myo-Inositol → D-Glucuronic acid + Water LEFT_TO_RIGHT 1-phosphatidyl-1D-myo-inositol 4-phosphate P29218 UniProt ReactionCatalysis2096 ACTIVATION 2.7.1.158 false 2.7.1.158 Adenosine triphosphate + Inositol 1,3,4,5,6-pentakisphosphate → Adenosine diphosphate + Myo-inositol hexakisphosphate LEFT_TO_RIGHT 391520 ChemSpider 2.7.1.127 false 2.7.1.127 Adenosine triphosphate + Inositol 1,4,5-trisphosphate → Adenosine diphosphate + Inositol 1,3,4,5-tetraphosphate LEFT_TO_RIGHT 5.5.1.4 false 5.5.1.4 Glucose 6-phosphate → Myo-inositol 1-phosphate LEFT_TO_RIGHT Reaction1137 false Adenosine diphosphate + Inositol 1,3,4,5,6-pentakisphosphate → Adenosine triphosphate + D-Myo-inositol 3,4,5,6-tetrakisphosphate LEFT_TO_RIGHT 6556-12-3 CAS Reaction1377 false Myo-inositol 1-phosphate + Water → Phosphate + myo-Inositol LEFT_TO_RIGHT HMDB0001187 HMDB C6H16O18P4 Inositol 1,3,4,5-tetraphosphate 499.9287 ATP BioCyc Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 1.0 559142 ChemSpider Adenosine diphosphate 17216102 ChemSpider C6H16O18P4 1D-Myo-inositol 1,3,4,6-tetrakisphosphate 499.9287 HMDB0061341 HMDB 5743 ChemSpider Inositol monophosphatase 1 5742 ChemSpider 1.0 CHEBI:16595 ChEBI 952 ChemSpider 2.7.1.67 false 2.7.1.67 1-Phosphatidyl-D-myo-inositol + Adenosine triphosphate → 1-phosphatidyl-1D-myo-inositol 4-phosphate + Adenosine diphosphate LEFT_TO_RIGHT Reaction2244 false 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Adenosine triphosphate → Adenosine diphosphate + Phosphatidylinositol-3,4,5-trisphosphate LEFT_TO_RIGHT 3.1.4.11 false 3.1.4.11 Inositol 1,4,5-trisphosphate + Water → 1,2-diacylglycerol + 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate LEFT_TO_RIGHT 2.7.1.150 false 2.7.1.150 1-phosphatidyl-1D-myo-inositol 4-phosphate + Adenosine triphosphate → 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Adenosine diphosphate LEFT_TO_RIGHT MYO-INOSITOL BioCyc SMILES OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Reaction2245 false Adenosine diphosphate + Phosphatidylinositol-3,4,5-trisphosphate → 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Adenosine triphosphate LEFT_TO_RIGHT ReactionCatalysis842 ACTIVATION Reaction2246 false 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + Water → 1-phosphatidyl-1D-myo-inositol 4-phosphate + Phosphate LEFT_TO_RIGHT C6H18O24P6 Myo-inositol hexakisphosphate 659.8614 Q9H8X2 UniProt 1D-myo-Inositol 3-phosphate 2.0 Reaction1385 true 1-Phosphatidyl-1D-myo-inositol 3-phosphate → Phosphatidylinositol-3,4,5-trisphosphate LEFT_TO_RIGHT 3.1.3.56 false 3.1.3.56 Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,3,4-trisphosphate + Phosphate LEFT_TO_RIGHT HMDB0004249 HMDB 1.0 Reaction1140 false Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,4,5-trisphosphate + Phosphate LEFT_TO_RIGHT ReactionCatalysis838 ACTIVATION ReactionCatalysis839 ACTIVATION PPI BioCyc 1.0 ReactionCatalysis834 ACTIVATION ReactionCatalysis832 ACTIVATION Reaction1147 false 1D-Myo-inositol 1,3,4,6-tetrakisphosphate + Water → 1D-Myo-inositol 3,4-bisphosphate + Pyrophosphate LEFT_TO_RIGHT ReactionCatalysis833 ACTIVATION 3.1.3.66 false 3.1.3.66 1D-Myo-inositol 3,4-bisphosphate + Water → 1D-myo-Inositol 3-phosphate + Phosphate LEFT_TO_RIGHT Reaction1145 false Adenosine triphosphate + Inositol 1,3,4-trisphosphate → Adenosine diphosphate + Inositol 1,3,4,5-tetraphosphate LEFT_TO_RIGHT ReactionCatalysis831 ACTIVATION 1.0 CHEBI:17268 ChEBI 10239179 ChemSpider 1.0 444791 PubChem-compound Cytosol C01204 KEGG Compound 1.0 SMILES O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O 1-PHOSPHATIDYL-MYO-INOSITOL BioCyc Phosphoinositide 3-kinase regulatory subunit 4 1D-Myo-inositol 1,3,4,6-tetrakisphosphate 7664-38-2 CAS 1-L-MYO-INOSITOL-1-P BioCyc ReactionCatalysis1084 ACTIVATION inositol_1,4,5-trisphosphate BioCyc ReactionCatalysis1089 ACTIVATION SMILES OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O C00009 KEGG Compound C00008 KEGG Compound C00007 KEGG Compound ReactionCatalysis1092 ACTIVATION 1D-Myo-inositol 1,4,5,6-tetrakisphosphate ReactionCatalysis1094 ACTIVATION ReactionCatalysis1093 ACTIVATION C00001 KEGG Compound CHEBI:18361 ChEBI 1.0 CHEBI:18367 ChEBI 1032 ChemSpider 388561 ChemSpider C00002 KEGG Compound 388562 ChemSpider CHEBI:16067 ChEBI Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A Inositol polyphosphate 1-phosphatase Type I inositol 3,4-bisphosphate 4-phosphatase Phosphate ReactionCatalysis1098 ACTIVATION ReactionCatalysis1097 ACTIVATION SMILES CC(=O)OCC(CO)OC(C)=O 1.0 SMILES OC1C(O)C(OP(O)(=O)OCCOC(=O)COC=O)C(O)C(O)C1OP(O)(O)=O C01220 KEGG Compound C00137 KEGG Compound PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT BioCyc CHEBI:16155 ChEBI C00013 KEGG Compound 2.0 83-86-3 CAS CHEBI:18348 ChEBI CHEBI:18228 ChEBI 1.0 1.0 56-65-5 CAS 102850-29-3 CAS CHEBI:26078 ChEBI 1.0 440194 PubChem-compound 1.0 110298-84-5 CAS C01243 KEGG Compound C03546 KEGG Compound 443266 PubChem-compound Q99570 UniProt SMILES CC(=O)OC(COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(C)=O C01245 KEGG Compound Phosphatidylinositol-3,4,5-trisphosphate Inositol oxygenase 1.0 Adenosine diphosphate Inositol polyphosphate 1-phosphatase HMDB0000250 HMDB Myo-inositol 1-phosphate SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB 1.0 SubPathwayInteraction786 SubPathway786Reaction SubPathwayReaction Q9UNW1 UniProt HMDB0003529 HMDB C04520 KEGG Compound CHEBI:18169 ChEBI 1-phosphatidylinositol-3-phosphate 5-kinase SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 1D-Myo-inositol 3,4-bisphosphate Q8NFU5 UniProt C05981 KEGG Compound 1,2-diacylglycerol 46495-39-0 CAS SMILES OC1C(O)C(O)C(OP(O)(=O)OCCOC(=O)COC=O)C(O)C1O C6H13O9P 1D-myo-Inositol 3-phosphate 260.02972 CHEBI:17283 ChEBI 7732-18-5 CAS CHEBI:4170 ChEBI P49441 UniProt HMDB0006814 HMDB C6H16O18P4 D-Myo-inositol 3,4,5,6-tetrakisphosphate 499.9287 C01272 KEGG Compound C11H20O16P2 1-Phosphatidyl-1D-myo-inositol 3-phosphate 470.02264 C6H14O12P2 1D-Myo-inositol 1,4-bisphosphate 339.99606 C6H15O15P3 Inositol 1,3,4-trisphosphate 419.96237 C10H16N5O13P3 Adenosine triphosphate 506.99576 Phosphoric acid C04549 KEGG Compound CHEBI:18384 ChEBI Inositol oxygenase 6857403 PubChem-compound 892 PubChem-compound 890 PubChem-compound HMDB0001498 HMDB SMILES O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1O HMDB0001377 HMDB C00191 KEGG Compound C01284 KEGG Compound HMDB0004527 HMDB 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate 1.0 1.0 1.0 Inositol-trisphosphate 3-kinase A 962 PubChem-compound Protein VAC14 homolog 5800 ChemSpider CPD-177 BioCyc 979 ChemSpider Phosphatidylinositol 3-kinase catalytic subunit type 3 1.0 SMILES O=O H3O4P Phosphoric acid 97.9769 HMDB0006953 HMDB HMDB0002111 HMDB Phosphatidylinositol-3,4,5-trisphosphate HMDB0001143 HMDB 14265-44-2 CAS 58-64-0 CAS C00092 KEGG Compound SMILES OC1C(O)[C@H](O)C(OP(O)(=O)OCC(COC=O)OC=O)[C@H](O)[C@H]1O 1.0 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 644102 PubChem-compound Myo-inositol hexakisphosphate Inositol-tetrakisphosphate 1-kinase Multiple inositol polyphosphate phosphatase 1 Q9NPH2 UniProt 56-73-5 CAS Q9UGB7 UniProt Polyphosphoinositide phosphatase 1.0 H2O Water 18.010565 C01194 KEGG Compound Nucleus Q08AM6 UniProt 977 PubChem-compound Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A 53477912 PubChem-compound 1-phosphatidylinositol 3-phosphate 5-kinase 1.0 866 ChemSpider Adenosine triphosphate SMILES O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O HMDB0001059 HMDB Inositol 1,4,5-trisphosphate HMDB0002142 HMDB SMILES O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O 1.0 17215924 ChemSpider 1.0 Phosphatidylinositol 4-kinase alpha Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEBI:15844 ChEBI C04477 KEGG Compound D-Myo-inositol 4-phosphate SMILES O Glycerolipid Metabolism SubPathway Inositol polyphosphate multikinase 1.0 Inositol polyphosphate multikinase HMDB0000538 HMDB 1.0 C04006 KEGG Compound D-Glucuronic acid 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 1004 PubChem-compound Multiple inositol polyphosphate phosphatase 1 1.0 Inositol 1,3,4-trisphosphate C6H13O9P D-Myo-inositol 4-phosphate 260.02972 ADP BioCyc 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 1-Phosphatidyl-1D-myo-inositol 3-phosphate SubPathwayOutput INOSITOL-1-3-4-TRIPHOSPHATE BioCyc GO:0005829 GENE ONTOLOGY HMDB0001401 HMDB Q9Y2I7 UniProt 108765 ChemSpider 85166-31-0 CAS Inositol 1,3,4,5-tetraphosphate C6H13O9P Myo-inositol 1-phosphate 260.02972 C6H12O6 myo-Inositol 180.06339 Pyrophosphate O4P Phosphate 94.95342 C6H14O12P2 1D-Myo-inositol 3,4-bisphosphate 339.99606 Phosphoinositide 3-kinase regulatory subunit 4 Adenosine triphosphate ReactionCatalysis1118 ACTIVATION 1.0 121920 PubChem-compound 10333900 ChemSpider 87-89-8 CAS Mitochondrion 1-Phosphatidyl-D-myo-inositol Activating molecule in BECN1-regulated autophagy protein 1 Polyphosphoinositide phosphatase Beclin-1 1.0 myo-Inositol CPD-6641 BioCyc HMDB0000211 HMDB HMDB0000213 HMDB Water Activating molecule in BECN1-regulated autophagy protein 1 SMILES [O-]P([O-])([O-])=O P23677 UniProt CHEBI:17816 ChEBI Inositol-pentakisphosphate 2-kinase Inositol 1,3,4,5,6-pentakisphosphate 2831-74-5 CAS HMDB0001429 HMDB SMILES O[C@H]1[C@H](O)[C@H](O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1O HMDB0003848 HMDB SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O Protein VAC14 homolog D-MYO-INOSITOL-4-PHOSPHATE BioCyc SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O C6H10O7 D-Glucuronic acid 194.04265 HMDB0001313 HMDB C6H16O18P4 1D-Myo-inositol 1,4,5,6-tetrakisphosphate 499.9287 121010-58-0 CAS GO:0005634 GENE ONTOLOGY 1.0 CHEBI:16618 ChEBI HMDB0003850 HMDB 1.0 PHOSPHATIDYLINOSITOL-345-TRIPHOSPHATE BioCyc Inositol monophosphatase 1 Inositol-trisphosphate 3-kinase A 1.0 Inositol-3-phosphate synthase 1 C12H24O22P4 Phosphatidylinositol-3,4,5-trisphosphate 643.97095 1.0 1.0 SMILES OP(O)(O)=O Inositol Metabolism HMDB0003502 HMDB O7P2 Pyrophosphate 173.91193 5958 PubChem-compound C04063 KEGG Compound 5957 PubChem-compound 98102-63-7 CAS 5256742 ChemSpider 389196 ChemSpider 1.0 Type I inositol 3,4-bisphosphate 4-phosphatase Q8N3E9 UniProt Q9C0C7 UniProt Adenosine triphosphate GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 Inositol 1,4,5-trisphosphate HMDB0000127 HMDB GO:0005737 GENE ONTOLOGY 1.0 C7H12O5 1,2-diacylglycerol 176.06847 Q96PE3 UniProt C11H20O16P2 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate 470.02264 Phosphatidylinositol 4-kinase alpha CPD-8587 BioCyc 1.0 D-Myo-inositol 3,4,5,6-tetrakisphosphate Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1.0 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform HMDB0006235 HMDB Q15735 UniProt C6H13O9P Glucose 6-phosphate 260.02972 14000-31-8 CAS CHEBI:42717 ChEBI CHEBI:16783 ChEBI Adenosine diphosphate 389182 ChemSpider Myo-inositol 1-phosphate 96919 ChemSpider Q8WUK0 UniProt Cytoplasm 2.7.1.137 false 2.7.1.137 1-Phosphatidyl-D-myo-inositol + Adenosine triphosphate → 1-Phosphatidyl-1D-myo-inositol 3-phosphate + Adenosine diphosphate LEFT_TO_RIGHT SMP0000011 SMPDB Q8NEB9 UniProt CHEBI:15422 ChEBI Homo sapiens 1.0 Inositol-pentakisphosphate 2-kinase SMILES O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O 439455 PubChem-compound O2 Oxygen 31.98983 Phosphatidylinositol 3-kinase catalytic subunit type 3 439456 PubChem-compound Beclin-1 CHEBI:16749 ChEBI Water 107758 PubChem-compound 1.0 Phosphatidylinositol 3-kinase catalytic subunit type 3 1-phosphatidyl-1D-myo-inositol 4-phosphate SMP0000039 SMPDB CHEBI:16761 ChEBI SMILES O[C@H]1C(OP(O)(O)=O)[C@H](O)[C@@H](OP(O)(O)=O)C(OP(O)(O)=O)[C@H]1OP(O)(O)=O 7782-44-7 CAS GLC-6-P BioCyc 17216082 ChemSpider 1.0 C11H19O13P 1-Phosphatidyl-D-myo-inositol 390.05634 CHEBI:28858 ChEBI 1.0 9606 TAXONOMY PW000144 PathWhiz PW000143 PathWhiz 1.0 C11H19O13P 1-phosphatidyl-1D-myo-inositol 4-phosphate 390.05634 HMDB0000968 HMDB SMILES OC1[C@H](O)[C@H](O)C(OP(O)(O)=O)[C@@H](O)[C@@H]1O 1-phosphatidylinositol-3-phosphate 5-kinase SMILES O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O Inositol-tetrakisphosphate 1-kinase SMILES O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1OP(O)(O)=O P42356 UniProt SMILES O[C@@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@H]1OP(O)(O)=O SMILES O[C@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@@H](OP(O)(=O)OC[C@@H](CC(O)=O)C(O)=O)[C@@H]1O ReactionCatalysis1121 ACTIVATION CHEBI:15377 ChEBI CHEBI:15379 ChEBI Q92562 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Phosphate ReactionCatalysis2105 ACTIVATION Oxygen 20298-95-7 CAS 440211 PubChem-compound ReactionCatalysis2107 ACTIVATION ReactionCatalysis2106 ACTIVATION ReactionCatalysis2109 ACTIVATION Q14457 UniProt Inositol 1,3,4,5,6-pentakisphosphate CPD-505 BioCyc CPD-506 BioCyc CHEBI:17401 ChEBI Q13572 UniProt Reaction337 false D-Myo-inositol 4-phosphate + Water → Phosphoric acid + myo-Inositol LEFT_TO_RIGHT CHEBI:17526 ChEBI 1D-Myo-inositol 1,4-bisphosphate MI-HEXAKISPHOSPHATE BioCyc 1.0 1.0 P42336 UniProt 17216032 ChemSpider 69256-53-7 CAS ReactionCatalysis2110 ACTIVATION ReactionCatalysis2111 ACTIVATION CHEBI:16322 ChEBI 1061 PubChem-compound Glucose 6-phosphate Reaction349 false Adenosine triphosphate + Inositol 1,3,4-trisphosphate → 1D-Myo-inositol 1,3,4,6-tetrakisphosphate + Adenosine diphosphate LEFT_TO_RIGHT 1.0 Inositol-3-phosphate synthase 1 INOSITOL-1,4-BISPHOSPHATE BioCyc 2.7.1.151 false 2.7.1.151 2 Adenosine triphosphate + Inositol 1,4,5-trisphosphate → 1D-Myo-inositol 1,4,5,6-tetrakisphosphate + 2 Adenosine diphosphate LEFT_TO_RIGHT 2.7.1.151 false 2.7.1.151 1D-Myo-inositol 1,4,5,6-tetrakisphosphate + 2 Adenosine triphosphate → 2 Adenosine diphosphate + Inositol 1,3,4,5,6-pentakisphosphate LEFT_TO_RIGHT 3.1.3.57 false 3.1.3.57 1D-Myo-inositol 1,4-bisphosphate + Water → D-Myo-inositol 4-phosphate + Phosphoric acid LEFT_TO_RIGHT C11555 KEGG Compound 112791-61-4 CAS