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CHEBI:16015 ChEBI SubPathwayInteraction277 SubPathwayReaction SubPathway277Reaction 6022 PubChem-compound 937 ChemSpider CHEBI:16134 ChEBI 1.0 1.0 439153 PubChem-compound SubPathwayInteraction271 SubPathway271Reaction SubPathwayReaction 1.0 SubPathwayInteraction272 SubPathwayReaction SubPathway272Reaction Tetrahydrofolic acid SubPathwayOutput SubPathwayInput 58-05-9 CAS SubPathwayInteraction270 SubPathway270Reaction SubPathwayReaction 10-FORMYL-THF BioCyc SubPathwayInteraction275 SubPathway275Reaction SubPathwayReaction Methylenetetrahydrofolate reductase SubPathwayInteraction276 SubPathway276Reaction SubPathwayReaction SubPathwayInteraction273 SubPathwayReaction SubPathway273Reaction 10-Formyltetrahydrofolate SubPathwayInteraction274 SubPathway274Reaction SubPathwayReaction SubPathwayInteraction268 SubPathway268Reaction SubPathwayReaction L-Glutamic acid PW000056 PathWhiz SubPathwayInteraction269 SubPathway269Reaction SubPathwayReaction CHEBI:20506 ChEBI SubPathwayInteraction266 SubPathwayReaction SubPathway266Reaction 7444-29-3 CAS SubPathwayInteraction267 SubPathwayReaction SubPathway267Reaction C19H21N7O6 Dihydrofolic acid 443.15533 CHEBI:17119 ChEBI C00440 KEGG Compound ATP BioCyc C00445 KEGG Compound 1.0 PW000052 PathWhiz 5-METHYL-THF BioCyc 18714427 ChemSpider 2.0 Proton-coupled folate transporter SubPathwayInteraction265 SubPathway265Reaction SubPathwayReaction 390680 ChemSpider PW000043 PathWhiz 5742 ChemSpider CHEBI:16474 ChEBI PW000160 PathWhiz Carbon dioxide Formimidoyltransferase-cyclodeaminase 439175 PubChem-compound P42898 UniProt 5-formyltetrahydrofolate cyclo-ligase 1.0 PW000157 PathWhiz METHYLENE-THF BioCyc 1010 ChemSpider 6037 PubChem-compound C00101 KEGG Compound C6H9NO5 N-Formyl-L-glutamic acid 175.04807 1.0 45479706 PubChem-compound L-Glutamic acid SubPathwayOutput Tetrahydrofolyl-[Glu](n) C00234 KEGG Compound 5-FORMYL-THF BioCyc 1.0 122347 PubChem-compound C00009 KEGG Compound C00008 KEGG Compound Q6UB35 UniProt C00006 KEGG Compound 5-Methyltetrahydrofolic acid SubPathwayOutput N-Formyl-L-glutamic acid CHEBI:18009 ChEBI O75891 UniProt C00001 KEGG Compound C00005 KEGG Compound CHEBI:18367 ChEBI SMILES OC(=O)CC[C@H](NC=O)C(O)=O C00004 KEGG Compound 135-16-0 CAS 1032 ChemSpider C00003 KEGG Compound NADP C00002 KEGG Compound 388320 ChemSpider Q96NT5 UniProt 1.0 Phosphate 1.0 1.0 Tetrahydrofolyl-[Glu](n) C21H28N7O14P2 NAD 664.11694 Adenosine triphosphate C00011 KEGG Compound HMDB0000902 HMDB Formimidoyltransferase-cyclodeaminase C00014 KEGG Compound 1.0 Extracellular Space NAD(P) BioCyc 11267158 ChemSpider H Hydrogen Ion 1.007825 C00143 KEGG Compound 56-65-5 CAS 53-84-9 CAS C00025 KEGG Compound C-1-tetrahydrofolate synthase, cytoplasmic 3432-99-3 CAS 8.0 C-1-tetrahydrofolate synthase, cytoplasmic C03541 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 1.0 Adenosine diphosphate 98792 PubChem-compound L-methionyl-tRNA(Met) HMDB0001341 HMDB N-formylmethionyl-tRNA(fMet) 644350 PubChem-compound 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Folylpolyglutamate synthase, mitochondrial DIHYDROFOLATE BioCyc HMDB0001354 HMDB L-methionyl-tRNA(Met) HMDB0000148 HMDB 1.0 Methylenetetrahydrofolate reductase HMDB0000142 HMDB 2.0 Cytosolic 10-formyltetrahydrofolate dehydrogenase 7732-18-5 CAS C00058 KEGG Compound HMDB0001487 HMDB NAD AMMONIA BioCyc SMILES N 56-86-0 CAS FORMATE BioCyc Adenosine diphosphate C10H16N5O13P3 Adenosine triphosphate 506.99576 C20H23N7O7 10-Formyltetrahydrofolate 473.1659 442163 PubChem-compound Q92820 UniProt C24H30N8O9 Tetrahydrofolyl-[Glu](2) 574.21356 C29H37N9O12 Tetrahydrofolyl-[Glu](n) 703.25616 2800-34-2 CAS 530 PubChem-compound 4033-27-6 CAS HMDB0006825 HMDB HMDB0006826 HMDB Ammonia 1.0 962 PubChem-compound 5,10-Methylene-THF SubPathwayInput 5800 ChemSpider C01045 KEGG Compound CO2 Carbon dioxide 43.98983 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial C-1-tetrahydrofolate synthase, cytoplasmic C00080 KEGG Compound Glutamate Metabolism SubPathway HMDB0000051 HMDB HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O SMILES OC=O 14265-44-2 CAS 5,10-methenyl-thf BioCyc Methionyl-tRNA formyltransferase, mitochondrial Monofunctional C1-tetrahydrofolate synthase, mitochondrial 58-64-0 CAS C03479 KEGG Compound CHEBI:209153 ChEBI SMILES NC1=NC2=C(N(C=O)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 FOLATE BioCyc SMILES CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2 10-Formyltetrahydrofolate SubPathwayInput HMDB0001396 HMDB 1.0 64-18-6 CAS 1.0 SMILES [H][C@@]12CN(C=[N+]1C1=C(NC2)NC(N)=NC1=O)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O 1.0 SMILES NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1 22833512 PubChem-compound N-formylmethionyl-tRNA(fMet) H2O Water 18.010565 Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.0 NADH BioCyc 5-Formiminotetrahydrofolic acid SubPathwayOutput NAD BioCyc 5815 ChemSpider HMDB0059597 HMDB 559356 ChemSpider 5,10-Methenyltetrahydrofolic acid 1.0 Formimidoyltransferase-cyclodeaminase Formic acid SMILES NC1=NC2=C(N(C=N)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 SMILES [H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O 134-35-0 CAS NAD HMDB0003470 HMDB HMDB0001056 HMDB 1.0 30572 ChemSpider 17215925 ChemSpider 2.0 Folic acid 5-formyltetrahydrofolate cyclo-ligase Dihydrofolic acid SubPathwayInput Methionine Metabolism SubPathway SMILES O Methionyl-tRNA formyltransferase, mitochondrial H3N Ammonia 17.026548 1.0 2.0 HMDB0000538 HMDB Gamma-glutamyl hydrolase Dihydrofolate reductase Histidine Metabolism SubPathway Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Water CHEBI:15846 ChEBI Folic acid ADP BioCyc Pyrimidine Metabolism SubPathway 53-59-8 CAS Lysosome P00374 UniProt 1.0 CHEBI:48309 ChEBI 1038 PubChem-compound 143 PubChem-compound Folate Metabolism 278 ChemSpider C19H23N7O6 Tetrahydrofolic acid 445.171 2.0 Purine Metabolism SubPathway 274 ChemSpider Hydrogen Ion CHEBI:16908 ChEBI 1.5.1.20 false 1.5.1.20 5,10-Methylene-THF + NADH → 5-Methyltetrahydrofolic acid + NAD LEFT_TO_RIGHT Reaction789 false 5-Formiminotetrahydrofolic acid ↔ 5,10-Methenyltetrahydrofolic acid + Ammonia REVERSIBLE O4P Phosphate 94.95342 Gamma-glutamyl hydrolase Dihydrofolate reductase HMDB0001533 HMDB Adenosine triphosphate HMDB0001534 HMDB TransportCatalysis229 ACTIVATION C21H30N7O17P3 NADPH 745.0911 6.3.3.2 false 6.3.3.2 Adenosine triphosphate + N5-Formyl-THF → 5,10-Methenyltetrahydrofolic acid + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT 140 ChemSpider Reaction787 false 5,10-Methenyltetrahydrofolic acid + NADPH ↔ 5,10-Methylene-THF + NADP REVERSIBLE Reaction784 false L-Glutamic acid + N5-Formyl-THF → N-Formyl-L-glutamic acid + Tetrahydrofolic acid LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 Reaction785 false 10-Formyltetrahydrofolate + Hydrogen Ion ↔ 5,10-Methenyltetrahydrofolic acid + Water REVERSIBLE Mitochondrion THF BioCyc Reaction782 false Adenosine triphosphate + Formic acid + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT 1.5.1.6 false 1.5.1.6 10-Formyltetrahydrofolate + NADP + Water → Carbon dioxide + NADPH + Tetrahydrofolic acid LEFT_TO_RIGHT 1.5.1.3 false 1.5.1.3 NADP + Tetrahydrofolic acid ↔ Dihydrofolic acid + NADPH REVERSIBLE CHEBI:15641 ChEBI NADPH BioCyc 1.0 O95954 UniProt 217 ChemSpider SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 58-68-4 CAS Water SMILES [O-]P([O-])([O-])=O C20H21N7O6 5,10-Methenyltetrahydrofolic acid 455.15533 HMDB0000217 HMDB 1.0 Dihydrofolate reductase CHEBI:15637 ChEBI 124-38-9 CAS CHEBI:15639 ChEBI GO:0005764 GENE ONTOLOGY SMP0000046 SMPDB C19H19N7O6 Folic acid 441.13968 SMP0000044 SMPDB Tetrahydrofolyl-[Glu](2) HMDB0001429 HMDB P13995 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMP0000050 SMPDB HMDB0000221 HMDB 1.0 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C20H23N7O6 5,10-Methylene-THF 457.171 C20H24N8O6 5-Formiminotetrahydrofolic acid 472.1819 Q96DP5 UniProt GLT BioCyc 7664-41-7 CAS Glycine and Serine Metabolism SubPathway SMP0000053 SMPDB 53-57-6 CAS P11586 UniProt SMILES O=C=O 1.0 222 PubChem-compound Proton-coupled folate transporter Monofunctional C1-tetrahydrofolate synthase, mitochondrial C21H29N7O14P2 NADH 665.12476 1.0 5-FORMIMINO-THF BioCyc 5957 PubChem-compound 1681-96-5 CAS HMDB0001562 HMDB CHEBI:15633 ChEBI CHEBI:15636 ChEBI Folylpolyglutamate synthase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial 5,10-Methenyltetrahydrofolic acid SMP0000072 SMPDB 1.0 GO:0005739 GENE ONTOLOGY Monofunctional C1-tetrahydrofolate synthase, mitochondrial C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY 1.0 HMDB0000121 HMDB 1.5.1.3 false 1.5.1.3 Dihydrofolic acid + NADP ↔ Folic acid + NADPH REVERSIBLE Transport24 false Folic acid (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 1.0 NADH CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O Transport22 false Tetrahydrofolic acid (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT 5682 ChemSpider Q05932 UniProt 1.0 1.0 SMP0000004 SMPDB 21231977 ChemSpider 5675 ChemSpider P49914 UniProt 18971002 PubChem-compound Cytoplasm 5,10-Methylene-THF SubPathwayInput NADPH Gamma-glutamyl hydrolase CHEBI:15422 ChEBI CHEBI:16635 ChEBI ReactionCatalysis330 ACTIVATION Homo sapiens 388299 ChemSpider Hydrogen Ion CH2O2 Formic acid 46.005478 Tetrahydrofolyl-[Glu](2) CHEBI:28624 ChEBI 1.0 ReactionCatalysis328 ACTIVATION ReactionCatalysis329 ACTIVATION ReactionCatalysis326 ACTIVATION ReactionCatalysis324 ACTIVATION CHEBI:27650 ChEBI C5H9NO4 L-Glutamic acid 147.05316 ReactionCatalysis325 ACTIVATION C00504 KEGG Compound 33032 PubChem-compound ReactionCatalysis322 ACTIVATION ReactionCatalysis323 ACTIVATION 1.0 ReactionCatalysis320 ACTIVATION Water ReactionCatalysis321 ACTIVATION CHEBI:16526 ChEBI SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1 CHEBI:16761 ChEBI C20H23N7O7 N5-Formyl-THF 473.1659 C20H25N7O6 5-Methyltetrahydrofolic acid 459.18665 ReactionCatalysis319 ACTIVATION ReactionCatalysis317 ACTIVATION ReactionCatalysis318 ACTIVATION ReactionCatalysis315 ACTIVATION ReactionCatalysis316 ACTIVATION NADH SMP0000033 SMPDB ReactionCatalysis313 ACTIVATION ReactionCatalysis314 ACTIVATION PW000024 PathWhiz 9606 TAXONOMY 1.0 1.0 1.0 5893 PubChem-compound Formic acid 439234 PubChem-compound 6.3.2.17 false 6.3.2.17 Adenosine triphosphate + L-Glutamic acid + Tetrahydrofolic acid → Adenosine diphosphate + Phosphate + Tetrahydrofolyl-[Glu](2) LEFT_TO_RIGHT HMDB0000972 HMDB CHEBI:30751 ChEBI SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 2.0 CHEBI:27470 ChEBI Methylenetetrahydrofolate reductase 2.1.2.9 false 2.1.2.9 10-Formyltetrahydrofolate + L-methionyl-tRNA(Met) → N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid LEFT_TO_RIGHT Reaction794 false 5,10-Methenyltetrahydrofolic acid + NADH ↔ 5,10-Methylene-THF + NAD REVERSIBLE 6.3.2.17 false 6.3.2.17 Adenosine triphosphate + L-Glutamic acid + Tetrahydrofolyl-[Glu](2) → Adenosine diphosphate + Phosphate + Tetrahydrofolyl-[Glu](n) LEFT_TO_RIGHT 3.4.19.9 false 3.4.19.9 Tetrahydrofolyl-[Glu](n) + Water → L-Glutamic acid + Tetrahydrofolyl-[Glu](2) LEFT_TO_RIGHT 1.0 CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound SMILES NC1=NC2=C(NC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)CN2)C(=O)N1 1.0 Phosphate SMILES NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1 1.0 280 PubChem-compound C00415 KEGG Compound PW000003 PathWhiz 89228 ChemSpider 388371 ChemSpider 1.0 388496 ChemSpider 2311-81-1 CAS 439376 PubChem-compound 1061 PubChem-compound CPD-600 BioCyc 109092 ChemSpider HMDB0001846 HMDB HMDB0001967 HMDB C00664 KEGG Compound Tetrahydrofolic acid SubPathwayInput 13781857 PubChem-compound N5-Formyl-THF 1.0 59-30-3 CAS Proton-coupled folate transporter Dihydrofolate reductase Dihydrofolate reductase C-1- tetrahydrofolate synthase, cytoplasmic Cytosolic 10- formyltetrahydrofolate dehydrogenase Formimidoyltransferase- cyclodeaminase C-1- tetrahydrofolate synthase, cytoplasmic 5- formyltetrahydrofolate cyclo-ligase C-1- tetrahydrofolate synthase, cytoplasmic Methylenetetrahydrofolate reductase Formimidoyltransferase- cyclodeaminase Folylpolyglutamate synthase, mitochondrial Folylpolyglutamate synthase, mitochondrial Gamma-glutamyl hydrolase Monofunctional C1- tetrahydrofolate synthase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Methionyl-tRNA formyltransferase, mitochondrial Tetrahydrofolic acid Dihydrofolic acid L-Glutamic acid 5-Formiminotetrahydrofolic acid 5,10-Methylene-THF 5-Methyltetrahydrofolic acid 10-Formyltetrahydrofolate Tetrahydrofolic acid 5,10-Methylene-THF Folic acid Folic acid NADP NADPH NADP NADPH ATP Formic acid ADP P i NADP H 2 O CO 2 NADPH N5-Formyl-THF N-Formyl-L- glutamic acid H + 5,10-Methenyltetrahydrofolic acid H 2 O ATP ADP P i NADPH NADP NADH NAD NH 3 L-Glutamic acid ATP Tetrahydrofolyl-[Glu](2) ADP P i ATP L-Glutamic acid Tetrahydrofolyl-[Glu](n) ADP P i H 2 O L-Glutamic acid ATP Formic acid ADP 10-Formyltetrahydrofolate P i H + 5,10-Methenyltetrahydrofolic acid H 2 O NADH NAD Pyridoxal 5'-phosphate Magnesium FAD Pyridoxal 5'-phosphate Calcium Calcium Magnesium Magnesium L- methionyl- tRNA(Met) N- formylmethionyl- tRNA(fMet) Histidine Metabolism Purine Metabolism Methionine Metabolism Glycine and Serine Metabolism Pyrimidine Metabolism Glutamate Metabolism Histidine Metabolism Glycine and Serine Metabolism Pyrimidine Metabolism Methionine Metabolism Purine Metabolism Glycine and Serine Metabolism Glycine and Serine Metabolism Mitochondria Lysosome Extracellular Space Intracellular Space Mitochondrial matrix
CHEBI:16015 ChEBI SubPathwayInteraction277 SubPathwayReaction SubPathway277Reaction 6022 PubChem-compound 937 ChemSpider CHEBI:16134 ChEBI 1.0 1.0 439153 PubChem-compound SubPathwayInteraction271 SubPathway271Reaction SubPathwayReaction 1.0 SubPathwayInteraction272 SubPathwayReaction SubPathway272Reaction Tetrahydrofolic acid SubPathwayOutput SubPathwayInput 58-05-9 CAS SubPathwayInteraction270 SubPathway270Reaction SubPathwayReaction 10-FORMYL-THF BioCyc SubPathwayInteraction275 SubPathway275Reaction SubPathwayReaction Methylenetetrahydrofolate reductase SubPathwayInteraction276 SubPathway276Reaction SubPathwayReaction SubPathwayInteraction273 SubPathwayReaction SubPathway273Reaction 10-Formyltetrahydrofolate SubPathwayInteraction274 SubPathway274Reaction SubPathwayReaction SubPathwayInteraction268 SubPathway268Reaction SubPathwayReaction L-Glutamic acid PW000056 PathWhiz SubPathwayInteraction269 SubPathway269Reaction SubPathwayReaction CHEBI:20506 ChEBI SubPathwayInteraction266 SubPathwayReaction SubPathway266Reaction 7444-29-3 CAS SubPathwayInteraction267 SubPathwayReaction SubPathway267Reaction C19H21N7O6 Dihydrofolic acid 443.15533 CHEBI:17119 ChEBI C00440 KEGG Compound ATP BioCyc C00445 KEGG Compound 1.0 PW000052 PathWhiz 5-METHYL-THF BioCyc 18714427 ChemSpider 2.0 Proton-coupled folate transporter SubPathwayInteraction265 SubPathway265Reaction SubPathwayReaction 390680 ChemSpider PW000043 PathWhiz 5742 ChemSpider CHEBI:16474 ChEBI PW000160 PathWhiz Carbon dioxide Formimidoyltransferase-cyclodeaminase 439175 PubChem-compound P42898 UniProt 5-formyltetrahydrofolate cyclo-ligase 1.0 PW000157 PathWhiz METHYLENE-THF BioCyc 1010 ChemSpider 6037 PubChem-compound C00101 KEGG Compound C6H9NO5 N-Formyl-L-glutamic acid 175.04807 1.0 45479706 PubChem-compound L-Glutamic acid SubPathwayOutput Tetrahydrofolyl-[Glu](n) C00234 KEGG Compound 5-FORMYL-THF BioCyc 1.0 122347 PubChem-compound C00009 KEGG Compound C00008 KEGG Compound Q6UB35 UniProt C00006 KEGG Compound 5-Methyltetrahydrofolic acid SubPathwayOutput N-Formyl-L-glutamic acid CHEBI:18009 ChEBI O75891 UniProt C00001 KEGG Compound C00005 KEGG Compound CHEBI:18367 ChEBI SMILES OC(=O)CC[C@H](NC=O)C(O)=O C00004 KEGG Compound 135-16-0 CAS 1032 ChemSpider C00003 KEGG Compound NADP C00002 KEGG Compound 388320 ChemSpider Q96NT5 UniProt 1.0 Phosphate 1.0 1.0 Tetrahydrofolyl-[Glu](n) C21H28N7O14P2 NAD 664.11694 Adenosine triphosphate C00011 KEGG Compound HMDB0000902 HMDB Formimidoyltransferase-cyclodeaminase C00014 KEGG Compound 1.0 Extracellular Space NAD(P) BioCyc 11267158 ChemSpider H Hydrogen Ion 1.007825 C00143 KEGG Compound 56-65-5 CAS 53-84-9 CAS C00025 KEGG Compound C-1-tetrahydrofolate synthase, cytoplasmic 3432-99-3 CAS 8.0 C-1-tetrahydrofolate synthase, cytoplasmic C03541 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 1.0 Adenosine diphosphate 98792 PubChem-compound L-methionyl-tRNA(Met) HMDB0001341 HMDB N-formylmethionyl-tRNA(fMet) 644350 PubChem-compound 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Folylpolyglutamate synthase, mitochondrial DIHYDROFOLATE BioCyc HMDB0001354 HMDB L-methionyl-tRNA(Met) HMDB0000148 HMDB 1.0 Methylenetetrahydrofolate reductase HMDB0000142 HMDB 2.0 Cytosolic 10-formyltetrahydrofolate dehydrogenase 7732-18-5 CAS C00058 KEGG Compound HMDB0001487 HMDB NAD AMMONIA BioCyc SMILES N 56-86-0 CAS FORMATE BioCyc Adenosine diphosphate C10H16N5O13P3 Adenosine triphosphate 506.99576 C20H23N7O7 10-Formyltetrahydrofolate 473.1659 442163 PubChem-compound Q92820 UniProt C24H30N8O9 Tetrahydrofolyl-[Glu](2) 574.21356 C29H37N9O12 Tetrahydrofolyl-[Glu](n) 703.25616 2800-34-2 CAS 530 PubChem-compound 4033-27-6 CAS HMDB0006825 HMDB HMDB0006826 HMDB Ammonia 1.0 962 PubChem-compound 5,10-Methylene-THF SubPathwayInput 5800 ChemSpider C01045 KEGG Compound CO2 Carbon dioxide 43.98983 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial C-1-tetrahydrofolate synthase, cytoplasmic C00080 KEGG Compound Glutamate Metabolism SubPathway HMDB0000051 HMDB HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O SMILES OC=O 14265-44-2 CAS 5,10-methenyl-thf BioCyc Methionyl-tRNA formyltransferase, mitochondrial Monofunctional C1-tetrahydrofolate synthase, mitochondrial 58-64-0 CAS C03479 KEGG Compound CHEBI:209153 ChEBI SMILES NC1=NC2=C(N(C=O)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 FOLATE BioCyc SMILES CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2 10-Formyltetrahydrofolate SubPathwayInput HMDB0001396 HMDB 1.0 64-18-6 CAS 1.0 SMILES [H][C@@]12CN(C=[N+]1C1=C(NC2)NC(N)=NC1=O)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O 1.0 SMILES NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1 22833512 PubChem-compound N-formylmethionyl-tRNA(fMet) H2O Water 18.010565 Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.0 NADH BioCyc 5-Formiminotetrahydrofolic acid SubPathwayOutput NAD BioCyc 5815 ChemSpider HMDB0059597 HMDB 559356 ChemSpider 5,10-Methenyltetrahydrofolic acid 1.0 Formimidoyltransferase-cyclodeaminase Formic acid SMILES NC1=NC2=C(N(C=N)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 SMILES [H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O 134-35-0 CAS NAD HMDB0003470 HMDB HMDB0001056 HMDB 1.0 30572 ChemSpider 17215925 ChemSpider 2.0 Folic acid 5-formyltetrahydrofolate cyclo-ligase Dihydrofolic acid SubPathwayInput Methionine Metabolism SubPathway SMILES O Methionyl-tRNA formyltransferase, mitochondrial H3N Ammonia 17.026548 1.0 2.0 HMDB0000538 HMDB Gamma-glutamyl hydrolase Dihydrofolate reductase Histidine Metabolism SubPathway Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Water CHEBI:15846 ChEBI Folic acid ADP BioCyc Pyrimidine Metabolism SubPathway 53-59-8 CAS Lysosome P00374 UniProt 1.0 CHEBI:48309 ChEBI 1038 PubChem-compound 143 PubChem-compound Folate Metabolism 278 ChemSpider C19H23N7O6 Tetrahydrofolic acid 445.171 2.0 Purine Metabolism SubPathway 274 ChemSpider Hydrogen Ion CHEBI:16908 ChEBI 1.5.1.20 false 1.5.1.20 5,10-Methylene-THF + NADH → 5-Methyltetrahydrofolic acid + NAD LEFT_TO_RIGHT Reaction789 false 5-Formiminotetrahydrofolic acid ↔ 5,10-Methenyltetrahydrofolic acid + Ammonia REVERSIBLE O4P Phosphate 94.95342 Gamma-glutamyl hydrolase Dihydrofolate reductase HMDB0001533 HMDB Adenosine triphosphate HMDB0001534 HMDB TransportCatalysis229 ACTIVATION C21H30N7O17P3 NADPH 745.0911 6.3.3.2 false 6.3.3.2 Adenosine triphosphate + N5-Formyl-THF → 5,10-Methenyltetrahydrofolic acid + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT 140 ChemSpider Reaction787 false 5,10-Methenyltetrahydrofolic acid + NADPH ↔ 5,10-Methylene-THF + NADP REVERSIBLE Reaction784 false L-Glutamic acid + N5-Formyl-THF → N-Formyl-L-glutamic acid + Tetrahydrofolic acid LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 Reaction785 false 10-Formyltetrahydrofolate + Hydrogen Ion ↔ 5,10-Methenyltetrahydrofolic acid + Water REVERSIBLE Mitochondrion THF BioCyc Reaction782 false Adenosine triphosphate + Formic acid + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT 1.5.1.6 false 1.5.1.6 10-Formyltetrahydrofolate + NADP + Water → Carbon dioxide + NADPH + Tetrahydrofolic acid LEFT_TO_RIGHT 1.5.1.3 false 1.5.1.3 NADP + Tetrahydrofolic acid ↔ Dihydrofolic acid + NADPH REVERSIBLE CHEBI:15641 ChEBI NADPH BioCyc 1.0 O95954 UniProt 217 ChemSpider SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 58-68-4 CAS Water SMILES [O-]P([O-])([O-])=O C20H21N7O6 5,10-Methenyltetrahydrofolic acid 455.15533 HMDB0000217 HMDB 1.0 Dihydrofolate reductase CHEBI:15637 ChEBI 124-38-9 CAS CHEBI:15639 ChEBI GO:0005764 GENE ONTOLOGY SMP0000046 SMPDB C19H19N7O6 Folic acid 441.13968 SMP0000044 SMPDB Tetrahydrofolyl-[Glu](2) HMDB0001429 HMDB P13995 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMP0000050 SMPDB HMDB0000221 HMDB 1.0 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C20H23N7O6 5,10-Methylene-THF 457.171 C20H24N8O6 5-Formiminotetrahydrofolic acid 472.1819 Q96DP5 UniProt GLT BioCyc 7664-41-7 CAS Glycine and Serine Metabolism SubPathway SMP0000053 SMPDB 53-57-6 CAS P11586 UniProt SMILES O=C=O 1.0 222 PubChem-compound Proton-coupled folate transporter Monofunctional C1-tetrahydrofolate synthase, mitochondrial C21H29N7O14P2 NADH 665.12476 1.0 5-FORMIMINO-THF BioCyc 5957 PubChem-compound 1681-96-5 CAS HMDB0001562 HMDB CHEBI:15633 ChEBI CHEBI:15636 ChEBI Folylpolyglutamate synthase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial 5,10-Methenyltetrahydrofolic acid SMP0000072 SMPDB 1.0 GO:0005739 GENE ONTOLOGY Monofunctional C1-tetrahydrofolate synthase, mitochondrial C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY 1.0 HMDB0000121 HMDB 1.5.1.3 false 1.5.1.3 Dihydrofolic acid + NADP ↔ Folic acid + NADPH REVERSIBLE Transport24 false Folic acid (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 1.0 NADH CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O Transport22 false Tetrahydrofolic acid (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT 5682 ChemSpider Q05932 UniProt 1.0 1.0 SMP0000004 SMPDB 21231977 ChemSpider 5675 ChemSpider P49914 UniProt 18971002 PubChem-compound Cytoplasm 5,10-Methylene-THF SubPathwayInput NADPH Gamma-glutamyl hydrolase CHEBI:15422 ChEBI CHEBI:16635 ChEBI ReactionCatalysis330 ACTIVATION Homo sapiens 388299 ChemSpider Hydrogen Ion CH2O2 Formic acid 46.005478 Tetrahydrofolyl-[Glu](2) CHEBI:28624 ChEBI 1.0 ReactionCatalysis328 ACTIVATION ReactionCatalysis329 ACTIVATION ReactionCatalysis326 ACTIVATION ReactionCatalysis324 ACTIVATION CHEBI:27650 ChEBI C5H9NO4 L-Glutamic acid 147.05316 ReactionCatalysis325 ACTIVATION C00504 KEGG Compound 33032 PubChem-compound ReactionCatalysis322 ACTIVATION ReactionCatalysis323 ACTIVATION 1.0 ReactionCatalysis320 ACTIVATION Water ReactionCatalysis321 ACTIVATION CHEBI:16526 ChEBI SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1 CHEBI:16761 ChEBI C20H23N7O7 N5-Formyl-THF 473.1659 C20H25N7O6 5-Methyltetrahydrofolic acid 459.18665 ReactionCatalysis319 ACTIVATION ReactionCatalysis317 ACTIVATION ReactionCatalysis318 ACTIVATION ReactionCatalysis315 ACTIVATION ReactionCatalysis316 ACTIVATION NADH SMP0000033 SMPDB ReactionCatalysis313 ACTIVATION ReactionCatalysis314 ACTIVATION PW000024 PathWhiz 9606 TAXONOMY 1.0 1.0 1.0 5893 PubChem-compound Formic acid 439234 PubChem-compound 6.3.2.17 false 6.3.2.17 Adenosine triphosphate + L-Glutamic acid + Tetrahydrofolic acid → Adenosine diphosphate + Phosphate + Tetrahydrofolyl-[Glu](2) LEFT_TO_RIGHT HMDB0000972 HMDB CHEBI:30751 ChEBI SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 2.0 CHEBI:27470 ChEBI Methylenetetrahydrofolate reductase 2.1.2.9 false 2.1.2.9 10-Formyltetrahydrofolate + L-methionyl-tRNA(Met) → N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid LEFT_TO_RIGHT Reaction794 false 5,10-Methenyltetrahydrofolic acid + NADH ↔ 5,10-Methylene-THF + NAD REVERSIBLE 6.3.2.17 false 6.3.2.17 Adenosine triphosphate + L-Glutamic acid + Tetrahydrofolyl-[Glu](2) → Adenosine diphosphate + Phosphate + Tetrahydrofolyl-[Glu](n) LEFT_TO_RIGHT 3.4.19.9 false 3.4.19.9 Tetrahydrofolyl-[Glu](n) + Water → L-Glutamic acid + Tetrahydrofolyl-[Glu](2) LEFT_TO_RIGHT 1.0 CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound SMILES NC1=NC2=C(NC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)CN2)C(=O)N1 1.0 Phosphate SMILES NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1 1.0 280 PubChem-compound C00415 KEGG Compound PW000003 PathWhiz 89228 ChemSpider 388371 ChemSpider 1.0 388496 ChemSpider 2311-81-1 CAS 439376 PubChem-compound 1061 PubChem-compound CPD-600 BioCyc 109092 ChemSpider HMDB0001846 HMDB HMDB0001967 HMDB C00664 KEGG Compound Tetrahydrofolic acid SubPathwayInput 13781857 PubChem-compound N5-Formyl-THF 1.0 59-30-3 CAS