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Acyl-coenzyme A synthetase ACSM1, mitochondrial 388357 ChemSpider C4H8O2 Butyric acid 88.05243 C23H38N7O17P3S Acetyl-CoA 809.1258 439161 PubChem-compound 937 ChemSpider Adenosine triphosphate 1.0 Butyric acid 388353 ChemSpider 259 ChemSpider 439153 PubChem-compound SMILES O Enoyl-CoA hydratase, mitochondrial C10H14N5O7P Adenosine monophosphate 347.06308 CHEBI:16027 ChEBI CHEBI:57371 ChEBI HMDB0000538 HMDB ATP BioCyc 6816 PubChem-compound 559142 ChemSpider CHEBI:15846 ChEBI 102680-35-3 CAS C4H6O3 Acetoacetic acid 102.03169 ReactionCatalysis177 ACTIVATION ReactionCatalysis178 ACTIVATION 1.0 1553-55-5 CAS ReactionCatalysis175 ACTIVATION ReactionCatalysis176 ACTIVATION CHEBI:15380 ChEBI 5280381 PubChem-compound 5742 ChemSpider 1038 PubChem-compound C25H40N7O19P3S Succinyl-CoA 867.1312 265 PubChem-compound P35914 UniProt Intestinal Microflora SubPathway C00332 KEGG Compound 264 PubChem-compound 440045 PubChem-compound C25H40N7O17P3S Crotonoyl-CoA 835.1414 Hydroxymethylglutaryl-CoA lyase, mitochondrial Reduced electron-transfer flavoprotein Butyryl-CoA CHEBI:16908 ChEBI HMDB0001088 HMDB 5858 ChemSpider 4.0 CHEBI:30772 ChEBI 1010 ChemSpider Enoyl-CoA hydratase, mitochondrial 107-92-6 CAS SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 1.0 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial PPI BioCyc 260 ChemSpider Mitochondrion SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O electron-transfer flavoprotein P16219 UniProt C00356 KEGG Compound CHEBI:5086 ChEBI 4444072 ChemSpider SUC BioCyc 58-68-4 CAS Short-chain specific acyl-CoA dehydrogenase, mitochondrial HMDB0001423 HMDB Adenosine monophosphate 1.0 SMILES C\C=C\C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C(N)N=CN=C12 94 ChemSpider P30084 UniProt 2.0 2.0 Acetyl-CoA acetyltransferase, mitochondrial ReactionCatalysis185 ACTIVATION C00001 KEGG Compound 1.0 ReactionCatalysis182 ACTIVATION ReactionCatalysis183 ACTIVATION CHEBI:18361 ChEBI NADH CPD-1083 BioCyc C00004 KEGG Compound C00246 KEGG Compound C00003 KEGG Compound Acetyl-CoA acetyltransferase, mitochondrial C00002 KEGG Compound 1.0 4.0 2.0 GO:0005759 GENE ONTOLOGY Pyrophosphate P24752 UniProt Coenzyme A Q08AH1 UniProt SMILES C[C@@H](O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N CHEBI:15741 ChEBI C21H28N7O14P2 NAD 664.11694 C00010 KEGG Compound HMDB0000902 HMDB C00136 KEGG Compound P55809 UniProt 1110 PubChem-compound Hydrogen Ion C00013 KEGG Compound 1.0 O7P2 Pyrophosphate 173.91193 C25H40N7O18P3S Acetoacetyl-CoA 851.13635 C21H29N7O14P2 NADH 665.12476 3-HYDROXY-3-METHYL-GLUTARYL-COA BioCyc HMDB0001206 HMDB 5957 PubChem-compound C4H6O4 Succinic acid 118.02661 H Hydrogen Ion 1.007825 C25H42N7O17P3S Butyryl-CoA 837.15704 3-oxoacid CoA-transferase 1 388307 ChemSpider 56-65-5 CAS 53-84-9 CAS C00020 KEGG Compound C00024 KEGG Compound SMP0000073 SMPDB 1.0 Short-chain specific acyl-CoA dehydrogenase, mitochondrial GO:0005739 GENE ONTOLOGY SMP0000071 SMPDB 1.0 GO:0005737 GENE ONTOLOGY Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Hydroxymethylglutaryl-CoA lyase, mitochondrial 1.0 3-KETOBUTYRATE BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O electron-transfer flavoprotein 1.0 2-METHYL-3-HYDROXY-BUTYRYL-COA BioCyc 5682 ChemSpider Short-chain specific acyl-CoA dehydrogenase, mitochondrial SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Reduced electron-transfer flavoprotein CHEBI:1146900 ChEBI HMDB0000254 HMDB 2871-66-1 CAS SMILES CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N SMILES OC(=O)CCC(O)=O AMP BioCyc Mitochondrial Matrix HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS CO-A BioCyc Transport13 false Butyric acid (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT C00164 KEGG Compound C00042 KEGG Compound 72-89-9 CAS 1078 ChemSpider Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial CPD-12174 BioCyc CHEBI:15452 ChEBI 1.0 389056 ChemSpider SMILES CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N C03561 KEGG Compound C21H36N7O16P3S Coenzyme A 767.11523 604-98-8 CAS Cytoplasm 3-Hydroxybutyryl-CoA Q16836 UniProt ACETOACETYL-COA BioCyc Succinyl-CoA CHEBI:15422 ChEBI 6557 ChemSpider 1.0 Homo sapiens SMILES CCCC(O)=O SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 7732-18-5 CAS 388299 ChemSpider Crotonoyl-CoA HMDB0001487 HMDB C27H44N7O20P3S 3-Hydroxy-3-methylglutaryl-CoA 911.1575 61-19-8 CAS 2140-48-9 CAS 2.0 SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 439214 PubChem-compound 1.0 HMDB0000039 HMDB 1.0 Acetoacetyl-CoA 1.0 HMDB0001484 HMDB 439218 PubChem-compound 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 Butyric acid SubPathwayInput NAD Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial HMDB0000045 HMDB SMILES CC(=O)CC(O)=O Acyl-coenzyme A synthetase ACSM1, mitochondrial HMDB0001375 HMDB 9606 TAXONOMY 962 PubChem-compound C00877 KEGG Compound Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.0 Acetoacetic acid SubPathwayInput PW000028 PathWhiz 1.3.8.1 false 1.3.8.1 Butyryl-CoA + electron-transfer flavoprotein ↔ Crotonoyl-CoA + Reduced electron-transfer flavoprotein REVERSIBLE 4.2.1.17 false 4.2.1.17 3-Hydroxybutyryl-CoA ↔ Crotonoyl-CoA + Water REVERSIBLE 392413 ChemSpider 3-Hydroxy-3-methylglutaryl-CoA C25H42N7O18P3S 3-Hydroxybutyryl-CoA 853.152 5893 PubChem-compound C00080 KEGG Compound 110-15-6 CAS Water Butyrate Metabolism Ketone Body Metabolism SubPathway Enoyl-CoA hydratase, mitochondrial HMDB0002111 HMDB 1420-36-6 CAS SMILES C[C@](O)(CC(O)=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N Butyryl-CoA SubPathwayInteraction870 SubPathway870Reaction SubPathwayReaction HMDB0001022 HMDB Hydroxymethylglutaryl-CoA lyase, mitochondrial CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PW000014 PathWhiz 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 6.0 1.1.1.35 false 1.1.1.35 3-Hydroxybutyryl-CoA + NAD → Acetoacetyl-CoA + Hydrogen Ion + NADH LEFT_TO_RIGHT C00091 KEGG Compound HMDB0002009 HMDB 1.0 HMDB0000060 HMDB 6.2.1.2 false 6.2.1.2 Adenosine triphosphate + Butyric acid + Coenzyme A → Adenosine monophosphate + Butyryl-CoA + Pyrophosphate LEFT_TO_RIGHT 2.8.3.5 false 2.8.3.5 Acetoacetic acid + Succinyl-CoA ↔ Acetoacetyl-CoA + Succinic acid REVERSIBLE 96 PubChem-compound 4.1.3.4 false 4.1.3.4 3-Hydroxy-3-methylglutaryl-CoA → Acetoacetic acid + Acetyl-CoA LEFT_TO_RIGHT 2.3.1.9 false 2.3.1.9 2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A REVERSIBLE Reaction682 false Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A LEFT_TO_RIGHT CHEBI:15344 ChEBI CHEBI:15467 ChEBI CHEBI:15345 ChEBI 644102 PubChem-compound 444493 PubChem-compound Succinic acid 6083 PubChem-compound Crotonoyl-CoA ACETYL-COA BioCyc H2O Water 18.010565 1.0 541-50-4 CAS NADH BioCyc 3-METHYLBENZYLSUCCINYL-COA BioCyc HMDB0001166 HMDB NAD BioCyc 1.0 Acetyl-CoA acetyltransferase, mitochondrial HMDB0059597 HMDB CHEBI:15351 ChEBI CHEBI:15473 ChEBI Acetyl-CoA 85-61-0 CAS SubPathwayInteraction17 SubPathway17Reaction SubPathwayReaction Enoyl-CoA hydratase, mitochondrial Hydroxyacyl- coenzyme A dehydrogenase, mitochondrial Acetyl-CoA acetyltransferase, mitochondrial Hydroxymethylglutaryl- CoA synthase, mitochondrial Succinyl- CoA:3- ketoacid coenzyme A transferase 1, mitochondrial Hydroxymethylglutaryl- CoA lyase, mitochondrial Acyl-coenzyme A synthetase ACSM1, mitochondrial Short-chain specific acyl-CoA dehydrogenase, mitochondrial Butyric acid Acetoacetic acid Butyric acid 3-Hydroxybutyryl-CoA Crotonoyl-CoA H 2 O NAD Acetoacetyl-CoA NADH Acetyl-CoA CoA H 2 O 3-Hydroxy-3-methylglutaryl-CoA CoA Succinyl-CoA Succinic acid Acetyl-CoA ATP CoA AMP PP i Butyryl-CoA Magnesium FAD electron- transfer flavoprotein Reduced electron- transfer flavoprotein Ketone Body Metabolism Mitochondrion Mitochondrial matrix Inner Mitochondria Membrane Outer Mitochondria Membrane Intracellular Space Extracellular Space Intracellular Space Extracellular Space
Acyl-coenzyme A synthetase ACSM1, mitochondrial 388357 ChemSpider C4H8O2 Butyric acid 88.05243 C23H38N7O17P3S Acetyl-CoA 809.1258 439161 PubChem-compound 937 ChemSpider Adenosine triphosphate 1.0 Butyric acid 388353 ChemSpider 259 ChemSpider 439153 PubChem-compound SMILES O Enoyl-CoA hydratase, mitochondrial C10H14N5O7P Adenosine monophosphate 347.06308 CHEBI:16027 ChEBI CHEBI:57371 ChEBI HMDB0000538 HMDB ATP BioCyc 6816 PubChem-compound 559142 ChemSpider CHEBI:15846 ChEBI 102680-35-3 CAS C4H6O3 Acetoacetic acid 102.03169 ReactionCatalysis177 ACTIVATION ReactionCatalysis178 ACTIVATION 1.0 1553-55-5 CAS ReactionCatalysis175 ACTIVATION ReactionCatalysis176 ACTIVATION CHEBI:15380 ChEBI 5280381 PubChem-compound 5742 ChemSpider 1038 PubChem-compound C25H40N7O19P3S Succinyl-CoA 867.1312 265 PubChem-compound P35914 UniProt Intestinal Microflora SubPathway C00332 KEGG Compound 264 PubChem-compound 440045 PubChem-compound C25H40N7O17P3S Crotonoyl-CoA 835.1414 Hydroxymethylglutaryl-CoA lyase, mitochondrial Reduced electron-transfer flavoprotein Butyryl-CoA CHEBI:16908 ChEBI HMDB0001088 HMDB 5858 ChemSpider 4.0 CHEBI:30772 ChEBI 1010 ChemSpider Enoyl-CoA hydratase, mitochondrial 107-92-6 CAS SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 1.0 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial PPI BioCyc 260 ChemSpider Mitochondrion SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O electron-transfer flavoprotein P16219 UniProt C00356 KEGG Compound CHEBI:5086 ChEBI 4444072 ChemSpider SUC BioCyc 58-68-4 CAS Short-chain specific acyl-CoA dehydrogenase, mitochondrial HMDB0001423 HMDB Adenosine monophosphate 1.0 SMILES C\C=C\C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C(N)N=CN=C12 94 ChemSpider P30084 UniProt 2.0 2.0 Acetyl-CoA acetyltransferase, mitochondrial ReactionCatalysis185 ACTIVATION C00001 KEGG Compound 1.0 ReactionCatalysis182 ACTIVATION ReactionCatalysis183 ACTIVATION CHEBI:18361 ChEBI NADH CPD-1083 BioCyc C00004 KEGG Compound C00246 KEGG Compound C00003 KEGG Compound Acetyl-CoA acetyltransferase, mitochondrial C00002 KEGG Compound 1.0 4.0 2.0 GO:0005759 GENE ONTOLOGY Pyrophosphate P24752 UniProt Coenzyme A Q08AH1 UniProt SMILES C[C@@H](O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N CHEBI:15741 ChEBI C21H28N7O14P2 NAD 664.11694 C00010 KEGG Compound HMDB0000902 HMDB C00136 KEGG Compound P55809 UniProt 1110 PubChem-compound Hydrogen Ion C00013 KEGG Compound 1.0 O7P2 Pyrophosphate 173.91193 C25H40N7O18P3S Acetoacetyl-CoA 851.13635 C21H29N7O14P2 NADH 665.12476 3-HYDROXY-3-METHYL-GLUTARYL-COA BioCyc HMDB0001206 HMDB 5957 PubChem-compound C4H6O4 Succinic acid 118.02661 H Hydrogen Ion 1.007825 C25H42N7O17P3S Butyryl-CoA 837.15704 3-oxoacid CoA-transferase 1 388307 ChemSpider 56-65-5 CAS 53-84-9 CAS C00020 KEGG Compound C00024 KEGG Compound SMP0000073 SMPDB 1.0 Short-chain specific acyl-CoA dehydrogenase, mitochondrial GO:0005739 GENE ONTOLOGY SMP0000071 SMPDB 1.0 GO:0005737 GENE ONTOLOGY Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Hydroxymethylglutaryl-CoA lyase, mitochondrial 1.0 3-KETOBUTYRATE BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O electron-transfer flavoprotein 1.0 2-METHYL-3-HYDROXY-BUTYRYL-COA BioCyc 5682 ChemSpider Short-chain specific acyl-CoA dehydrogenase, mitochondrial SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Reduced electron-transfer flavoprotein CHEBI:1146900 ChEBI HMDB0000254 HMDB 2871-66-1 CAS SMILES CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N SMILES OC(=O)CCC(O)=O AMP BioCyc Mitochondrial Matrix HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS CO-A BioCyc Transport13 false Butyric acid (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT C00164 KEGG Compound C00042 KEGG Compound 72-89-9 CAS 1078 ChemSpider Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial CPD-12174 BioCyc CHEBI:15452 ChEBI 1.0 389056 ChemSpider SMILES CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N C03561 KEGG Compound C21H36N7O16P3S Coenzyme A 767.11523 604-98-8 CAS Cytoplasm 3-Hydroxybutyryl-CoA Q16836 UniProt ACETOACETYL-COA BioCyc Succinyl-CoA CHEBI:15422 ChEBI 6557 ChemSpider 1.0 Homo sapiens SMILES CCCC(O)=O SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 7732-18-5 CAS 388299 ChemSpider Crotonoyl-CoA HMDB0001487 HMDB C27H44N7O20P3S 3-Hydroxy-3-methylglutaryl-CoA 911.1575 61-19-8 CAS 2140-48-9 CAS 2.0 SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 439214 PubChem-compound 1.0 HMDB0000039 HMDB 1.0 Acetoacetyl-CoA 1.0 HMDB0001484 HMDB 439218 PubChem-compound 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 Butyric acid SubPathwayInput NAD Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial HMDB0000045 HMDB SMILES CC(=O)CC(O)=O Acyl-coenzyme A synthetase ACSM1, mitochondrial HMDB0001375 HMDB 9606 TAXONOMY 962 PubChem-compound C00877 KEGG Compound Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.0 Acetoacetic acid SubPathwayInput PW000028 PathWhiz 1.3.8.1 false 1.3.8.1 Butyryl-CoA + electron-transfer flavoprotein ↔ Crotonoyl-CoA + Reduced electron-transfer flavoprotein REVERSIBLE 4.2.1.17 false 4.2.1.17 3-Hydroxybutyryl-CoA ↔ Crotonoyl-CoA + Water REVERSIBLE 392413 ChemSpider 3-Hydroxy-3-methylglutaryl-CoA C25H42N7O18P3S 3-Hydroxybutyryl-CoA 853.152 5893 PubChem-compound C00080 KEGG Compound 110-15-6 CAS Water Butyrate Metabolism Ketone Body Metabolism SubPathway Enoyl-CoA hydratase, mitochondrial HMDB0002111 HMDB 1420-36-6 CAS SMILES C[C@](O)(CC(O)=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N Butyryl-CoA SubPathwayInteraction870 SubPathway870Reaction SubPathwayReaction HMDB0001022 HMDB Hydroxymethylglutaryl-CoA lyase, mitochondrial CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PW000014 PathWhiz 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 6.0 1.1.1.35 false 1.1.1.35 3-Hydroxybutyryl-CoA + NAD → Acetoacetyl-CoA + Hydrogen Ion + NADH LEFT_TO_RIGHT C00091 KEGG Compound HMDB0002009 HMDB 1.0 HMDB0000060 HMDB 6.2.1.2 false 6.2.1.2 Adenosine triphosphate + Butyric acid + Coenzyme A → Adenosine monophosphate + Butyryl-CoA + Pyrophosphate LEFT_TO_RIGHT 2.8.3.5 false 2.8.3.5 Acetoacetic acid + Succinyl-CoA ↔ Acetoacetyl-CoA + Succinic acid REVERSIBLE 96 PubChem-compound 4.1.3.4 false 4.1.3.4 3-Hydroxy-3-methylglutaryl-CoA → Acetoacetic acid + Acetyl-CoA LEFT_TO_RIGHT 2.3.1.9 false 2.3.1.9 2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A REVERSIBLE Reaction682 false Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A LEFT_TO_RIGHT CHEBI:15344 ChEBI CHEBI:15467 ChEBI CHEBI:15345 ChEBI 644102 PubChem-compound 444493 PubChem-compound Succinic acid 6083 PubChem-compound Crotonoyl-CoA ACETYL-COA BioCyc H2O Water 18.010565 1.0 541-50-4 CAS NADH BioCyc 3-METHYLBENZYLSUCCINYL-COA BioCyc HMDB0001166 HMDB NAD BioCyc 1.0 Acetyl-CoA acetyltransferase, mitochondrial HMDB0059597 HMDB CHEBI:15351 ChEBI CHEBI:15473 ChEBI Acetyl-CoA 85-61-0 CAS SubPathwayInteraction17 SubPathway17Reaction SubPathwayReaction Mitochondria ECHS1 HADH ACAT1 HMGCS2 OXCT1 HMGCL ACSM1 ACADS Butyric acid Acetoacetic acid Butyric acid 3- Hydroxybutyryl- CoA Crotonoyl-CoA Water NAD Acetoacetyl-CoA NADH Acetyl-CoA Coenzyme A Water 3-Hydroxy-3- methylglutaryl- CoA Coenzyme A Succinyl-CoA Succinic acid Acetyl-CoA Adenosine triphosphate Coenzyme A Adenosine monophosphate Pyrophosphate Butyryl-CoA electron- transfer flavoprotein Reduced electron- transfer flavoprotein Intestinal Microflora Ketone Body Metabolism