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247 PubChem-compound 454-29-5 CAS 249 PubChem-compound 937 ChemSpider S-adenosylmethionine synthase isoform type-2 C05330 KEGG Compound 1.0 439153 PubChem-compound SMILES O HMDB0000092 HMDB C10H13N5O4 Adenosine 267.09674 Tetrahydrofolic acid SubPathwayInput CHEBI:15958 ChEBI HMDB0000097 HMDB HMDB0001185 HMDB C5H11NO2 Betaine 117.07898 Alpha-aminoadipic semialdehyde dehydrogenase CHEBI:20506 ChEBI HMDB0061372 HMDB HMDB0061371 HMDB HMDB0000538 HMDB Betaine CHEBI:17230 ChEBI C00440 KEGG Compound ATP BioCyc 6137 PubChem-compound 5-METHYL-THF BioCyc Homocysteine Methionine synthase S-adenosylmethionine synthase isoform type-2 1.0 18714427 ChemSpider 244 ChemSpider Water 242 ChemSpider 559142 ChemSpider CHEBI:15846 ChEBI Betaine 49791978 PubChem-compound Betaine--homocysteine S-methyltransferase 1 C15H23N6O5S S-Adenosylmethionine 399.14505 1.0 5742 ChemSpider ReactionCatalysis170 ACTIVATION C00576 KEGG Compound Q93088 UniProt C00212 KEGG Compound One Carbon Pool by Folate SubPathway SMILES CSCC[C@H](N)C(O)=O CHEBI:15022 ChEBI Alpha-aminoadipic semialdehyde dehydrogenase GO:0005829 GENE ONTOLOGY C19H23N7O6 Tetrahydrofolic acid 445.171 1.0 Phosphatidylethanolamine N-methyltransferase BETAINE_ALDEHYDE BioCyc 107-43-7 CAS CHEBI:16908 ChEBI ReactionCatalysis168 ACTIVATION ReactionCatalysis169 ACTIVATION ReactionCatalysis166 ACTIVATION ReactionCatalysis167 ACTIVATION ReactionCatalysis164 ACTIVATION 2.1.1.5 false 2.1.1.5 Betaine + Homocysteine → Dimethylglycine + L-Methionine LEFT_TO_RIGHT ADENOSYL-HOMO-CYS BioCyc 1.0 CHEBI:15710 ChEBI ReactionCatalysis165 ACTIVATION Reaction667 false Betaine aldehyde + NAD + Water → Betaine + NADH LEFT_TO_RIGHT 1.1.99.1 false 1.1.99.1 Acceptor + Choline → Betaine aldehyde + Reduced acceptor LEFT_TO_RIGHT 485-80-3 CAS O4P Phosphate 94.95342 7418-61-3 CAS C00101 KEGG Compound 1.0 PPI BioCyc 1.0 Mitochondrion THF BioCyc CHEBI:15641 ChEBI SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N 979-92-0 CAS Cytosol 1.0 C00114 KEGG Compound C14H20N6O5S S-Adenosylhomocysteine 384.12158 58-68-4 CAS SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 Water HMDB0000696 HMDB SMILES [O-]P([O-])([O-])=O C00009 KEGG Compound 5-Methyltetrahydrofolic acid SubPathwayOutput CHEBI:15414 ChEBI Choline C00001 KEGG Compound HMDB0001429 HMDB Adenosine 1.0 Acceptor CHEBI:18361 ChEBI C00004 KEGG Compound 673 PubChem-compound CHEBI:18367 ChEBI C00003 KEGG Compound 135-16-0 CAS 1032 ChemSpider C00002 KEGG Compound Q8NE62 UniProt Q99707 UniProt 4.0 Betaine Metabolism C5H12NO Betaine aldehyde 102.09189 C00019 KEGG Compound 60961 PubChem-compound 1.0 C21H28N7O14P2 NAD 664.11694 1.0 Adenosine triphosphate S-ADENOSYLMETHIONINE BioCyc HMDB0000902 HMDB Extracellular Space C00013 KEGG Compound Homocysteine O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 1.0 1.0 5957 PubChem-compound 1.0 SMILES NC(CCS)C(O)=O 1.0 Phosphatidyl-N-methylethanolamine SMILES CCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN(C)C)OC(=O)CCCCCCC\C=C/CCCC 388301 ChemSpider SMILES CCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCC[N](C)(C)C)OC(=O)CCCCCCC\C=C/CCCC CPD-563 BioCyc MET BioCyc 56-65-5 CAS C00021 KEGG Compound 53-84-9 CAS 1.0 1.0 GO:0005739 GENE ONTOLOGY GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY 1118-68-9 CAS 1.0 1.0 C5H14NO Choline 104.10754 C4H9NO2 Dimethylglycine 103.06333 C5H11NO2S L-Methionine 149.05106 Methionine adenosyltransferase 2 subunit beta Phosphatidyl-ethanolamide SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc SMILES C[N+](C)(C)CC=O 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 653 ChemSpider Transport9 false Betaine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT 1.0 C00719 KEGG Compound SMP0000123 SMPDB HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS Phosphatidylethanolamine N-methyltransferase C36H69NO8P Phosphatidyl-N-methylethanolamine 674.4761 C35H66NO8P Phosphatidyl-ethanolamide 659.4526 CHEBI:15339 ChEBI Adenosylhomocysteinase CHEBI:17750 ChEBI S-Adenosylmethionine Transport10 false Choline (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT HMDB0000939 HMDB SMILES C[N+](C)(C)CCO Dimethylglycine Cytoplasm SMILES CN(C)CC(O)=O Choline dehydrogenase, mitochondrial CHEBI:15422 ChEBI 305 PubChem-compound CHEBI:17724 ChEBI Homo sapiens Methionine adenosyltransferase 2 subunit beta 7732-18-5 CAS 388299 ChemSpider Acceptor Reduced acceptor C01026 KEGG Compound NAD HMDB0001487 HMDB SMILES C[N+](C)(C)CC([O-])=O L-Methionine SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1 63-68-3 CAS 1.0 P31153 UniProt 5907 ChemSpider Water CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 Q9UBM1 UniProt 58-61-7 CAS Pyrophosphate P23526 UniProt S-Adenosylhomocysteine 1.0 C00073 KEGG Compound C20H25N7O6 5-Methyltetrahydrofolic acid 459.18665 2.0 S-adenosylmethionine synthase 1.0 HMDB0001252 HMDB NADH HMDB0000043 HMDB 9606 TAXONOMY 962 PubChem-compound 1.0 DIMETHYL-GLYCINE BioCyc 31983 ChemSpider CHEBI:16335 ChEBI 1.0 Alpha-aminoadipic semialdehyde dehydrogenase Adenosylhomocysteinase 5893 PubChem-compound 439234 PubChem-compound BETAINE BioCyc Betaine aldehyde 299 ChemSpider Methionine synthase Adenosylhomocysteinase HMDB0000050 HMDB HMDB0002111 HMDB Reaction672 false Phosphatidyl-ethanolamide + S-Adenosylmethionine → Phosphatidyl-N-methylethanolamine + S-Adenosylhomocysteine LEFT_TO_RIGHT 3.3.1.1 false 3.3.1.1 S-Adenosylhomocysteine + Water → Adenosine + Homocysteine LEFT_TO_RIGHT 2.1.1.13 false 2.1.1.13 5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid LEFT_TO_RIGHT C4H9NO2S Homocysteine 135.0354 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine LEFT_TO_RIGHT ADENOSINE BioCyc CHEBI:15377 ChEBI PW000012 PathWhiz 14265-44-2 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 4.0 1.0 1.0 Phosphate HOMO-CYS BioCyc Choline dehydrogenase, mitochondrial HMDB0000742 HMDB SMILES CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2 HMDB0001396 HMDB 4.0 4462 PubChem-compound 644102 PubChem-compound Q9NZL9 UniProt Betaine 388371 ChemSpider 1.0 SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O 757 ChemSpider 25246222 PubChem-compound 1.0 H2O Water 18.010565 54923 ChemSpider NADH BioCyc NAD BioCyc Choline CHEBI:15354 ChEBI 1061 PubChem-compound Reduced acceptor HMDB0001846 HMDB 1.0 CHEBI:16680 ChEBI 62-49-7 CAS Betaine--homocysteine S-methyltransferase 1 Betaine aldehyde P49419 UniProt Betaine--homocysteine S-methyltransferase 1 24762165 PubChem-compound SubPathwayInteraction16 SubPathwayReaction SubPathway16Reaction Choline 134-35-0 CAS 1.0 13781857 PubChem-compound S-Adenosylmethionine Alpha- aminoadipic semialdehyde dehydrogenase Betaine-- homocysteine S- methyltransferase 1 Methionine synthase S- adenosylmethionine synthase isoform type-2 Methionine adenosyltransferase 2 subunit beta Adenosylhomocysteinase Choline dehydrogenase, mitochondrial Phosphatidylethanolamine N- methyltransferase Tetrahydrofolic acid 5-Methyltetrahydrofolic acid Betaine Betaine Choline Choline Betaine aldehyde NAD H 2 O NADH Homocysteine Dimethylglycine L-Methionine ATP H 2 O S-Adenosylmethionine P i PP i S-Adenosylhomocysteine H 2 O Adenosine Phosphatidyl-ethanolamide Phosphatidyl-N- methylethanolamine Zinc (II) ion Zinc (II) ion Magnesium Potassium NAD FAD Acceptor Reduced acceptor One Carbon Pool by Folate Extracellular Space Intracellular Space Liver Kidney
247 PubChem-compound 454-29-5 CAS 249 PubChem-compound 937 ChemSpider S-adenosylmethionine synthase isoform type-2 C05330 KEGG Compound 1.0 439153 PubChem-compound SMILES O HMDB0000092 HMDB C10H13N5O4 Adenosine 267.09674 Tetrahydrofolic acid SubPathwayInput CHEBI:15958 ChEBI HMDB0000097 HMDB HMDB0001185 HMDB C5H11NO2 Betaine 117.07898 Alpha-aminoadipic semialdehyde dehydrogenase CHEBI:20506 ChEBI HMDB0061372 HMDB HMDB0061371 HMDB HMDB0000538 HMDB Betaine CHEBI:17230 ChEBI C00440 KEGG Compound ATP BioCyc 6137 PubChem-compound 5-METHYL-THF BioCyc Homocysteine Methionine synthase S-adenosylmethionine synthase isoform type-2 1.0 18714427 ChemSpider 244 ChemSpider Water 242 ChemSpider 559142 ChemSpider CHEBI:15846 ChEBI Betaine 49791978 PubChem-compound Betaine--homocysteine S-methyltransferase 1 C15H23N6O5S S-Adenosylmethionine 399.14505 1.0 5742 ChemSpider ReactionCatalysis170 ACTIVATION C00576 KEGG Compound Q93088 UniProt C00212 KEGG Compound One Carbon Pool by Folate SubPathway SMILES CSCC[C@H](N)C(O)=O CHEBI:15022 ChEBI Alpha-aminoadipic semialdehyde dehydrogenase GO:0005829 GENE ONTOLOGY C19H23N7O6 Tetrahydrofolic acid 445.171 1.0 Phosphatidylethanolamine N-methyltransferase BETAINE_ALDEHYDE BioCyc 107-43-7 CAS CHEBI:16908 ChEBI ReactionCatalysis168 ACTIVATION ReactionCatalysis169 ACTIVATION ReactionCatalysis166 ACTIVATION ReactionCatalysis167 ACTIVATION ReactionCatalysis164 ACTIVATION 2.1.1.5 false 2.1.1.5 Betaine + Homocysteine → Dimethylglycine + L-Methionine LEFT_TO_RIGHT ADENOSYL-HOMO-CYS BioCyc 1.0 CHEBI:15710 ChEBI ReactionCatalysis165 ACTIVATION Reaction667 false Betaine aldehyde + NAD + Water → Betaine + NADH LEFT_TO_RIGHT 1.1.99.1 false 1.1.99.1 Acceptor + Choline → Betaine aldehyde + Reduced acceptor LEFT_TO_RIGHT 485-80-3 CAS O4P Phosphate 94.95342 7418-61-3 CAS C00101 KEGG Compound 1.0 PPI BioCyc 1.0 Mitochondrion THF BioCyc CHEBI:15641 ChEBI SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N 979-92-0 CAS Cytosol 1.0 C00114 KEGG Compound C14H20N6O5S S-Adenosylhomocysteine 384.12158 58-68-4 CAS SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 Water HMDB0000696 HMDB SMILES [O-]P([O-])([O-])=O C00009 KEGG Compound 5-Methyltetrahydrofolic acid SubPathwayOutput CHEBI:15414 ChEBI Choline C00001 KEGG Compound HMDB0001429 HMDB Adenosine 1.0 Acceptor CHEBI:18361 ChEBI C00004 KEGG Compound 673 PubChem-compound CHEBI:18367 ChEBI C00003 KEGG Compound 135-16-0 CAS 1032 ChemSpider C00002 KEGG Compound Q8NE62 UniProt Q99707 UniProt 4.0 Betaine Metabolism C5H12NO Betaine aldehyde 102.09189 C00019 KEGG Compound 60961 PubChem-compound 1.0 C21H28N7O14P2 NAD 664.11694 1.0 Adenosine triphosphate S-ADENOSYLMETHIONINE BioCyc HMDB0000902 HMDB Extracellular Space C00013 KEGG Compound Homocysteine O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 1.0 1.0 5957 PubChem-compound 1.0 SMILES NC(CCS)C(O)=O 1.0 Phosphatidyl-N-methylethanolamine SMILES CCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN(C)C)OC(=O)CCCCCCC\C=C/CCCC 388301 ChemSpider SMILES CCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCC[N](C)(C)C)OC(=O)CCCCCCC\C=C/CCCC CPD-563 BioCyc MET BioCyc 56-65-5 CAS C00021 KEGG Compound 53-84-9 CAS 1.0 1.0 GO:0005739 GENE ONTOLOGY GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY 1118-68-9 CAS 1.0 1.0 C5H14NO Choline 104.10754 C4H9NO2 Dimethylglycine 103.06333 C5H11NO2S L-Methionine 149.05106 Methionine adenosyltransferase 2 subunit beta Phosphatidyl-ethanolamide SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc SMILES C[N+](C)(C)CC=O 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 653 ChemSpider Transport9 false Betaine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT 1.0 C00719 KEGG Compound SMP0000123 SMPDB HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS Phosphatidylethanolamine N-methyltransferase C36H69NO8P Phosphatidyl-N-methylethanolamine 674.4761 C35H66NO8P Phosphatidyl-ethanolamide 659.4526 CHEBI:15339 ChEBI Adenosylhomocysteinase CHEBI:17750 ChEBI S-Adenosylmethionine Transport10 false Choline (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT HMDB0000939 HMDB SMILES C[N+](C)(C)CCO Dimethylglycine Cytoplasm SMILES CN(C)CC(O)=O Choline dehydrogenase, mitochondrial CHEBI:15422 ChEBI 305 PubChem-compound CHEBI:17724 ChEBI Homo sapiens Methionine adenosyltransferase 2 subunit beta 7732-18-5 CAS 388299 ChemSpider Acceptor Reduced acceptor C01026 KEGG Compound NAD HMDB0001487 HMDB SMILES C[N+](C)(C)CC([O-])=O L-Methionine SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1 63-68-3 CAS 1.0 P31153 UniProt 5907 ChemSpider Water CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 Q9UBM1 UniProt 58-61-7 CAS Pyrophosphate P23526 UniProt S-Adenosylhomocysteine 1.0 C00073 KEGG Compound C20H25N7O6 5-Methyltetrahydrofolic acid 459.18665 2.0 S-adenosylmethionine synthase 1.0 HMDB0001252 HMDB NADH HMDB0000043 HMDB 9606 TAXONOMY 962 PubChem-compound 1.0 DIMETHYL-GLYCINE BioCyc 31983 ChemSpider CHEBI:16335 ChEBI 1.0 Alpha-aminoadipic semialdehyde dehydrogenase Adenosylhomocysteinase 5893 PubChem-compound 439234 PubChem-compound BETAINE BioCyc Betaine aldehyde 299 ChemSpider Methionine synthase Adenosylhomocysteinase HMDB0000050 HMDB HMDB0002111 HMDB Reaction672 false Phosphatidyl-ethanolamide + S-Adenosylmethionine → Phosphatidyl-N-methylethanolamine + S-Adenosylhomocysteine LEFT_TO_RIGHT 3.3.1.1 false 3.3.1.1 S-Adenosylhomocysteine + Water → Adenosine + Homocysteine LEFT_TO_RIGHT 2.1.1.13 false 2.1.1.13 5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid LEFT_TO_RIGHT C4H9NO2S Homocysteine 135.0354 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine LEFT_TO_RIGHT ADENOSINE BioCyc CHEBI:15377 ChEBI PW000012 PathWhiz 14265-44-2 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 4.0 1.0 1.0 Phosphate HOMO-CYS BioCyc Choline dehydrogenase, mitochondrial HMDB0000742 HMDB SMILES CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2 HMDB0001396 HMDB 4.0 4462 PubChem-compound 644102 PubChem-compound Q9NZL9 UniProt Betaine 388371 ChemSpider 1.0 SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O 757 ChemSpider 25246222 PubChem-compound 1.0 H2O Water 18.010565 54923 ChemSpider NADH BioCyc NAD BioCyc Choline CHEBI:15354 ChEBI 1061 PubChem-compound Reduced acceptor HMDB0001846 HMDB 1.0 CHEBI:16680 ChEBI 62-49-7 CAS Betaine--homocysteine S-methyltransferase 1 Betaine aldehyde P49419 UniProt Betaine--homocysteine S-methyltransferase 1 24762165 PubChem-compound SubPathwayInteraction16 SubPathwayReaction SubPathway16Reaction Choline 134-35-0 CAS 1.0 13781857 PubChem-compound S-Adenosylmethionine ALDH7A1 BHMT MTR MAT2A MAT2B AHCY CHDH PEMT Tetrahydrofolic acid 5- Methyltetrahydrofolic acid Betaine Betaine Choline Choline Betaine aldehyde NAD Water NADH Homocysteine Dimethylglycine L-Methionine Adenosine triphosphate Water S- Adenosylmethionine Phosphate Pyrophosphate S- Adenosylhomocysteine Water Adenosine Phosphatidyl- ethanolamide Phosphatidyl- N- methylethanolamine Acceptor Reduced acceptor One Carbon Pool by Folate