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CHEBI:16015 ChEBI 1.0 CHEBI:17345 ChEBI C10H14N5O7P 2'-Deoxyguanosine 5'-monophosphate 347.06308 IDP BioCyc 1.0 C00672 KEGG Compound Q5MY95 UniProt 1.0 CHEBI:16497 ChEBI Phosphoribosylformylglycineamidine C01762 KEGG Compound 1.0 1.0 165388 PubChem-compound Inosine triphosphate pyrophosphatase Deoxyadenosine 1.0 439153 PubChem-compound 5'-Phosphoribosyl-N-formylglycinamide 1.0 Tetrahydrofolic acid 1.0 C00206 KEGG Compound CHEBI:20506 ChEBI CHEBI:16027 ChEBI Uric acid D-Ribose 5-phosphate CHEBI:17596 ChEBI 2.0 1.0 CHEBI:17111 ChEBI 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE BioCyc Q8NBU5 UniProt 559142 ChemSpider NAD CHEBI:16235 ChEBI 1.0 9679 PubChem-compound CHEBI:18413 ChEBI 8583 PubChem-compound 8582 PubChem-compound 5746 ChemSpider 1.0 5745 ChemSpider 5742 ChemSpider 15993 PubChem-compound L-ASPARTATE BioCyc 2.0 1142 ChemSpider C00212 KEGG Compound CHEBI:16474 ChEBI P00813 UniProt 7540-64-9 CAS Carbon dioxide SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 Guanosine triphosphate Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] CPD-3762 BioCyc Deoxyadenosine triphosphate 958-09-8 CAS C04823 KEGG Compound CHEBI:16240 ChEBI P23921 UniProt ATPase family AAA domain-containing protein 1 C10H12N5O7P Guanosine 2',3'-cyclic phosphate 345.04742 439167 PubChem-compound Xanthine dehydrogenase/oxidase 83792 ChemSpider 64959 PubChem-compound Guanine 1.0 Ribonucleoside-diphosphate reductase subunit M2 L-Glutamic acid Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Ribonucleoside-diphosphate reductase large subunit C00234 KEGG Compound Ribonucleoside-diphosphate reductase subunit M2 Glycineamideribotide Xanthine dehydrogenase/oxidase 165186 PubChem-compound 7664-38-2 CAS 1.0 1.0 Adenosine C00009 KEGG Compound C00008 KEGG Compound C13H19N4O12P SAICAR 454.0737 C00007 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound 1151 ChemSpider C00242 KEGG Compound C00005 KEGG Compound C00004 KEGG Compound 1.0 135-16-0 CAS C00003 KEGG Compound C00002 KEGG Compound NADP 3.6.1.17 false 3.6.1.17 Diguanosine tetraphosphate + Water → Guanosine monophosphate + Guanosine triphosphate LEFT_TO_RIGHT SMILES NC1=NC(=O)C2=C(N1)N(C=N2)[C@@H]1O[C@H](CO)[C@H]2OP(O)(=O)O[C@@H]12 Nucleoside diphosphate kinase 6 ADP-sugar pyrophosphatase ReactionCatalysis617 ACTIVATION C5H12NO7P 5-Phosphoribosylamine 229.03514 Adenylosuccinate lyase P20839 UniProt CPD-3709 BioCyc 3.6.1.3 false 3.6.1.3 Adenosine triphosphate + Water → Adenosine diphosphate + Phosphoric acid LEFT_TO_RIGHT 58569 ChemSpider AMP deaminase 1 ReactionCatalysis653 ACTIVATION CHEBI:16039 ChEBI CHEBI:17368 ChEBI Adenylosuccinate synthetase isozyme 2 1.0 Ribonucleoside-diphosphate reductase large subunit ReactionCatalysis2191 ACTIVATION C00011 KEGG Compound GMP reductase 1 1.0 C00014 KEGG Compound C00013 KEGG Compound Hypoxanthine IDP AICAR 1.0 Deoxyguanosine Guanylate cyclase 1.0 644173 PubChem-compound 56-65-5 CAS 58570 ChemSpider CHEBI:16284 ChEBI C00020 KEGG Compound 53-84-9 CAS C00262 KEGG Compound 2.0 388420 ChemSpider 1.0 C00027 KEGG Compound C00025 KEGG Compound CHEBI:26078 ChEBI 5-Phosphoribosylamine 60-92-4 CAS Reaction186 false Guanosine diphosphate + Water → Guanosine monophosphate + Phosphate LEFT_TO_RIGHT 764 PubChem-compound P31939 UniProt C00037 KEGG Compound C00035 KEGG Compound HMDB0000134 HMDB HMDB0000133 HMDB 1927-31-7 CAS 1.0 69-93-2 CAS 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0000132 HMDB Q9Y233 UniProt dGDP C00044 KEGG Compound C00286 KEGG Compound Water L-Glutamine 2.4.2.14 false 2.4.2.14 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate ↔ L-Glutamine + Phosphoribosyl pyrophosphate + Water REVERSIBLE Phosphoribosylformylglycinamidine synthase C00049 KEGG Compound C04640 KEGG Compound C03794 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)N3C=NC4=C3N=C(N)NC4=O)[C@@H](O)[C@H]2O)C(=O)N1 7062 ChemSpider Adenylosuccinate lyase HMDB0001235 HMDB C00294 KEGG Compound HMDB0000148 HMDB Reaction2295 false Phosphate + dADP → Deoxyadenosine triphosphate + Water LEFT_TO_RIGHT 13730 PubChem-compound 784 PubChem-compound 6.3.4.4 false 6.3.4.4 Guanosine triphosphate + Inosinic acid + L-Aspartic acid ↔ Adenylsuccinic acid + Guanosine diphosphate + Phosphate REVERSIBLE dADP 4.3.2.2 false 4.3.2.2 Adenylsuccinic acid ↔ Adenosine monophosphate + Fumaric acid REVERSIBLE FUM BioCyc dADP Amidophosphoribosyltransferase Trifunctional purine biosynthetic protein adenosine-3 1.0 CHEBI:18012 ChEBI HMDB0001487 HMDB HMDB0001489 HMDB Xanthine HMDB0000157 HMDB 187790 PubChem-compound Phosphoric acid GMP synthase [glutamine-hydrolyzing] Adenosine diphosphate 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 Trifunctional purine biosynthetic protein adenosine-3 C14H18N5O11P Adenylsuccinic acid 463.07404 CHEBI:17172 ChEBI SMILES O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O XANTHOSINE-5-PHOSPHATE BioCyc C00064 KEGG Compound 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE BioCyc 58-61-7 CAS O75356 UniProt C05512 KEGG Compound Pyrophosphate Ectonucleoside triphosphate diphosphohydrolase 5 144813 ChemSpider cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 962 PubChem-compound Deoxyadenosine triphosphate 2564-35-4 CAS 1.0 C04677 KEGG Compound CO2 Carbon dioxide 43.98983 C00081 KEGG Compound 9298 ChemSpider SMILES O=O DEOXYGUANOSINE BioCyc HMDB0002111 HMDB HMDB0000175 HMDB 5-Aminoimidazole ribonucleotide 14265-44-2 CAS 4.0 92823 PubChem-compound HMDB0000189 HMDB 1.0 1.0 1.0 HMDB0001273 HMDB 10-Formyltetrahydrofolate 644102 PubChem-compound 5-Aminoimidazole ribonucleotide 160913 PubChem-compound C10H12N4O6 Xanthosine 284.07568 1.0 dGTP Xanthosine 1.0 SMILES O=C1NC2=C(NC=N2)C(=O)N1 58-63-9 CAS C03373 KEGG Compound 1.0 Ectonucleoside triphosphate diphosphohydrolase 5 SMILES OC[C@H]1OC(C[C@@H]1O)OP(O)(O)=O SMILES O=C1NC2=C(N1)C(=O)NC(=O)N2 CHEBI:18050 ChEBI H2O2 Hydrogen peroxide 34.005478 890-38-0 CAS SMILES O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O HMDB0000191 HMDB 1.0 NADH BioCyc 1.0 HMDB0000195 HMDB HMDB0001044 HMDB 977 PubChem-compound 1.0 25635-88-5 CAS Adenylosuccinate lyase Ribose-phosphate pyrophosphokinase 3 1.0 Adenylate kinase isoenzyme 1 1.0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9UKK9 UniProt 5-P-BETA-D-RIBOSYL-AMINE BioCyc NAD HMDB0002142 HMDB 1.0 1.0 141370 ChemSpider 30572 ChemSpider 1.0 17215925 ChemSpider 1.0 Adenylosuccinate synthetase isozyme 2 1.0 Inosine-5'-monophosphate dehydrogenase 1 Bifunctional purine biosynthesis protein PURH SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=C(O)N=C2O Ectonucleoside triphosphate diphosphohydrolase 5 4.0 21883788 PubChem-compound HMDB0000536 HMDB SMILES OO H3N Ammonia 17.026548 C10H13N5O4 Adenosine 267.09674 2.0 C10H14N5O7P Adenosine monophosphate 347.06308 1.0 2'-Deoxyguanosine 5'-monophosphate Thioredoxin HMDB0000538 HMDB C9H14N3O9P 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate 339.04675 Multifunctional protein ADE2 5961 PubChem-compound P23109 UniProt GMP synthase [glutamine-hydrolyzing] Water CHEBI:37737 ChEBI Guanosine 2',3'-cyclic phosphate GMP synthase [glutamine-hydrolyzing] C10H12N5O6P cAMP 329.05252 Adenylosuccinate Lyase Deficiency P00491 UniProt P00492 UniProt 1.0 Phosphoribosyl pyrophosphate SubPathwayOutput cAMP-specific 3',5'-cyclic phosphodiesterase 4D 2.0 2793-06-8 CAS 2.0 CHEBI:2030 ChEBI 3031-95-6 CAS Q02153 UniProt HMDB0000797 HMDB 274 ChemSpider Phosphoribosylformylglycinamidine synthase 634-02-6 CAS Xanthine dehydrogenase/oxidase Multifunctional protein ADE2 Phosphate Q16774 UniProt Ribose-phosphate pyrophosphokinase 3 O4P Phosphate 94.95342 Guanylate cyclase soluble subunit alpha-2 1.0 6830 PubChem-compound Adenosine triphosphate C10H15N4O9P Phosphoribosyl formamidocarboxamide 366.05768 C10H16N5O13P3 dGTP 506.99576 C7H15N2O8P Glycineamideribotide 286.0566 3.5.4.3 false 3.5.4.3 Guanine + Water → Ammonia + Xanthine LEFT_TO_RIGHT C5H5N5 Adenine 135.05449 1.0 NADPH BioCyc Diguanosine tetraphosphate Deoxyguanosine kinase, mitochondrial CPD-6641 BioCyc 141175 ChemSpider 217 ChemSpider 58-68-4 CAS CHEBI:28843 ChEBI SMILES [O-]P([O-])([O-])=O C9H15N4O8P AICAR 338.06274 C2H5NO2 Glycine 75.03203 C10H15N5O9P2 dADP 411.03452 CHEBI:17712 ChEBI CHEBI:17713 ChEBI Guanylate cyclase soluble subunit alpha-2 HMDB0001429 HMDB 790 PubChem-compound Guanylate cyclase soluble subunit beta-1 2.0 cAMP-specific 3',5'-cyclic phosphodiesterase 4D Ribonucleoside-diphosphate reductase 1 SMILES NC(=O)C1=C(NC=O)N(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0000101 HMDB C10H16N5O12P3 Deoxyadenosine triphosphate 491.00082 GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE BioCyc SMILES NCC(=O)N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O SMILES NC1=C2NC=NC2=NC=N1 SMILES NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)N1 C04051 KEGG Compound C4H4O4 Fumaric acid 116.010956 C10H13N5O5 Guanosine 283.09167 C5H5N5O Guanine 151.04941 GUANINE BioCyc 65059 PubChem-compound 65058 PubChem-compound CAMP BioCyc 6802 PubChem-compound SMILES O=C=O HMDB0001439 HMDB HMDB0001201 HMDB C10H12N4O4 Deoxyinosine 252.08586 P47989 UniProt C21H29N7O14P2 NADH 665.12476 15194 ChemSpider 1.0 3493-09-2 CAS C5H11O8P Ribose 1-phosphate 230.01915 6804 PubChem-compound 5957 PubChem-compound C10H13N5O4 Deoxyguanosine 267.09674 1.0 Adenylosuccinate synthetase isozyme 2 Adenylate cyclase type 2 HMDB0001440 HMDB 68-94-0 CAS Deoxyadenosine monophosphate ADP-sugar pyrophosphatase CHEBI:15996 ChEBI Xanthylic acid HMDB0000123 HMDB Adenylate kinase isoenzyme 1 GO:0005739 GENE ONTOLOGY P22234 UniProt GO:0005737 GENE ONTOLOGY 2.0 C10H13N5O3 Deoxyadenosine 251.10184 Bifunctional purine biosynthesis protein PURH Purine nucleoside phosphorylase Cytosolic purine 5'-nucleotidase Q9BY32 UniProt NADH 5682 ChemSpider P49902 UniProt CHEBI:52742 ChEBI 1.0 1.0 Adenine phosphoribosyltransferase Reaction354 false Adenosine monophosphate + Adenosine triphosphate → 2 Adenosine diphosphate LEFT_TO_RIGHT 4.6.1.1 false 4.6.1.1 Adenosine triphosphate → Pyrophosphate + cAMP LEFT_TO_RIGHT 14000-31-8 CAS 5675 ChemSpider 1.0 2.7.4.8 false 2.7.4.8 Adenosine triphosphate + Guanosine monophosphate ↔ Adenosine diphosphate + Guanosine diphosphate REVERSIBLE Oxygen P49915 UniProt 4.0 Water Inosine triphosphate pyrophosphatase 1.0 1.0 ReactionCatalysis655 ACTIVATION Ribose 1-phosphate ReactionCatalysis697 ACTIVATION ReactionCatalysis695 ACTIVATION 1.0 SMILES NC1=NC(=O)C2=C(N1)N(C=N2)[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1 1.0 Guanosine diphosphate CHEBI:28862 ChEBI 5-Aminoimidazole-4-carboxamide INOSINE BioCyc 1.0 GO:0005789 GENE ONTOLOGY GO:0005783 GENE ONTOLOGY C5H9NO4 L-Glutamic acid 147.05316 Water 33032 PubChem-compound 1.0 1.0 6544 ChemSpider 1.0 6545 ChemSpider Phosphoric acid Phosphoric acid 7782-44-7 CAS C10H13N4O9P Xanthylic acid 364.04202 HMDB0000960 HMDB GO:0005777 GENE ONTOLOGY 2.0 C5H11O8P D-Ribose 5-phosphate 230.01915 3.5.4.6 false 3.5.4.6 Adenosine monophosphate + Water ↔ Ammonia + Inosinic acid REVERSIBLE Hypoxanthine-guanine phosphoribosyltransferase P21108 UniProt Thioredoxin SMP0000031 SMPDB 9606 TAXONOMY 1.0 HMDB0006273 HMDB 1.0 1.0 1175 PubChem-compound 1.0 HMDB0000972 HMDB Amidophosphoribosyltransferase 1.0 ADENOSINE BioCyc CHEBI:15377 ChEBI Cell Membrane CHEBI:15379 ChEBI 6569 ChemSpider Guanine deaminase CHEBI:18406 ChEBI SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O GMP reductase 1 SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CN=C2NC(CC(O)=O)C(O)=O 1.0 CHEBI:17552 ChEBI 1.0 C15H23N5O14P2 Adenosine diphosphate ribose 559.07166 HMDB0011629 HMDB ReactionCatalysis698 ACTIVATION Reaction579 false NAD + Water + Xanthine → NADH + Uric acid LEFT_TO_RIGHT 388373 ChemSpider 69-89-6 CAS 1.0 7830994 ChemSpider PRPP BioCyc 440122 PubChem-compound 192 PubChem-compound 190 PubChem-compound 1.1.1.205 false 1.1.1.205 Inosinic acid + NAD + Water → NADH + Xanthylic acid LEFT_TO_RIGHT Reaction578 false Hypoxanthine + Oxygen + Water → Hydrogen peroxide + Xanthine LEFT_TO_RIGHT 4.0 86-01-1 CAS P31350 UniProt 1.0 CHEBI:17775 ChEBI 523-98-8 CAS SAICAR 109092 ChemSpider HMDB0001846 HMDB HMDB0000999 HMDB C00301 KEGG Compound SMILES NC1=C(N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](CC(O)=O)C(O)=O 1188 PubChem-compound Inosine-5'-monophosphate dehydrogenase 1 CHEBI:28413 ChEBI 1.0 SMILES N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O CPD-609 BioCyc C00559 KEGG Compound 388359 ChemSpider 6021 PubChem-compound 6022 PubChem-compound 7722-84-1 CAS CHEBI:18319 ChEBI P30566 UniProt 937 ChemSpider CHEBI:16134 ChEBI L-Aspartic acid HMDB0003125 HMDB 110-17-8 CAS 10-FORMYL-THF BioCyc 1.0 ReactionCatalysis701 ACTIVATION C03838 KEGG Compound 85-32-5 CAS C8H14N3O7P 5-Aminoimidazole ribonucleotide 295.05695 PW000055 PathWhiz Q08499 UniProt Adenosine deaminase ATP BioCyc C4H6N4O 5-Aminoimidazole-4-carboxamide 126.05416 Adenine phosphoribosyltransferase 18714427 ChemSpider AMP deaminase 1 ReactionCatalysis730 ACTIVATION CHEBI:17202 ChEBI Q08462 UniProt Multifunctional protein ADE2 58484 ChemSpider Adenosine diphosphate C00330 KEGG Compound C00575 KEGG Compound Guanosine monophosphate 952 ChemSpider ReactionCatalysis728 ACTIVATION ReactionCatalysis729 ACTIVATION ReactionCatalysis726 ACTIVATION ReactionCatalysis725 ACTIVATION ReactionCatalysis722 ACTIVATION HYPOXANTHINE BioCyc ReactionCatalysis720 ACTIVATION XANTHINE BioCyc ReactionCatalysis721 ACTIVATION 5858 ChemSpider Adenosine monophosphate 5851 ChemSpider C00104 KEGG Compound 12599 PubChem-compound C10H15N5O11P2 Guanosine diphosphate 443.02432 C00101 KEGG Compound 10074-18-7 CAS ReactionCatalysis719 ACTIVATION ReactionCatalysis718 ACTIVATION PPI BioCyc 439287 PubChem-compound ReactionCatalysis715 ACTIVATION ReactionCatalysis716 ACTIVATION ReactionCatalysis712 ACTIVATION ReactionCatalysis710 ACTIVATION 1.0 C00119 KEGG Compound ReactionCatalysis751 ACTIVATION ReactionCatalysis752 ACTIVATION C00117 KEGG Compound 388313 ChemSpider C10H16N5O14P3 Guanosine triphosphate 522.99066 1.0 C5H10N2O3 L-Glutamine 146.06914 Water P07741 UniProt P30520 UniProt CHEBI:16174 ChEBI Cytosol Amidophosphoribosyltransferase 2.7.4.8 false 2.7.4.8 2'-Deoxyguanosine 5'-monophosphate + Adenosine triphosphate ↔ Adenosine diphosphate + dGDP REVERSIBLE C00360 KEGG Compound 141854 ChemSpider 122347 PubChem-compound ReactionCatalysis746 ACTIVATION ReactionCatalysis747 ACTIVATION ReactionCatalysis744 ACTIVATION ReactionCatalysis745 ACTIVATION ReactionCatalysis742 ACTIVATION ReactionCatalysis743 ACTIVATION O75414 UniProt ReactionCatalysis740 ACTIVATION ReactionCatalysis741 ACTIVATION ADENINE BioCyc 53477733 PubChem-compound C00122 KEGG Compound C00362 KEGG Compound C00361 KEGG Compound CHEBI:18361 ChEBI DEOXY-RIBOSE-1P BioCyc SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 CHEBI:18367 ChEBI C10H14N4O11P2 IDP 428.01343 1032 ChemSpider C00366 KEGG Compound 73323 PubChem-compound Fumaric acid 2.7.6.1 false 2.7.6.1 Adenosine triphosphate + D-Ribose 5-phosphate ↔ Adenosine monophosphate + Phosphoribosyl pyrophosphate REVERSIBLE 66054 ChemSpider ReactionCatalysis739 ACTIVATION ReactionCatalysis737 ACTIVATION 37721-04-3 CAS ReactionCatalysis735 ACTIVATION ReactionCatalysis736 ACTIVATION ReactionCatalysis733 ACTIVATION ReactionCatalysis734 ACTIVATION 1.0 1.0 ReactionCatalysis731 ACTIVATION 1.17.4.1 false 1.17.4.1 Thioredoxin Disulfide + Water + dGDP ↔ Guanosine diphosphate + Thioredoxin REVERSIBLE ReactionCatalysis732 ACTIVATION ReactionCatalysis773 ACTIVATION C10H14N5O6P Deoxyadenosine monophosphate 331.06818 CHEBI:17489 ChEBI 118-00-3 CAS C21H28N7O14P2 NAD 664.11694 ReactionCatalysis770 ACTIVATION Hydrogen peroxide 44367445 PubChem-compound Adenosine triphosphate 2.4.2.1 false 2.4.2.1 Deoxyadenosine + Phosphate ↔ Adenine + Deoxyribose 1-phosphate REVERSIBLE 7339 PubChem-compound C00131 KEGG Compound C04734 KEGG Compound C00130 KEGG Compound HMDB0000902 HMDB HMDB0000905 HMDB 1.0 2.4.2.1 false 2.4.2.1 Deoxyinosine + Phosphate ↔ Deoxyribose 1-phosphate + Hypoxanthine REVERSIBLE NAD(P) BioCyc Guanosine monophosphate 2.4.2.8 false 2.4.2.8 Inosinic acid + Pyrophosphate ↔ Hypoxanthine + Phosphoribosyl pyrophosphate REVERSIBLE ReactionCatalysis768 ACTIVATION ReactionCatalysis767 ACTIVATION ReactionCatalysis765 ACTIVATION SubPathwayInteraction132 SubPathway132Reaction SubPathwayReaction CHEBI:18349 ChEBI CHEBI:18107 ChEBI ReactionCatalysis763 ACTIVATION PW000076 PathWhiz ReactionCatalysis761 ACTIVATION HMDB0003192 HMDB C00144 KEGG Compound C00385 KEGG Compound 2.4.2.8 false 2.4.2.8 Pyrophosphate + Xanthylic acid ↔ Phosphoribosyl pyrophosphate + Xanthine REVERSIBLE SMILES NC1=C2N=CN(C3OC(COP(O)(=O)OP(O)(=O)OCC4OC(O)C(O)C4O)C(O)C3O)C2=NC=N1 C00147 KEGG Compound CHEBI:17256 ChEBI C00387 KEGG Compound DGDP BioCyc Reaction1066 false 10-Formyltetrahydrofolate + AICAR ↔ Phosphoribosyl formamidocarboxamide + Tetrahydrofolic acid REVERSIBLE 3.6.1.19 false 3.6.1.19 Guanosine triphosphate + Water → Guanosine monophosphate + Pyrophosphate LEFT_TO_RIGHT Reaction1064 false Adenosine diphosphate ribose + Water → Adenosine monophosphate + D-Ribose 5-phosphate LEFT_TO_RIGHT Reaction1065 false 10-Formyltetrahydrofolate + Glycineamideribotide → 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolic acid LEFT_TO_RIGHT 2.4.2.7 false 2.4.2.7 Guanosine monophosphate + Pyrophosphate ↔ Guanine + Phosphoribosyl pyrophosphate REVERSIBLE Adenosine monophosphate 2.4.2.1 false 2.4.2.1 Deoxyguanosine + Phosphate ↔ Deoxyribose 1-phosphate + Guanine REVERSIBLE ReactionCatalysis755 ACTIVATION ReactionCatalysis756 ACTIVATION 6.3.5.2 false 6.3.5.2 Adenosine triphosphate + Ammonia + Xanthylic acid → Adenosine monophosphate + Guanosine monophosphate + Pyrophosphate LEFT_TO_RIGHT 73-24-5 CAS 1.7.1.7 false 1.7.1.7 Ammonia + Inosinic acid + NADP ↔ Guanosine monophosphate + NADPH REVERSIBLE ReactionCatalysis754 ACTIVATION cAMP Guanosine diphosphate Adenine phosphoribosyltransferase 166760 PubChem-compound C04751 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 146-80-5 CAS AMP BioCyc Inosine triphosphate pyrophosphatase Peroxisome 3.6.1.5 false 3.6.1.5 Inosine triphosphate + Water → IDP + Phosphate LEFT_TO_RIGHT 2.4.2.7 false 2.4.2.7 AICAR + Pyrophosphate ↔ 5-Aminoimidazole-4-carboxamide + Phosphoribosyl pyrophosphate REVERSIBLE 3.6.1.19 false 3.6.1.19 Inosine triphosphate + Water → Inosinic acid + Pyrophosphate LEFT_TO_RIGHT SMILES NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)N1 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + IDP ↔ Adenosine diphosphate + Inosine triphosphate REVERSIBLE SMILES OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H]1O HYDROGEN-PEROXIDE BioCyc Reaction1093 false Guanosine 2',3'-cyclic phosphate + Water → Guanosine monophosphate LEFT_TO_RIGHT 3.6.1.5 false 3.6.1.5 IDP + Water → Inosinic acid + Phosphate LEFT_TO_RIGHT Adenosine diphosphate AICAR BioCyc HMDB0001340 HMDB C8H16N3O8P Phosphoribosylformylglycineamidine 313.0675 2'-Deoxyguanosine 5'-monophosphate HMDB0000250 HMDB 1.0 SMILES OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2=C1N=CN=C2O HMDB0001341 HMDB Q9Y2T3 UniProt 1.0 NADH 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + dADP ↔ Adenosine diphosphate + Deoxyadenosine triphosphate REVERSIBLE 4.6.1.2 false 4.6.1.2 Guanosine triphosphate → Guanosine 2',3'-cyclic phosphate + Pyrophosphate LEFT_TO_RIGHT Reaction1090 false Adenosine triphosphate + Deoxyadenosine monophosphate ↔ Adenosine diphosphate + dADP REVERSIBLE 1.0 768 ChemSpider 8265 ChemSpider 1.17.4.1 false 1.17.4.1 Thioredoxin Disulfide + Water + dADP ↔ Adenosine diphosphate + Thioredoxin REVERSIBLE ADENOSINE_DIPHOSPHATE_RIBOSE BioCyc 763 ChemSpider 73-40-5 CAS C01261 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](CO)O1 2.4.2.7 false 2.4.2.7 Adenosine monophosphate + Pyrophosphate ↔ Adenine + Phosphoribosyl pyrophosphate REVERSIBLE Guanine deaminase 12079 ChemSpider 1.0 P50583 UniProt HMDB0001351 HMDB 1.0 10197150 ChemSpider C10H15N5O10P2 dGDP 427.02942 CHEBI:28181 ChEBI 7732-18-5 CAS Q06203 UniProt Water Cytosolic purine 5'-nucleotidase 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 HMDB0000034 HMDB SMILES NC1=C(N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O)C(O)=O HMDB0001128 HMDB CHEBI:16192 ChEBI AMMONIA BioCyc SMILES N 56-86-0 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1 Hypoxanthine 1.0 13135 ChemSpider ADP-sugar pyrophosphatase C20H23N7O7 10-Formyltetrahydrofolate 473.1659 CHEBI:17053 ChEBI 56-40-6 CAS 2800-34-2 CAS Hypoxanthine-guanine phosphoribosyltransferase HMDB0001377 HMDB HMDB0000045 HMDB HMDB0000289 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O CHEBI:18381 ChEBI 1.0 HMDB0000280 HMDB Ammonia Cytosolic purine 5'-nucleotidase Inosine 1.0 559208 ChemSpider Deoxyinosine Adenosine deaminase 5800 ChemSpider 979 ChemSpider Adenylate cyclase type 2 AMP deaminase 1 DADP BioCyc HMDB0000299 HMDB 730 ChemSpider 4130-19-2 CAS HMDB0000058 HMDB H3O4P Phosphoric acid 97.9769 HMDB0000051 HMDB HMDB0000292 HMDB HMDB0000050 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O CHEBI:15919 ChEBI Purine nucleoside phosphorylase C10H13N4O8P Inosinic acid 348.0471 58-64-0 CAS GTP BioCyc Phosphoribosyl formamidocarboxamide Guanylate kinase PHOSPHORIBOSYL-FORMAMIDO-CARBOXAMIDE BioCyc SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1NC(=O)NC2=O HMDB0003335 HMDB RIBOSE-5P BioCyc SMILES OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O C4H7NO4 L-Aspartic acid 133.0375 439905 PubChem-compound Bifunctional purine biosynthesis protein PURH C10H15N4O14P3 Inosine triphosphate 507.97977 HMDB0001397 HMDB PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE BioCyc Inosinic acid 6083 PubChem-compound 1.0 GMP reductase 1 144983 ChemSpider Inosine-5'-monophosphate dehydrogenase 1 22833512 PubChem-compound Adenosine diphosphate ribose H2O Water 18.010565 SMILES NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O SMILES NCC(O)=O HMDB0000071 HMDB 54923 ChemSpider 388939 ChemSpider SMILES NC1=NC=NC2=C1N=CN2C1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O1 NAD BioCyc 6076 PubChem-compound DGMP BioCyc 56-84-8 CAS 163230 ChemSpider Guanine deaminase 744 ChemSpider SMILES OC(=O)\C=C\C(O)=O SMILES NC1=NC=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(=O)N1 HMDB0001178 HMDB SMILES NC1=NC(=O)C2=C(N1)N=CN2 1.0 146-91-8 CAS C5H4N4O Hypoxanthine 136.03851 902-04-5 CAS HMDB0000085 HMDB HMDB0002022 HMDB DGTP BioCyc ReactionCatalysis17 ACTIVATION cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 65110 PubChem-compound RIBOSE-1P BioCyc 653-63-4 CAS 3031-94-5 CAS Pentose Phosphate Pathway SubPathway SMILES O 1.0 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + dGDP → Adenosine diphosphate + dGTP LEFT_TO_RIGHT P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE BioCyc 65103 PubChem-compound 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + Guanosine diphosphate ↔ Adenosine diphosphate + Guanosine triphosphate REVERSIBLE Deoxyguanosine kinase, mitochondrial 1004 PubChem-compound C8H15N2O9P 5'-Phosphoribosyl-N-formylglycinamide 314.0515 HMDB0001508 HMDB Ectonucleoside triphosphate diphosphohydrolase 8 1.0 Adenine 1.0 ITP BioCyc 131-99-7 CAS SMILES OC1=NC=NC2=C1NC=N2 CHEBI:15846 ChEBI ADP BioCyc Glycine 53-59-8 CAS 1.0 C10H12N4O5 Inosine 268.08078 HMDB0001517 HMDB 3.5.4.4 false 3.5.4.4 Deoxyadenosine + Water ↔ Ammonia + Deoxyinosine REVERSIBLE 2.0 3.5.4.4 false 3.5.4.4 Adenosine + Water → Ammonia + Inosine LEFT_TO_RIGHT C04376 KEGG Compound SMILES O[C@H]1[C@@H](O)[C@H](NC(=N)CNC=O)O[C@@H]1COP(O)(O)=O GO:0005829 GENE ONTOLOGY 1.0 C19H23N7O6 Tetrahydrofolic acid 445.171 4.0 Ectonucleoside triphosphate diphosphohydrolase 8 CHEBI:16908 ChEBI Guanosine diphosphate Deoxyguanosine Guanosine diphosphate ReactionCatalysis44 ACTIVATION HMDB0001532 HMDB Adenosine triphosphate 1.0 C21H30N7O17P3 NADPH 745.0911 Mitochondrion C21H29N7O17P3 NADP 744.08325 THF BioCyc CHEBI:15883 ChEBI 145893 ChemSpider GLY BioCyc P10599 UniProt 3.0 Guanosine triphosphate 3.1.3.5 false 3.1.3.5 Water + Xanthylic acid → Phosphate + Xanthosine LEFT_TO_RIGHT SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1NC=NC2=O 3.1.3.5 false 3.1.3.5 Deoxyadenosine monophosphate + Water ↔ Deoxyadenosine + Phosphoric acid REVERSIBLE SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 C5H11O7P Deoxyribose 1-phosphate 214.02425 Guanosine 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate C5H13O14P3 Phosphoribosyl pyrophosphate 389.9518 86-04-4 CAS GMP BioCyc GUANOSINE BioCyc P22102 UniProt HMDB0001548 HMDB HMDB0000217 HMDB 1.0 GO:0005886 GENE ONTOLOGY CHEBI:15637 ChEBI 124-38-9 CAS SMP0000167 SMPDB C5H4N4O2 Xanthine 152.03343 C5H4N4O3 Uric acid 168.02834 CHEBI:15652 ChEBI Adenylsuccinic acid HMDB0001308 HMDB ATPase family AAA domain-containing protein 1 19046-78-7 CAS SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 5257127 PubChem-compound HMDB0001554 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc Ectonucleoside triphosphate diphosphohydrolase 8 7664-41-7 CAS GLT BioCyc P00568 UniProt 53-57-6 CAS 60961 PubChem-compound 1.0 O15067 UniProt 1.0 222 PubChem-compound SMILES OP(O)(O)=O 8264 ChemSpider O7P2 Pyrophosphate 173.91193 SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CNC2=O Trifunctional purine biosynthetic protein adenosine-3 C03090 KEGG Compound CHEBI:16708 ChEBI 3.1.3.5 false 3.1.3.5 2'-Deoxyguanosine 5'-monophosphate + Water ↔ Deoxyguanosine + Phosphate REVERSIBLE CHEBI:16960 ChEBI 8.0 3.1.3.5 false 3.1.3.5 Guanosine monophosphate + Water → Guanosine + Phosphoric acid LEFT_TO_RIGHT 3.1.3.5 false 3.1.3.5 Inosinic acid + Water → Inosine + Phosphate LEFT_TO_RIGHT SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CN=C2O C20H28N10O21P4 Diguanosine tetraphosphate 868.0381 Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CC(O)=O)C(O)=O ReactionCatalysis80 ACTIVATION CHEBI:17808 ChEBI 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL BioCyc 58620 ChemSpider 1.0 4.0 ReactionCatalysis790 ACTIVATION Endoplasmic Reticulum Endoplasmic Reticulum Membrane 161500 PubChem-compound CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O Deoxyguanosine kinase SMILES NC1=NC=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1 IMP BioCyc C10H14N5O8P Guanosine monophosphate 363.058 3.6.1.5 false 3.6.1.5 Guanosine triphosphate + Water → Guanosine diphosphate + Phosphate LEFT_TO_RIGHT Purine nucleoside phosphorylase 2.0 ReactionCatalysis788 ACTIVATION ReactionCatalysis789 ACTIVATION Xanthine 2.4.2.1 false 2.4.2.1 Phosphate + Xanthosine ↔ Ribose 1-phosphate + Xanthine REVERSIBLE ReactionCatalysis786 ACTIVATION ReactionCatalysis787 ACTIVATION ReactionCatalysis784 ACTIVATION CHEBI:16300 ChEBI ReactionCatalysis785 ACTIVATION ReactionCatalysis782 ACTIVATION Guanylate kinase ReactionCatalysis783 ACTIVATION 5799 ChemSpider ReactionCatalysis780 ACTIVATION ReactionCatalysis781 ACTIVATION Hypoxanthine-guanine phosphoribosyltransferase Adenosine diphosphate 440417 PubChem-compound CHEBI:28997 ChEBI Adenosine diphosphate 1.0 4.0 4.3.2.2 false 4.3.2.2 SAICAR ↔ AICAR + Fumaric acid REVERSIBLE Cytoplasm Reaction487 false 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + Adenosine triphosphate + L-Aspartic acid ↔ Adenosine diphosphate + Phosphoric acid + SAICAR REVERSIBLE 6.3.5.3 false 6.3.5.3 5'-Phosphoribosyl-N-formylglycinamide + Adenosine triphosphate + L-Glutamine + Water → Adenosine diphosphate + L-Glutamic acid + Phosphoribosylformylglycineamidine + Phosphoric acid LEFT_TO_RIGHT ReactionCatalysis777 ACTIVATION Reaction486 false 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-Aminoimidazole ribonucleotide + Carbon dioxide REVERSIBLE 1.0 Reaction483 false 5-Phosphoribosylamine + Adenosine triphosphate + Glycine → Adenosine diphosphate + Glycineamideribotide + Phosphate LEFT_TO_RIGHT NADPH ReactionCatalysis775 ACTIVATION 1.0 Reaction484 false Adenosine triphosphate + Phosphoribosylformylglycineamidine → 5-Aminoimidazole ribonucleotide + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT 14075-00-4 CAS CHEBI:15422 ChEBI 2.0 Phosphate Homo sapiens 388299 ChemSpider CHEBI:16750 ChEBI 1.0 Reaction250 false Adenosine diphosphate + Water ↔ Adenosine monophosphate + Phosphoric acid REVERSIBLE Reaction490 false Inosinic acid + Water ↔ Phosphoribosyl formamidocarboxamide REVERSIBLE O2 Oxygen 31.98983 360-97-4 CAS Phosphoribosylformylglycineamidine 1.0 dADP 1.0 DAMP BioCyc CHEBI:16526 ChEBI 349-34-8 CAS SMILES NC(=O)C1=C(N)N=CN1 8977 PubChem-compound 160666 PubChem-compound C00620 KEGG Compound P36959 UniProt CHEBI:16761 ChEBI SMILES NC1=CN=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O Guanylate cyclase soluble subunit beta-1 CHEBI:15428 ChEBI 115687 ChemSpider 1.0 132-06-9 CAS CHEBI:16335 ChEBI 1.0 SMILES NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O2)C(=O)N1 130805 PubChem-compound 8630 ChemSpider 5893 PubChem-compound 389122 ChemSpider 439236 PubChem-compound SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 Nucleoside diphosphate kinase 6 1.0 DATP BioCyc 1.0 5886 PubChem-compound 1.0 Phosphate Phosphate 439220 PubChem-compound 280 PubChem-compound C06194 KEGG Compound 1.0 3.1.4.53 false 3.1.4.53 Water + cAMP → Adenosine monophosphate LEFT_TO_RIGHT Phosphate DEOXYINOSINE BioCyc C00655 KEGG Compound SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 17210-42-3 CAS Ribose-phosphate pyrophosphokinase 3 SMILES N[C@@H](CCC(N)=O)C(O)=O Deoxyribose 1-phosphate 961-07-9 CAS Inosine triphosphate dGDP CHEBI:28542 ChEBI 58613 ChemSpider URATE BioCyc P33402 UniProt 1061 PubChem-compound Q16854 UniProt 2.4.2.1 false 2.4.2.1 Guanosine + Phosphate ↔ Guanine + Ribose 1-phosphate REVERSIBLE HMDB0001967 HMDB SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)OC([C@@H]1O)N1C=NC2=C1NC=NC2=O HMDB0000641 HMDB 187 ChemSpider 20762-30-5 CAS 2.4.2.1 false 2.4.2.1 Adenosine + Phosphate ↔ Adenine + Ribose 1-phosphate REVERSIBLE 185 ChemSpider 2.7.1.113 false 2.7.1.113 Adenosine triphosphate + Deoxyguanosine ↔ 2'-Deoxyguanosine 5'-monophosphate + Adenosine diphosphate REVERSIBLE 13781857 PubChem-compound 2.4.2.1 false 2.4.2.1 Inosine + Phosphate ↔ Hypoxanthine + Ribose 1-phosphate REVERSIBLE 1.0 4300-28-1 CAS