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SubPathwayInteraction796 SubPathwayReaction SubPathway796Reaction SubPathwayInteraction797 SubPathway797Reaction SubPathwayReaction 51-41-2 CAS C9H13N5O3 Dihydrobiopterin 239.10184 CL:0000000 CELL TYPE ONTOLOGY 937 ChemSpider CHEBI:28918 ChEBI HMDB01185 HMDB 1.0 Tyrosine 3-monooxygenase 1.0 SMILES NCCC1=CC(O)=C(O)C=C1 SMILES O 1.0 L-Tyrosine P11086 UniProt BIOPTERIN BioCyc HMDB00787 HMDB 5833 ChemSpider 1.0 Epinephrine Parasympathetic Nervous System InhibitorySubPathway S-Adenosylmethionine Sympathetic Nervous System ActivatingSubPathway Phenylethanolamine N-methyltransferase 247 ChemSpider Epinephrine SMILES N[C@@H](CC1=CC=C(O)C=C1)C(O)=O 59-92-7 CAS Aromatic-L-amino-acid decarboxylase Cytoplasm L-DOPA BioCyc HMDB00939 HMDB Cell ReactionCatalysis213 ACTIVATION C15H23N6O5S S-Adenosylmethionine 399.14505 51-61-6 CAS Epinephrine SubPathwayInput 1.0 SMILES CC(O)C(O)C1=NC2=C(NC1)N=C(N)NC2=O HMDB00073 HMDB 62989-33-7 CAS 1.0 7732-18-5 CAS 6047 PubChem-compound 952 ChemSpider GO:0005829 GENE ONTOLOGY O2 Oxygen 31.98983 Adrenal Medulla 274 ChemSpider 7991951 ChemSpider Dihydrobiopterin TYR BioCyc Water NOREPINEPHRINE BioCyc false L-Tyrosine + Oxygen + Sapropterin → Dihydrobiopterin + L-Dopa + Water LEFT_TO_RIGHT 60-18-4 CAS 1.0 ADENOSYL-HOMO-CYS BioCyc 5611 ChemSpider DOPAMINE BioCyc Transport262 false Epinephrine (→) Transport: Homo sapiens, Kidney to Homo sapiens, Brain, Cell, Cytoplasm LEFT_TO_RIGHT CHEBI:16526 ChEBI 252 PubChem-compound 7782-44-7 CAS Sapropterin SMP00170 SMPDB S-Adenosylhomocysteine SMILES CNC[C@H](O)C1=CC(O)=C(O)C=C1 661 ChemSpider BiologicalState20 HMDB01967 HMDB 1.0 Dopamine C8H11NO3 Norepinephrine 169.0739 9606 TAXONOMY C9H15N5O3 Sapropterin 241.1175 962 PubChem-compound 31983 ChemSpider CHEBI:18357 ChEBI SubPathwayControl27 SubPathway27Control ActivatingSubPathwayControl P07101 UniProt CHEBI:15765 ChEBI SubPathwayControl28 SubPathway28Control InhibitorySubPathwayControl HMDB00216 HMDB C9H11NO3 L-Tyrosine 181.0739 CHEBI:64491 ChEBI 51-43-4 CAS SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 388394 ChemSpider 979-92-0 CAS Carbon dioxide Cytosol CPD-6641 BioCyc CO2 Carbon dioxide 43.98983 C00355 KEGG Compound 681 PubChem-compound HMDB02111 HMDB C14H20N6O5S S-Adenosylhomocysteine 384.12158 SMILES O=O 5816 PubChem-compound Phenylethanolamine N-methyltransferase C00082 KEGG Compound 124-38-9 CAS Sympathetic Nervous System SubPathway Parasympathetic Nervous System SubPathway CHEBI:15377 ChEBI 6057 PubChem-compound Norepinephrine HMDB00068 HMDB C00007 KEGG Compound CHEBI:15379 ChEBI C9H11NO4 L-Dopa 197.0688 CHEBI:15414 ChEBI C03758 KEGG Compound L-EPINEPHRINE BioCyc C00001 KEGG Compound HMDB00181 HMDB PW000090 PathWhiz 1.0 CHEBI:18243 ChEBI Oxygen SMILES NC[C@H](O)C1=CC(O)=C(O)C=C1 P20711 UniProt 280 PubChem-compound 9816201 PubChem-compound ReactionCatalysis218 ACTIVATION 1.0 ReactionCatalysis214 ACTIVATION 5824 ChemSpider CHEBI:64277 ChEBI C00019 KEGG Compound HMDB00158 HMDB 1.0 HMDB00038 HMDB C9H13NO3 Epinephrine 183.08954 439260 PubChem-compound C00011 KEGG Compound SMILES O=C=O S-ADENOSYLMETHIONINE BioCyc C02953 KEGG Compound SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O SMILES C[C@H](O)[C@H](O)C1CNC2=C(N1)C(=O)N=C(N)N2 6779-87-9 CAS 25246222 PubChem-compound L-Dopa H2O Water 18.010565 1.0 C8H11NO2 Dopamine 153.07898 BTO:0000049 BRENDA TISSUE ONTOLOGY 29908-03-0 CAS HMDB01377 HMDB C00547 KEGG Compound CHEBI:17895 ChEBI 388301 ChemSpider C00788 KEGG Compound 977 PubChem-compound 1.0 Aromatic L-Aminoacid Decarboxylase Deficiency Tyrosine 3-monooxygenase SMILES N[C@@H](CC1=CC(O)=C(O)C=C1)C(O)=O C00021 KEGG Compound CHEBI:16680 ChEBI 24762165 PubChem-compound C00272 KEGG Compound GO:0005737 GENE ONTOLOGY false L-Dopa → Carbon dioxide + Dopamine LEFT_TO_RIGHT false Norepinephrine + S-Adenosylmethionine → Epinephrine + S-Adenosylhomocysteine LEFT_TO_RIGHT 1.0 Aromatic-L-amino-acid decarboxylase Tyrosine 3-monooxygenase Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Phenylethanolamine N- methyltransferase Dissipation Epinephrine L-Tyrosine Sapropterin O 2 Accumulation L-Dopa Dihydrobiopterin H 2 O Dissipation Dopamine CO 2 Ascorbic acid O 2 Dissipation Norepinephrine Dehydroascorbic acid