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6022 PubChem-compound 1.0 C01528 KEGG Compound 937 ChemSpider CHEBI:16134 ChEBI S-adenosylmethionine synthase isoform type-2 1.0 57 ChemSpider Selenocysteine lyase CHEBI:16027 ChEBI CHEBI:17115 ChEBI Selenohomocysteine ATP BioCyc S-adenosylmethionine synthase isoform type-2 559142 ChemSpider 2.0 17615371 ChemSpider 5742 ChemSpider CHEBI:9100 ChEBI C00212 KEGG Compound 1.0 1.0 1.0 HMDB0004119 HMDB HMDB0004113 HMDB HMDB0004112 HMDB 5858 ChemSpider 5736 ChemSpider Adenosine monophosphate 5735 ChemSpider C00109 KEGG Compound SMILES NC(CC[SeH])C(O)=O SMILES NC(C[Se][Se]CC(N)C(O)=O)C(O)=O 24892762 PubChem-compound Adenosylhomocysteinase 24892761 PubChem-compound PPI BioCyc 10236-58-5 CAS Se-Adenosylselenomethionine SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)O[Se](O)(=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SMILES C[Se]C[C@H](N)C(O)=O CHEBI:28450 ChEBI HMDB0004122 HMDB 1.0 SubPathwayInteraction239 SubPathwayReaction SubPathway239Reaction Q8TCB7 UniProt SubPathwayInteraction237 SubPathway237Reaction SubPathwayReaction SubPathwayInteraction238 SubPathway238Reaction SubPathwayReaction Cytosol 7664-38-2 CAS HMDB0003288 HMDB Methyltransferase-like protein 6 Adenosine C00009 KEGG Compound C00008 KEGG Compound CH3-R L-ALPHA-ALANINE BioCyc C00001 KEGG Compound 56-41-7 CAS CHEBI:18361 ChEBI 2-OXOBUTANOATE BioCyc C00002 KEGG Compound Phosphoroselenoic acid Methionine--tRNA ligase, cytoplasmic Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 4.0 389628 ChemSpider C05704 KEGG Compound 1.0 SMILES O[Se](O)(=O)=O Adenosine triphosphate 1061 ChemSpider CHEBI:18212 ChEBI C00014 KEGG Compound C00013 KEGG Compound 389629 ChemSpider 1059 ChemSpider C3H7NO2Se Selenocysteine 168.9642 1058 ChemSpider 389632 ChemSpider 129633 ChemSpider 56-65-5 CAS C00020 KEGG Compound Se-Methylselenocysteine SubPathwayOutput Cystathionine gamma-lyase 1.0 Se-Methylselenocysteine CHEBI:26078 ChEBI HMDB0010716 HMDB 4.0 SubPathwayInteraction240 SubPathway240Reaction SubPathwayReaction HMDB0006343 HMDB SubPathwayInteraction241 SubPathwayReaction SubPathway241Reaction 1.0 C7H14N2O4Se Selenocystathionine 270.01187 AMP BioCyc C00041 KEGG Compound Selenocystathionine Selenomethionyl-tRNA(Met) CHEBI:29173 ChEBI 30785505 ChemSpider HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O Intestinal Digestion and Absorption SubPathway HMDB0001341 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES C[Se]CC(NC(=O)CCC(N)C(O)=O)C(O)=O Reaction2297 true Selenohomocysteine → Selenomethionine LEFT_TO_RIGHT 14375 ChemSpider 14376 ChemSpider P32929 UniProt 7732-18-5 CAS H3O3PSe Phosphoroselenoic acid 161.8985 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 AMMONIA BioCyc SMILES N SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1 26046-90-2 CAS Adenosine diphosphate 533 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 C00065 KEGG Compound 58-61-7 CAS Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Pyrophosphate HMDB0000045 HMDB CHEBI:29269 ChEBI Gamma-glutamyltranspeptidase 1 2.0 Ammonia HMDB0000161 HMDB S-adenosylmethionine synthase 962 PubChem-compound C3H7NO2 L-Alanine 89.047676 5800 ChemSpider 979 ChemSpider Adenosylhomocysteinase Selenide, water dikinase 2 25758-66-1 CAS 1.0 SMILES [SeH2] H3O4P Phosphoric acid 97.9769 P56192 UniProt Glutamate Metabolism SubPathway HMDB0000051 HMDB Cystathionine beta-synthase HMDB0000050 HMDB HMDB0002111 HMDB 1.0 1.0 Adenosylhomocysteinase 58-64-0 CAS Cystathionine gamma-lyase SMILES NC(CC[Se]C[C@H]1O[C@@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O C4H6O3 2-Ketobutyric acid 102.03169 SMILES [O-][Se]([O-])=O SMILES C[Se+](CCC(N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N C3H7NO3 L-Serine 105.042595 Hydrogen selenide HMDB0000187 HMDB 644102 PubChem-compound HMDB0060694 HMDB 6083 PubChem-compound 518 ChemSpider 1.0 1.0 H2O Water 18.010565 1.0 CHEBI:18170 ChEBI 54923 ChemSpider SMILES C[Se]CCC(N)C(O)=O Selenomethionine C05684 KEGG Compound SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)O[Se](O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]3O)C2=NC=N1 98223 PubChem-compound HMDB0002142 HMDB 1.0 C05689 KEGG Compound tRNA(Met) C05686 KEGG Compound C05688 KEGG Compound C05692 KEGG Compound C05695 KEGG Compound Q99611 UniProt C05691 KEGG Compound SMILES O H3N Ammonia 17.026548 C10H13N5O4 Adenosine 267.09674 C10H14N5O7P Adenosine monophosphate 347.06308 D-Arginine and D-Ornithine Metabolism SubPathway 1.0 14124-67-5 CAS 1.0 HMDB0000538 HMDB 1004 PubChem-compound C05697 KEGG Compound C05696 KEGG Compound C05699 KEGG Compound C05698 KEGG Compound C05335 KEGG Compound CHEBI:3274 ChEBI Water 2.7.9.3 false 2.7.9.3 Adenosine triphosphate + Hydrogen selenide + Water ↔ Adenosine monophosphate + Phosphoric acid + Phosphoroselenoic acid REVERSIBLE ADP BioCyc 58 PubChem-compound O43252 UniProt Selenocysteine lyase SMILES NC(CC[Se]CC(N)C(O)=O)C(O)=O Cystathionine beta-synthase 88693 ChemSpider GO:0005829 GENE ONTOLOGY Alanine Metabolism SubPathway CHEBI:27812 ChEBI Adenylylselenate 1.0 R SER BioCyc Aspartate Metabolism SubPathway SELENOMETHIONINE BioCyc 600-18-0 CAS 16682731 PubChem-compound Gamma-glutamyltranspeptidase 1 Cystathionine beta-synthase 4.0 CHEBI:16977 ChEBI Selenite SubPathwayOutput HMDB0011104 HMDB R L-SELENOCYSTEINE BioCyc CH3-R 217 ChemSpider HMDB0003840 HMDB HMDB0003966 HMDB GO:0005886 GENE ONTOLOGY HMDB0011110 HMDB 1464-43-3 CAS CHEBI:16503 ChEBI HMDB0011118 HMDB HMDB0011117 HMDB C5H11NO2Se Selenomethionine 196.9955 Gamma-Glutamyl-Se-methylselenocysteine 7664-41-7 CAS P35520 UniProt SMP0000055 SMPDB 2.1.1.- false 2.1.1.- R + Se-Adenosylselenomethionine → CH3-R + Se-Adenosylselenohomocysteine LEFT_TO_RIGHT 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + Selenomethionine + Water → Phosphoric acid + Pyrophosphate + Se-Adenosylselenomethionine LEFT_TO_RIGHT 4.2.1.22 false 4.2.1.22 L-Serine + Selenohomocysteine → Selenocystathionine + Water LEFT_TO_RIGHT 60961 PubChem-compound 3.3.1.1 false 3.3.1.1 Se-Adenosylselenohomocysteine + Water → Adenosine + Selenohomocysteine LEFT_TO_RIGHT Reaction614 true Selenocysteine → Selenocystine LEFT_TO_RIGHT 4.4.1.1 false 4.4.1.1 Selenocystathionine + Water → 2-Ketobutyric acid + Ammonia + Selenocysteine LEFT_TO_RIGHT Reaction612 false Se-Methylselenocysteine → Gamma-Glutamyl-Se-methylselenocysteine LEFT_TO_RIGHT 4.4.1.16 false 4.4.1.16 Selenocysteine → Hydrogen selenide + L-Alanine LEFT_TO_RIGHT SMILES C[C@H](N)C(O)=O 1.0 5950 PubChem-compound 222 PubChem-compound 5951 PubChem-compound SMILES OP(O)(O)=O 440763 PubChem-compound O7P2 Pyrophosphate 173.91193 440760 PubChem-compound 1.0 25076 PubChem-compound 5957 PubChem-compound HMDB0011119 HMDB SMP0000067 SMPDB Selenomethionine 1.0 Reaction623 false Adenosine triphosphate + Adenylylselenate → 3-Phosphoadenylylselenate + Adenosine diphosphate LEFT_TO_RIGHT 440758 PubChem-compound 3-Phosphoadenylylselenate 1.0 SMP0000072 SMPDB CHEBI:26630 ChEBI SMILES N[C@@H](CO)C(O)=O CHEBI:2485 ChEBI C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 C9H16N2O5Se Gamma-Glutamyl-Se-methylselenocysteine 312.02243 GO:0005737 GENE ONTOLOGY HMDB0000005 HMDB SMILES CCC(=O)C(O)=O Reaction621 true Selenite → Selenic acid LEFT_TO_RIGHT Reaction622 false Adenosine triphosphate + Selenic acid → Adenylylselenate + Pyrophosphate LEFT_TO_RIGHT Selenoamino Acid Metabolism 6.1.1.10 false 6.1.1.10 Adenosine triphosphate + Selenomethionine + tRNA(Met) → Adenosine monophosphate + Pyrophosphate + Selenomethionyl-tRNA(Met) LEFT_TO_RIGHT Methionine adenosyltransferase 2 subunit beta 1090 PubChem-compound H2O4Se Selenic acid 145.91183 1092 PubChem-compound ReactionCatalysis96 ACTIVATION ReactionCatalysis97 ACTIVATION ReactionCatalysis98 ACTIVATION ReactionCatalysis99 ACTIVATION CHEBI:30831 ChEBI 1.0 Selenocysteine SubPathwayOutput C05172 KEGG Compound 14000-31-8 CAS SMILES N[C@@H](C[SeH])C(O)=O 7783-08-6 CAS 1089 PubChem-compound C4H9NO2Se Se-Methylselenocysteine 182.97984 C4H9NO2Se Selenohomocysteine 182.97984 C6H12N2O4Se2 Selenocystine 335.91275 Cytoplasm 1.0 C10H14N5O10PSe Adenylylselenate 474.96436 Selenomethionyl-tRNA(Met) CHEBI:16633 ChEBI CHEBI:15422 ChEBI SMP0000029 SMPDB Se-Adenosylselenohomocysteine Homo sapiens Methionine adenosyltransferase 2 subunit beta C10H15N5O13P2Se 3-Phosphoadenylylselenate 554.93066 1.0 H2Se Hydrogen selenide 81.932175 P31153 UniProt 1464-42-2 CAS 7783-07-5 CAS Selenide, water dikinase 2 SELENOHOMOCYSTEINE BioCyc C14H20N6O5Se Se-Adenosylselenohomocysteine 432.06604 Phosphoric acid Cystathionine gamma-lyase 15103 PubChem-compound 15104 PubChem-compound CHEBI:16761 ChEBI Methionine--tRNA ligase, cytoplasmic Selenocysteine lyase P23526 UniProt O3Se Selenite 127.90127 SMP0000036 SMPDB C15H23N6O5Se Se-Adenosylselenomethionine 447.0895 9606 TAXONOMY CHEBI:16335 ChEBI 1.0 SMILES OP(O)(O)=[Se] 29412-93-9 CAS 1.0 147004 PubChem-compound 2196-58-9 CAS 1.0 L-Alanine SubPathwayInput PW000019 PathWhiz ReactionCatalysis106 ACTIVATION P19440 UniProt ReactionCatalysis104 ACTIVATION 1.0 ADENOSINE BioCyc ReactionCatalysis105 ACTIVATION Cell Membrane CHEBI:15377 ChEBI ReactionCatalysis102 ACTIVATION ReactionCatalysis103 ACTIVATION ReactionCatalysis100 ACTIVATION ReactionCatalysis101 ACTIVATION SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 56-45-1 CAS 1.0 23436 ChemSpider 1.0 CHEBI:17792 ChEBI Q96I15 UniProt L-Serine PW000007 PathWhiz CHEBI:28553 ChEBI CHEBI:27585 ChEBI PW000002 PathWhiz PW000001 PathWhiz Q9NZL9 UniProt PW000003 PathWhiz Selenic acid tRNA(Met) Selenohomocysteine Methyltransferase-like protein 6 2-Ketobutyric acid Selenocystine Selenocysteine lyase Selenide, water dikinase 2 Cystathionine gamma-lyase Cystathionine beta-synthase Adenosylhomocysteinase Methyltransferase- like protein 6 S- adenosylmethionine synthase isoform type-2 Methionine adenosyltransferase 2 subunit beta Methionine-- tRNA ligase, cytoplasmic Bifunctional 3'- phosphoadenosine 5'- phosphosulfate synthase 1 Bifunctional 3'- phosphoadenosine 5'- phosphosulfate synthase 1 Gamma- glutamyltranspeptidase 1 Se-Methylselenocysteine Selenite Selenocysteine L-Alanine Hydrogen selenide ATP H 2 O AMP Phosphoroselenoic acid P i Selenocystathionine H 2 O NH 3 2-Ketobutyric acid L-Serine Selenohomocysteine H 2 O Se-Adenosylselenohomocysteine H 2 O Adenosine Se-Adenosylselenomethionine Selenomethionine ATP H 2 O Phosphoric acid PP i ATP AMP PP i ATP Selenic acid Adenylylselenate PP i ATP 3-Phosphoadenylylselenate ADP Gamma-Glutamyl-Se- methylselenocysteine Selenocystine Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate NAD tRNA(Met) Selenomethionyl- tRNA(Met) Intestinal Digestion and Absorption Aspartate Metabolism Glutamate Metabolism Alanine Metabolism D-Arginine and D-Ornithine Metabolism Extracellular Space Intracellular Space Extracellular Space
6022 PubChem-compound 1.0 C01528 KEGG Compound 937 ChemSpider CHEBI:16134 ChEBI S-adenosylmethionine synthase isoform type-2 1.0 57 ChemSpider Selenocysteine lyase CHEBI:16027 ChEBI CHEBI:17115 ChEBI Selenohomocysteine ATP BioCyc S-adenosylmethionine synthase isoform type-2 559142 ChemSpider 2.0 17615371 ChemSpider 5742 ChemSpider CHEBI:9100 ChEBI C00212 KEGG Compound 1.0 1.0 1.0 HMDB0004119 HMDB HMDB0004113 HMDB HMDB0004112 HMDB 5858 ChemSpider 5736 ChemSpider Adenosine monophosphate 5735 ChemSpider C00109 KEGG Compound SMILES NC(CC[SeH])C(O)=O SMILES NC(C[Se][Se]CC(N)C(O)=O)C(O)=O 24892762 PubChem-compound Adenosylhomocysteinase 24892761 PubChem-compound PPI BioCyc 10236-58-5 CAS Se-Adenosylselenomethionine SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)O[Se](O)(=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SMILES C[Se]C[C@H](N)C(O)=O CHEBI:28450 ChEBI HMDB0004122 HMDB 1.0 SubPathwayInteraction239 SubPathwayReaction SubPathway239Reaction Q8TCB7 UniProt SubPathwayInteraction237 SubPathway237Reaction SubPathwayReaction SubPathwayInteraction238 SubPathway238Reaction SubPathwayReaction Cytosol 7664-38-2 CAS HMDB0003288 HMDB Methyltransferase-like protein 6 Adenosine C00009 KEGG Compound C00008 KEGG Compound CH3-R L-ALPHA-ALANINE BioCyc C00001 KEGG Compound 56-41-7 CAS CHEBI:18361 ChEBI 2-OXOBUTANOATE BioCyc C00002 KEGG Compound Phosphoroselenoic acid Methionine--tRNA ligase, cytoplasmic Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 4.0 389628 ChemSpider C05704 KEGG Compound 1.0 SMILES O[Se](O)(=O)=O Adenosine triphosphate 1061 ChemSpider CHEBI:18212 ChEBI C00014 KEGG Compound C00013 KEGG Compound 389629 ChemSpider 1059 ChemSpider C3H7NO2Se Selenocysteine 168.9642 1058 ChemSpider 389632 ChemSpider 129633 ChemSpider 56-65-5 CAS C00020 KEGG Compound Se-Methylselenocysteine SubPathwayOutput Cystathionine gamma-lyase 1.0 Se-Methylselenocysteine CHEBI:26078 ChEBI HMDB0010716 HMDB 4.0 SubPathwayInteraction240 SubPathway240Reaction SubPathwayReaction HMDB0006343 HMDB SubPathwayInteraction241 SubPathwayReaction SubPathway241Reaction 1.0 C7H14N2O4Se Selenocystathionine 270.01187 AMP BioCyc C00041 KEGG Compound Selenocystathionine Selenomethionyl-tRNA(Met) CHEBI:29173 ChEBI 30785505 ChemSpider HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O Intestinal Digestion and Absorption SubPathway HMDB0001341 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES C[Se]CC(NC(=O)CCC(N)C(O)=O)C(O)=O Reaction2297 true Selenohomocysteine → Selenomethionine LEFT_TO_RIGHT 14375 ChemSpider 14376 ChemSpider P32929 UniProt 7732-18-5 CAS H3O3PSe Phosphoroselenoic acid 161.8985 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 AMMONIA BioCyc SMILES N SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1 26046-90-2 CAS Adenosine diphosphate 533 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 C00065 KEGG Compound 58-61-7 CAS Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Pyrophosphate HMDB0000045 HMDB CHEBI:29269 ChEBI Gamma-glutamyltranspeptidase 1 2.0 Ammonia HMDB0000161 HMDB S-adenosylmethionine synthase 962 PubChem-compound C3H7NO2 L-Alanine 89.047676 5800 ChemSpider 979 ChemSpider Adenosylhomocysteinase Selenide, water dikinase 2 25758-66-1 CAS 1.0 SMILES [SeH2] H3O4P Phosphoric acid 97.9769 P56192 UniProt Glutamate Metabolism SubPathway HMDB0000051 HMDB Cystathionine beta-synthase HMDB0000050 HMDB HMDB0002111 HMDB 1.0 1.0 Adenosylhomocysteinase 58-64-0 CAS Cystathionine gamma-lyase SMILES NC(CC[Se]C[C@H]1O[C@@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O C4H6O3 2-Ketobutyric acid 102.03169 SMILES [O-][Se]([O-])=O SMILES C[Se+](CCC(N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N C3H7NO3 L-Serine 105.042595 Hydrogen selenide HMDB0000187 HMDB 644102 PubChem-compound HMDB0060694 HMDB 6083 PubChem-compound 518 ChemSpider 1.0 1.0 H2O Water 18.010565 1.0 CHEBI:18170 ChEBI 54923 ChemSpider SMILES C[Se]CCC(N)C(O)=O Selenomethionine C05684 KEGG Compound SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)O[Se](O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]3O)C2=NC=N1 98223 PubChem-compound HMDB0002142 HMDB 1.0 C05689 KEGG Compound tRNA(Met) C05686 KEGG Compound C05688 KEGG Compound C05692 KEGG Compound C05695 KEGG Compound Q99611 UniProt C05691 KEGG Compound SMILES O H3N Ammonia 17.026548 C10H13N5O4 Adenosine 267.09674 C10H14N5O7P Adenosine monophosphate 347.06308 D-Arginine and D-Ornithine Metabolism SubPathway 1.0 14124-67-5 CAS 1.0 HMDB0000538 HMDB 1004 PubChem-compound C05697 KEGG Compound C05696 KEGG Compound C05699 KEGG Compound C05698 KEGG Compound C05335 KEGG Compound CHEBI:3274 ChEBI Water 2.7.9.3 false 2.7.9.3 Adenosine triphosphate + Hydrogen selenide + Water ↔ Adenosine monophosphate + Phosphoric acid + Phosphoroselenoic acid REVERSIBLE ADP BioCyc 58 PubChem-compound O43252 UniProt Selenocysteine lyase SMILES NC(CC[Se]CC(N)C(O)=O)C(O)=O Cystathionine beta-synthase 88693 ChemSpider GO:0005829 GENE ONTOLOGY Alanine Metabolism SubPathway CHEBI:27812 ChEBI Adenylylselenate 1.0 R SER BioCyc Aspartate Metabolism SubPathway SELENOMETHIONINE BioCyc 600-18-0 CAS 16682731 PubChem-compound Gamma-glutamyltranspeptidase 1 Cystathionine beta-synthase 4.0 CHEBI:16977 ChEBI Selenite SubPathwayOutput HMDB0011104 HMDB R L-SELENOCYSTEINE BioCyc CH3-R 217 ChemSpider HMDB0003840 HMDB HMDB0003966 HMDB GO:0005886 GENE ONTOLOGY HMDB0011110 HMDB 1464-43-3 CAS CHEBI:16503 ChEBI HMDB0011118 HMDB HMDB0011117 HMDB C5H11NO2Se Selenomethionine 196.9955 Gamma-Glutamyl-Se-methylselenocysteine 7664-41-7 CAS P35520 UniProt SMP0000055 SMPDB 2.1.1.- false 2.1.1.- R + Se-Adenosylselenomethionine → CH3-R + Se-Adenosylselenohomocysteine LEFT_TO_RIGHT 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + Selenomethionine + Water → Phosphoric acid + Pyrophosphate + Se-Adenosylselenomethionine LEFT_TO_RIGHT 4.2.1.22 false 4.2.1.22 L-Serine + Selenohomocysteine → Selenocystathionine + Water LEFT_TO_RIGHT 60961 PubChem-compound 3.3.1.1 false 3.3.1.1 Se-Adenosylselenohomocysteine + Water → Adenosine + Selenohomocysteine LEFT_TO_RIGHT Reaction614 true Selenocysteine → Selenocystine LEFT_TO_RIGHT 4.4.1.1 false 4.4.1.1 Selenocystathionine + Water → 2-Ketobutyric acid + Ammonia + Selenocysteine LEFT_TO_RIGHT Reaction612 false Se-Methylselenocysteine → Gamma-Glutamyl-Se-methylselenocysteine LEFT_TO_RIGHT 4.4.1.16 false 4.4.1.16 Selenocysteine → Hydrogen selenide + L-Alanine LEFT_TO_RIGHT SMILES C[C@H](N)C(O)=O 1.0 5950 PubChem-compound 222 PubChem-compound 5951 PubChem-compound SMILES OP(O)(O)=O 440763 PubChem-compound O7P2 Pyrophosphate 173.91193 440760 PubChem-compound 1.0 25076 PubChem-compound 5957 PubChem-compound HMDB0011119 HMDB SMP0000067 SMPDB Selenomethionine 1.0 Reaction623 false Adenosine triphosphate + Adenylylselenate → 3-Phosphoadenylylselenate + Adenosine diphosphate LEFT_TO_RIGHT 440758 PubChem-compound 3-Phosphoadenylylselenate 1.0 SMP0000072 SMPDB CHEBI:26630 ChEBI SMILES N[C@@H](CO)C(O)=O CHEBI:2485 ChEBI C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 C9H16N2O5Se Gamma-Glutamyl-Se-methylselenocysteine 312.02243 GO:0005737 GENE ONTOLOGY HMDB0000005 HMDB SMILES CCC(=O)C(O)=O Reaction621 true Selenite → Selenic acid LEFT_TO_RIGHT Reaction622 false Adenosine triphosphate + Selenic acid → Adenylylselenate + Pyrophosphate LEFT_TO_RIGHT Selenoamino Acid Metabolism 6.1.1.10 false 6.1.1.10 Adenosine triphosphate + Selenomethionine + tRNA(Met) → Adenosine monophosphate + Pyrophosphate + Selenomethionyl-tRNA(Met) LEFT_TO_RIGHT Methionine adenosyltransferase 2 subunit beta 1090 PubChem-compound H2O4Se Selenic acid 145.91183 1092 PubChem-compound ReactionCatalysis96 ACTIVATION ReactionCatalysis97 ACTIVATION ReactionCatalysis98 ACTIVATION ReactionCatalysis99 ACTIVATION CHEBI:30831 ChEBI 1.0 Selenocysteine SubPathwayOutput C05172 KEGG Compound 14000-31-8 CAS SMILES N[C@@H](C[SeH])C(O)=O 7783-08-6 CAS 1089 PubChem-compound C4H9NO2Se Se-Methylselenocysteine 182.97984 C4H9NO2Se Selenohomocysteine 182.97984 C6H12N2O4Se2 Selenocystine 335.91275 Cytoplasm 1.0 C10H14N5O10PSe Adenylylselenate 474.96436 Selenomethionyl-tRNA(Met) CHEBI:16633 ChEBI CHEBI:15422 ChEBI SMP0000029 SMPDB Se-Adenosylselenohomocysteine Homo sapiens Methionine adenosyltransferase 2 subunit beta C10H15N5O13P2Se 3-Phosphoadenylylselenate 554.93066 1.0 H2Se Hydrogen selenide 81.932175 P31153 UniProt 1464-42-2 CAS 7783-07-5 CAS Selenide, water dikinase 2 SELENOHOMOCYSTEINE BioCyc C14H20N6O5Se Se-Adenosylselenohomocysteine 432.06604 Phosphoric acid Cystathionine gamma-lyase 15103 PubChem-compound 15104 PubChem-compound CHEBI:16761 ChEBI Methionine--tRNA ligase, cytoplasmic Selenocysteine lyase P23526 UniProt O3Se Selenite 127.90127 SMP0000036 SMPDB C15H23N6O5Se Se-Adenosylselenomethionine 447.0895 9606 TAXONOMY CHEBI:16335 ChEBI 1.0 SMILES OP(O)(O)=[Se] 29412-93-9 CAS 1.0 147004 PubChem-compound 2196-58-9 CAS 1.0 L-Alanine SubPathwayInput PW000019 PathWhiz ReactionCatalysis106 ACTIVATION P19440 UniProt ReactionCatalysis104 ACTIVATION 1.0 ADENOSINE BioCyc ReactionCatalysis105 ACTIVATION Cell Membrane CHEBI:15377 ChEBI ReactionCatalysis102 ACTIVATION ReactionCatalysis103 ACTIVATION ReactionCatalysis100 ACTIVATION ReactionCatalysis101 ACTIVATION SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 56-45-1 CAS 1.0 23436 ChemSpider 1.0 CHEBI:17792 ChEBI Q96I15 UniProt L-Serine PW000007 PathWhiz CHEBI:28553 ChEBI CHEBI:27585 ChEBI PW000002 PathWhiz PW000001 PathWhiz Q9NZL9 UniProt PW000003 PathWhiz Selenic acid tRNA(Met) Selenohomocysteine Methyltransferase-like protein 6 2-Ketobutyric acid Selenocystine