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Bis(5'- nucleosyl)- tetraphosphatase [asymmetrical] Nucleoside diphosphate kinase 6 Ectonucleoside triphosphate diphosphohydrolase 5 Ectonucleoside triphosphate diphosphohydrolase 8 Guanylate kinase Nucleoside diphosphate kinase 6 Guanylate kinase Cytosolic purine 5'-nucleotidase Deoxyguanosine kinase Adenine phosphoribosyltransferase Cytosolic purine 5'-nucleotidase Purine nucleoside phosphorylase Hypoxanthine- guanine phosphoribosyltransferase Purine nucleoside phosphorylase Guanine deaminase ADP-sugar pyrophosphatase Ribose- phosphate pyrophosphokinase 3 Amidophosphoribosyltransferase Trifunctional purine biosynthetic protein adenosine-3 Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylformylglycinamidine synthase Multifunctional protein ADE2 Multifunctional protein ADE2 Adenylosuccinate lyase Bifunctional purine biosynthesis protein PURH Bifunctional purine biosynthesis protein PURH Inosine triphosphate pyrophosphatase GMP synthase [glutamine- hydrolyzing] Inosine-5'- monophosphate dehydrogenase 1 GMP reductase 1 Cytosolic purine 5'-nucleotidase Purine nucleoside phosphorylase Cytosolic purine 5'-nucleotidase Hypoxanthine- guanine phosphoribosyltransferase Purine nucleoside phosphorylase Hypoxanthine- guanine phosphoribosyltransferase Xanthine dehydrogenase/oxidase Xanthine dehydrogenase/oxidase Purine nucleoside phosphorylase Adenylosuccinate synthetase isozyme 2 AMP deaminase 1 Adenylosuccinate lyase Adenosine deaminase Purine nucleoside phosphorylase Purine nucleoside phosphorylase Adenosine deaminase Adenine phosphoribosyltransferase Ectonucleoside triphosphate diphosphohydrolase 5 Adenylate kinase isoenzyme 1 ATPase family AAA domain- containing protein 1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D Adenylate cyclase type 10 Adenylate kinase isoenzyme 1 Cytosolic purine 5'-nucleotidase Nucleoside diphosphate kinase 6 Guanylate cyclase cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Ectonucleoside triphosphate diphosphohydrolase 8 Inosine triphosphate pyrophosphatase Nucleoside diphosphate kinase 6 Ectonucleoside triphosphate diphosphohydrolase 8 Adenine phosphoribosyltransferase Trifunctional purine biosynthetic protein adenosine-3 Thioredoxin Thioredoxin Ribonucleoside- diphosphate reductase large subunit Ribonucleoside- diphosphate reductase subunit M2 Ectonucleoside triphosphate diphosphohydrolase 5 Thioredoxin Thioredoxin Ribonucleoside- diphosphate reductase large subunit Ribonucleoside- diphosphate reductase subunit M2 Phosphoribosyl pyrophosphate Diguanosine tetraphosphate H2O Guanosine triphosphate Guanosine monophosphate ATP Guanosine diphosphate ADP H2O Guanosine monophosphate Pi H2O Pi ATP ADP ATP dGDP ADP dGTP ATP 2'-Deoxyguanosine 5'-monophosphate ADP H2O Deoxyguanosine Pi ATP ADP PPi Guanine Phosphoribosyl pyrophosphate H2O Guanosine Pi Pi Ribose 1-phosphate PPi Phosphoribosyl pyrophosphate Pi Deoxyribose 1-phosphate H2O Accumulation Xanthine NH3 Adenosine diphosphate ribose H2O AMP D-Ribose 5-phosphate ATP AMP 5-Phosphoribosylamine PPi L-Glutamic acid L-Glutamine H2O ATP Glycine ADP Pi Glycineamideribotide 10-Formyltetrahydrofolate Tetrahydrofolic acid 5'-Phosphoribosyl-N- formylglycinamide ATP H2O ADP Pi Phosphoribosylformylglycineamidine 5-amino-1-(5-phospho-D- ribosyl)imidazole-4- carboxylate 5-Aminoimidazole ribonucleotide CO2 ATP L-Aspartic acid ADP Pi SAICAR Fumaric acid AICAR 10-Formyltetrahydrofolate Tetrahydrofolic acid Phosphoribosyl formamidocarboxamide Inosinic acid H2O H2O PPi ATP Xanthylic acid NH3 AMP PPi NAD H2O NADH NH3 NADP NADPH H2O Xanthosine Pi Pi Ribose 1-phosphate H2O Inosine Pi PPi Phosphoribosyl pyrophosphate Pi Accumulation Hypoxanthine Ribose 1-phosphate PPi O2 H2O H2O2 NAD H2O Uric acid NADH Deoxyinosine Pi Deoxyribose 1-phosphate GTP L-Aspartic acid GDP Pi Adenylsuccinic acid Adenosine monophosphate H2O NH3 Fumaric acid Adenosine H2O NH3 Pi Adenine Ribose 1-phosphate Deoxyadenosine Pi Deoxyribose 1-phosphate H2O NH3 PPi Phosphoribosyl pyrophosphate Adenosine diphosphate H2O Pi Adenosine triphosphate H2O Pi cAMP H2O PPi ATP Deoxyadenosine monophosphate ADP dADP H2O Pi ATP ADP Deoxyadenosine triphosphate Guanosine 2',3'-cyclic phosphate PPi H2O IDP H2O Pi Inosine triphosphate H2O PPi ATP ADP H2O Pi PPi 5-Aminoimidazole-4-carboxamide Phosphoribosyl pyrophosphate ATP ADP Pi H2O Pi H2O H2O Calcium Magnesium Zinc (II) ion Magnesium Magnesium Magnesium Potassium FAD FAD Magnesium Zinc (II) ion Zinc (II) ion Zinc (II) ion Calcium Magnesium Magnesium Magnesium Heme Magnesium Calcium Disulfide Calcium Magnesium Disulfide Pentose Phosphate Pathway Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Zinc (II) ion Magnesium Zinc (II) ion Magnesium Calcium Magnesium Fe3+ Fe3+ Magnesium Calcium Endoplasmic Reticulum Peroxisome Endoplasmic Reticulum Peroxisome Intracellular Space Extracellular Space Mitochondria Cytosol Mitochondria
NUDT2 NME6 ENTPD5 ENTPD8 GUK1 NME6 GUK1 NT5C2 DGUOK APRT NT5C2 PNP HPRT1 PNP GDA NUDT5 PRPS1L1 PPAT GART GART PFAS PAICS PAICS ADSL ATIC ATIC ITPA GMPS IMPDH1 GMPR NT5C2 PNP NT5C2 HPRT1 PNP HPRT1 XDH XDH PNP ADSS AMPD1 ADSL ADA PNP PNP ADA APRT ENTPD5 AK1 ATAD1 PDE4D ADCY10 AK1 NT5C2 NME6 GUCY1A2 GUCY1B3 PDE10A ENTPD8 ITPA NME6 ENTPD8 APRT GART TXN TXN RRM1 RRM2 ENTPD5 TXN TXN RRM1 RRM2 Phosphoribosyl pyrophosphate Diguanosine tetraphosphate Water Guanosine triphosphate Guanosine monophosphate Adenosine triphosphate Guanosine diphosphate Adenosine diphosphate Water Guanosine monophosphate Phosphate Water Phosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate dGDP Adenosine diphosphate dGTP Adenosine triphosphate 2'- Deoxyguanosine 5'- monophosphate Adenosine diphosphate Water Deoxyguanosine Phosphate Adenosine triphosphate Adenosine diphosphate Pyrophosphate Guanine Phosphoribosyl pyrophosphate Water Guanosine Phosphoric acid Phosphate Ribose 1-phosphate Pyrophosphate Phosphoribosyl pyrophosphate Phosphate Deoxyribose 1-phosphate Water Accumulation Xanthine Ammonia Adenosine diphosphate ribose Water Adenosine monophosphate D-Ribose 5-phosphate Adenosine triphosphate Adenosine monophosphate 5- Phosphoribosylamine Pyrophosphate L-Glutamic acid L-Glutamine Water Adenosine triphosphate Glycine Adenosine diphosphate Phosphate Glycineamideribotide 10- Formyltetrahydrofolate Tetrahydrofolic acid 5'- Phosphoribosyl- N- formylglycinamide Adenosine triphosphate Water Adenosine diphosphate Phosphoric acid Phosphoribosylformylglycineamidine 5-amino-1-(5- phospho-D- ribosyl)imidazole- 4-carboxylate 5- Aminoimidazole ribonucleotide Carbon dioxide Adenosine triphosphate L-Aspartic acid Adenosine diphosphate Phosphoric acid SAICAR Fumaric acid AICAR 10- Formyltetrahydrofolate Tetrahydrofolic acid Phosphoribosyl formamidocarboxamide Inosinic acid Water Water Pyrophosphate Adenosine triphosphate Xanthylic acid Ammonia Adenosine monophosphate Pyrophosphate NAD Water NADH Ammonia NADP NADPH Water Xanthosine Phosphate Phosphate Ribose 1-phosphate Water Inosine Phosphate Pyrophosphate Phosphoribosyl pyrophosphate Phosphate Accumulation Hypoxanthine Ribose 1-phosphate Pyrophosphate Oxygen Water Hydrogen peroxide NAD Water Uric acid NADH Deoxyinosine Phosphate Deoxyribose 1-phosphate Guanosine triphosphate L-Aspartic acid Guanosine diphosphate Phosphate Adenylsuccinic acid Adenosine monophosphate Water Ammonia Fumaric acid Adenosine Water Ammonia Phosphate Adenine Ribose 1-phosphate Deoxyadenosine Phosphate Deoxyribose 1-phosphate Water Ammonia Pyrophosphate Phosphoribosyl pyrophosphate Adenosine diphosphate Water Phosphoric acid Adenosine triphosphate Water Phosphoric acid cAMP Water Pyrophosphate Adenosine triphosphate Deoxyadenosine monophosphate Adenosine diphosphate dADP Water Phosphoric acid Adenosine triphosphate Adenosine diphosphate Deoxyadenosine triphosphate Guanosine 2',3'-cyclic phosphate Pyrophosphate Water IDP Water Phosphate Inosine triphosphate Water Pyrophosphate Adenosine triphosphate Adenosine diphosphate Water Phosphate Pyrophosphate 5- Aminoimidazole- 4-carboxamide Phosphoribosyl pyrophosphate Adenosine triphosphate Adenosine diphosphate Phosphate Water Phosphate Water Water Pentose Phosphate Pathway
NUDT2 NME6 ENTPD5 ENTPD8 GUK1 NME6 GUK1 NT5C2 DGUOK APRT NT5C2 PNP HPRT1 PNP GDA NUDT5 PRPS1L1 PPAT GART GART PFAS PAICS PAICS ADSL ATIC ATIC ITPA GMPS IMPDH1 GMPR NT5C2 PNP NT5C2 HPRT1 PNP HPRT1 XDH XDH PNP ADSS AMPD1 ADSL ADA PNP PNP ADA APRT ENTPD5 AK1 ATAD1 PDE4D ADCY10 AK1 NT5C2 NME6 GUCY1A2 GUCY1B3 PDE10A ENTPD8 ITPA NME6 ENTPD8 APRT GART TXN TXN RRM1 RRM2 ENTPD5 TXN TXN RRM1 RRM2 PRPP Guan2P4 H2O GTP GSMP ATP GDP ADP H2O GSMP Pi H2O Pi ATP ADP ATP dGDP ADP dGTP ATP dGMP ADP H2O doxyG Pi ATP ADP PPi Guanine PRPP H2O Guo Pi Pi Rib-1P PPi PRPP Pi D1P H2O Accumulation Xanthin NH3 ADP-Rib H2O AMP DRib-5P ATP AMP 5-PPRSA PPi Glu Gln H2O ATP Gly ADP Pi Glyadbt 10-FTHF THFA 5PPNFG ATP H2O ADP Pi FGAM CR 5-AnRbn CO2 ATP Asp ADP Pi SAICAR Fumarat AICAR 10-FTHF THFA FosbFca Imp H2O H2O PPi ATP XntylcA NH3 AMP PPi NAD H2O NADH NH3 NADP NADPH H2O Xanthos Pi Pi Rib-1P H2O Inosine Pi PPi PRPP Pi Accumulation Hyp Rib-1P PPi O2 H2O H2O2 NAD H2O Urate NADH D-Ino Pi D1P GTP Asp GDP Pi Asuca AMP H2O NH3 Fumarat Adenosi H2O NH3 Pi Adenine Rib-1P DA Pi D1P H2O NH3 PPi PRPP ADP H2O Pi ATP H2O Pi cAMP H2O PPi ATP dAMP ADP dADP H2O Pi ATP ADP doATP 23CGMP PPi H2O IDP H2O Pi Ino3P H2O PPi ATP ADP H2O Pi PPi 5Ai4Ca PRPP ATP ADP Pi H2O Pi H2O H2O Ca2+ Mg2+ Zinc Mg2+ Mg2+ Mg2+ K+ FAD FAD Mg2+ Zinc Zinc Zinc Ca2+ Mg2+ Mg2+ Mg2+ Heme Mg2+ Ca2+ Disulfi Ca2+ Mg2+ Disulfi PW000055 Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ Zinc Mg2+ Zinc Mg2+ Ca2+ Mg2+ Fe3+ Fe3+ Mg2+ Ca2+ Endoplasmic Reticulum Peroxisome Endoplasmic Reticulum Peroxisome Intracellular Space Extracellular Space Mitochondria Cytosol Mitochondria
NUDT2 NME6 ENTPD5 ENTPD8 GUK1 NME6 GUK1 NT5C2 DGUOK APRT NT5C2 PNP HPRT1 PNP GDA NUDT5 PRPS1L1 PPAT GART GART PFAS PAICS PAICS ADSL ATIC ATIC ITPA GMPS IMPDH1 GMPR NT5C2 PNP NT5C2 HPRT1 PNP HPRT1 XDH XDH PNP ADSS AMPD1 ADSL ADA PNP PNP ADA APRT ENTPD5 AK1 ATAD1 PDE4D ADCY10 AK1 NT5C2 NME6 GUCY1A2 GUCY1B3 PDE10A ENTPD8 ITPA NME6 ENTPD8 APRT GART TXN TXN RRM1 RRM2 ENTPD5 TXN TXN RRM1 RRM2 PRPP Guan2P4 H2O GTP GSMP ATP GDP ADP H2O GSMP Pi H2O Pi ATP ADP ATP dGDP ADP dGTP ATP dGMP ADP H2O doxyG Pi ATP ADP Ppi Guanine PRPP H2O Guo PhosfrA Pi Rib-1P Ppi PRPP Pi D1P H2O Accumulation Xanthin NH3 ADP-Rib H2O AMP DRib-5P ATP AMP 5-PPRSA Ppi Glu Gln H2O ATP Gly ADP Pi Glyadbt 10-FTHF THFA 5PPNFG ATP H2O ADP PhosfrA FGAM CR 5-AnRbn CO2 ATP Asp ADP PhosfrA SAICAR Fumarat AICAR 10-FTHF THFA FosbFca Imp H2O H2O Ppi ATP XntylcA NH3 AMP Ppi NAD H2O NADH NH3 NADP NADPH H2O Xanthos Pi Pi Rib-1P H2O Inosine Pi Ppi PRPP Pi Accumulation Hyp Rib-1P Ppi O2 H2O H2O2 NAD H2O Urate NADH D-Ino Pi D1P GTP Asp GDP Pi Asuca AMP H2O NH3 Fumarat Adenosi H2O NH3 Pi Adenine Rib-1P DA Pi D1P H2O NH3 Ppi PRPP ADP H2O PhosfrA ATP H2O PhosfrA cAMP H2O Ppi ATP dAMP ADP dADP H2O PhosfrA ATP ADP doATP 23CGMP Ppi H2O IDP H2O Pi Ino3P H2O Ppi ATP ADP H2O Pi Ppi 5Ai4Ca PRPP ATP ADP Pi H2O Pi H2O H2O PW000055